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<meta name="DC.Title" content="Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide 133Xe-SPECT in Occlusive Carotid Disease" />
<meta name="DC.Date" content="2001-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: We generated regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) studies from dynamic susceptibility contrast-enhanced MR images after an intravenous bolus injection of contrast agent (perfusion-weighted imaging [PWI]) by applying indicator dilution theory. We used a multishot echo-planar imaging (EPI) sequence to obtain adequate arterial input function (AIF). Our purpose was to compare the cerebral hemodynamics measured by PWI with the rCBF values and cerebral perfusion reserve obtained by xenon-133 single-photon emission CT (133Xe-SPECT).

METHODS: Eight patients with chronic internal carotid artery occlusion or stenosis were examined. PWI data were acquired using a multishot EPI sequence, and the AIF was determined automatically. Our procedure was based on indicator dilution theory and deconvolution analysis. To eliminate the effect of superficial vessels, the automatic threshold selection method was used.

RESULTS: AIF was adequate to generate rCBF and rCBV images. The rCBF and rCBV images by PWI were superior to 133Xe-SPECT scans in spatial resolution, and the rCBF values obtained by PWI correlated well with those obtained by 133Xe-SPECT. The regions with severely decreased perfusion reserve, which were determined by pre- and post-acetazolamide 133Xe-SPECT, showed significantly lower rCBF and higher rCBV by PWI than did regions with normal and moderately decreased perfusion reserve.

CONCLUSION: The rCBF and rCBV images generated by our procedure using PWI data appear to provide important clinical information for evaluating the degree of cerebral perfusion reserve impairment in patients with chronic ischemia." />
<meta name="DC.Contributor" content="Keiichi Kikuchi" />
<meta name="DC.Contributor" content="Kenya Murase" />
<meta name="DC.Contributor" content="Hitoshi Miki" />
<meta name="DC.Contributor" content="Takanori Kikuchi" />
<meta name="DC.Contributor" content="Yoshifumi Sugawara" />
<meta name="DC.Contributor" content="Teruhito Mochizuki" />
<meta name="DC.Contributor" content="Junpei Ikezoe" />
<meta name="DC.Contributor" content="Shiro Ohue" />
<meta name="article:published_time" content="2001-02-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide 133Xe-SPECT in Occlusive Carotid Disease" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; We generated regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) studies from dynamic susceptibility contrast-enhanced MR images after an intravenous bolus injection of contrast agent (perfusion-weighted imaging [PWI]) by applying indicator dilution theory. We used a multishot echo-planar imaging (EPI) sequence to obtain adequate arterial input function (AIF). Our purpose was to compare the cerebral hemodynamics measured by PWI with the rCBF values and cerebral perfusion reserve obtained by xenon-133 single-photon emission CT (&lt;sup&gt;133&lt;/sup&gt;Xe-SPECT).&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Eight patients with chronic internal carotid artery occlusion or stenosis were examined. PWI data were acquired using a multishot EPI sequence, and the AIF was determined automatically. Our procedure was based on indicator dilution theory and deconvolution analysis. To eliminate the effect of superficial vessels, the automatic threshold selection method was used.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; AIF was adequate to generate rCBF and rCBV images. The rCBF and rCBV images by PWI were superior to &lt;sup&gt;133&lt;/sup&gt;Xe-SPECT scans in spatial resolution, and the rCBF values obtained by PWI correlated well with those obtained by &lt;sup&gt;133&lt;/sup&gt;Xe-SPECT. The regions with severely decreased perfusion reserve, which were determined by pre- and post-acetazolamide &lt;sup&gt;133&lt;/sup&gt;Xe-SPECT, showed significantly lower rCBF and higher rCBV by PWI than did regions with normal and moderately decreased perfusion reserve.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; The rCBF and rCBV images generated by our procedure using PWI data appear to provide important clinical information for evaluating the degree of cerebral perfusion reserve impairment in patients with chronic ischemia.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="2001/02/01" />
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<meta name="citation_issn" content="0195-6108" />
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<meta name="citation_author" content="Keiichi Kikuchi" />
<meta name="citation_author" content="Kenya Murase" />
<meta name="citation_author" content="Hitoshi Miki" />
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<meta name="twitter:title" content="Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide 133Xe-SPECT in Occlusive Carotid Disease" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: We generated regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) studies from dynamic susceptibility contrast-enhanced MR images after an intravenous bolus injection of contrast agent (perfusion-weighted imaging [PWI]) by applying indicator dilution theory. We used a multishot echo-planar imaging (EPI) sequence to obtain adequate arterial input function (AIF). Our purpose was to compare the cerebral hemodynamics measured by PWI with the rCBF values and cerebral perfusion reserve obtained by xenon-133 single-photon emission CT (133Xe-SPECT).

METHODS: Eight patients with chronic internal carotid artery occlusion or stenosis were examined. PWI data were acquired using a multishot EPI sequence, and the AIF was determined automatically. Our procedure was based on indicator dilution theory and deconvolution analysis. To eliminate the effect of superficial vessels, the automatic threshold selection method was used.

RESULTS: AIF was adequate to generate rCBF and rCBV images. The rCBF and rCBV images by PWI were superior to 133Xe-SPECT scans in spatial resolution, and the rCBF values obtained by PWI correlated well with those obtained by 133Xe-SPECT. The regions with severely decreased perfusion reserve, which were determined by pre- and post-acetazolamide 133Xe-SPECT, showed significantly lower rCBF and higher rCBV by PWI than did regions with normal and moderately decreased perfusion reserve.

CONCLUSION: The rCBF and rCBV images generated by our procedure using PWI data appear to provide important clinical information for evaluating the degree of cerebral perfusion reserve impairment in patients with chronic ischemia." />
<meta name="og-title" property="og:title" content="Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide 133Xe-SPECT in Occlusive Carotid Disease" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: We generated regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) studies from dynamic susceptibility contrast-enhanced MR images after an intravenous bolus injection of contrast agent (perfusion-weighted imaging [PWI]) by applying indicator dilution theory. We used a multishot echo-planar imaging (EPI) sequence to obtain adequate arterial input function (AIF). Our purpose was to compare the cerebral hemodynamics measured by PWI with the rCBF values and cerebral perfusion reserve obtained by xenon-133 single-photon emission CT (133Xe-SPECT).

METHODS: Eight patients with chronic internal carotid artery occlusion or stenosis were examined. PWI data were acquired using a multishot EPI sequence, and the AIF was determined automatically. Our procedure was based on indicator dilution theory and deconvolution analysis. To eliminate the effect of superficial vessels, the automatic threshold selection method was used.

RESULTS: AIF was adequate to generate rCBF and rCBV images. The rCBF and rCBV images by PWI were superior to 133Xe-SPECT scans in spatial resolution, and the rCBF values obtained by PWI correlated well with those obtained by 133Xe-SPECT. The regions with severely decreased perfusion reserve, which were determined by pre- and post-acetazolamide 133Xe-SPECT, showed significantly lower rCBF and higher rCBV by PWI than did regions with normal and moderately decreased perfusion reserve.

CONCLUSION: The rCBF and rCBV images generated by our procedure using PWI data appear to provide important clinical information for evaluating the degree of cerebral perfusion reserve impairment in patients with chronic ischemia." />
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      <h1 class="highwire-cite-title" id="page-title">Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide <sup>133</sup>Xe-SPECT in Occlusive Carotid Disease</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Keiichi Kikuchi</span>, <span class="highwire-citation-author" data-delta="1">Kenya Murase</span>, <span class="highwire-citation-author" data-delta="2">Hitoshi Miki</span>, <span class="highwire-citation-author" data-delta="3">Takanori Kikuchi</span>, <span class="highwire-citation-author" data-delta="4">Yoshifumi Sugawara</span>, <span class="highwire-citation-author" data-delta="5">Teruhito Mochizuki</span>, <span class="highwire-citation-author" data-delta="6">Junpei Ikezoe</span> and <span class="highwire-citation-author" data-delta="7">Shiro Ohue</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2001,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">22 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">248-254; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11283--81314274183" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Keiichi Kikuchi </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Keiichi%2BKikuchi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kikuchi%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AKeiichi%2BKikuchi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Kenya Murase 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      <div class="highwire-cite-title">Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide <sup>133</sup>Xe-SPECT in Occlusive Carotid Disease</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Keiichi</span> <span class="nlm-surname">Kikuchi</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Kenya</span> <span class="nlm-surname">Murase</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Hitoshi</span> <span class="nlm-surname">Miki</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Takanori</span> <span class="nlm-surname">Kikuchi</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Yoshifumi</span> <span class="nlm-surname">Sugawara</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Teruhito</span> <span class="nlm-surname">Mochizuki</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Junpei</span> <span class="nlm-surname">Ikezoe</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Shiro</span> <span class="nlm-surname">Ohue</span></span></span></div>
  
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