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<meta name="DC.Title" content="Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation" />
<meta name="DC.Date" content="2004-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Transplantation conditioning regimens have been shown to affect the brain imaging appearance in patients with cyclosporine or FK-506 neurotoxicity. We assessed whether the occurrence of neurotoxicity was affected by the choice of conditioning regimen used before allogeneic bone marrow transplantation (allo-BMT).

METHODS: An allo-BMT was performed in 290 patients conditioned before transplantation with myeloablative therapy. Neurotoxicity from cyclosporine or FK-506 developed in 21 (7.2%) of these patients, as confirmed with CT or MR imaging. Two hundred seventy-four (94%) of these 290 patients were conditioned with minor variations of one of five fundamental regimens: cyclophosphamide (Cy)/busulfan (n = 97), Cy/total body irradiation (TBI) (n = 122), Cy/thiotepa/TBI (n = 40), bischloroethylnitrosourea/etoposide/cytarabine/melphalan, or BEAM (n = 10), and Cy/thiotepa/busulfan (n = 5). The remaining 16 patients were prepared with variable regimens. The rates of occurrence of cyclosporine or FK-506 neurotoxicity relative to these conditioning regimens were compared.

RESULTS: The lowest rate of cyclosporine or FK-506 neurotoxicity was found in those patients conditioned with Cy (2 days)/busulfan (4 days) (5.1%) or Cy (2 days)/TBI (4 days) (5.9%). Rate of neurotoxicity increased with lengthier conditioning regimens. A high rate of neurotoxicity was present in those patients conditioned with Cy (4 days)/TBI (4 days) (13.7%), and this was statistically significant ( P &lt; .05) when compared with Cy (2 days)/busulfan (4 days).

CONCLUSION: The rate of occurrence of cyclosporine or FK-506 neurotoxicity varies with the conditioning regimen used, with lengthier regimens associated with a higher rate of neurotoxicity. As the length of the conditioning regimen equates to the total dose of chemotherapy administered, it suggests that the intensity of the regimen is correlated to the predisposition to neurotoxicity from cyclosporine or FK-506." />
<meta name="DC.Contributor" content="Walter S. Bartynski" />
<meta name="DC.Contributor" content="Zella R. Zeigler" />
<meta name="DC.Contributor" content="Richard K. Shadduck" />
<meta name="DC.Contributor" content="John Lister" />
<meta name="article:published_time" content="2004-02-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Transplantation conditioning regimens have been shown to affect the brain imaging appearance in patients with cyclosporine or FK-506 neurotoxicity. We assessed whether the occurrence of neurotoxicity was affected by the choice of conditioning regimen used before allogeneic bone marrow transplantation (allo-BMT).&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; An allo-BMT was performed in 290 patients conditioned before transplantation with myeloablative therapy. Neurotoxicity from cyclosporine or FK-506 developed in 21 (7.2%) of these patients, as confirmed with CT or MR imaging. Two hundred seventy-four (94%) of these 290 patients were conditioned with minor variations of one of five fundamental regimens: cyclophosphamide (Cy)/busulfan (n = 97), Cy/total body irradiation (TBI) (n = 122), Cy/thiotepa/TBI (n = 40), bischloroethylnitrosourea/etoposide/cytarabine/melphalan, or BEAM (n = 10), and Cy/thiotepa/busulfan (n = 5). The remaining 16 patients were prepared with variable regimens. The rates of occurrence of cyclosporine or FK-506 neurotoxicity relative to these conditioning regimens were compared.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The lowest rate of cyclosporine or FK-506 neurotoxicity was found in those patients conditioned with Cy (2 days)/busulfan (4 days) (5.1%) or Cy (2 days)/TBI (4 days) (5.9%). Rate of neurotoxicity increased with lengthier conditioning regimens. A high rate of neurotoxicity was present in those patients conditioned with Cy (4 days)/TBI (4 days) (13.7%), and this was statistically significant (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05) when compared with Cy (2 days)/busulfan (4 days).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; The rate of occurrence of cyclosporine or FK-506 neurotoxicity varies with the conditioning regimen used, with lengthier regimens associated with a higher rate of neurotoxicity. As the length of the conditioning regimen equates to the total dose of chemotherapy administered, it suggests that the intensity of the regimen is correlated to the predisposition to neurotoxicity from cyclosporine or FK-506.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_title=Complex Visual Hallucinations and Cyclosporine;citation_pages=329-330;citation_volume=41;citation_year=1984;citation_issue=3;citation_issn=0003-9942;citation_pmid=6582812;citation_doi=10.1001/archneur.1984.04050150111026" />
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<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Reversible Posterior Leukoencephalopathy Syndrome: Evaluation with Diffusion-Tensor MR Imaging;citation_pages=756-765;citation_volume=219;citation_year=2001;citation_issue=3;citation_issn=0033-8419;citation_pmid=11376265;citation_doi=10.1148/radiology.219.3.r01jn48756" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Posterior Reversible Encephalopathy Syndrome: Prognostic Utility of Quantitative Diffusion-Weighted MR Images;citation_pages=1038-1048;citation_volume=23;citation_year=2002;citation_issue=6;citation_issn=0195-6108;citation_pmid=12063238" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Posterior leukoencephalopathy without severe hypertension: Utility of diffusion-weighted MRI;citation_pages=1369-1376;citation_volume=51;citation_year=1998;citation_issue=5;citation_issn=0028-3878;citation_pmid=9818862" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome;citation_pages=415-417;citation_volume=19;citation_year=1998;citation_issue=3;citation_issn=0195-6108;citation_pmid=9541291" />
<meta name="citation_reference" content="citation_title=Diagnostic Neuroradiology;citation_pages=764;citation_year=1994" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Etiology of Cortical and White Matter Lesions in Cyclosporin-A and FK-506 Neurotoxicity;citation_pages=1901-1914;citation_volume=22;citation_year=2001;citation_issue=10;citation_issn=0195-6108;citation_pmid=11733324" />
<meta name="citation_reference" content="citation_title=Bone marrow transplantation;citation_journal_abbrev=Bone Marrow Transplant;citation_title=Bone marrow transplant-associated thrombotic microangiopathy: a case series.;citation_pages=247-253;citation_volume=15;citation_year=1995;citation_issue=2;citation_pmid=7773214" />
<meta name="citation_reference" content="citation_title=Journal of clinical apheresis;citation_journal_abbrev=J Clin Apheresis;citation_title=Plasma exchange and vincristine in the treatment of hemolytic uremic syndrome/thrombotic thrombocytopenic purpura associated with bone marrow transplantation.;citation_pages=16-20;citation_volume=6;citation_year=1991;citation_issue=1;citation_pmid=2045377;citation_doi=10.1002/jca.2920060104" />
<meta name="citation_reference" content="citation_title=Bone marrow transplantation;citation_journal_abbrev=Bone Marrow Transplant;citation_title=Haemolytic uraemic syndrome and renal dysfunction following BEAC (BCNU, etoposide, ara-C, cyclophosphamide) +/- TBI and autologous BMT for malignant lymphomas.;citation_pages=205-208;citation_volume=11;citation_year=1993;citation_issue=3;citation_pmid=8467284" />
<meta name="citation_reference" content="citation_title=Transplantation;citation_journal_abbrev=Transplantation;citation_title=Venoocclusive disease of the liver following bone marrow transplantation.;citation_pages=778-783;citation_volume=44;citation_year=1987;citation_issue=6;citation_pmid=3321587" />
<meta name="citation_reference" content="citation_title=Transplantation proceedings;citation_journal_abbrev=Transplant Proc;citation_title=Current status of FK 506 in liver transplantation.;citation_pages=1902-1905;citation_volume=23;citation_year=1991;citation_issue=3;citation_pmid=1712133" />
<meta name="citation_reference" content="citation_title=Cancer Principles &amp; Practice of Oncology;citation_pages=363;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Cancer Principles &amp; Practice of Oncology;citation_pages=376;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Cancer Principles &amp; Practice of Oncology;citation_pages=388;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Cancer Principles &amp; Practice of Oncology;citation_pages=415;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Cancer Principles &amp; Practice of Oncology;citation_pages=335;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Cancer Principles &amp; Practice of Oncology;citation_pages=265;citation_year=2001" />
<meta name="citation_reference" content="citation_title=American journal of hematology;citation_journal_abbrev=Am J Hematol;citation_title=Plasma von Willebrand Factor Antigen (vWF:AG) and thrombomodulin (TM) levels in Adult Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM).;citation_pages=213-220;citation_volume=53;citation_year=1996;citation_issue=4;citation_pmid=8948657;citation_doi=10.1002/(SICI)1096-8652(199612)53:4&lt;213::AID-AJH1&gt;3.0.CO;2-0" />
<meta name="citation_reference" content="citation_title=American Journal of Clinical Pathology;citation_journal_abbrev=Am J Clin Pathol;citation_title=The complexity of endothelial cells. A review.;citation_pages=241-250;citation_volume=92;citation_year=1989;citation_issue=2;citation_issn=0002-9173;citation_pmid=2667329" />
<meta name="citation_reference" content="citation_title=Atherosclerosis;citation_journal_abbrev=Atherosclerosis;citation_title=Mitosis patterns in aortic endothelium.;citation_pages=93-100;citation_volume=15;citation_year=1972;citation_issue=1;citation_pmid=5013281;citation_doi=10.1016/0021-9150(72)90042-1" />
<meta name="citation_reference" content="citation_title=Laboratory investigation; a journal of technical methods and pathology;citation_journal_abbrev=Lab Invest;citation_title=Cell replication in the aortic endothelium: a new method for study of the problem;citation_pages=699-707;citation_volume=28;citation_year=1973;citation_issue=6;citation_pmid=4576806" />
<meta name="citation_reference" content="citation_title=Circulation Research;citation_journal_abbrev=Circ. Res.;citation_title=Aortic endothelial cell replication. I. Effects of age and hypertension in the rat;citation_pages=248-255;citation_volume=41;citation_year=1977;citation_issue=2;citation_issn=0009-7330;citation_pmid=872300;citation_doi=10.1161/01.RES.41.2.248" />
<meta name="citation_reference" content="citation_title=Proc Soc Exp Mol Biol Med;citation_pages=1197;citation_volume=125;citation_year=1967" />
<meta name="citation_reference" content="citation_title=Cancer Research;citation_journal_abbrev=Cancer Res.;citation_title=The Proliferation of Capillary Endothelial Cells;citation_pages=77-82;citation_volume=32;citation_year=1972;citation_issue=1;citation_issn=0008-5472;citation_pmid=5007690" />
<meta name="citation_reference" content="citation_title=Endothelial Cells;citation_pages=13;citation_year=1988" />
<meta name="citation_reference" content="citation_title=Endothelial Cell Biology in Health Disease;citation_pages=123;citation_year=1988" />
<meta name="citation_reference" content="citation_title=PNAS;citation_journal_abbrev=Proc. Natl. Acad. Sci. USA;citation_title=Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.;citation_pages=2114-2117;citation_volume=83;citation_year=1986;citation_issue=7;citation_issn=0027-8424;citation_pmid=3457378;citation_doi=10.1073/pnas.83.7.2114" />
<meta name="citation_reference" content="citation_title=British Journal of Radiology;citation_journal_abbrev=Br. J. Radiol.;citation_title=Radiosensitivity of capillary endothelium;citation_pages=54-57;citation_volume=46;citation_year=1973;citation_issue=541;citation_issn=0007-1285;citation_pmid=4683331;citation_doi=10.1259/0007-1285-46-541-54" />
<meta name="citation_reference" content="citation_title=International journal of radiation oncology, biology, physics;citation_journal_abbrev=Int J Radiat Oncol Biol Phys;citation_title=Radiation sensitivity of cultured rabbit aortic endothelial cells.;citation_pages=1903-1906;citation_volume=10;citation_year=1984;citation_issue=10;citation_pmid=6490420" />
<meta name="citation_reference" content="citation_title=British Journal of Radiology;citation_journal_abbrev=Br. J. Radiol.;citation_title=Radiation response of endothelial cells in vitro;citation_pages=913-914;citation_volume=58;citation_year=1985;citation_issue=693;citation_issn=0007-1285;citation_pmid=3842295;citation_doi=10.1259/0007-1285-58-693-913" />
<meta name="citation_reference" content="citation_title=Radiation research;citation_journal_abbrev=Radiat Res;citation_title=The clonogenic response of bovine aortic endothelial cells in culture to radiation.;citation_pages=182-189;citation_volume=106;citation_year=1986;citation_issue=2;citation_pmid=3704110;citation_doi=10.2307/3576792" />
<meta name="citation_reference" content="citation_title=American Journal Of Pathology;citation_journal_abbrev=Am. J. Pathol.;citation_title=Experimental radiation-induced heart disease. I. Light microscopic studies;citation_pages=299-316;citation_volume=59;citation_year=1970;citation_issue=2;citation_issn=0002-9440;citation_pmid=5443637" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=An Ultrastructural Study of the Development of Radiation Injury in the Lung;citation_pages=49-54;citation_volume=87;citation_year=1966;citation_issue=1;citation_issn=0033-8419;citation_pmid=5940475;citation_doi=10.1148/87.1.49" />
<meta name="citation_reference" content="citation_title=International journal of radiation oncology, biology, physics;citation_journal_abbrev=Int J Radiat Oncol Biol Phys;citation_title=Therapeutic irradiation and brain injury.;citation_pages=1215-1228;citation_volume=6;citation_year=1980;citation_issue=9;citation_pmid=7007303;citation_doi=10.1016/0360-3016(80)90175-3" />
<meta name="citation_reference" content="citation_title=Principles and Practice of Radiation Oncology,;citation_pages=143;citation_year=1977" />
<meta name="citation_reference" content="citation_title=Therapy of Malignant Brain Tumors.;citation_pages=250;citation_year=1987" />
<meta name="citation_reference" content="citation_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_title=Reversible cerebral lesions associated with tiazofurin usage: MR demonstration.;citation_pages=1078-1081;citation_volume=12;citation_year=1988;citation_issue=6;citation_pmid=3183120" />
<meta name="citation_reference" content="citation_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_title=Cortical blindness during chemotherapy: clinical, CT, and MR correlations.;citation_pages=262-266;citation_volume=14;citation_year=1990;citation_issue=2;citation_pmid=2312856" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=High-dose cytarabine neurotoxicity: MR findings during the acute phase.;citation_pages=1014-1016;citation_volume=14;citation_year=1993;citation_issue=4;citation_issn=0195-6108;citation_pmid=8352140" />
<meta name="citation_reference" content="citation_title=Transplantation proceedings;citation_journal_abbrev=Transplant Proc;citation_title=Histopathology of cyclosporine nephrotoxicity.;citation_pages=759-771;citation_volume=20;citation_year=1988;citation_issue=3 Suppl 3;citation_pmid=3291311" />
<meta name="citation_reference" content="citation_title=American journal of kidney diseases :  the official journal of the National Kidney Foundation;citation_journal_abbrev=Am J Kidney Dis;citation_title=Renal vascular and thrombotic effects of cyclosporine;citation_pages=261-272;citation_volume=13;citation_year=1989;citation_issue=4;citation_pmid=2650537" />
<meta name="citation_reference" content="citation_title=Kidney international;citation_journal_abbrev=Kidney Int;citation_title=Role of endothelin in cyclosporine-induced glomerular dysfunction.;citation_pages=1487-1491;citation_volume=37;citation_year=1990;citation_issue=6;citation_pmid=2194067" />
<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Endothelial cell function: biologic and physiologic functions in health and disease;citation_pages=7-13;citation_volume=166;citation_year=1996;citation_issue=1;citation_issn=0361-803X;citation_pmid=8571908" />
<meta name="citation_reference" content="citation_title=Human pathology;citation_journal_abbrev=Hum Pathol;citation_title=Cell biology of endothelial cells.;citation_pages=234-239;citation_volume=18;citation_year=1987;citation_issue=3;citation_pmid=3546072" />
<meta name="citation_reference" content="citation_title=Annals of surgery;citation_journal_abbrev=Ann Surg;citation_title=The vascular endothelium. A new horizon.;citation_pages=593-609;citation_volume=218;citation_year=1993;citation_issue=5;citation_pmid=8239773" />
<meta name="citation_reference" content="citation_title=Nature; Physical Science (London);citation_journal_abbrev=Nature; Physical Science (London);citation_title=Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.;citation_pages=843-845;citation_volume=359;citation_year=1992;citation_issue=6398;citation_pmid=1279431;citation_doi=10.1038/359843a0" />
<meta name="citation_reference" content="citation_title=Journal of Biological Chemistry;citation_journal_abbrev=J Biol Chem;citation_title=Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia;citation_pages=13333-13340;citation_volume=270;citation_year=1995;citation_issue=22;citation_issn=0021-9258;citation_pmid=7768934;citation_doi=10.1074/jbc.270.22.13333" />
<meta name="citation_reference" content="citation_title=Journal of Biological Chemistry;citation_journal_abbrev=J Biol Chem;citation_title=Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins;citation_pages=15099-15103;citation_volume=273;citation_year=1998;citation_issue=24;citation_issn=0021-9258;citation_pmid=9614120;citation_doi=10.1074/jbc.273.24.15099" />
<meta name="citation_reference" content="citation_title=Brain;citation_journal_abbrev=Brain;citation_title=Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain;citation_pages=2549-2557;citation_volume=125;citation_year=2002;citation_issue=11;citation_issn=0006-8950;citation_pmid=12390979;citation_doi=10.1093/brain/awf257" />
<meta name="citation_reference" content="citation_title=Journal of Applied Physiology;citation_journal_abbrev=J. Appl. Physiol.;citation_title=Expression of hypoxia-inducible factor-1alpha  in the brain of rats during chronic hypoxia;citation_pages=1937-1942;citation_volume=89;citation_year=2000;citation_issue=5;citation_issn=0021-8987;citation_pmid=11053346" />
<meta name="citation_reference" content="citation_title=Brain research;citation_journal_abbrev=Brain Res;citation_title=Rapid increase in blood-brain barrier permeability during severe hypoxia and metabolic inhibition.;citation_pages=24-29;citation_volume=368;citation_year=1986;citation_issue=1;citation_pmid=3485464;citation_doi=10.1016/0006-8993(86)91038-3" />
<meta name="twitter:title" content="Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Transplantation conditioning regimens have been shown to affect the brain imaging appearance in patients with cyclosporine or FK-506 neurotoxicity. We assessed whether the occurrence of neurotoxicity was affected by the choice of conditioning regimen used before allogeneic bone marrow transplantation (allo-BMT).

METHODS: An allo-BMT was performed in 290 patients conditioned before transplantation with myeloablative therapy. Neurotoxicity from cyclosporine or FK-506 developed in 21 (7.2%) of these patients, as confirmed with CT or MR imaging. Two hundred seventy-four (94%) of these 290 patients were conditioned with minor variations of one of five fundamental regimens: cyclophosphamide (Cy)/busulfan (n = 97), Cy/total body irradiation (TBI) (n = 122), Cy/thiotepa/TBI (n = 40), bischloroethylnitrosourea/etoposide/cytarabine/melphalan, or BEAM (n = 10), and Cy/thiotepa/busulfan (n = 5). The remaining 16 patients were prepared with variable regimens. The rates of occurrence of cyclosporine or FK-506 neurotoxicity relative to these conditioning regimens were compared.

RESULTS: The lowest rate of cyclosporine or FK-506 neurotoxicity was found in those patients conditioned with Cy (2 days)/busulfan (4 days) (5.1%) or Cy (2 days)/TBI (4 days) (5.9%). Rate of neurotoxicity increased with lengthier conditioning regimens. A high rate of neurotoxicity was present in those patients conditioned with Cy (4 days)/TBI (4 days) (13.7%), and this was statistically significant ( P &lt; .05) when compared with Cy (2 days)/busulfan (4 days).

CONCLUSION: The rate of occurrence of cyclosporine or FK-506 neurotoxicity varies with the conditioning regimen used, with lengthier regimens associated with a higher rate of neurotoxicity. As the length of the conditioning regimen equates to the total dose of chemotherapy administered, it suggests that the intensity of the regimen is correlated to the predisposition to neurotoxicity from cyclosporine or FK-506." />
<meta name="og-title" property="og:title" content="Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/25/2/261" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Transplantation conditioning regimens have been shown to affect the brain imaging appearance in patients with cyclosporine or FK-506 neurotoxicity. We assessed whether the occurrence of neurotoxicity was affected by the choice of conditioning regimen used before allogeneic bone marrow transplantation (allo-BMT).

METHODS: An allo-BMT was performed in 290 patients conditioned before transplantation with myeloablative therapy. Neurotoxicity from cyclosporine or FK-506 developed in 21 (7.2%) of these patients, as confirmed with CT or MR imaging. Two hundred seventy-four (94%) of these 290 patients were conditioned with minor variations of one of five fundamental regimens: cyclophosphamide (Cy)/busulfan (n = 97), Cy/total body irradiation (TBI) (n = 122), Cy/thiotepa/TBI (n = 40), bischloroethylnitrosourea/etoposide/cytarabine/melphalan, or BEAM (n = 10), and Cy/thiotepa/busulfan (n = 5). The remaining 16 patients were prepared with variable regimens. The rates of occurrence of cyclosporine or FK-506 neurotoxicity relative to these conditioning regimens were compared.

RESULTS: The lowest rate of cyclosporine or FK-506 neurotoxicity was found in those patients conditioned with Cy (2 days)/busulfan (4 days) (5.1%) or Cy (2 days)/TBI (4 days) (5.9%). Rate of neurotoxicity increased with lengthier conditioning regimens. A high rate of neurotoxicity was present in those patients conditioned with Cy (4 days)/TBI (4 days) (13.7%), and this was statistically significant ( P &lt; .05) when compared with Cy (2 days)/busulfan (4 days).

CONCLUSION: The rate of occurrence of cyclosporine or FK-506 neurotoxicity varies with the conditioning regimen used, with lengthier regimens associated with a higher rate of neurotoxicity. As the length of the conditioning regimen equates to the total dose of chemotherapy administered, it suggests that the intensity of the regimen is correlated to the predisposition to neurotoxicity from cyclosporine or FK-506." />
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      <h1 class="highwire-cite-title" id="page-title">Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2004,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">25 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">261-269; </span></div>
  
  
  
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