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<meta name="DC.Title" content="Optic Nerve Diffusion Measurement from Diffusion-Weighted Imaging in Optic Neuritis" />
<meta name="DC.Date" content="2005-04-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Increases in apparent diffusion coefficient (ADC) from diffusion-weighted (DW) imaging are thought to be due to axonal disruption, and changes have been well documented in multiple sclerosis lesions. DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.

METHODS: The optic nerves of eighteen patients who had experienced an attack of optic neuritis 1 year previously and 11 control subjects were imaged with the diffusion sequence (usable data were available from 16 patients and 10 control subjects). The orbital optic nerves were segmented by a blinded observer by using a computer-assisted threshold-based contouring technique, and the mean ADC was determined.

RESULTS: The mean ADC from diseased optic nerves was 1324 × 10−6mm2/s, compared with 990 × 10−6mm2/s from healthy contralateral optic nerves ( P = .005 versus diseased optic nerves) and 928 × 10−6mm2/s from control optic nerves ( P = .006 versus diseased optic nerves and P = .40 versus healthy contralateral optic nerves). The diseased optic nerve ADC correlated with both visual (e.g., rS = 0.73; P = .001 for logMAR visual acuity) and electrophysiological parameters (e.g., rS = −0.57, P = .021 for visual evoked potential central field amplitude [VEP]).

CONCLUSION: It has been possible to apply DW imaging in a patient population, and, in the chronic phase following optic neuritis, the correlation of mean ADC with the clinical and electrophysiological parameters suggests that the ADC is giving a surrogate measure of axonal disruption in the chronic, postinflammatory optic nerve lesion." />
<meta name="DC.Contributor" content="Simon J. Hickman" />
<meta name="DC.Contributor" content="Claudia A. M. Wheeler-Kingshott" />
<meta name="DC.Contributor" content="Stephen J. Jones" />
<meta name="DC.Contributor" content="Katherine A. Miszkiel" />
<meta name="DC.Contributor" content="Gareth J. Barker" />
<meta name="DC.Contributor" content="Gordon T. Plant" />
<meta name="DC.Contributor" content="David H. Miller" />
<meta name="article:published_time" content="2005-04-01" />
<meta name="article:section" content="HEAD AND NECK" />
<meta name="citation_title" content="Optic Nerve Diffusion Measurement from Diffusion-Weighted Imaging in Optic Neuritis" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Increases in apparent diffusion coefficient (ADC) from diffusion-weighted (DW) imaging are thought to be due to axonal disruption, and changes have been well documented in multiple sclerosis lesions. DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; The optic nerves of eighteen patients who had experienced an attack of optic neuritis 1 year previously and 11 control subjects were imaged with the diffusion sequence (usable data were available from 16 patients and 10 control subjects). The orbital optic nerves were segmented by a blinded observer by using a computer-assisted threshold-based contouring technique, and the mean ADC was determined.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The mean ADC from diseased optic nerves was 1324 × 10&lt;sup&gt;−6&lt;/sup&gt;mm&lt;sup&gt;2&lt;/sup&gt;/s, compared with 990 × 10&lt;sup&gt;−6&lt;/sup&gt;mm&lt;sup&gt;2&lt;/sup&gt;/s from healthy contralateral optic nerves (&lt;i&gt;P&lt;/i&gt; = .005 versus diseased optic nerves) and 928 × 10&lt;sup&gt;−6&lt;/sup&gt;mm&lt;sup&gt;2&lt;/sup&gt;/s from control optic nerves (&lt;i&gt;P&lt;/i&gt; = .006 versus diseased optic nerves and &lt;i&gt;P&lt;/i&gt; = .40 versus healthy contralateral optic nerves). The diseased optic nerve ADC correlated with both visual (e.g., &lt;i&gt;r&lt;sub&gt;S&lt;/sub&gt;&lt;/i&gt; = 0.73; &lt;i&gt;P&lt;/i&gt; = .001 for logMAR visual acuity) and electrophysiological parameters (e.g., &lt;i&gt;r&lt;sub&gt;S&lt;/sub&gt;&lt;/i&gt; = −0.57, &lt;i&gt;P&lt;/i&gt; = .021 for visual evoked potential central field amplitude [VEP]).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; It has been possible to apply DW imaging in a patient population, and, in the chronic phase following optic neuritis, the correlation of mean ADC with the clinical and electrophysiological parameters suggests that the ADC is giving a surrogate measure of axonal disruption in the chronic, postinflammatory optic nerve lesion.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_title=Biophysical Journal;citation_journal_abbrev=Biophys. J;citation_title=MR diffusion tensor spectroscopy and imaging.;citation_pages=259-267;citation_volume=66;citation_year=1994;citation_issue=1;citation_issn=0006-3495;citation_pmid=8130344;citation_doi=10.1016/S0006-3495(94)80775-1" />
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<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Diffusion tensor magnetic resonance imaging in multiple sclerosis;citation_pages=304-311;citation_volume=56;citation_year=2001;citation_issue=3;citation_issn=0028-3878;citation_pmid=11171893;citation_doi=10.1212/WNL.56.3.304" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Increases in apparent diffusion coefficient (ADC) from diffusion-weighted (DW) imaging are thought to be due to axonal disruption, and changes have been well documented in multiple sclerosis lesions. DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.

METHODS: The optic nerves of eighteen patients who had experienced an attack of optic neuritis 1 year previously and 11 control subjects were imaged with the diffusion sequence (usable data were available from 16 patients and 10 control subjects). The orbital optic nerves were segmented by a blinded observer by using a computer-assisted threshold-based contouring technique, and the mean ADC was determined.

RESULTS: The mean ADC from diseased optic nerves was 1324 × 10−6mm2/s, compared with 990 × 10−6mm2/s from healthy contralateral optic nerves ( P = .005 versus diseased optic nerves) and 928 × 10−6mm2/s from control optic nerves ( P = .006 versus diseased optic nerves and P = .40 versus healthy contralateral optic nerves). The diseased optic nerve ADC correlated with both visual (e.g., rS = 0.73; P = .001 for logMAR visual acuity) and electrophysiological parameters (e.g., rS = −0.57, P = .021 for visual evoked potential central field amplitude [VEP]).

CONCLUSION: It has been possible to apply DW imaging in a patient population, and, in the chronic phase following optic neuritis, the correlation of mean ADC with the clinical and electrophysiological parameters suggests that the ADC is giving a surrogate measure of axonal disruption in the chronic, postinflammatory optic nerve lesion." />
<meta name="og-title" property="og:title" content="Optic Nerve Diffusion Measurement from Diffusion-Weighted Imaging in Optic Neuritis" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Increases in apparent diffusion coefficient (ADC) from diffusion-weighted (DW) imaging are thought to be due to axonal disruption, and changes have been well documented in multiple sclerosis lesions. DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.

METHODS: The optic nerves of eighteen patients who had experienced an attack of optic neuritis 1 year previously and 11 control subjects were imaged with the diffusion sequence (usable data were available from 16 patients and 10 control subjects). The orbital optic nerves were segmented by a blinded observer by using a computer-assisted threshold-based contouring technique, and the mean ADC was determined.

RESULTS: The mean ADC from diseased optic nerves was 1324 × 10−6mm2/s, compared with 990 × 10−6mm2/s from healthy contralateral optic nerves ( P = .005 versus diseased optic nerves) and 928 × 10−6mm2/s from control optic nerves ( P = .006 versus diseased optic nerves and P = .40 versus healthy contralateral optic nerves). The diseased optic nerve ADC correlated with both visual (e.g., rS = 0.73; P = .001 for logMAR visual acuity) and electrophysiological parameters (e.g., rS = −0.57, P = .021 for visual evoked potential central field amplitude [VEP]).

CONCLUSION: It has been possible to apply DW imaging in a patient population, and, in the chronic phase following optic neuritis, the correlation of mean ADC with the clinical and electrophysiological parameters suggests that the ADC is giving a surrogate measure of axonal disruption in the chronic, postinflammatory optic nerve lesion." />
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      <h1 class="highwire-cite-title" id="page-title">Optic Nerve Diffusion Measurement from Diffusion-Weighted Imaging in Optic Neuritis</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2005,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">951-956; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-1940--8436574197" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Simon J. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Simon J. Hickman</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-2"><span class="name">Claudia A. M. Wheeler-Kingshott</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">Stephen J. Jones</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-4"><span class="name">Katherine A. Miszkiel</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a>, </li><li class="contributor" id="contrib-5"><span class="name">Gareth J. Barker</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">e</a>, </li><li class="contributor" id="contrib-6"><span class="name">Gordon T. Plant</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a> and </li><li class="last" id="contrib-7"><span class="name">David H. Miller</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Department of Neuro-Ophthalmology, Moorfields Eye Hospital, London, United Kingdom</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>e</sup>Institute of Psychiatry, Kings College London, London, United Kingdom</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Address correspondence to Dr. Simon J. Hickman, NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom</li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/26/4/951.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Optic Nerve Diffusion Measurement from Diffusion-Weighted Imaging in Optic Neuritis</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Simon J.</span> <span class="nlm-surname">Hickman</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Claudia A. M.</span> <span class="nlm-surname">Wheeler-Kingshott</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Stephen J.</span> <span class="nlm-surname">Jones</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Katherine A.</span> <span class="nlm-surname">Miszkiel</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Gareth J.</span> <span class="nlm-surname">Barker</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Gordon T.</span> <span class="nlm-surname">Plant</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">David H.</span> <span class="nlm-surname">Miller</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">951-956; </span></div>
  
  
  
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