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    Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleBRAIN

  
      

  
      
Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection
  
    	
K. Aydin, A. Ucok and S. Cakir

  
    	
American Journal of Neuroradiology November 2007,  28 (10) 1968-1974; DOI: https://doi.org/10.3174/ajnr.A0691 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. ↵
    Wernicke C. Grundrisse der Psychiatrie. Leipzig, Germany: Thieme;1906
  2. ↵
    Stephan KE, Baldeweg T, Friston KJ. Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry 2006;59:929–39. Epub 2006 Jan 19
    CrossRefPubMedWeb of Science
  3. Friston KJ. The disconnection hypothesis. Schizophr Res 1998;30:115–25
    CrossRefPubMedWeb of Science
  4. ↵
    Crow TJ. Schizophrenia as a transcallosal misconnection syndrome. Schizophr Res 1998;30:111–14
    CrossRefPubMedWeb of Science
  5. ↵
    Lim KO, Hedehus M, Moseley M, et al. Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch Gen Psychiatry 1999;56:367–74
    CrossRefPubMedWeb of Science
  6. Park HJ, Westin CF, Kubicki M, et al. White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. Neuroimage 2004;23:213–23
    CrossRefPubMedWeb of Science
  7. ↵
    Kanaan RA, Kim JS, Kaufmann WE, et al. Diffusion tensor imaging in schizophrenia. Biol Psychiatry 2005;58:921–29. Epub 2005 Jul 25
    CrossRefPubMedWeb of Science
  8. ↵
    Buchsbaum MS, Friedman J, Buchsbaum BR, et al. Diffusion tensor imaging in schizophrenia. Biol Psychiatry 2006;60:1181–87. Epub 2006 Aug 7
    CrossRefPubMedWeb of Science
  9. ↵
    Foong J, Maier M, Barker GJ, et al. In vivo investigation of white matter pathology in schizophrenia with magnetization transfer imaging. J Neurol Neurosurg Psychiatry 2000;68:70–74
    Abstract/FREE Full Text
  10. ↵
    Foong J, Symms MR, Barker GJ, et al. Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging. Brain 2001;124:882–92
    Abstract/FREE Full Text
  11. ↵
    Hakak Y, Walker JR, Li C, et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 2001;98:4746–51
    Abstract/FREE Full Text
  12. ↵
    Iwamoto K, Bundo M, Yamada K, et al. DNA Methylation status of SOX 10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J Neurosci 2005;25:5376–81
    Abstract/FREE Full Text
  13. ↵
    Gazzaniga MS. Cerebral specialization and interhemispheric communication: does the corpus callosum enable the human condition. Brain 2000;123:1293–326
    Abstract/FREE Full Text
  14. ↵
    Crow TJ, Ball J, Bloom SR, et al. Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease. Arch Gen Psychiatry 1989;46:1145–50
    CrossRefPubMedWeb of Science
  15. ↵
    DeLisi LE, Sakuma M, Kushner M, et al. Anomalous cerebral asymmetry and language processing in schizophrenia. Schizophr Bull 1997;23:255–71
    Abstract/FREE Full Text
  16. ↵
    Downhill JE, Buchsbaum MS, Wei T, et al. Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr Res 2000;42:193–208
    CrossRefPubMedWeb of Science
  17. ↵
    Keshavan MS, Diwadkar VA, Harenski K, et al. Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia. J Neurol Neurosurg Psychiatry 2002;72:757–60
    Abstract/FREE Full Text
  18. Rosenthal R, Bigelow LB. Quantitative brain measurements in chronic schizophrenia. Br J Psychiatry 1972;121:259–64
    Abstract/FREE Full Text
  19. Nasrallah HA, Andreasen NC, Coffman JA, et al. A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry 1986;21:274–82
    CrossRefPubMedWeb of Science
  20. ↵
    Casanova MF, Sanders RD, Goldberg TE, et al. Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study. J Neurol Neurosurg Psychiatry 1990;53:416–21
    Abstract/FREE Full Text
  21. ↵
    Woodruff PW, McManus IC, David AS. Meta-analysis of corpus callosum size in schizophrenia. J Neuro Neurosurg Psychiatry 1995;58:457–61
    Abstract/FREE Full Text
  22. ↵
    Casanova MF, Zito M, Goldberg TE, et al. Corpus callosum curvature in schizophrenic twins. Biol Psychiatry 1990;28:83–84
    CrossRefPubMedWeb of Science
  23. Narr KL, Thompson PM, Sharma T, et al. Mapping morphology of the corpus callosum in schizophrenia. Cereb Cortex 2000;10:40–49
    Abstract/FREE Full Text
  24. ↵
    Frumin M, Golland P, Kikinis R, et al. Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder. Am J Psychiatry 2002;159:866–68
    CrossRefPubMedWeb of Science
  25. ↵
    Hulshoff Pol HE, Schnack HG, Mandl RC, et al. Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. Neuroimage 2004;21:27–35
    CrossRefPubMedWeb of Science
  26. ↵
    Diwadkar VA, DeBellis MD, Sweeney JA, et al. Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia. Schizophr Res 2004;67:277–82
    CrossRefPubMedWeb of Science
  27. ↵
    Steel RM, Bastin ME, McConnell S, et al. Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls. Psychiatry Res 2001;106:161–70
    PubMedWeb of Science
  28. ↵
    First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), Clinical Version. Washington, DC; American Psychiatric Press;1997
  29. ↵
    Pinals D, Malhotra A, Breier A. Informed consent in schizophrenia research. Psychitar Serv 1998;49:244
  30. ↵
    Lukoff D, Nuechterlien K, Ventura A. Manual for the expanded brief psychiatric rating scale. Schizophr Bull 1986;12:594–602
  31. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, Iowa; University of Iowa;1984
  32. ↵
    Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS). Iowa City, Iowa; University of Iowa;1983
  33. ↵
    Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain 1989;112:799–835
    Abstract/FREE Full Text
  34. ↵
    Highley JR, Esiri MM, McDonald B, et al. The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study. Brain 1999;122:99–110
    Abstract/FREE Full Text
  35. ↵
    Keevil SF, Barbiroli B, Brooks JC, et al. Absolute metabolite quantification by in vivo NMR spectroscopy. II. A multicenter trial of protocols for in vivo localised proton studies of human brain. Magn Reson Imaging 1998;16:1093–106
    CrossRefPubMed
  36. ↵
    Michaelis T, Merboldt KD, Bruhn H, et al. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 1993;187:219–27
    PubMedWeb of Science
  37. ↵
    Hoffman RE, McGlashan TH. Reduced corticocortical connectivity can induce perception pathology and hallucinated voices. Schizophr Res 1998;30:137–41
    CrossRefPubMedWeb of Science
  38. ↵
    Steen RG, Hamer RM, Lieberman JA. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 2005;30:1949–62
    CrossRefPubMedWeb of Science
  39. ↵
    Neale JH, Bzdega T, Wroblewska B. N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J Neurochem 2000;75:443–52
    CrossRefPubMedWeb of Science
  40. ↵
    Miller BL. A review of chemical issues in H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 1991;4:47–52
    CrossRefPubMedWeb of Science
  41. ↵
    Brandao LA, Domingues RC. MR Spectroscopy of the Brain. Philadelphia: Lippincott, Williams & Wilkins;2004 :17–128
  42. ↵
    Lentz MR, Kim JP, Westmoreland SV, et al. Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain. Radiology 2005;235:461–68
    PubMedWeb of Science
  43. ↵
    Najm IM, Wang Y, Shedid D, et al. MRS metabolic markers of seizures and seizure-induced neuronal damage. Epilepsia 1998;39:244–50
    CrossRefPubMedWeb of Science
  44. ↵
    Aydin K, Ciftci K, Terzibasioglu E, et al. Quantitative proton MR spectroscopic findings of cortical reorganization in the auditory cortex of musicians. AJNR Am J Neuroradiol 2005;26:128–36
    Abstract/FREE Full Text
  45. ↵
    Nasrallah HA, Mccalley-Whitters M, Bigelow LB, et al. A histological study of the corpus callosum in chronic schizophrenia. Psychiatry Res 1983;8:251–60
    CrossRefPubMedWeb of Science
  46. ↵
    Casanova MF, Zito M, Bigelow LB, et al. Axonal counts of the corpus callosum of schizophrenic patients. J Neuropsychiatry Clin Neurosci 1989;1:391–93
    PubMed
  47. ↵
    Lieberman JA, Perkins D, Belger A, et al. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry 2001;50:884–97
    CrossRefPubMedWeb of Science
  48. ↵
    Uranova NA, Vostrikov VM, Orlovskaya DD, et al. Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophr Res 2004;67:269–75
    CrossRefPubMedWeb of Science
  49. ↵
    Uranova N, Orlovskaya D, Vikhreva O, et al. Electron microscopy of oligodendroglia in severe mental illness. Brain Res Bull 2001;55:597–610
    CrossRefPubMedWeb of Science
  50. Hof PR, Haroutunian V, Copland C, et al. Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia. Neurochem Res 2002;27:1193–200
    CrossRefPubMedWeb of Science
  51. ↵
    Peirce TR, Bray NJ, Williams NM, et al. Convergent evidence for 2′,3′-cyclic nucleotide 3′-phosphodiesterase as a possible susceptibility gene for schizophrenia. Arch Gen Psychiatry 2006;63:18–24
    CrossRefPubMedWeb of Science
  52. ↵
    Hyde TM, Ziegler JC, Weinberger DR. Psychiatric disturbances in metachromatic leukodystrophy: insights into the neurobiology of psychosis. Arch Neurol 1993;50:401–06
  53. ↵
    MacKay A, Laule C, Vavasour I, et al. Insights into brain microstructure from the T2 distribution. Mag Reson Imaging 2006;24:515–25
    CrossRefPubMedWeb of Science
  54. ↵
    Flynn SW, Lang DJ, Mackay AL, et al. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Mol Psychiatry 2003;8:811–20
    CrossRefPubMedWeb of Science
  55. ↵
    Bertolino A, Callicott JH, Mattay VS, et al. The effect of treatment with antipsychotic drugs on brain N-acetylaspartate measures in patients with schizophrenia. Biol Psychiatry 2001;49:39–46
    CrossRefPubMedWeb of Science
  56. ↵
    Bustillo J, Wolff C, Myers-y-Gutierrez A, et al. Treatment of rats with antipsychotic drugs: lack of an effect on brain N-acetyl aspartate levels. Schizophr Res 2004;66:31–39
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection
  
    	
K. Aydin, A. Ucok, S. Cakir

  
    	
American Journal of Neuroradiology Nov 2007, 28 (10) 1968-1974; DOI: 10.3174/ajnr.A0691 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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