Research ArticleBRAIN
Not All Age-Related White Matter Hyperintensities Are the Same: A Magnetization Transfer Imaging Study
A. Spilt, R. Goekoop, R.G.J. Westendorp, G.J. Blauw, A.J.M. de Craen and M.A. van Buchem
American Journal of Neuroradiology October 2006, 27 (9) 1964-1968;
A. Spilt
R. Goekoop
R.G.J. Westendorp
G.J. Blauw
A.J.M. de Craen

References
- ↵Meyer JS, Kawamura J, Terayama Y. White matter lesions in the elderly. J Neurol Sci 1992;110:1–7
- ↵de Leeuw FE, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study—The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001;70:9–14
- ↵de Leeuw FE, de Groot JC, Oudkerk M, et al. Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. Stroke 2000;31:425–29
- ↵Longstreth WT Jr, Manolio TA, Arnold A, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: The Cardiovascular Health Study. Stroke 1996;27:1274–82. Comment in: Stroke 1996;27:1269–73, Stroke 1996;27:2338
- ↵Breteler MM, van Amerongen NM, van Swieten JC, et al. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging: The Rotterdam Study. Stroke 1994;25:1109–15
- ↵Wahlund LO, Basun H, Almkvist O, et al. White matter hyperintensities in dementia: does it matter? Magn Reson Imaging 1994;12:387–94
- ↵de Groot JC, de Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and cognitive function: The Rotterdam Scan Study. Ann Neurol 2000;47:145–51
- ↵O’Brien JT, Ames D. White matter lesions in depression and Alzheimer’s disease. Br J Psychiatry 1996;169:671
- ↵Braffman BH, Zimmerman RA, Trojanowski JQ, et al. Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly. AJR Am J Roentgenol 1988;151:559–66
- ↵Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993;43:1683–89
- ↵Dousset V, Grossman RI, Ramer KN, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992;182:483–91
- ↵Mehta RC, Pike GB, Enzmann DR. Measure of magnetization transfer in multiple sclerosis demyelinating plaques, white matter ischemic lesions, and edema. AJNR Am J Neuroradiol 1996;17:1051–55
- ↵Wong KT, Grossman RI, Boorstein JM, et al. Magnetization transfer imaging of periventricular hyperintense white matter in the elderly. AJNR Am J Neuroradiol 1995;16:253–58
- ↵Hanyu H, Asano T, Sakurai H, et al. Magnetization transfer ratio in cerebral white matter lesions of Binswanger’s disease. J Neurol Sci 1999;166:85–90
- ↵Shepherd J, Blauw GJ, Murphy MB, et al. The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER): PROSPER Study Group—Study of Pravastatin in the Elderly at Risk. Am J Cardiol 1999;84:1192–97
- ↵Scheltens P, Barkhof F, Leys D, et al. A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993;114:7–12
- ↵Tanabe JL, Ezekiel F, Jagust WJ, et al. Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia. AJNR Am J Neuroradiol 1999;20:839–44
- Tanabe JL, Ezekiel F, Jagust WJ, et al. Volumetric method for evaluating magnetization transfer ratio of tissue categories: application to areas of white matter signal hyperintensity in the elderly. Radiology 1997;204:570–75
- ↵Rovaris M, Iannucci G, Cercignani M, et al. Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis. Radiology 2003;227:731–38. Epub 2003 Apr 17
- ↵Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review. Stroke 1997;28:652–59
- ↵Ylikoski A, Erkinjuntti T, Raininko R, et al. White matter hyperintensities on MRI in the neurologically nondiseased elderly: analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke 1995;26:1171–77
- ↵Sze G, De Armond SJ, Brant ZM, et al. Foci of MRI signal (pseudo lesions) anterior to the frontal horns: histologic correlations of a normal finding. AJR Am J Roentgenol 1986;147:331–37
- ↵Pollay M, Curl F. Secretion of cerebrospinal fluid by the ventricular ependyma of the rabbit. Am J Physiol 1967;213:1031–38
- ↵Wen W, Sachdev P. The topography of white matter hyperintensities on brain MRI in healthy 60- to 64-year-old individuals. Neuroimage 2004;22:144–54
- ↵Scheltens P, Barkhof F, Leys D, et al. Histopathologic correlates of white matter changes on MRI in Alzheimer’s disease and normal aging. Neurology 1995;45:883–88
In this issue
Advertisement
Not All Age-Related White Matter Hyperintensities Are the Same: A Magnetization Transfer Imaging Study
A. Spilt, R. Goekoop, R.G.J. Westendorp, G.J. Blauw, A.J.M. de Craen, M.A. van Buchem
American Journal of Neuroradiology Oct 2006, 27 (9) 1964-1968;
Jump to section
Related Articles
- No related articles found.
Cited By...
- White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance
- Microstructural white matter changes preceding white matter hyperintensities in migraine
- What are White Matter Hyperintensities Made of? Relevance to Vascular Cognitive Impairment
- White Matter Hyperintensities and Their Penumbra Lie Along a Continuum of Injury in the Aging Brain
- Shades of White: Separating Degrees of Injury in the Aging Brain
- Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement