1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    













































































































    The Pathophysiology of Idiopathic Normal Pressure Hydrocephalus: Cerebral Ischemia or Altered Venous Hemodynamics? | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Research ArticleBRAIN

  
      

  
      
The Pathophysiology of Idiopathic Normal Pressure Hydrocephalus: Cerebral Ischemia or Altered Venous Hemodynamics?
  
    	
G.A. Bateman

  
    	
American Journal of Neuroradiology January 2008,  29 (1) 198-203; DOI: https://doi.org/10.3174/ajnr.A0739 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. ↵
    Adams RD, Fisher CM, Hakim S, et al. Symptomatic occult hydrocephalus with “normal” cerebrospinal pressure: a treatable syndrome. N Engl J Med 1965;273:117
    CrossRefPubMedWeb of Science
  2. ↵
    Borgesen SE, Gerris F. The predictive value of conductance to outflow of CSF in normal pressure hydrocephalus. Brain 1982;105:65–86
    FREE Full Text
  3. ↵
    Edwards RJ, Dombrowski SM, Luciano MG, et al. Chronic hydrocephalus in adults. Brain Pathol 2004;14:325–36
    PubMedWeb of Science
  4. ↵
    Oi S, Di Rocco C. Proposal of “evolution theory in cerebrospinal fluid dynamics” and minor pathway hydrocephalus in developing immature brain. Childs Nerv Syst 2006;22:662–69
    CrossRefPubMedWeb of Science
  5. ↵
    Bradley WG Jr, Scalzo D, Queralt J, et al. Normal-pressure hydrocephalus: evaluation with cerebrospinal fluid flow measurements at MR imaging. Radiology 1996;198:523–29
    PubMedWeb of Science
  6. ↵
    Bateman GA. Vascular compliance in normal pressure hydrocephalus. AJNR Am J Neuroradiol 2000;21:1574–85
    Abstract/FREE Full Text
  7. ↵
    Bateman GA. The reversibility of reduced cortical vein compliance in normal-pressure hydrocephalus following shunt insertion. Neuroradiology 2003;45:65–70
    PubMed
  8. ↵
    Stephensen H, Tisell M, Wikkelso C. There is no transmantle pressure gradient in either communicating or non-communicating hydrocephalus. Neurosurgery 2002;50:763–73
    CrossRefPubMedWeb of Science
  9. ↵
    Owler BK, Pickard JD. Normal pressure hydrocephalus and cerebral blood flow: a review. Acta Neurol Scand 2001;104:325–42
    CrossRefPubMedWeb of Science
  10. ↵
    Greitz TV, Grepe AO, Kalmer MS, et al. Pre- and post-operative evaluation of cerebral blood flow in low pressure hydrocephalus. J Neurosurg 1969;31:644–51
    PubMedWeb of Science
  11. ↵
    Vorstrup S, Christensen J, Gjerris F, et al. Cerebral blood flow in patients with normal pressure hydrocephalus before and after shunting. J Neurosurg 1987;66:379–87
    PubMedWeb of Science
  12. ↵
    Mamo HL, Meric PC, Ponsin JC, et al. Cerebral blood flow in normal pressure hydrocephalus. Stroke 1987;18:1074–80
    Abstract/FREE Full Text
  13. ↵
    Moretti JL, Sergent A, Louarn F, et al. Cortical perfusion assessment with 123I-isopropyl amphetamine (123I-IAMP) in normal pressure hydrocephalus (NPH). Eur J Nucl Med 1988;14:73–79
    PubMedWeb of Science
  14. ↵
    Mathew NT, Meyer JS, Hartmann A, et al. Abnormal cerebrospinal fluid-blood flow dynamics: implications in diagnosis, treatment, and prognosis in normal pressure hydrocephalus. Arch Neurol 1975;32:657–64
    CrossRefPubMedWeb of Science
  15. ↵
    Bradley WG Jr. Cerebrospinal fluid dynamics and shunt responsiveness in patients with normal-pressure hydrocephalus. Mayo Clin Proc 2002;77:507–08
    CrossRefPubMedWeb of Science
  16. ↵
    Marmarou A, Takagi H, Shulman K. Biomechanics of brain edema and effects on local cerebral blood flow. Adv Neurol 1980;28:345–58
    PubMed
  17. ↵
    Owler BK, Momjain S, Czosnyka Z, et al. Normal pressure hydrocephalus and cerebral blood flow: A PET study of baseline values. J Cereb Blood Flow Metab 2004;24:17–23
    CrossRefPubMedWeb of Science
  18. ↵
    Bateman GA, Levi CR, Schofield P, et al. The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded? Neuroradiology 2005;47:741–48
    CrossRefPubMed
  19. ↵
    Bateman GA. Pulse-wave encephalopathy: a comparative study of the hydrodynamics of leukoaraiosis and normal-pressure hydrocephalus. Neuroradiology 2002;44:740–48
    CrossRefPubMedWeb of Science
  20. ↵
    Evans AJ, Iwai F, Grist TA, et al. MR imaging of blood flow with a phase subtraction technique: in vitro and in vivo validation. Invest Radiol 1993;28:109–15
    CrossRefPubMedWeb of Science
  21. Laffon E, Valli N, Latrabe V, et al. A validation of a flow quantification by MR phase mapping software. Eur J Radiol 1998;27:166–72
    CrossRefPubMedWeb of Science
  22. ↵
    Powell AJ, Maiser SE, Chung T, et al. Phase-velocity cine magnetic resonance imaging measurement of pulsatile blood flow in children and young adults: in vitro and in vivo validation. Pediatr Cardiol 2000;21:104–10
    CrossRefPubMedWeb of Science
  23. ↵
    Black PM, Ojemann RG, Tzouras A. CSF shunts for dementia, incontinence, and gait disturbance. Clin Neurosurg 1985;32:632–51
    PubMed
  24. ↵
    Relkin N, Marmarou A, Klinge P, et al. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 2005;57(suppl):S4–16
    PubMed
  25. ↵
    Marmarou A, Bergsneider M, Kling P, et al. The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus. Neurosurgery 2005;57(suppl):S17–28
    CrossRefPubMed
  26. ↵
    Momjain S, Owler BK, Czosnyka Z, et al. Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus. Brain 2004;127:965–72
    Abstract/FREE Full Text
  27. ↵
    Brooks DJ, Beaney RP, Powell M, et al. Studies on cerebral oxygen metabolism, blood flow and blood volume, in patients with hydrocephalus before and after surgical decompression, using positron emission tomography. Brain 1986;109:613–28
    Abstract/FREE Full Text
  28. ↵
    Sugawara J, Hayashi K, Yokoi T, et al. Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens 2005;19:401–06
    CrossRefPubMedWeb of Science
  29. ↵
    Bergsneider M, Alwan AA, Falkson L, et al. The relationship of pulsatile cerebrospinal fluid flow to cerebral blood flow and intracranial pressure: a new theoretical model. Acta Neurochir Suppl 1998;71:266–68
    PubMed
  30. ↵
    Mase M, Miyati T, Yamada K, et al. Non-invasive measurement of intracranial compliance using cine MRI in normal pressure hydrocephalus. Acta Neurochir Suppl 2006;95:303–06
  31. ↵
    Kristensen B, Malm J, Fagerland M, et al. Regional cerebral blood flow, white matter abnormalities, and cerebrospinal fluid hydrodynamics in patients with idiopathic adult hydrocephalus syndrome. J Neurol Neurosurg Psychiatry 1996;60:282–88
    Abstract/FREE Full Text
  32. ↵
    Bateman GA. Association between arterial inflow and venous outflow in idiopathic and secondary intracranial hypertension. J Clin Neurosci 2006;13:550–56
    CrossRefPubMed
  33. ↵
    Shulman K, Ransohoff J. Sagittal sinus venous pressure in hydrocephalus. J Neurosurg 1976;45:20–25
    PubMedWeb of Science
  34. ↵
    Sainte-Rose C, LaCombe J, Pierre-Kahn A, et al. Intracranial venous sinus hypertension: cause or consequence of hydrocephalus in infants? J Neurosurg 1984;60:727–36
    PubMedWeb of Science
  35. ↵
    Shapiro K, Fried A, Takei F, et al. Effect of the skull and dura on neural axis pressure-volume relationships and CSF hydrodynamics. J Neurosurg 1985;63:76–81
    PubMed
  36. ↵
    Fodstad H, Love JA, Ekstedt J, et al. Effect of cranioplasty on cerebrospinal fluid hydrodynamics in patients with the syndrome of the trephined. Acta Neurochir (Wein)1984;70:21–30
    CrossRefPubMed
  37. ↵
    Czosnyka M, Czosnyka ZH, Whitfield PC, et al. Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus. J Neurosurg 2001;94:482–86
    PubMedWeb of Science
  38. ↵
    Rubenstein E. Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged. Lancet 1998;351:283–85
    CrossRefPubMedWeb of Science
  39. ↵
    Benabid AL, de Rougemont J, Barge M. Cerebral venous pressure, sinus pressure and intracranial pressure [in French]. Neurochurgie 1974;20:623–32
  40. ↵
    Deo-Narine V, Gomez DG, Vullo T, et al. Direct in vivo observation of transventricular absorption in the hydrocephalic dog using magnetic resonance imaging. Invest Radiol 1994;29:287–93
    CrossRefPubMed
  41. ↵
    Bateman GA. Extending the hydrodynamic hypothesis in chronic hydrocephalus. Neurosurg Rev 2005;28:333–34
    CrossRefPubMed
  42. ↵
    Bunge RP, Settlage PH. Neurological lesions in cats following cerebrospinal fluid manipulation. J Neuropathol Exp Neurol 1957;16:471–91
    PubMedWeb of Science
  43. ↵
    Hara M, Nakamura M, Kadowaki C, et al. Cerebrospinal fluid absorption mechanism-based on measurement of CSF flow rate in shunt tube [in Japanese]. No To Shinkei 1985;37:365–70
    PubMed
  44. ↵
    Meier U, Mutze S. Does the ventricular size change after shunt operation of normal-pressure hydrocephalus? Acta Neurochir Suppl 2005;95:257–59
    PubMed
  45. ↵
    Vullo T, Manzo R, Gomez DG, et al. A canine model of acute hydrocephalus with MR correlation. AJNR Am J Neuroradiol 1998;19:1123–25
    Abstract
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
The Pathophysiology of Idiopathic Normal Pressure Hydrocephalus: Cerebral Ischemia or Altered Venous Hemodynamics?
  
    	
G.A. Bateman

  
    	
American Journal of Neuroradiology Jan 2008, 29 (1) 198-203; DOI: 10.3174/ajnr.A0739 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement