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<meta name="DC.Title" content="Hydroxyapatite Ceramics As a Particulate Embolic Material: Report of the Clinical Experience" />
<meta name="DC.Date" content="2003-09-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Our newly developed biocompatible embolic materials, hydroxyapatite ceramic microparticles, have good visibility during injection control and were shown to be capable of producing effective occlusion of the distal arteriocapillary bed in an experimental animal study. The purpose of this present study was to evaluate hydroxyapatite ceramic microparticles for use in human meningioma embolization.

METHODS: Thirteen patients with meningiomas underwent preoperative superselective embolization with the use of hydroxyapatite microparticles. Radiologic and histopathologic studies of the surgical specimens were performed.

RESULTS: During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen.

CONCLUSION: Hydroxyapatite microparticles are excellent embolic materials for the treatment of human meningioma. They have excellent biocompatibility and good injection control, which produces occlusion of the distal arteriocapillary bed." />
<meta name="DC.Contributor" content="Michiya Kubo" />
<meta name="DC.Contributor" content="Naoya Kuwayama" />
<meta name="DC.Contributor" content="Yutaka Hirashima" />
<meta name="DC.Contributor" content="Akira Takaku" />
<meta name="DC.Contributor" content="Tetsuro Ogawa" />
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<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Our newly developed biocompatible embolic materials, hydroxyapatite ceramic microparticles, have good visibility during injection control and were shown to be capable of producing effective occlusion of the distal arteriocapillary bed in an experimental animal study. The purpose of this present study was to evaluate hydroxyapatite ceramic microparticles for use in human meningioma embolization.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Thirteen patients with meningiomas underwent preoperative superselective embolization with the use of hydroxyapatite microparticles. Radiologic and histopathologic studies of the surgical specimens were performed.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Hydroxyapatite microparticles are excellent embolic materials for the treatment of human meningioma. They have excellent biocompatibility and good injection control, which produces occlusion of the distal arteriocapillary bed.&lt;/p&gt;" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Our newly developed biocompatible embolic materials, hydroxyapatite ceramic microparticles, have good visibility during injection control and were shown to be capable of producing effective occlusion of the distal arteriocapillary bed in an experimental animal study. The purpose of this present study was to evaluate hydroxyapatite ceramic microparticles for use in human meningioma embolization.

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RESULTS: During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen.

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METHODS: Thirteen patients with meningiomas underwent preoperative superselective embolization with the use of hydroxyapatite microparticles. Radiologic and histopathologic studies of the surgical specimens were performed.

RESULTS: During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen.

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      <h1 class="highwire-cite-title" id="page-title">Hydroxyapatite Ceramics As a Particulate Embolic Material: Report of the Clinical Experience</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Michiya Kubo</span>, <span class="highwire-citation-author" data-delta="1">Naoya Kuwayama</span>, <span class="highwire-citation-author" data-delta="2">Yutaka Hirashima</span>, <span class="highwire-citation-author" data-delta="3">Akira Takaku</span>, <span class="highwire-citation-author" data-delta="4">Tetsuro Ogawa</span> and <span class="highwire-citation-author" data-delta="5">Shunro Endo</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2003,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1545-1547; </span></div>
  
  
  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Michiya Kubo</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">Naoya Kuwayama</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">Yutaka Hirashima</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">Akira Takaku</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-5"><span class="name">Tetsuro Ogawa</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a> and </li><li class="last" id="contrib-6"><span class="name">Shunro Endo</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama, Japan</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>New Ceramics Division, Life Care Business Headquarters, PENTAX Corporation, Tokyo, Japan</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Address reprint requests to Michiya Kubo, MD, Department of Neurosurgery, Toyama Medical &amp; Pharmaceutical University, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan</li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/24/8/1545.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 24</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 8 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2003 </div></div>
      
      
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      <div class="highwire-cite-title">Hydroxyapatite Ceramics As a Particulate Embolic Material: Report of the Clinical Experience</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Michiya</span> <span class="nlm-surname">Kubo</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Naoya</span> <span class="nlm-surname">Kuwayama</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Yutaka</span> <span class="nlm-surname">Hirashima</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Akira</span> <span class="nlm-surname">Takaku</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Tetsuro</span> <span class="nlm-surname">Ogawa</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Shunro</span> <span class="nlm-surname">Endo</span></span></span></div>
  
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      <div class="highwire-cite-title">Hydroxyapatite Ceramics As a Particulate Embolic Material: Report of the Clinical Experience</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Michiya</span> <span class="nlm-surname">Kubo</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Naoya</span> <span class="nlm-surname">Kuwayama</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Yutaka</span> <span class="nlm-surname">Hirashima</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Akira</span> <span class="nlm-surname">Takaku</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Tetsuro</span> <span class="nlm-surname">Ogawa</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Shunro</span> <span class="nlm-surname">Endo</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2003, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1545-1547; </span></div>
  
  
  
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