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<meta name="DC.Title" content="Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease" />
<meta name="DC.Date" content="2004-08-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: There may be some differences in the pathophysiology between men and women with Alzheimer disease (AD). This study was undertaken to explore the possible influence of sex on regional cerebral blood flow (rCBF) patterns in patients with AD.

METHODS: Single photon emission CT (SPECT) was performed in 30 men and 30 women with AD, and the SPECT data were analyzed by using 3D stereotactic surface projections.

RESULTS: There were no significant differences in age, duration of disease, years of education, cognitive deficits and patterns, and MR imaging findings (grade of brain atrophy and extent of white matter hyperintensity lesions) between the two groups. Both male and female patient groups showed decreased rCBF patterns in the parietotemporal lobe, posterior cingulate cortex, and precuneus, which are considered to be the characteristic SPECT findings of AD. There were, however, some differences in rCBF patterns: men had a more severe decrease of rCBF in the parietal and posterior cingulate cortex, whereas women had a more severe decrease of rCBF in the medial temporal region and frontal lobe.

CONCLUSION: These data provide evidence that patterns of rCBF deficits differ between the sexes, a finding that supports the concept of heterogeneity of the underlying pathophysiology of AD." />
<meta name="DC.Contributor" content="Haruo Hanyu" />
<meta name="DC.Contributor" content="Soichiro Shimizu" />
<meta name="DC.Contributor" content="Yuriko Tanaka" />
<meta name="DC.Contributor" content="Masaru Takasaki" />
<meta name="DC.Contributor" content="Kiyoshi Koizumi" />
<meta name="DC.Contributor" content="Kimihiko Abe" />
<meta name="article:published_time" content="2004-08-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; There may be some differences in the pathophysiology between men and women with Alzheimer disease (AD). This study was undertaken to explore the possible influence of sex on regional cerebral blood flow (rCBF) patterns in patients with AD.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Single photon emission CT (SPECT) was performed in 30 men and 30 women with AD, and the SPECT data were analyzed by using 3D stereotactic surface projections.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; There were no significant differences in age, duration of disease, years of education, cognitive deficits and patterns, and MR imaging findings (grade of brain atrophy and extent of white matter hyperintensity lesions) between the two groups. Both male and female patient groups showed decreased rCBF patterns in the parietotemporal lobe, posterior cingulate cortex, and precuneus, which are considered to be the characteristic SPECT findings of AD. There were, however, some differences in rCBF patterns: men had a more severe decrease of rCBF in the parietal and posterior cingulate cortex, whereas women had a more severe decrease of rCBF in the medial temporal region and frontal lobe.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; These data provide evidence that patterns of rCBF deficits differ between the sexes, a finding that supports the concept of heterogeneity of the underlying pathophysiology of AD.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="2004/08/01" />
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<meta name="citation_author" content="Haruo Hanyu" />
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<meta name="twitter:title" content="Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: There may be some differences in the pathophysiology between men and women with Alzheimer disease (AD). This study was undertaken to explore the possible influence of sex on regional cerebral blood flow (rCBF) patterns in patients with AD.

METHODS: Single photon emission CT (SPECT) was performed in 30 men and 30 women with AD, and the SPECT data were analyzed by using 3D stereotactic surface projections.

RESULTS: There were no significant differences in age, duration of disease, years of education, cognitive deficits and patterns, and MR imaging findings (grade of brain atrophy and extent of white matter hyperintensity lesions) between the two groups. Both male and female patient groups showed decreased rCBF patterns in the parietotemporal lobe, posterior cingulate cortex, and precuneus, which are considered to be the characteristic SPECT findings of AD. There were, however, some differences in rCBF patterns: men had a more severe decrease of rCBF in the parietal and posterior cingulate cortex, whereas women had a more severe decrease of rCBF in the medial temporal region and frontal lobe.

CONCLUSION: These data provide evidence that patterns of rCBF deficits differ between the sexes, a finding that supports the concept of heterogeneity of the underlying pathophysiology of AD." />
<meta name="og-title" property="og:title" content="Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: There may be some differences in the pathophysiology between men and women with Alzheimer disease (AD). This study was undertaken to explore the possible influence of sex on regional cerebral blood flow (rCBF) patterns in patients with AD.

METHODS: Single photon emission CT (SPECT) was performed in 30 men and 30 women with AD, and the SPECT data were analyzed by using 3D stereotactic surface projections.

RESULTS: There were no significant differences in age, duration of disease, years of education, cognitive deficits and patterns, and MR imaging findings (grade of brain atrophy and extent of white matter hyperintensity lesions) between the two groups. Both male and female patient groups showed decreased rCBF patterns in the parietotemporal lobe, posterior cingulate cortex, and precuneus, which are considered to be the characteristic SPECT findings of AD. There were, however, some differences in rCBF patterns: men had a more severe decrease of rCBF in the parietal and posterior cingulate cortex, whereas women had a more severe decrease of rCBF in the medial temporal region and frontal lobe.

CONCLUSION: These data provide evidence that patterns of rCBF deficits differ between the sexes, a finding that supports the concept of heterogeneity of the underlying pathophysiology of AD." />
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      <h1 class="highwire-cite-title" id="page-title">Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2004,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">25 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1199-1204; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 25</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Aug 2004 </div></div>
      
      
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