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<meta name="DC.Title" content="Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0496" />
<meta name="DC.Date" content="2007-06-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: High cortical signal intensity on diffusion-weighted (DW) or fluid-attenuated inversion recovery (FLAIR) images is increasingly described in sporadic Creutzfeldt-Jakob disease (sCJD). The aim of this study was to assess the extent and location of high cortical signal intensity, to investigate whether DW or FLAIR is superior in showing changes in cortical signal intensity, and to find out whether the distribution of the signal intensity changes is random or follows a common pattern.

MATERIALS AND METHODS: We analyzed FLAIR and DW MR imaging scans of 39 patients with sCJD for hyperintense cortical signal intensity. We compared the sensitivity of the DW and FLAIR scans. We correlated the extent and location of the cortical signal intensity changes with concomitant changes in deep gray matter and the genotype of codon 129 of the prion protein gene.

RESULTS: There was high signal intensity in the insula, the cingulate gyrus, and the superior frontal gyrus in 95%. The cortical areas near the midline also frequently showed the abnormal signal intensity (precuneus 87%, paracentral lobe 77%). The precentral and postcentral gyri were affected less frequently (41% and 28%, respectively). The DW MR imaging showed the cortical changes more effectively than FLAIR. There was no correlation between the distribution of changes and additional signal alterations in deep gray matter or the genotype of codon 129.

CONCLUSION: The distribution of cortical signal intensity abnormalities in patients with sCJD follows a common pattern, affecting mainly the cortical areas near the midline, the insula, cingulum, and the superior frontal cortex. DW imaging is superior to FLAIR in the detection of cortical high signal intensity." />
<meta name="DC.Contributor" content="H.J. Tschampa" />
<meta name="DC.Contributor" content="K. Kallenberg" />
<meta name="DC.Contributor" content="H.A. Kretzschmar" />
<meta name="DC.Contributor" content="B. Meissner" />
<meta name="DC.Contributor" content="M. Knauth" />
<meta name="DC.Contributor" content="H. Urbach" />
<meta name="DC.Contributor" content="I. Zerr" />
<meta name="article:published_time" content="2007-06-01" />
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<meta name="citation_title" content="Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease" />
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<meta name="twitter:title" content="Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: High cortical signal intensity on diffusion-weighted (DW) or fluid-attenuated inversion recovery (FLAIR) images is increasingly described in sporadic Creutzfeldt-Jakob disease (sCJD). The aim of this study was to assess the extent and location of high cortical signal intensity, to investigate whether DW or FLAIR is superior in showing changes in cortical signal intensity, and to find out whether the distribution of the signal intensity changes is random or follows a common pattern.

MATERIALS AND METHODS: We analyzed FLAIR and DW MR imaging scans of 39 patients with sCJD for hyperintense cortical signal intensity. We compared the sensitivity of the DW and FLAIR scans. We correlated the extent and location of the cortical signal intensity changes with concomitant changes in deep gray matter and the genotype of codon 129 of the prion protein gene.

RESULTS: There was high signal intensity in the insula, the cingulate gyrus, and the superior frontal gyrus in 95%. The cortical areas near the midline also frequently showed the abnormal signal intensity (precuneus 87%, paracentral lobe 77%). The precentral and postcentral gyri were affected less frequently (41% and 28%, respectively). The DW MR imaging showed the cortical changes more effectively than FLAIR. There was no correlation between the distribution of changes and additional signal alterations in deep gray matter or the genotype of codon 129.

CONCLUSION: The distribution of cortical signal intensity abnormalities in patients with sCJD follows a common pattern, affecting mainly the cortical areas near the midline, the insula, cingulum, and the superior frontal cortex. DW imaging is superior to FLAIR in the detection of cortical high signal intensity." />
<meta name="og-title" property="og:title" content="Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: High cortical signal intensity on diffusion-weighted (DW) or fluid-attenuated inversion recovery (FLAIR) images is increasingly described in sporadic Creutzfeldt-Jakob disease (sCJD). The aim of this study was to assess the extent and location of high cortical signal intensity, to investigate whether DW or FLAIR is superior in showing changes in cortical signal intensity, and to find out whether the distribution of the signal intensity changes is random or follows a common pattern.

MATERIALS AND METHODS: We analyzed FLAIR and DW MR imaging scans of 39 patients with sCJD for hyperintense cortical signal intensity. We compared the sensitivity of the DW and FLAIR scans. We correlated the extent and location of the cortical signal intensity changes with concomitant changes in deep gray matter and the genotype of codon 129 of the prion protein gene.

RESULTS: There was high signal intensity in the insula, the cingulate gyrus, and the superior frontal gyrus in 95%. The cortical areas near the midline also frequently showed the abnormal signal intensity (precuneus 87%, paracentral lobe 77%). The precentral and postcentral gyri were affected less frequently (41% and 28%, respectively). The DW MR imaging showed the cortical changes more effectively than FLAIR. There was no correlation between the distribution of changes and additional signal alterations in deep gray matter or the genotype of codon 129.

CONCLUSION: The distribution of cortical signal intensity abnormalities in patients with sCJD follows a common pattern, affecting mainly the cortical areas near the midline, the insula, cingulum, and the superior frontal cortex. DW imaging is superior to FLAIR in the detection of cortical high signal intensity." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node7026--5" data-node-nid="7026" id="top-node-7026--6967072957" data-pisa="ajnr;28/6/1114" data-pisa-master="ajnr;28/6/1114" data-apath="/ajnr/28/6/1114.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H.J. Tschampa</span>, <span class="highwire-citation-author" data-delta="1">K. Kallenberg</span>, <span class="highwire-citation-author" data-delta="2">H.A. Kretzschmar</span>, <span class="highwire-citation-author" data-delta="3">B. Meissner</span>, <span class="highwire-citation-author" data-delta="4">M. Knauth</span>, <span class="highwire-citation-author" data-delta="5">H. Urbach</span> and <span class="highwire-citation-author" data-delta="6">I. Zerr</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2007,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">28 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1114-1118; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0496 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7026--6967072957" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H.J. Tschampa </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.J.%2BTschampa%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tschampa%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.J.%2BTschampa%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">K. 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Urbach </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BUrbach%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Urbach%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.%2BUrbach%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">I. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-other" id="cit-28.6.1114.1"><div class="cit-metadata"><cite><strong>Human transmissible spongiform encephalopathies.</strong> <span class="cit-source">Wkly Epidemiol Rec</span> <span class="cit-pub-date">1998</span>;<span class="cit-vol">73</span>:<span class="cit-fpage">361</span>–65</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=9844549&amp;link_type=MED&amp;atom=%2Fajnr%2F28%2F6%2F1114.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2 in text" id="ref-2">↵</a><div class="cit ref-cit ref-other" id="cit-28.6.1114.2" data-doi="10.1001/archneur.57.12.1751"><div class="cit-metadata"><cite>Schroter A, Zerr I, Henkel K, et al. <strong>Magnetic resonance imaging in the clinical diagnosis of Creutzfeldt-Jakob disease.</strong> <span class="cit-source">Arch Neurol</span> <span class="cit-pub-date">2000</span>;<span class="cit-vol">57</span>:<span class="cit-fpage">1751</span>–57</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1001/archneur.57.12.1751&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11115241&amp;link_type=MED&amp;atom=%2Fajnr%2F28%2F6%2F1114.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000165810400011&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3 in text" id="ref-3">↵</a><div class="cit ref-cit ref-other" id="cit-28.6.1114.3" data-doi="10.1093/brain/awh575"><div class="cit-metadata"><cite>Tschampa HJ, Kallenberg K, Urbach H, et al. <strong>MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement.</strong> <span class="cit-source">Brain</span> <span class="cit-pub-date">2005</span>;<span class="cit-vol">128</span>:<span class="cit-fpage">2026</span>–33</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToiYnJhaW4iO3M6NToicmVzaWQiO3M6MTA6IjEyOC85LzIwMjYiO3M6NDoiYXRvbSI7czoyMDoiL2FqbnIvMjgvNi8xMTE0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 28</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">June 2007 </div></div>
      
      
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      <div class="highwire-cite-title">Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease</div>  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Tschampa</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Kallenberg</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Kretzschmar</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Meissner</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Knauth</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Urbach</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Zerr</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2007, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">28 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1114-1118; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0496 </span></div>
  
  
  
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