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<meta name="DC.Title" content="Extent of Preoperative Abnormalities and Focus Lateralization Predict Postoperative Normalization of Contralateral 1H-Magnetic Resonance Spectroscopy Metabolite Levels in Patients with Temporal Lobe Epilepsy" />
<meta name="DC.Date" content="2006-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Magnetic resonance (MR) spectroscopy can be used to determine the side of seizure onset in patients with temporal lobe epilepsy. Some patients with abnormal MR spectroscopy findings also have contralateral abnormalities, which in some cases have been reported to normalize after temporal lobe resection. With the aim of better understanding the mechanisms underlying abnormal MR spectroscopy findings, the current study was performed to define patient features that would predict this postoperative normalization.

METHODS: Fifteen patients with temporal lobe epilepsy were subjected to preoperative and postoperative 1H-MR spectroscopy investigations, and the preoperative and postoperative metabolite levels in the contralateral hippocampus and contralateral lateral temporal lobe (CLTL) were determined.

RESULTS: In the CLTL, postoperative normalization was more pronounced for patients showing extensive preoperative ipsilateral and contralateral abnormalities on MR spectroscopy. A second factor that influenced the degree to which the metabolite levels changed postoperatively was the focus lateralization. Surgery tended to have a more pronounced effect on the contralateral metabolite levels in patients with a right temporal focus, whereas in patients with left temporal foci, postoperative metabolite levels were virtually unchanged. In the contralateral hippocampal region, neither preoperative abnormalities nor focus side was related to postoperative normalization.

CONCLUSIONS: We have thus identified 2 different factors (widespread preoperative MR spectroscopy abnormalities and right-sided focus) that predict postoperative normalization of contralateral MR spectroscopy abnormalities. We suggest that both factors indicate a more generalized epileptic disease (ie, that the patients in whom the MR spectroscopy abnormalities normalize are recovering from a more severe impairment)." />
<meta name="DC.Contributor" content="G. Lantz" />
<meta name="DC.Contributor" content="M. Seeck" />
<meta name="DC.Contributor" content="F. Lazeyras" />
<meta name="article:published_time" content="2006-09-01" />
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<meta name="citation_title" content="Extent of Preoperative Abnormalities and Focus Lateralization Predict Postoperative Normalization of Contralateral 1H-Magnetic Resonance Spectroscopy Metabolite Levels in Patients with Temporal Lobe Epilepsy" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Magnetic resonance (MR) spectroscopy can be used to determine the side of seizure onset in patients with temporal lobe epilepsy. Some patients with abnormal MR spectroscopy findings also have contralateral abnormalities, which in some cases have been reported to normalize after temporal lobe resection. With the aim of better understanding the mechanisms underlying abnormal MR spectroscopy findings, the current study was performed to define patient features that would predict this postoperative normalization.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS:&lt;/b&gt; Fifteen patients with temporal lobe epilepsy were subjected to preoperative and postoperative 1H-MR spectroscopy investigations, and the preoperative and postoperative metabolite levels in the contralateral hippocampus and contralateral lateral temporal lobe (CLTL) were determined.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; In the CLTL, postoperative normalization was more pronounced for patients showing extensive preoperative ipsilateral and contralateral abnormalities on MR spectroscopy. A second factor that influenced the degree to which the metabolite levels changed postoperatively was the focus lateralization. Surgery tended to have a more pronounced effect on the contralateral metabolite levels in patients with a right temporal focus, whereas in patients with left temporal foci, postoperative metabolite levels were virtually unchanged. In the contralateral hippocampal region, neither preoperative abnormalities nor focus side was related to postoperative normalization.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; We have thus identified 2 different factors (widespread preoperative MR spectroscopy abnormalities and right-sided focus) that predict postoperative normalization of contralateral MR spectroscopy abnormalities. We suggest that both factors indicate a more generalized epileptic disease (ie, that the patients in whom the MR spectroscopy abnormalities normalize are recovering from a more severe impairment).&lt;/p&gt;" />
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<meta name="twitter:title" content="Extent of Preoperative Abnormalities and Focus Lateralization Predict Postoperative Normalization of Contralateral 1H-Magnetic Resonance Spectroscopy Metabolite Levels in Patients with Temporal Lobe Epilepsy" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Magnetic resonance (MR) spectroscopy can be used to determine the side of seizure onset in patients with temporal lobe epilepsy. Some patients with abnormal MR spectroscopy findings also have contralateral abnormalities, which in some cases have been reported to normalize after temporal lobe resection. With the aim of better understanding the mechanisms underlying abnormal MR spectroscopy findings, the current study was performed to define patient features that would predict this postoperative normalization.

METHODS: Fifteen patients with temporal lobe epilepsy were subjected to preoperative and postoperative 1H-MR spectroscopy investigations, and the preoperative and postoperative metabolite levels in the contralateral hippocampus and contralateral lateral temporal lobe (CLTL) were determined.

RESULTS: In the CLTL, postoperative normalization was more pronounced for patients showing extensive preoperative ipsilateral and contralateral abnormalities on MR spectroscopy. A second factor that influenced the degree to which the metabolite levels changed postoperatively was the focus lateralization. Surgery tended to have a more pronounced effect on the contralateral metabolite levels in patients with a right temporal focus, whereas in patients with left temporal foci, postoperative metabolite levels were virtually unchanged. In the contralateral hippocampal region, neither preoperative abnormalities nor focus side was related to postoperative normalization.

CONCLUSIONS: We have thus identified 2 different factors (widespread preoperative MR spectroscopy abnormalities and right-sided focus) that predict postoperative normalization of contralateral MR spectroscopy abnormalities. We suggest that both factors indicate a more generalized epileptic disease (ie, that the patients in whom the MR spectroscopy abnormalities normalize are recovering from a more severe impairment)." />
<meta name="og-title" property="og:title" content="Extent of Preoperative Abnormalities and Focus Lateralization Predict Postoperative Normalization of Contralateral 1H-Magnetic Resonance Spectroscopy Metabolite Levels in Patients with Temporal Lobe Epilepsy" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Magnetic resonance (MR) spectroscopy can be used to determine the side of seizure onset in patients with temporal lobe epilepsy. Some patients with abnormal MR spectroscopy findings also have contralateral abnormalities, which in some cases have been reported to normalize after temporal lobe resection. With the aim of better understanding the mechanisms underlying abnormal MR spectroscopy findings, the current study was performed to define patient features that would predict this postoperative normalization.

METHODS: Fifteen patients with temporal lobe epilepsy were subjected to preoperative and postoperative 1H-MR spectroscopy investigations, and the preoperative and postoperative metabolite levels in the contralateral hippocampus and contralateral lateral temporal lobe (CLTL) were determined.

RESULTS: In the CLTL, postoperative normalization was more pronounced for patients showing extensive preoperative ipsilateral and contralateral abnormalities on MR spectroscopy. A second factor that influenced the degree to which the metabolite levels changed postoperatively was the focus lateralization. Surgery tended to have a more pronounced effect on the contralateral metabolite levels in patients with a right temporal focus, whereas in patients with left temporal foci, postoperative metabolite levels were virtually unchanged. In the contralateral hippocampal region, neither preoperative abnormalities nor focus side was related to postoperative normalization.

CONCLUSIONS: We have thus identified 2 different factors (widespread preoperative MR spectroscopy abnormalities and right-sided focus) that predict postoperative normalization of contralateral MR spectroscopy abnormalities. We suggest that both factors indicate a more generalized epileptic disease (ie, that the patients in whom the MR spectroscopy abnormalities normalize are recovering from a more severe impairment)." />
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    <title>Extent of Preoperative Abnormalities and Focus Lateralization Predict Postoperative Normalization of Contralateral 1H-Magnetic Resonance Spectroscopy Metabolite Levels in Patients with Temporal Lobe Epilepsy | American Journal of Neuroradiology</title>  
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      <h1 class="highwire-cite-title" id="page-title">Extent of Preoperative Abnormalities and Focus Lateralization Predict Postoperative Normalization of Contralateral 1H-Magnetic Resonance Spectroscopy Metabolite Levels in Patients with Temporal Lobe Epilepsy</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">G. Lantz</span>, <span class="highwire-citation-author" data-delta="1">M. Seeck</span> and <span class="highwire-citation-author" data-delta="2">F. Lazeyras</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2006,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1766-1769; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7290--61822383209" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">G. Lantz </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BLantz%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lantz%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BLantz%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M. Seeck </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BSeeck%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Seeck%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BSeeck%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">F. Lazeyras </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BLazeyras%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lazeyras%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BLazeyras%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-other" id="cit-27.8.1766.1"><div class="cit-metadata"><cite>Connelly A, Jackson GD, Duncan JS, et al. <strong>Magnetic resonance spectroscopy in temporal lobe epilepsy.</strong> <span class="cit-source">Neurology</span> <span class="cit-pub-date">1994</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">1411</span>–17</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjk6IjQ0LzgvMTQxMSI7czo0OiJhdG9tIjtzOjIwOiIvYWpuci8yNy84LzE3NjYuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" 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data-doi="10.1002/ana.410420603"><div class="cit-metadata"><cite>Knowlton RC, Laxer KD, Ende G, et al. <strong>Presurgical multimodality neuroimaging in electroencephalographic lateralized temporal lobe epilepsy.</strong> <span class="cit-source">Ann Neurol</span> <span class="cit-pub-date">1997</span>;<span class="cit-vol">42</span>:<span class="cit-fpage">829</span>–37</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/ana.410420603&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9403474&amp;link_type=MED&amp;atom=%2Fajnr%2F27%2F8%2F1766.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000070935900002&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 27</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 8 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">September 2006 </div></div>
      
      
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