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      <h1 class="highwire-cite-title" id="page-title">2006: A Stroke Odyssey</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2006,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2019-2021; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7440--6953439394" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Thomas A. Tomsick </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Thomas%2BA.%2BTomsick%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tomsick%20TA&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AThomas%2BA.%2BTomsick%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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Time to IV treatment was significantly earlier in the NINDS rtPA trial (108 minutes) compared with that in the 3 IV/IA treatment groups (126, 139, 140 minutes)." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-1795751802" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;Modified Rankin scale 0&#x2013;2 outcomes in pre-IMS, IMS I, and IMS II compared with historical control of NINDS study rtPA and placebo control groups. Time to IV treatment was significantly earlier in the NINDS rtPA trial (108 minutes) compared with that in the 3 IV/IA treatment groups (126, 139, 140 minutes).&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="Fig 1." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F1.medium.gif" width="440" height="334"/><noscript><img class="highwire-fragment fragment-image" alt="Fig 1." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F1.medium.gif" width="440" height="334"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F1.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 1." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F1.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/23382" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label"><strong>Fig 1.</strong></span> <p id="p-19">Modified Rankin scale 0–2 outcomes in pre-IMS, IMS I, and IMS II compared with historical control of NINDS study rtPA and placebo control groups. Time to IV treatment was significantly earlier in the NINDS rtPA trial (108 minutes) compared with that in the 3 IV/IA treatment groups (126, 139, 140 minutes).</p><div class="sb-div caption-clear"></div></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li><li><div class="element-fig-data clearfix figure-caption"><div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="fig-expansion" id="F2"><span class="highwire-journal-article-marker-start"></span><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F2.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Percentage modified Rankin scale 0&#x2013;2 compared with onset to IA rtPA bolus (following reduced-dose IV therapy). A trend toward better outcomes with earlier therapy is demonstrated. No difference of post-IV IA therapy begun at 4&#x2013;5 hours, compared with IV therapy (NINDS rtPA), is also shown. In IMS I and II, IA therapy began within 5 hours." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-1795751802" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;Percentage modified Rankin scale 0&#x2013;2 compared with onset to IA rtPA bolus (following reduced-dose IV therapy). A trend toward better outcomes with earlier therapy is demonstrated. No difference of post-IV IA therapy begun at 4&#x2013;5 hours, compared with IV therapy (NINDS rtPA), is also shown. In IMS I and II, IA therapy began within 5 hours.&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="Fig 2." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F2.medium.gif" width="440" height="340"/><noscript><img class="highwire-fragment fragment-image" alt="Fig 2." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F2.medium.gif" width="440" height="340"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F2.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 2." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F2.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/23389" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label"><strong>Fig 2.</strong></span> <p id="p-20">Percentage modified Rankin scale 0–2 compared with onset to IA rtPA bolus (following reduced-dose IV therapy). A trend toward better outcomes with earlier therapy is demonstrated. No difference of post-IV IA therapy begun at 4–5 hours, compared with IV therapy (NINDS rtPA), is also shown. In IMS I and II, IA therapy began within 5 hours.</p><div class="sb-div caption-clear"></div></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li><li class="last"><div class="element-fig-data clearfix figure-caption"><div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="fig-expansion" id="F3"><span class="highwire-journal-article-marker-start"></span><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F3.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Percentage modified Rankin scale 0&#x2013;2 versus baseline NIHSS score. Improved outcomes at higher NIHSS scores in pre-IMS and IMS I are achieved." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-1795751802" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;Percentage modified Rankin scale 0&#x2013;2 versus baseline NIHSS score. Improved outcomes at higher NIHSS scores in pre-IMS and IMS I are achieved.&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="Fig 3." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F3.medium.gif" width="440" height="323"/><noscript><img class="highwire-fragment fragment-image" alt="Fig 3." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F3.medium.gif" width="440" height="323"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F3.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 3." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/27/10/2019/F3.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/23413" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label"><strong>Fig 3.</strong></span> <p id="p-21">Percentage modified Rankin scale 0–2 versus baseline NIHSS score. Improved outcomes at higher NIHSS scores in pre-IMS and IMS I are achieved.</p><div class="sb-div caption-clear"></div></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li></ul></div></div></div>  </div>

  
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