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<meta name="DC.Title" content="Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy" />
<meta name="DC.Date" content="2005-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Poor treatment outcome remains high in patients with squamous cell carcinoma (SCC) of the head and neck region. Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed. MR spectroscopy has been used previously to differentiate between malignant and adjacent normal specimen in these cancers. This study explores the capability of MR spectroscopy in providing an indication of the aggressiveness of a tumor and its response to treatment.

METHODS: Thirty-six SCC patients with treatment failure, and 22 other patients who were treated concurrently at the same center but with no indication of failure for a period of 3 years, were selected for the study. Tumor specimens were kept frozen at −70°C, and later subjected to 1H-MR spectroscopy at 25°C. The resonance areas for 6 spectral regions were determined, and their ratio calculated. The mean values of the ratios were then compared between the 2 groups by using the Student t test.

RESULTS: The choline-to-creatine (3.2/3.0 parts per million [ppm]) and the 1.3/0.9 ppm spectral intensity ratios (signal due to lipid or lactic acid) were the 2 most notable ones to be significantly elevated in the group with poor response. Using these ratios, a sensitivity of 83% and a specificity of 82% were obtained in predicting which head and neck cancer patients would fail treatment.

CONCLUSIONS: These preliminary results suggest that MR spectroscopy has the potential to contribute to an accurate and early prediction of tumor behavior and response to treatment in squamous cell carcinoma of the head and neck region." />
<meta name="DC.Contributor" content="Tedros Bezabeh" />
<meta name="DC.Contributor" content="Olva Odlum" />
<meta name="DC.Contributor" content="Richard Nason" />
<meta name="DC.Contributor" content="Paul Kerr" />
<meta name="DC.Contributor" content="Donna Sutherland" />
<meta name="DC.Contributor" content="Rakesh Patel" />
<meta name="DC.Contributor" content="Ian C.P. Smith" />
<meta name="article:published_time" content="2005-09-01" />
<meta name="article:section" content="HEAD AND NECK" />
<meta name="citation_title" content="Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Poor treatment outcome remains high in patients with squamous cell carcinoma (SCC) of the head and neck region. Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed. MR spectroscopy has been used previously to differentiate between malignant and adjacent normal specimen in these cancers. This study explores the capability of MR spectroscopy in providing an indication of the aggressiveness of a tumor and its response to treatment.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Thirty-six SCC patients with treatment failure, and 22 other patients who were treated concurrently at the same center but with no indication of failure for a period of 3 years, were selected for the study. Tumor specimens were kept frozen at −70°C, and later subjected to &lt;sup&gt;1&lt;/sup&gt;H-MR spectroscopy at 25°C. The resonance areas for 6 spectral regions were determined, and their ratio calculated. The mean values of the ratios were then compared between the 2 groups by using the Student &lt;i&gt;t&lt;/i&gt; test.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The choline-to-creatine (3.2/3.0 parts per million [ppm]) and the 1.3/0.9 ppm spectral intensity ratios (signal due to lipid or lactic acid) were the 2 most notable ones to be significantly elevated in the group with poor response. Using these ratios, a sensitivity of 83% and a specificity of 82% were obtained in predicting which head and neck cancer patients would fail treatment.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSIONS:&lt;/i&gt; These preliminary results suggest that MR spectroscopy has the potential to contribute to an accurate and early prediction of tumor behavior and response to treatment in squamous cell carcinoma of the head and neck region.&lt;/p&gt;" />
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<meta name="twitter:title" content="Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Poor treatment outcome remains high in patients with squamous cell carcinoma (SCC) of the head and neck region. Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed. MR spectroscopy has been used previously to differentiate between malignant and adjacent normal specimen in these cancers. This study explores the capability of MR spectroscopy in providing an indication of the aggressiveness of a tumor and its response to treatment.

METHODS: Thirty-six SCC patients with treatment failure, and 22 other patients who were treated concurrently at the same center but with no indication of failure for a period of 3 years, were selected for the study. Tumor specimens were kept frozen at −70°C, and later subjected to 1H-MR spectroscopy at 25°C. The resonance areas for 6 spectral regions were determined, and their ratio calculated. The mean values of the ratios were then compared between the 2 groups by using the Student t test.

RESULTS: The choline-to-creatine (3.2/3.0 parts per million [ppm]) and the 1.3/0.9 ppm spectral intensity ratios (signal due to lipid or lactic acid) were the 2 most notable ones to be significantly elevated in the group with poor response. Using these ratios, a sensitivity of 83% and a specificity of 82% were obtained in predicting which head and neck cancer patients would fail treatment.

CONCLUSIONS: These preliminary results suggest that MR spectroscopy has the potential to contribute to an accurate and early prediction of tumor behavior and response to treatment in squamous cell carcinoma of the head and neck region." />
<meta name="og-title" property="og:title" content="Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Poor treatment outcome remains high in patients with squamous cell carcinoma (SCC) of the head and neck region. Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed. MR spectroscopy has been used previously to differentiate between malignant and adjacent normal specimen in these cancers. This study explores the capability of MR spectroscopy in providing an indication of the aggressiveness of a tumor and its response to treatment.

METHODS: Thirty-six SCC patients with treatment failure, and 22 other patients who were treated concurrently at the same center but with no indication of failure for a period of 3 years, were selected for the study. Tumor specimens were kept frozen at −70°C, and later subjected to 1H-MR spectroscopy at 25°C. The resonance areas for 6 spectral regions were determined, and their ratio calculated. The mean values of the ratios were then compared between the 2 groups by using the Student t test.

RESULTS: The choline-to-creatine (3.2/3.0 parts per million [ppm]) and the 1.3/0.9 ppm spectral intensity ratios (signal due to lipid or lactic acid) were the 2 most notable ones to be significantly elevated in the group with poor response. Using these ratios, a sensitivity of 83% and a specificity of 82% were obtained in predicting which head and neck cancer patients would fail treatment.

CONCLUSIONS: These preliminary results suggest that MR spectroscopy has the potential to contribute to an accurate and early prediction of tumor behavior and response to treatment in squamous cell carcinoma of the head and neck region." />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Tedros</span> <span class="nlm-surname">Bezabeh</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Olva</span> <span class="nlm-surname">Odlum</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Richard</span> <span class="nlm-surname">Nason</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Paul</span> <span class="nlm-surname">Kerr</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Donna</span> <span class="nlm-surname">Sutherland</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Rakesh</span> <span class="nlm-surname">Patel</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Ian C.P.</span> <span class="nlm-surname">Smith</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2108-2113; </span></div>
  
  
  
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