Left Vertebral Artery Origin from the Thyrocervical Trunk: A Unique Vascular Variant

W.M. Strub; J.L. Leach; T.A. Tomsick

Abstract

SUMMARY: The vertebral artery normally arises from the subclavian artery, and variations in its origin have been described. We describe a unique case of the left vertebral artery arising from the thyrocervical trunk.

Anomalies of the extracranial branches of the vertebral artery are rare.1 Patients with cervical vertebral anomalies may present with symptoms of vertebral basilar insufficiency2 or may be asymptomatic. This report describes a case of anomalous origin of the left vertebral artery from the thyrocervical trunk discovered on CT angiography in a patient with a family member with known aberrant vertebral artery origins. To the best of our knowledge, this vascular variant has not been previously described in the English-language literature.

Case Report

The patient is a 36-year-old woman with a history of prior posterior fossa decompression for Chiari malformation who presented for preoperative evaluation of her cerebral vasculature for an upcoming neurosurgical procedure. The patient’s father was known to have bilateral persistent proatlantal intersegmental arteries with absence of the vertebral arteries. These angiographic findings have been reported elsewhere.3

Imaging was performed on a 64-section SOMATOM Sensation scanner (Siemens, Malvern, Pa). Omnipaque 370 (GE Healthcare, Piscataway, NJ) contrast was injected through a 20-gauge intravenous needle in the patient’s right antecubital fossa at a rate of 4 mL/s for a total of 80 mL. By use of bolus-tracking software, scanning was performed 5 seconds after contrast was identified in the internal carotid arteries in the neck. Helical acquisition was performed by using the 64 × 0.6 mm scanner configuration, and images were reconstructed at 1.0 mm with an overlap of 0.6 mm. Multiplanar reformations, thin-section maximum intensity projections, and volume-rendered images were performed.

The left vertebral artery was identified arising from the thyrocervical trunk (Fig 1) and was seen at the C1–C2 level extending along the lateral aspect of C1 in a normal location and entering the dura in the foramen magnum. There was no evidence of collateral vessel formation to suggest occlusion of the vertebral artery and subsequent filling by peripheral vessels. A continuation of the left vertebral artery from the posterior inferior cerebellar artery to the basilar artery was not visualized. The vertebral foramen on the left were hypoplastic compared with those on the right (Fig 2). The right vertebral artery originated from the subclavian artery in the normal fashion.

Fig 1.

A, Oblique, volume-rendered CT angiogram projection. Note the left vertebral artery arising directly from the thyrocervical trunk and extending cephalad outside of the transverse foramina of the vertebral bodies (arrows). The suprascapular artery is noted arising directly from this vessel in the lower neck (arrowhead).

B, Posterior, volume-rendered CT angiogram projection. There has been a decompressive occipital craniectomy, and resection of the posterior arch of C1. The left vertebral artery is well seen continuing intracranially (arrows).

Fig 2.

A, Axial image of the cervical spine at C4 in bone algorithm. Note the absence of the foramen transversarium on the left (arrow).

B, Axial image of the cervical spine at C4 in soft tissue algorithm showing the course of the left vertebral artery (arrow).

Discussion

During embryologic development, 8 cervical segmental arteries develop and originate from the aorta. The first of these cervical segmental arteries is also known as the proatlantal intersegmental artery.4–6 A persistent proatlantal artery can be seen with aplasia of the ipsilateral and hypoplasia or aplasia of the contralateral vertebral artery.6 Taking this further, a persistent proatlantal artery that connects the internal carotid to the vertebral artery can be considered as an anomalous origin of the vertebral artery.6 Our patient’s father, who had type II proatlantal intersegmental arteries, also had bilateral absence of the vertebral arteries.

During development, longitudinal anastomoses are formed between the 8 cervical segmental arteries, though the first 6 ventral segments between the aorta and the longitudinal anastomoses will disappear when the embryo is 14–17 mm in length. The proximal vertebral artery is formed from the ventral portion of the seventh segmental artery.7,8 The longitudinal anastomoses between the first 7 cervical segments will comprise the distal vertebral artery.7 An atypical origin of the vertebral artery can be accounted for by incomplete involution of one of the first 6 segmental arteries.2,7,9

The distal cervical part will typically maintain its relation to the skeleton and run within the foramen of the cervical vertebrae whereas the proximal segment will run outside of the canal.10 The transverse foramina form around the developing vertebral arteries, and the foramina may be absent or present in duplicate or triplicate form.11 It has recently been shown that the size of the transverse foramen and the accompanying vertebral artery show only a weak relationship.11 One or both of the vertebral arteries may ultimately terminate in a posterior inferior cerebellar artery.11

Anomalous origins of the vertebral artery have been described elsewhere. Variations in the origin of the left vertebral artery usually occur on the left,12–14 and an anomalous origin of the left vertebral artery may be present in about 5% of individuals.9 In fact, the second-most-common anomaly in the embryologic development of vessels arising from the aorta is the left vertebral artery arising from the aortic arch between the left common carotid and the left subclavian arteries.15 Other anomalous origins include the vertebral artery arising from the common carotid artery,8 bifid origin of the left vertebral artery from the aortic arch,15 bifid origin of the right vertebral artery,16 bilateral arch origin of the vertebral arteries,17 and anomalous origin of the right vertebral artery from the aortic arch proximal to the left subclavian artery.18 Origins of the right vertebral artery from the thyrocervical trunk have also been described.19

The uses of 3D CT angiography for imaging vertebral artery aneurysms has been described elsewhere.20 Advantages of 3D CT angiography compared with conventional angiography include ability for unrestricted reconstruction of the image, more rapid imaging acquisition, and lack of potential angiographic complications.5 In addition, with respect to the vertebral artery, CT angiography is not dependent on flow physiology and can be performed in a more expedited manner than sonography or MR imaging.20

Conclusion

It is important for the neurovascular interventionalist and the neurosurgeon to be aware of this variant. Vertebral artery injury is a known complication of extended lateral decompression during anterior cervical spine surgery that can result in exsanguinations and permanent neurologic deficits.21 During surgery at the cranial vertebral junction, injury of the vertebral artery can cause brain stem ischemia and cerebellar infarction.5 Anomalous vertebral artery origins present a pitfall at diagnostic cerebral angiography because they may be assumed to be occluded or diseased if they cannot be catheterized.17 To prevent complications, it is essential to assess the vasculature in this region before conducting medical procedures.22 Furthermore, this observation and the finding of vertebral anomalies in the patient’s father lead us to hypothesize that vascular variations may be hereditary.

References

↵
Chiras J, Launay C, Gaston A, et al. Thoracic vertebral artery. Neuroradiology 1982;24:67–70
PubMed
↵
Koenigsberg R, Pereira L, Nair B, et al. Unusual vertebral artery origins : examples and related pathology. Cath Cardiovasc Interv 2003;59:244–50
↵
Luh G, Dean B, Tomsick T, et al. The persistent fetal carotid-vertebrobasilar anastomoses. AJR Am J Roentgenol 1999;172:1427–32
PubMed
↵
Anderson R, Sondheimer F. Rare carotid-vertebrobasilar anastomoses with notes on the differentiation between proatlantal and hypoglossal arteries. Neuroradiology 1976;11:113–18
CrossRef PubMed
↵
Yamazaki M, Koda M, Yoneda M, et al. Anomalous vertebral artery at the craniovertebral junction in a patient with Down syndrome. J Neurosurg Spine 2004;3:338–41
↵
Kolbinger R, Heindel W, Pawlik G, et al. Right proatlantal artery type I, right internal carotid occlusion, and left internal carotid stenosis case report and review of the literature. J Neurol Sci 1993;117:232–39
CrossRef PubMed
↵
Newton TH, Mani RL. The vertebral artery. In: Newton TM, Potts DG, eds. Radiology of the skull and brain. St. Louis: Mosby;1974 :1659–72
↵
Chen C, Wang L, Wong Y. Abnormal origin of the vertebral artery from the common carotid artery. AJNR Am J Neuroradiol 1998;19:1414–16
Abstract
↵
Haughton VM, Rosebaum AE. The normal and anomalous aortic arch and brachiocephalic arteries. In: Newton TM, Potts DG, eds. Radiology of the skull and brain. St. Louis: Mosby;1974 :1145–63
↵
Rieger P, Huber G. Fenestration and duplicate origin of the left vertebral artery in angiography. Neuroradiology 1983;25:45–50
CrossRef PubMed
↵
Sanelli P, Tong S, Gonzalez R, et al. Normal variations of the vertebral artery on CT angiography and its implications to diagnosis of acquired pathology. J Comput Assist Tomogr 2002;26:464–70
↵
Argenson C, Francke J, Sylla A, et al. The vertebral arteries. Anat Clin 1980;2:29–32
Cavdar S, Arisan E. Variations in the extracranial origin of the human vertebral artery. Acta Anat 1989;135:236–38
PubMed
↵
Suzuki S, Kuwabara Y, Hatano R, et al. Duplicate origin of the left vertebral artery. Neuroradiology 1978;15:27–29
CrossRef PubMed
↵
Eisenberg R, Vines F, Taylor S. Bifid origin of the left vertebral artery. Radiology 1986;159:429–30
PubMed
↵
Kiss J. Bifid origin of the right vertebral artery: a case report. Radiology 1968;92:931
↵
Albayram S, Gailloud P, Wasserman B. Bilateral arch origin of the vertebral arteries. AJNR Am J Neuroradiol 2002;23:455–58
Abstract/FREE Full Text
↵
Wasserman B, Mikulis D, Manzione J. Origin of the right vertebral artery from the left side of the aortic arch proximal to the origin of the left subclavian artery. AJNR Am J Neuroradiol 1992;13:355–58
FREE Full Text
↵
Adachi B. Das arteriensystem der Japaner. Kyoto, Japan: Kaiserlich-Japanischen Universitate zu Kyoto;1928 [in German]
↵
Matsumoto M, Sato M, Nakano M, et al. Three-dimensional computed tomography angiography-guided surgery of acutely ruptured cerebral aneurysms. J Neurosurg 2001;94:718–27
PubMed
↵
Lu J, Ebraheim N. The vertebral artery: surgical anatomy. Orthopedics 1999;22:1081–85
PubMed
↵
Gluncic V, Ivkic G, Marin D, et al. Anomalous origin of both vertebral arteries. Clin Anat 1999;12:281–84
PubMed

Received June 13, 2005.
Accepted after revision July 10, 2005.

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Dangerous Extracranial-Intracranial Anastomoses and Supply to the Cranial Nerves: Vessels the Neurointerventionalist Needs to Know

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[1] ↵
Chiras J, Launay C, Gaston A, et al. Thoracic vertebral artery. Neuroradiology 1982;24:67–70
PubMed

[2] ↵
Koenigsberg R, Pereira L, Nair B, et al. Unusual vertebral artery origins : examples and related pathology. Cath Cardiovasc Interv 2003;59:244–50

[3] ↵
Luh G, Dean B, Tomsick T, et al. The persistent fetal carotid-vertebrobasilar anastomoses. AJR Am J Roentgenol 1999;172:1427–32
PubMed

[4] ↵
Anderson R, Sondheimer F. Rare carotid-vertebrobasilar anastomoses with notes on the differentiation between proatlantal and hypoglossal arteries. Neuroradiology 1976;11:113–18
CrossRef PubMed

[5] ↵
Yamazaki M, Koda M, Yoneda M, et al. Anomalous vertebral artery at the craniovertebral junction in a patient with Down syndrome. J Neurosurg Spine 2004;3:338–41

[6] ↵
Kolbinger R, Heindel W, Pawlik G, et al. Right proatlantal artery type I, right internal carotid occlusion, and left internal carotid stenosis case report and review of the literature. J Neurol Sci 1993;117:232–39
CrossRef PubMed

[7] ↵
Newton TH, Mani RL. The vertebral artery. In: Newton TM, Potts DG, eds. Radiology of the skull and brain. St. Louis: Mosby;1974 :1659–72

[8] ↵
Chen C, Wang L, Wong Y. Abnormal origin of the vertebral artery from the common carotid artery. AJNR Am J Neuroradiol 1998;19:1414–16
Abstract

[9] ↵
Haughton VM, Rosebaum AE. The normal and anomalous aortic arch and brachiocephalic arteries. In: Newton TM, Potts DG, eds. Radiology of the skull and brain. St. Louis: Mosby;1974 :1145–63

[10] ↵
Rieger P, Huber G. Fenestration and duplicate origin of the left vertebral artery in angiography. Neuroradiology 1983;25:45–50
CrossRef PubMed

[11] ↵
Sanelli P, Tong S, Gonzalez R, et al. Normal variations of the vertebral artery on CT angiography and its implications to diagnosis of acquired pathology. J Comput Assist Tomogr 2002;26:464–70

[12] ↵
Argenson C, Francke J, Sylla A, et al. The vertebral arteries. Anat Clin 1980;2:29–32

[13] Cavdar S, Arisan E. Variations in the extracranial origin of the human vertebral artery. Acta Anat 1989;135:236–38
PubMed

[14] ↵
Suzuki S, Kuwabara Y, Hatano R, et al. Duplicate origin of the left vertebral artery. Neuroradiology 1978;15:27–29
CrossRef PubMed

[15] ↵
Eisenberg R, Vines F, Taylor S. Bifid origin of the left vertebral artery. Radiology 1986;159:429–30
PubMed

[16] ↵
Kiss J. Bifid origin of the right vertebral artery: a case report. Radiology 1968;92:931

[17] ↵
Albayram S, Gailloud P, Wasserman B. Bilateral arch origin of the vertebral arteries. AJNR Am J Neuroradiol 2002;23:455–58
Abstract/FREE Full Text

[18] ↵
Wasserman B, Mikulis D, Manzione J. Origin of the right vertebral artery from the left side of the aortic arch proximal to the origin of the left subclavian artery. AJNR Am J Neuroradiol 1992;13:355–58
FREE Full Text

[19] ↵
Adachi B. Das arteriensystem der Japaner. Kyoto, Japan: Kaiserlich-Japanischen Universitate zu Kyoto;1928 [in German]

[20] ↵
Matsumoto M, Sato M, Nakano M, et al. Three-dimensional computed tomography angiography-guided surgery of acutely ruptured cerebral aneurysms. J Neurosurg 2001;94:718–27
PubMed

[21] ↵
Lu J, Ebraheim N. The vertebral artery: surgical anatomy. Orthopedics 1999;22:1081–85
PubMed

[22] ↵
Gluncic V, Ivkic G, Marin D, et al. Anomalous origin of both vertebral arteries. Clin Anat 1999;12:281–84
PubMed

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Left Vertebral Artery Origin from the Thyrocervical Trunk: A Unique Vascular Variant

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Left Vertebral Artery Origin from the Thyrocervical Trunk: A Unique Vascular Variant

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