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<meta name="DC.Title" content="Measurement Error of Percent Diameter Carotid Stenosis Determined by Conventional Angiography: Implications for Noninvasive Evaluation" />
<meta name="DC.Date" content="2005-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Our aim was to quantitate the range of error in measurement of percent diameter carotid stenosis using conventional angiography in order to estimate the misclassification rate in selecting patients for carotid endarterectomy.

METHODS: A secondary or meta-analysis of published data regarding carotid stenosis measurement error associated with angiography yielded a narrow range of standard deviation across several studies using different measurement protocols. A simulation of the measurement process was developed to model this error and allow estimation of misclassification rates compared with true values for stenosis.

RESULTS: A standard deviation of 8% describes the average error observed at 60% diameter stenosis across a number of studies. Using the measurement model, for a population with 30% prevalence of 60% stenosis, this finding implies a misclassification rate of approximately 4% overall for conventional angiography.

CONCLUSION: Like all diagnostic tests, angiography is associated with measurement error. This does not affect the results of carotid stenosis therapy trials using angiography but does need to be taken into account when evaluating noninvasive alternative tests for carotid stenosis." />
<meta name="DC.Contributor" content="Joseph E. Heiserman" />
<meta name="article:published_time" content="2005-09-01" />
<meta name="article:section" content="HEAD AND NECK" />
<meta name="citation_title" content="Measurement Error of Percent Diameter Carotid Stenosis Determined by Conventional Angiography: Implications for Noninvasive Evaluation" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Our aim was to quantitate the range of error in measurement of percent diameter carotid stenosis using conventional angiography in order to estimate the misclassification rate in selecting patients for carotid endarterectomy.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; A secondary or meta-analysis of published data regarding carotid stenosis measurement error associated with angiography yielded a narrow range of standard deviation across several studies using different measurement protocols. A simulation of the measurement process was developed to model this error and allow estimation of misclassification rates compared with true values for stenosis.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; A standard deviation of 8% describes the average error observed at 60% diameter stenosis across a number of studies. Using the measurement model, for a population with 30% prevalence of 60% stenosis, this finding implies a misclassification rate of approximately 4% overall for conventional angiography.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Like all diagnostic tests, angiography is associated with measurement error. This does not affect the results of carotid stenosis therapy trials using angiography but does need to be taken into account when evaluating noninvasive alternative tests for carotid stenosis.&lt;/p&gt;" />
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<meta name="twitter:title" content="Measurement Error of Percent Diameter Carotid Stenosis Determined by Conventional Angiography: Implications for Noninvasive Evaluation" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Our aim was to quantitate the range of error in measurement of percent diameter carotid stenosis using conventional angiography in order to estimate the misclassification rate in selecting patients for carotid endarterectomy.

METHODS: A secondary or meta-analysis of published data regarding carotid stenosis measurement error associated with angiography yielded a narrow range of standard deviation across several studies using different measurement protocols. A simulation of the measurement process was developed to model this error and allow estimation of misclassification rates compared with true values for stenosis.

RESULTS: A standard deviation of 8% describes the average error observed at 60% diameter stenosis across a number of studies. Using the measurement model, for a population with 30% prevalence of 60% stenosis, this finding implies a misclassification rate of approximately 4% overall for conventional angiography.

CONCLUSION: Like all diagnostic tests, angiography is associated with measurement error. This does not affect the results of carotid stenosis therapy trials using angiography but does need to be taken into account when evaluating noninvasive alternative tests for carotid stenosis." />
<meta name="og-title" property="og:title" content="Measurement Error of Percent Diameter Carotid Stenosis Determined by Conventional Angiography: Implications for Noninvasive Evaluation" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Our aim was to quantitate the range of error in measurement of percent diameter carotid stenosis using conventional angiography in order to estimate the misclassification rate in selecting patients for carotid endarterectomy.

METHODS: A secondary or meta-analysis of published data regarding carotid stenosis measurement error associated with angiography yielded a narrow range of standard deviation across several studies using different measurement protocols. A simulation of the measurement process was developed to model this error and allow estimation of misclassification rates compared with true values for stenosis.

RESULTS: A standard deviation of 8% describes the average error observed at 60% diameter stenosis across a number of studies. Using the measurement model, for a population with 30% prevalence of 60% stenosis, this finding implies a misclassification rate of approximately 4% overall for conventional angiography.

CONCLUSION: Like all diagnostic tests, angiography is associated with measurement error. This does not affect the results of carotid stenosis therapy trials using angiography but does need to be taken into account when evaluating noninvasive alternative tests for carotid stenosis." />
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-other" id="cit-26.8.2102.1" data-doi="10.1053/ejvs.2002.1946"><div class="cit-metadata"><cite>Naylor AR, Rothwell PM, Bell PR. <strong>Overview of the principal results and secondary analyses from the European and North American randomised trials of endarterectomy for symptomatic carotid stenosis.</strong> <span class="cit-source">Eur J Vasc Endovasc Surg</span> <span class="cit-pub-date">2003</span>;<span class="cit-vol">26</span>:<span class="cit-fpage">115</span>–129</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1053/ejvs.2002.1946&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi 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carotid stenosis from angiograms: North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group.</strong> <span class="cit-source">Stroke</span> <span class="cit-pub-date">1994</span>;<span class="cit-vol">25</span>:<span class="cit-fpage">2445</span>–2449</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjEwOiIyNS8xMi8yNDQ1IjtzOjQ6ImF0b20iO3M6MjA6Ii9ham5yLzI2LzgvMjEwMi5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7 in text" id="ref-7">↵</a><div class="cit ref-cit ref-other" id="cit-26.8.2102.7"><div class="cit-metadata"><cite>Rothwell PM, Gibson RJ, Slattery J, Sellar RJ, Warlow CP. <strong>Equivalence of measurements of carotid stenosis: a comparison of three methods on 1001 angiograms—European Carotid Surgery Trialists’ Collaborative Group.</strong> <span class="cit-source">Stroke</span> <span class="cit-pub-date">1994</span>;<span class="cit-vol">25</span>:<span class="cit-fpage">2435</span>–2439</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjEwOiIyNS8xMi8yNDM1IjtzOjQ6ImF0b20iO3M6MjA6Ii9ham5yLzI2LzgvMjEwMi5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 26</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 8 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2005 </div></div>
      
      
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