1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    




































































































    Imaging Findings of Bisphosphonate-Associated Osteonecrosis of the Jaws | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Research ArticleHEAD & NECK

  
      

  
      
Imaging Findings of Bisphosphonate-Associated Osteonecrosis of the Jaws
  
    	
P.M. Phal, R.W.T. Myall, L.A. Assael and J.L. Weissman

  
    	
American Journal of Neuroradiology June 2007,  28 (6) 1139-1145; DOI: https://doi.org/10.3174/ajnr.A0518 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. ↵
    Sparidans RW, Twiss IM, Talbot S. Bisphosphonates in bone diseases. Pharm World Sci 1998;20:206–13
    CrossRefPubMedWeb of Science
  2. ↵
    Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003;61:1115–17
    CrossRefPubMedWeb of Science
  3. ↵
    Ruggiero SL, Mehrotra B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 2004;62:527–34
    CrossRefPubMedWeb of Science
  4. ↵
    Marx RE, Sawatari Y, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005;63:1567–75
    CrossRefPubMedWeb of Science
  5. Migliorati CA, Schubert MM, Peterson DE, et al. Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer 2005;104:83–93
    CrossRefPubMedWeb of Science
  6. Bagan JV, Murillo J, Jimenez Y, et al. Avascular jaw osteonecrosis in association with cancer chemotherapy: series of 10 cases. J Oral Pathol Med 2005;34:120–23
    CrossRefPubMedWeb of Science
  7. ↵
    Carneiro E, Vibhute P, Montazem A, et al. Bisphosphonate-associated mandibular osteonecrosis. AJNR Am J Neuroradiol 2006;27:1096–97
    Abstract/FREE Full Text
  8. ↵
    Kolata G. Drug for bones is linked to jaw disease. New York Times June 2,2006;sect A:1
  9. ↵
    Novartis. Expert Panel Recommendation for the Prevention, Diagnosis and Treatment of Osteonecrosis of the Jaw. East Hanover, NJ: Novartis;2005 . Available at: http://www.fda.gov/OHRMS/DOCKETS/AC/05/briefing/20054095B2_02_12-Novartis-Zometa-App-11.pdf
  10. ↵
    Tolar J, Teitelbaum SL, Orchard PJ. Osteopetrosis. N Engl J Med 2004;351:2839–49
    CrossRefPubMedWeb of Science
  11. ↵
    Reszka AA, Rodan GA. Mechanism of action of bisphosphonates. Curr Osteoporos Rep 2003;1:45–52
    PubMed
  12. ↵
    Reszka AA, Rodan GA. Nitrogen-containing bisphosphonate mechanism of action. Mini Rev Med Chem 2004;4:711–19
    PubMedWeb of Science
  13. ↵
    Hellstein JW, Marek CL. Bisphosphonate osteochemonecrosis (bis-phossy jaw): is this phossy jaw of the 21st century? J Oral Maxillofac Surg 2005;63:682–89
    CrossRefPubMedWeb of Science
  14. ↵
    Whyte MP, Wenkert D, Clements KL, et al. Bisphosphonate-induced osteopetrosis. N Engl J Med 2003;349:457–63
    CrossRefPubMedWeb of Science
  15. ↵
    Junquera L, Rodriguez-Recio C, Villarreal P, et al. Autosomal dominant osteopetrosis and maxillomandibular osteomyelitis. Am J Otolaryngol 2005;26:275–78
    CrossRefPubMedWeb of Science
  16. ↵
    Batra P, Shah N. Recalcitrant osteomyelitis following tooth extraction in a case of malignant osteopetrosis. Int Dent J 2004;54:418–23
    PubMed
  17. ↵
    Wood J, Bonjean K, Ruetz S, et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 2002;302:1055–61
    Abstract/FREE Full Text
  18. ↵
    Fournier P, Boissier S, Filleur S, et al. Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Res 2002;62:6538–44
    Abstract/FREE Full Text
  19. ↵
    Miesse AM, Willey JS, Bateman TA. Potential role of proinflammatory cytokines in nerve damage related bone loss. Biomed Sci Instrum 2004;40:266–71
    PubMed
  20. ↵
    Donoghue AM. Bisphosphonates and osteonecrosis: analogy to phossy jaw. Med J Aust 2005;183:163–64
    PubMedWeb of Science
  21. ↵
    Miles AE. Phosphorus necrosis of the jaw: ‘phossy jaw’. Br Dent J 1972;133:203–06
    CrossRefPubMedWeb of Science
  22. ↵
    Seeman E, Delmas PD. Bone quality–the material and structural basis of bone strength and fragility. N Engl J Med 2006;354:2250–61
    CrossRefPubMedWeb of Science
  23. ↵
    Polizzotto MN, Cousins V, Schwarer AP. Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Haematol 2006;132:114
    CrossRefPubMedWeb of Science
  24. ↵
    White S, Pharoah M. Oral Radiology, Principles and Interpretation, 4th ed. St. Louis: Mosby;2000
  25. ↵
    Ruggiero SL. Bisphosphonate-induced osteonecrosis: OMS perspective. Paper presented at: Meeting of the American Association of Oral Maxillofacial Surgeons,2005; Boston, September 20-25, 2005
  26. ↵
    Chiandussi S, Biasotto M, Dore F, et al. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol 2006;35:236–43
    Abstract/FREE Full Text
  27. ↵
    Hino S, Murase R, Terakado N, et al. Response of diffuse sclerosing osteomyelitis of the mandible to alendronate: follow-up study by 99mTc scintigraphy. Int J Oral Maxillofac Surg 2005;34:576–78
    CrossRefPubMed
  28. ↵
    Orpe EC, Lee L, Pharoah MJ. A radiological analysis of chronic sclerosing osteomyelitis of the mandible. Dentomaxillofac Radiol 1996;25:125–29
    Abstract
  29. ↵
    Resnick D, Kransdorf M. Bone and Joint Imaging, 3rd ed. Philadelphia: Elsevier Saunders;2005
  30. ↵
    van der Waal RI, Buter J, van der Waal I. Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg 2003;41:3–6
    CrossRefPubMedWeb of Science
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
Imaging Findings of Bisphosphonate-Associated Osteonecrosis of the Jaws
  
    	
P.M. Phal, R.W.T. Myall, L.A. Assael, J.L. Weissman

  
    	
American Journal of Neuroradiology Jun 2007, 28 (6) 1139-1145; DOI: 10.3174/ajnr.A0518 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement