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<meta name="DC.Title" content="Correlation of Myo-inositol Levels and Grading of Cerebral Astrocytomas" />
<meta name="DC.Date" content="2000-10-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: In a limited number of patients, the level of myo -inositol (MI), as seen by proton magnetic resonance spectroscopy (HMRS), has been shown to differ for gliomas of different histologic grades. We sought to determine if MI levels correlate with cerebral astrocytoma grade.

METHODS: Five control subjects, 14 patients with low-grade astrocytoma, 10 patients with anaplastic astrocytoma, and 10 patients with glioblastoma multiforme (GBM) underwent single-volume HMRS with an echo time of 20 ms. Twenty-five patients had received surgery, chemotherapy, and/or radiation therapy previously. Using the curve-fitting program supplied by the manufacturer, peak areas for n -acetyl aspartate (NAA), choline (Cho), and MI were normalized with respect to the peak area of creatine (Cr). Ratios for MI/Cr, Cho/Cr, and NAA/Cr were obtained for each lesion and retrospectively compared with the histologic grade of the lesion.

RESULTS: Levels of MI/Cr were higher (0.82 ± 0.25) in patients with low-grade astrocytoma, intermediate (0.49 ± 0.07) in control subjects, and lower in patients with anaplastic astrocytoma (0.33 ± 0.16) and GBM (0.15 ± 0.12).

CONCLUSION: Our study shows a trend toward lower MI levels in the presence of anaplastic astrocytomas and GBMs compared with those of low-grade astrocytomas. MI levels may have implications in the grading of cerebral astrocytomas." />
<meta name="DC.Contributor" content="Mauricio Castillo" />
<meta name="DC.Contributor" content="J. Keith Smith" />
<meta name="DC.Contributor" content="Lester Kwock" />
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<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; In a limited number of patients, the level of &lt;i&gt;myo&lt;/i&gt;-inositol (MI), as seen by proton magnetic resonance spectroscopy (HMRS), has been shown to differ for gliomas of different histologic grades. We sought to determine if MI levels correlate with cerebral astrocytoma grade.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Five control subjects, 14 patients with low-grade astrocytoma, 10 patients with anaplastic astrocytoma, and 10 patients with glioblastoma multiforme (GBM) underwent single-volume HMRS with an echo time of 20 ms. Twenty-five patients had received surgery, chemotherapy, and/or radiation therapy previously. Using the curve-fitting program supplied by the manufacturer, peak areas for &lt;i&gt;n&lt;/i&gt;-acetyl aspartate (NAA), choline (Cho), and MI were normalized with respect to the peak area of creatine (Cr). Ratios for MI/Cr, Cho/Cr, and NAA/Cr were obtained for each lesion and retrospectively compared with the histologic grade of the lesion.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; Levels of MI/Cr were higher (0.82 ± 0.25) in patients with low-grade astrocytoma, intermediate (0.49 ± 0.07) in control subjects, and lower in patients with anaplastic astrocytoma (0.33 ± 0.16) and GBM (0.15 ± 0.12).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Our study shows a trend toward lower MI levels in the presence of anaplastic astrocytomas and GBMs compared with those of low-grade astrocytomas. MI levels may have implications in the grading of cerebral astrocytomas.&lt;/p&gt;" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: In a limited number of patients, the level of myo -inositol (MI), as seen by proton magnetic resonance spectroscopy (HMRS), has been shown to differ for gliomas of different histologic grades. We sought to determine if MI levels correlate with cerebral astrocytoma grade.

METHODS: Five control subjects, 14 patients with low-grade astrocytoma, 10 patients with anaplastic astrocytoma, and 10 patients with glioblastoma multiforme (GBM) underwent single-volume HMRS with an echo time of 20 ms. Twenty-five patients had received surgery, chemotherapy, and/or radiation therapy previously. Using the curve-fitting program supplied by the manufacturer, peak areas for n -acetyl aspartate (NAA), choline (Cho), and MI were normalized with respect to the peak area of creatine (Cr). Ratios for MI/Cr, Cho/Cr, and NAA/Cr were obtained for each lesion and retrospectively compared with the histologic grade of the lesion.

RESULTS: Levels of MI/Cr were higher (0.82 ± 0.25) in patients with low-grade astrocytoma, intermediate (0.49 ± 0.07) in control subjects, and lower in patients with anaplastic astrocytoma (0.33 ± 0.16) and GBM (0.15 ± 0.12).

CONCLUSION: Our study shows a trend toward lower MI levels in the presence of anaplastic astrocytomas and GBMs compared with those of low-grade astrocytomas. MI levels may have implications in the grading of cerebral astrocytomas." />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: In a limited number of patients, the level of myo -inositol (MI), as seen by proton magnetic resonance spectroscopy (HMRS), has been shown to differ for gliomas of different histologic grades. We sought to determine if MI levels correlate with cerebral astrocytoma grade.

METHODS: Five control subjects, 14 patients with low-grade astrocytoma, 10 patients with anaplastic astrocytoma, and 10 patients with glioblastoma multiforme (GBM) underwent single-volume HMRS with an echo time of 20 ms. Twenty-five patients had received surgery, chemotherapy, and/or radiation therapy previously. Using the curve-fitting program supplied by the manufacturer, peak areas for n -acetyl aspartate (NAA), choline (Cho), and MI were normalized with respect to the peak area of creatine (Cr). Ratios for MI/Cr, Cho/Cr, and NAA/Cr were obtained for each lesion and retrospectively compared with the histologic grade of the lesion.

RESULTS: Levels of MI/Cr were higher (0.82 ± 0.25) in patients with low-grade astrocytoma, intermediate (0.49 ± 0.07) in control subjects, and lower in patients with anaplastic astrocytoma (0.33 ± 0.16) and GBM (0.15 ± 0.12).

CONCLUSION: Our study shows a trend toward lower MI levels in the presence of anaplastic astrocytomas and GBMs compared with those of low-grade astrocytomas. MI levels may have implications in the grading of cerebral astrocytomas." />
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      <h1 class="highwire-cite-title" id="page-title">Correlation of <em>Myo</em>-inositol Levels and Grading of Cerebral Astrocytomas</h1>  
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<div id="hw-article-author-popups-top-node-2391--8440145071" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Mauricio Castillo </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Mauricio%2BCastillo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Castillo%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AMauricio%2BCastillo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J. Keith Smith </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BKeith%2BSmith%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Smith%20JK&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2BKeith%2BSmith%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Lester Kwock </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Lester%2BKwock%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kwock%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ALester%2BKwock%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Mauricio Castillo</span><a id="xref-fn-1-1" class="xref-fn" href="#fn-1"></a><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">J. Keith Smith</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a> and </li><li class="last" id="contrib-3"><span class="name">Lester Kwock</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Department of Radiology, University of North Carolina School of Medicine, Chapel Hill.</address></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/21/9/1645.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 21</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 2000 </div></div>
      
      
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