Research ArticleBRAIN
Changes in Brain Morphology in Alzheimer Disease and Normal Aging: Is Alzheimer Disease an Exaggerated Aging Process?
Takashi Ohnishi, Hiroshi Matsuda, Takeshi Tabira, Takashi Asada and Masatake Uno
American Journal of Neuroradiology October 2001, 22 (9) 1680-1685;
Takashi Ohnishi
Hiroshi Matsuda
Takeshi Tabira
Takashi Asada

References
- ↵Morris JC, McKeel DW Jr, Storand M. Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology 1991;41:469-478
- Berg L, Hughes CP, Coben LA. Mild senile dementia of Alzheimer type: research diagnostic criteria, recruitment, and description of a study population. J Neurol Neurosurg Psychiatry 1982;45:962-968
- ↵Bartus RT, Dean RLI, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;217:408-414
- Brayne C, Calloway P. Normal ageing, impaired cognitive function and senile dementia of the Alzheimer's type: a continuum? Lancet 1988;1:1265-1267
- ↵Terry RD, Peck A, DeTeresa R. Some morphometric aspects of the brain in senile dementia of Alzheimer's type. Ann Neurol 1981;10:184-192
- Coleman PD, Flood DG. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 1987;8:521-545
- Bouras C, Hof PR, Morrison JH. Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathological changes. Neurosci Lett 1993;153:131-135
- Price JL. The relationship between tangle and plaque formation during healthy aging and mild dementia. Neurobiol Aging 1993;14:661-663
- Price JL, Davis PB, Morris JC, White DL. The distribution of tangle, plaque and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 1991;12:295-312
- Delaere P, Duyckaerts C, Masters C. Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci Lett 1990;166:87-93
- Arnold SE, Hyman BT, Flory J. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1991;1:103-116
- ↵Arriagada PV, Marzoloff K, Hyman BT. Distribution of Alzheimer-type pathological changes in nondemented elderly matches the pattern in Alzheimer's disease. Neurology 1992;42:1681-1688
- Morris JC, Fulling K. Early Alzheimer's disease: diagnostic consideration. Arch Neurol 1988;45:345-349
- Linn RT, Wolf PA, Bachman DL. The “preclinical phase” of probable Alzheimer's disease. Arch Neurol 1995;52:485-490
- ↵Gomez-Isla T, Price JL, McKeel DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 1996;16:4491-4500
- ↵Ashburner J, Friston KJ. Voxel-based morphometry: the methods. Neuroimage 2000;11:805-821
- ↵Kogure D, Matsuda H, Ohnishi T, et al. Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT. J Nucl Med 2000;41:1155-1162
- ↵Talairach J, Tournoux P. Co-planar Stereotactic Atlas of the Human Brain. Stuttgart, Germany: Thieme Verlag; 1988:
- Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62
- ↵Parkin AJ, Walter BM. Recollective experience, normal aging and frontal dysfunction. Psychol Aging 1992;7:340-345
- ↵Rabbitt PMA. An age decrement in the ability to ignore irrelevant information. J Gerontol 1965;20:233-238
- ↵McDowd JM, Oseas-Kreger DM. Aging, inhibitory processes and negative priming. J Gerontol 1991;46:340-345
- Haug H. Are neurons of the human cerebral cortex really lost during aging? A morphometric examination. In: Tarber J, Gispen WH, eds. Senile Dementia of Alzheimer Type. Berlin, Germany: Springer-Verlag; 1985; 150–163
- ↵Kemper TL. Neuroanatomical and neuropathological changes during aging and in dementia. In: Albert ML, Knoepfel EJE, eds. Clinical Neurology of Aging 2nd ed. New York, NY: Oxford University Press; 1994:3–67
- ↵Raz N, Gunning FM, Head D, et al. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 1997;7:268-282
- Heinsen H, Henn R, Eisenner W, et al. Quantitative investigation on human entorhinal cortex: left-right asymmetry and age-related changes. Anat Embryol 1994;190:181-194
- ↵Corbetta M, Meizin FM, Dobmeyer S, Shulman GL, Petersen SE. Selective and divided attention during visual discriminations of shape, color and speed: functional anatomy by positron emission tomography. J Neurosci 1991;11:2383-2402
- Pardo JV, Pardo PJ, Janer KW, Raichle ME. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci U S A 1990;87:256-259
- ↵Madden DJ, Plude DJ. Selective preservation of selective attention. In: Cerebella J, Rybash J, Hoyer W, Commons ML, eds. Adult Information Processing: Limits on Loss. San Diego, Calif: Academic Press; 1993;273–300
- MacDowd JM, Birren JE. Aging and attentional processes. In: Birren JE, Schaie KW, eds. Handbook of the Psychology of Aging 3 rd ed. San Diego, Calif: Academic Press; 1990;222–233
- ↵
- Rabbitt P. Age and discrimination between complex stimuli. In: Welford AT, Birren JE, eds. Behavior, Aging, and the Nervous System. Springfield, Ill: Charles C Thomas; 1965:35–53
- ↵Petit-Taboue MC, Landeau B, Desson JF, Desgranges B, Baron JC. Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping. Neuroimage 1998;7:176-184
- Martin AJ, Friston KJ, Colebatch JG, Frackowiak RS. Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab 1991;11:684-689
- ↵Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev 1996;22:229-244
- Mesulam MM, Mufson EJ. Neural inputs into the nucleus basalis of the substantia innominata (Ch4) in the rhesus monkey. Brain 1984;107:253-274
- ↵Foundas AL, Leonard CM, Mahoney SM, Agee OF, Heilman KM. Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study. Neuropsychiatr Neuropsychol Behav Neurol 1997;10:81-89
- ↵Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991;82:239-259
- Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 1995;16:271-278
- ↵Flood DG, Coleman PD. Neuron numbers and size in aging brain: comparison of human, monkey and rodent data. Neurobiol Aging 1988;9:453-463
- Raz N. Neuroanatomy of aging brain: evidence from structural MRI. In: Bigler ED, ed. Neuroimaging, II: Clinical Application New York, NY: Plenum Press; 1996:
- ↵West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 1994;344:769-772
- ↵Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. Age-related decline in MR volumes of temporal gray matter but not hippocampus. Neurobiol Aging 1995;16:591-606
- ↵Wickelgren I. The aging brain: for the cortex, neuron loss may be less than thought. Science 1996;273:48-50
- Becker JT. Working memory and secondary memory deficits in Alzheimer's disease. J Clin Exp Neuropsychol 1988;10:739-753
- Becker JT, Mintun MA, Diehl DJ. Functional neuroanatomy of verbal free recall: a replication study. Hum Brain Map 1994;1:284-292
- Deweer B, Lehericy S, Pillon B, Baulac M. Memory disorder in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI. J Neurol Neurosurg Psychiatry 1995;58:590-597
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Changes in Brain Morphology in Alzheimer Disease and Normal Aging: Is Alzheimer Disease an Exaggerated Aging Process?
Takashi Ohnishi, Hiroshi Matsuda, Takeshi Tabira, Takashi Asada, Masatake Uno
American Journal of Neuroradiology Oct 2001, 22 (9) 1680-1685;
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