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<meta name="DC.Title" content="Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis" />
<meta name="DC.Date" content="2005-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: In the early stage of Multiple Sclerosis (MS), conventional MR imaging parameters such as T2 lesion load fail to explain the clinical status of patients. In the present work, we aimed to determine the ability of magnification transfer imaging to better reflect the relationship between local tissue damage and functional status of MS patients.

METHODS: We performed a comparative statistical mapping analysis on brain tissue magnetization transfer ratio (MTR) data measured in 18 patients with clinically isolated syndrome suggestive of MS (CISSMS) and 18 matched control subjects.

RESULTS: In the patients with CISSMS, a pattern of significant low MTR values was observed in the white matter, corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right superior longitudinal fasciculus (SLF), right inferior longitudinal fasciculus, optica radiata, parietal white matter, right cingulum, gray matter, bilateral thalamus, bilateral caudate, right insula, and left Brodmann area (BA) 8. No correlation was found between local MTR decrease and Expanded Disability Status Scale score. Significant correlations between MTR and MS Functional Composite scores (Spearman rank test, P &lt; .05) were observed in the left BA40, right SLF, right frontal white matter, splenium, and anterior corpus callosum. Local MTR values correlated with Paced Auditory Serial Addition Test scores in the left BA40, right BA4, right SLF, and splenium.

CONCLUSION: Statistical mapping analysis of brain MTR data provides valuable information on the relationship between the location of brain tissue damage and its functional impact in patients with MS, even in the earliest stage of the disease." />
<meta name="DC.Contributor" content="Jean-Philippe Ranjeva" />
<meta name="DC.Contributor" content="Bertrand Audoin" />
<meta name="DC.Contributor" content="My Van Au Duong" />
<meta name="DC.Contributor" content="Danielle Ibarrola" />
<meta name="DC.Contributor" content="Sylviane Confort-Gouny" />
<meta name="DC.Contributor" content="Irina Malikova" />
<meta name="DC.Contributor" content="Elisabeth Soulier" />
<meta name="DC.Contributor" content="Patrick Viout" />
<meta name="DC.Contributor" content="André Ali-Chérif" />
<meta name="DC.Contributor" content="Jean Pelletier" />
<meta name="DC.Contributor" content="Patrick Cozzone" />
<meta name="article:published_time" content="2005-01-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; In the early stage of Multiple Sclerosis (MS), conventional MR imaging parameters such as T2 lesion load fail to explain the clinical status of patients. In the present work, we aimed to determine the ability of magnification transfer imaging to better reflect the relationship between local tissue damage and functional status of MS patients.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; We performed a comparative statistical mapping analysis on brain tissue magnetization transfer ratio (MTR) data measured in 18 patients with clinically isolated syndrome suggestive of MS (CISSMS) and 18 matched control subjects.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; In the patients with CISSMS, a pattern of significant low MTR values was observed in the white matter, corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right superior longitudinal fasciculus (SLF), right inferior longitudinal fasciculus, optica radiata, parietal white matter, right cingulum, gray matter, bilateral thalamus, bilateral caudate, right insula, and left Brodmann area (BA) 8. No correlation was found between local MTR decrease and Expanded Disability Status Scale score. Significant correlations between MTR and MS Functional Composite scores (Spearman rank test, &lt;i&gt;P&lt;/i&gt; &amp;lt; .05) were observed in the left BA40, right SLF, right frontal white matter, splenium, and anterior corpus callosum. Local MTR values correlated with Paced Auditory Serial Addition Test scores in the left BA40, right BA4, right SLF, and splenium.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Statistical mapping analysis of brain MTR data provides valuable information on the relationship between the location of brain tissue damage and its functional impact in patients with MS, even in the earliest stage of the disease.&lt;/p&gt;" />
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<meta name="twitter:title" content="Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: In the early stage of Multiple Sclerosis (MS), conventional MR imaging parameters such as T2 lesion load fail to explain the clinical status of patients. In the present work, we aimed to determine the ability of magnification transfer imaging to better reflect the relationship between local tissue damage and functional status of MS patients.

METHODS: We performed a comparative statistical mapping analysis on brain tissue magnetization transfer ratio (MTR) data measured in 18 patients with clinically isolated syndrome suggestive of MS (CISSMS) and 18 matched control subjects.

RESULTS: In the patients with CISSMS, a pattern of significant low MTR values was observed in the white matter, corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right superior longitudinal fasciculus (SLF), right inferior longitudinal fasciculus, optica radiata, parietal white matter, right cingulum, gray matter, bilateral thalamus, bilateral caudate, right insula, and left Brodmann area (BA) 8. No correlation was found between local MTR decrease and Expanded Disability Status Scale score. Significant correlations between MTR and MS Functional Composite scores (Spearman rank test, P &lt; .05) were observed in the left BA40, right SLF, right frontal white matter, splenium, and anterior corpus callosum. Local MTR values correlated with Paced Auditory Serial Addition Test scores in the left BA40, right BA4, right SLF, and splenium.

CONCLUSION: Statistical mapping analysis of brain MTR data provides valuable information on the relationship between the location of brain tissue damage and its functional impact in patients with MS, even in the earliest stage of the disease." />
<meta name="og-title" property="og:title" content="Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: In the early stage of Multiple Sclerosis (MS), conventional MR imaging parameters such as T2 lesion load fail to explain the clinical status of patients. In the present work, we aimed to determine the ability of magnification transfer imaging to better reflect the relationship between local tissue damage and functional status of MS patients.

METHODS: We performed a comparative statistical mapping analysis on brain tissue magnetization transfer ratio (MTR) data measured in 18 patients with clinically isolated syndrome suggestive of MS (CISSMS) and 18 matched control subjects.

RESULTS: In the patients with CISSMS, a pattern of significant low MTR values was observed in the white matter, corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right superior longitudinal fasciculus (SLF), right inferior longitudinal fasciculus, optica radiata, parietal white matter, right cingulum, gray matter, bilateral thalamus, bilateral caudate, right insula, and left Brodmann area (BA) 8. No correlation was found between local MTR decrease and Expanded Disability Status Scale score. Significant correlations between MTR and MS Functional Composite scores (Spearman rank test, P &lt; .05) were observed in the left BA40, right SLF, right frontal white matter, splenium, and anterior corpus callosum. Local MTR values correlated with Paced Auditory Serial Addition Test scores in the left BA40, right BA4, right SLF, and splenium.

CONCLUSION: Statistical mapping analysis of brain MTR data provides valuable information on the relationship between the location of brain tissue damage and its functional impact in patients with MS, even in the earliest stage of the disease." />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Jean-Philippe Ranjeva</span>, <span class="highwire-citation-author" data-delta="1">Bertrand Audoin</span>, <span class="highwire-citation-author" data-delta="2">My Van Au Duong</span>, <span class="highwire-citation-author" data-delta="3">Danielle Ibarrola</span>, <span class="highwire-citation-author" data-delta="4">Sylviane Confort-Gouny</span>, <span class="highwire-citation-author" data-delta="5">Irina Malikova</span>, <span class="highwire-citation-author" data-delta="6">Elisabeth Soulier</span>, <span class="highwire-citation-author" data-delta="7">Patrick Viout</span>, <span class="highwire-citation-author" data-delta="8">André Ali-Chérif</span>, <span class="highwire-citation-author" data-delta="9">Jean Pelletier</span> and <span class="highwire-citation-author" data-delta="10">Patrick Cozzone</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2005,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">119-127; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-2975--81353386033" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Jean-Philippe Ranjeva </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Jean-Philippe%2BRanjeva%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ranjeva%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJean-Philippe%2BRanjeva%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div 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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">vol. 26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">no. 1 </span><span  class="highwire-cite-metadata-page-string highwire-cite-metadata">119-127 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Jean-Philippe</span> <span class="nlm-surname">Ranjeva</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Bertrand</span> <span class="nlm-surname">Audoin</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">My</span> <span class="nlm-surname">Van Au Duong</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Danielle</span> <span class="nlm-surname">Ibarrola</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Sylviane</span> <span class="nlm-surname">Confort-Gouny</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Irina</span> <span class="nlm-surname">Malikova</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Elisabeth</span> <span class="nlm-surname">Soulier</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Patrick</span> <span class="nlm-surname">Viout</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">André</span> <span class="nlm-surname">Ali-Chérif</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Jean</span> <span class="nlm-surname">Pelletier</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">Patrick</span> <span class="nlm-surname">Cozzone</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">119-127; </span></div>
  
  
  
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      <div class="highwire-cite-title">Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Jean-Philippe</span> <span class="nlm-surname">Ranjeva</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Bertrand</span> <span class="nlm-surname">Audoin</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">My</span> <span class="nlm-surname">Van Au Duong</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Danielle</span> <span class="nlm-surname">Ibarrola</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Sylviane</span> <span class="nlm-surname">Confort-Gouny</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Irina</span> <span class="nlm-surname">Malikova</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Elisabeth</span> <span class="nlm-surname">Soulier</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Patrick</span> <span class="nlm-surname">Viout</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">André</span> <span class="nlm-surname">Ali-Chérif</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Jean</span> <span class="nlm-surname">Pelletier</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">Patrick</span> <span class="nlm-surname">Cozzone</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">119-127; </span></div>
  
  
  
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