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<meta name="DC.Description" content="Summary: We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion. We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate." />
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<meta name="DC.Contributor" content="Somasundaram Jayabose" />
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<meta name="citation_author" content="Claudio Sandoval" />
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      <h1 class="highwire-cite-title" id="page-title">Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Claudio Sandoval</span>, <span class="highwire-citation-author" data-delta="1">Martin Kutscher</span>, <span class="highwire-citation-author" data-delta="2">Somasundaram Jayabose</span> and <span class="highwire-citation-author" data-delta="3">Michael Tenner</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2003,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1887-1890; </span></div>
  
  
  
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      <div class="highwire-cite-title">Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Claudio</span> <span class="nlm-surname">Sandoval</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Martin</span> <span class="nlm-surname">Kutscher</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Somasundaram</span> <span class="nlm-surname">Jayabose</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Michael</span> <span class="nlm-surname">Tenner</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2003, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1887-1890; </span></div>
  
  
  
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