Research ArticleBRAIN
Dilatation of the Virchow-Robin Space Is a Sensitive Indicator of Cerebral Microvascular Disease: Study in Elderly Patients with Dementia
Tufail F. Patankar, Dipayan Mitra, Anoop Varma, Julie Snowden, David Neary and Alan Jackson
American Journal of Neuroradiology June 2005, 26 (6) 1512-1520;
Tufail F. Patankar
Dipayan Mitra
Anoop Varma
Julie Snowden
David Neary

References
- ↵Hirabuki N, Fujita N, Fujii K, Hashimoto T, Kozuka T. MR appearance of Virchow-Robin spaces along lenticulostriate arteries: spin-echo and two-dimensional fast low-angle shot imaging. AJNR Am J Neuroradiol 1994;15:277–281
- ↵Heier LA, Bauer CJ, Schwartz L, Zimmerman RD, Morgello S, Deck MD. Large Virchow-Robin spaces: MR-clinical correlation. AJNR Am J Neuroradiol 1989;10:929–936
- Braffman BH, Zimmerman RA, Trojanowski JQ, Gonatas NK, Hickey WF, Schlaepfer WW. Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces. AJR Am J Roentgenol 1988;151:551–558
- ↵Machado MA Jr, Matos AS, Goyanna F, Barbosa VA, Vieira LC. [Dilatation of Virchow-Robin spaces in patients with migraine]. Ar Qneuropsiquiatr 2001;59:206–209
- ↵Bokura H, Kobayashi S, Yamaguchi S. Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study. J Neurol 1998;245:116–122
- ↵
- ↵Achiron A, Faibel M. Sandlike appearance of Virchow-Robin spaces in early multiple sclerosis: a novel neuroradiologic marker. AJNR Am J Neuroradiol 2002;23:376–380
- Afifi AK. Enlarged Virchow-Robin spaces along the medullary perforators in a child with seizures. J Neuroimaging 1996;6:197–198
- Schick S, Gahleitner A, Wober-Bingol C, et al. Virchow-Robin spaces in childhood migraine. Neuroradiology 1999;41:283–287
- Simpson SW, Jackson A, Baldwin RC, Burns A. 1997 IPA/Bayer Research Awards in Psychogeriatrics: subcortical hyperintensities in late-life depression: acute response to treatment and neuropsychological impairment. Int Psychogeriatr 1997;9:257–275
- Andreula CF, Burdi N, Carella A. CNS cryptococcosis in AIDS: spectrum of MR findings. J Comput Assist Tomogr 1993;17:438–441
- Auer RN, Budny J, Drake CG, Ball MJ. Frontal lobe perivascular schwannoma. Case report. J Neurosurg 1982;56:154–157
- Bastos AC, Andermann F, Melancon D, et al. Late-onset temporal lobe epilepsy and dilatation of the hippocampal sulcus by an enlarged Virchow-Robin space. Neurology 1998;50:784–787
- Chuang YC, Lui CC, Hsu SP, Chang CS, Lin TK. Unusual dilatation of Virchow-Robin spaces: case report. Changgeng Yi Xue Za Zhi 1999;22:671–675
- ↵Esiri MM WG, Morris JH. Neuropathological assessment ofthe lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry 1997;63:749–753
- Rollins NK, Deline C, Morriss MC. Prevalence and clinical significance of dilated Virchow-Robin spaces in childhood. Radiology 1993;189:53–57
- ↵Erkinjuntti T, Benavente O, Eliasziw M, et al. Diffuse vacuolization (spongiosis) and arteriolosclerosis in the frontal white matter occurs in vascular dementia. Arch Neurol 1996;53:325–332
- ↵Hommel M, Gray F. Microvascular pathology. In: Caplan L, ed. Brain Ischaemia: Basic Concepts and Clinical Relevance. New York: Springer-Verlag Berlin;1995 :215–223
- ↵Furuta A, Ishii N, Nishihara Y, Horie A. Medullary arteries in aging and dementia. Stroke 1991;22:442–446
- ↵Brun A, Fredriksson K, Gustafson L. Pure subcortical arteriosclerotic encephalopathy (Binswanger’s disease): a clinicopathological study. Part 2: Pathological features. Cerebrovasc Dis 1992;2:87–92
- ↵Thomas AJ, O’Brien JT, Davis S, et al. Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. Arch Gen Psychiatry 2002;59:785–792
- Thomas AJ, Perry R, Barber R, Kalaria RN, O’Brien JT. Pathologies and pathological mechanisms for white matter hyperintensities in depression. Ann N Y Acad Sci 2002;977:333–339
- Krishnan KR, McDonald WM. Arteriosclerotic depression. Med Hypotheses 1995;44:111–115
- Krishnan KR, Hays JC, Blazer DG. MRI-defined vascular depression. Am J Psychiatry 1997;154:497–501
- Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. “Vascular depression” hypothesis. Arch Gen Psychiatry 1997;54:915–922
- Greenwald BS, Kramer-Ginsberg E, Krishnan KR, et al. A controlled study of MRI signal hyperintensities in older depressed patients with and without hypertension. J Am Geriatr Soc 2001;49:1218–1225
- ↵
- ↵Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology 1993;43:250–260
- ↵McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944
- ↵Brun A, Gustafson L, Passant U. A new kind of degenerative dementia: localization, rather than type is significant in frontal lobe dementia. Lakartidningen 1994;91:4751–4757
- ↵Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51:1546–1554
- ↵McKeith IG, Perry RH, Fairbairn AF, Jabeen S, Perry EK. Operational criteria for senile dementia of Lewy body type (SDLT). Psychol Med 1992;22:911–922
- ↵Scheltens P, Barkhof F, Leys D, et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993;114:7–12
- ↵Thacker NA, Varma AR, Bathgate D, et al. Dementing disorders: volumetric measurement of cerebrospinal fluid to distinguish normal from pathologic findings: feasibility study. Radiology 2002;224:278–285
- ↵Zhang ET, Inman CB, Weller RO. Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J Anat 1990;170:111–123
- ↵Poirier J, Derouesne C. Cerebral lacunae: a proposed new classification [letter]. Clin Neuropathol 1984;3:266
- ↵Fazekas F, Kleinert R, Offenbacher H, et al. The morphologic correlate of incidental punctate white matter hyperintensities on MR images. AJNR Am J Neuroradiol 1991;12:915–921
- ↵Ogawa T, Okudera T, Fukasawa H, et al. Unusual widening of Virchow-Robin spaces: MR appearance. AJNR Am J Neuroradiol 1995;16:1238–1242
- ↵Hughes W. Origin of lacunes. Lancet 19651:19–21
- ↵Benhaiem-Sigaux N, Gray F, Gherardi R, Roucayrol AM, Poirier J. Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger’s subcortical arteriosclerotic encephalopathy. Stroke 1987;18:1087–1092
- ↵Derouesne C, Gray F, Escourolle R, Castaigne P. “Expanding cerebral lacunae” in a hypertensive patient with normal pressure hydrocephalus. Neuropathol Appl Neurobiol 1987;13:309–320
- ↵Pullicino PM, Miller LL, Alexandrov AV, Ostrow PT. Infraputaminal “lacunes”: clinical and pathological correlations. Stroke 1995;26:1598–1602
- ↵Jellinger KA. The pathology of ischemic-vascular dementia: an update. J Neurol Sci 2002;203–204:153–157
- ↵Hulette C ND, McKeel D, Morris K, Mirras SS, Sumi SM, et. a. Clinical-neuropathologic findings in multi-infarct dementia: a reportof six autopsied cases. Neurology 1997;48:668–672
- ↵Erkinjuntti T. Diagnosis and management of vascular cognitive impairment and dementia. J Neural Transm Suppl2002 :91–109
- Wahlund LO, Basun H, Almkvist O, Andersson-Lundman G, Julin P, Saaf J. White matter hyperintensities in dementia: does it matter? Magn Reson Imaging 1994;12:387–394
- ↵Leys D, Pasquier F, Lucas C, Pruvo JP. Magnetic resonance imaging in vascular dementia. J Mal Vasc 1995;20:194–202
- ↵Barber R, Scheltens P, Gholkar A, et al. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging. J Neurol Neurosurg Psychiatry 1999;67:66–72
- Pasquier F, Henon H, Leys D. Relevance of white matter changes to pre- and poststroke dementia. Ann N Y Acad Sci 2000;903:466–469
- ↵Udaka F, Sawada H, Kameyama M. White matter lesions and dementia: MRI-pathological correlation. Ann N Y Acad Sci 2002;977:411–415
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Dilatation of the Virchow-Robin Space Is a Sensitive Indicator of Cerebral Microvascular Disease: Study in Elderly Patients with Dementia
Tufail F. Patankar, Dipayan Mitra, Anoop Varma, Julie Snowden, David Neary, Alan Jackson
American Journal of Neuroradiology Jun 2005, 26 (6) 1512-1520;
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