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<meta name="DC.Title" content="Apparent Diffusion Coefficient Reveals Gray and White Matter Disease, and T2 Mapping Detects White Matter Disease in the Brain in Feline Alpha-Mannosidosis" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0791" />
<meta name="DC.Date" content="2008-02-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Methods to locate and identify brain pathology are critical for monitoring disease progression and for evaluating the efficacy of therapeutic intervention. The purpose of this study was to detect cell swelling, abnormal myelin, and astrogliosis in the feline model of the lysosomal storage disease α-mannosidosis (AMD) by using diffusion and T2 mapping.

MATERIALS AND METHODS: Average apparent diffusion coefficient (ADCav) and T2 were measured by imaging the brains of five 16-week-old cats with feline AMD on a 4.7T magnet. ADCav and T2 data from affected cats were compared with data from age-matched normal cats. Brains were collected from both affected and normal cats following imaging, and histology was compared with quantitative imaging data.

RESULTS: Gray matter from AMD cats demonstrated a 13%–15% decrease in ADCav compared with that in normal cats. White matter from AMD cats exhibited an 11%–16% decrease in ADCav and a 5%–12% increase in T2 values compared with those in normal control cats. Histologic evidence of neuronal and glial swelling, abnormal myelin, and astrogliosis was consistent with changes in ADCav and T2.

CONCLUSION: ADCav and T2 data can be used to quantify differences in the gray and white matter in the feline AMD brain and may serve as surrogate markers of neuronal swelling, abnormal myelin, and astrogliosis associated with this disease. These studies may be helpful in assessing the efficacy of experimental therapies for central nervous system disease associated with lysosomal storage diseases." />
<meta name="DC.Contributor" content="C.H. Vite" />
<meta name="DC.Contributor" content="S. Magnitsky" />
<meta name="DC.Contributor" content="D. Aleman" />
<meta name="DC.Contributor" content="P. O’Donnell" />
<meta name="DC.Contributor" content="K. Cullen" />
<meta name="DC.Contributor" content="W. Ding" />
<meta name="DC.Contributor" content="S. Pickup" />
<meta name="DC.Contributor" content="J.H. Wolfe" />
<meta name="DC.Contributor" content="H. Poptani" />
<meta name="article:published_time" content="2008-02-01" />
<meta name="article:section" content="PEDIATRICS" />
<meta name="citation_title" content="Apparent Diffusion Coefficient Reveals Gray and White Matter Disease, and T2 Mapping Detects White Matter Disease in the Brain in Feline Alpha-Mannosidosis" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Methods to locate and identify brain pathology are critical for monitoring disease progression and for evaluating the efficacy of therapeutic intervention. The purpose of this study was to detect cell swelling, abnormal myelin, and astrogliosis in the feline model of the lysosomal storage disease α-mannosidosis (AMD) by using diffusion and T2 mapping.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; Average apparent diffusion coefficient (ADC&lt;sub&gt;av&lt;/sub&gt;) and T2 were measured by imaging the brains of five 16-week-old cats with feline AMD on a 4.7T magnet. ADC&lt;sub&gt;av&lt;/sub&gt; and T2 data from affected cats were compared with data from age-matched normal cats. Brains were collected from both affected and normal cats following imaging, and histology was compared with quantitative imaging data.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Gray matter from AMD cats demonstrated a 13%–15% decrease in ADC&lt;sub&gt;av&lt;/sub&gt; compared with that in normal cats. White matter from AMD cats exhibited an 11%–16% decrease in ADC&lt;sub&gt;av&lt;/sub&gt; and a 5%–12% increase in T2 values compared with those in normal control cats. Histologic evidence of neuronal and glial swelling, abnormal myelin, and astrogliosis was consistent with changes in ADC&lt;sub&gt;av&lt;/sub&gt; and T2.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; ADC&lt;sub&gt;av&lt;/sub&gt; and T2 data can be used to quantify differences in the gray and white matter in the feline AMD brain and may serve as surrogate markers of neuronal swelling, abnormal myelin, and astrogliosis associated with this disease. These studies may be helpful in assessing the efficacy of experimental therapies for central nervous system disease associated with lysosomal storage diseases.&lt;/p&gt;" />
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<meta name="twitter:title" content="Apparent Diffusion Coefficient Reveals Gray and White Matter Disease, and T2 Mapping Detects White Matter Disease in the Brain in Feline Alpha-Mannosidosis" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Methods to locate and identify brain pathology are critical for monitoring disease progression and for evaluating the efficacy of therapeutic intervention. The purpose of this study was to detect cell swelling, abnormal myelin, and astrogliosis in the feline model of the lysosomal storage disease α-mannosidosis (AMD) by using diffusion and T2 mapping.

MATERIALS AND METHODS: Average apparent diffusion coefficient (ADCav) and T2 were measured by imaging the brains of five 16-week-old cats with feline AMD on a 4.7T magnet. ADCav and T2 data from affected cats were compared with data from age-matched normal cats. Brains were collected from both affected and normal cats following imaging, and histology was compared with quantitative imaging data.

RESULTS: Gray matter from AMD cats demonstrated a 13%–15% decrease in ADCav compared with that in normal cats. White matter from AMD cats exhibited an 11%–16% decrease in ADCav and a 5%–12% increase in T2 values compared with those in normal control cats. Histologic evidence of neuronal and glial swelling, abnormal myelin, and astrogliosis was consistent with changes in ADCav and T2.

CONCLUSION: ADCav and T2 data can be used to quantify differences in the gray and white matter in the feline AMD brain and may serve as surrogate markers of neuronal swelling, abnormal myelin, and astrogliosis associated with this disease. These studies may be helpful in assessing the efficacy of experimental therapies for central nervous system disease associated with lysosomal storage diseases." />
<meta name="og-title" property="og:title" content="Apparent Diffusion Coefficient Reveals Gray and White Matter Disease, and T2 Mapping Detects White Matter Disease in the Brain in Feline Alpha-Mannosidosis" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Methods to locate and identify brain pathology are critical for monitoring disease progression and for evaluating the efficacy of therapeutic intervention. The purpose of this study was to detect cell swelling, abnormal myelin, and astrogliosis in the feline model of the lysosomal storage disease α-mannosidosis (AMD) by using diffusion and T2 mapping.

MATERIALS AND METHODS: Average apparent diffusion coefficient (ADCav) and T2 were measured by imaging the brains of five 16-week-old cats with feline AMD on a 4.7T magnet. ADCav and T2 data from affected cats were compared with data from age-matched normal cats. Brains were collected from both affected and normal cats following imaging, and histology was compared with quantitative imaging data.

RESULTS: Gray matter from AMD cats demonstrated a 13%–15% decrease in ADCav compared with that in normal cats. White matter from AMD cats exhibited an 11%–16% decrease in ADCav and a 5%–12% increase in T2 values compared with those in normal control cats. Histologic evidence of neuronal and glial swelling, abnormal myelin, and astrogliosis was consistent with changes in ADCav and T2.

CONCLUSION: ADCav and T2 data can be used to quantify differences in the gray and white matter in the feline AMD brain and may serve as surrogate markers of neuronal swelling, abnormal myelin, and astrogliosis associated with this disease. These studies may be helpful in assessing the efficacy of experimental therapies for central nervous system disease associated with lysosomal storage diseases." />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">PEDIATRICS</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Apparent Diffusion Coefficient Reveals Gray and White Matter Disease, and T2 Mapping Detects White Matter Disease in the Brain in Feline Alpha-Mannosidosis</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">C.H. Vite</span>, <span class="highwire-citation-author" data-delta="1">S. Magnitsky</span>, <span class="highwire-citation-author" data-delta="2">D. Aleman</span>, <span class="highwire-citation-author" data-delta="3">P. O’Donnell</span>, <span class="highwire-citation-author" data-delta="4">K. Cullen</span>, <span class="highwire-citation-author" data-delta="5">W. Ding</span>, <span class="highwire-citation-author" data-delta="6">S. Pickup</span>, <span class="highwire-citation-author" data-delta="7">J.H. Wolfe</span> and <span class="highwire-citation-author" data-delta="8">H. Poptani</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2008,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">308-313; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0791 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7866--6266688574" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">C.H. Vite </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.H.%2BVite%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vite%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.H.%2BVite%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S. 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O’Donnell </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BO%E2%80%99Donnell%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=O%E2%80%99Donnell%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.%2BO%25E2%2580%2599Donnell%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">K. 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Diffusion MR imaging and proton MR spectroscopy.</strong> <span class="cit-source">Acta Radiol</span> <span class="cit-pub-date">2003</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">440</span>–43</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1034/j.1600-0455.2003.00094.x&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12846696&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F2%2F308.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-41-1" title="View reference 41 in text" id="ref-41">↵</a><div class="cit ref-cit ref-other" id="cit-29.2.308.41" data-doi="10.1055/s-2004-821301"><div class="cit-metadata"><cite>Oguz KK, Anlar B, Senbil N, et al. <strong>Diffusion-weighted imaging findings in juvenile metachromatic leukodystrophy.</strong> <span class="cit-source">Neuropediatrics</span> <span class="cit-pub-date">2004</span>;<span class="cit-vol">35</span>:<span class="cit-fpage">279</span>–82</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1055/s-2004-821301&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15534760&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F2%2F308.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000225338500004&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-42-1" title="View reference 42 in text" id="ref-42">↵</a><div class="cit ref-cit ref-other" id="cit-29.2.308.42" data-doi="10.1007/s002340100607"><div class="cit-metadata"><cite>Patlas M, Shapira MY, Nagler A, et al. <strong>MRI of mannosidosis.</strong> <span class="cit-source">Neuroradiology</span> <span class="cit-pub-date">2001</span>;<span class="cit-vol">43</span>:<span class="cit-fpage">941</span>–43</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s002340100607&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11760797&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F2%2F308.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li></ol></div></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">C.H.</span> <span class="nlm-surname">Vite</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Magnitsky</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Aleman</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">P.</span> <span class="nlm-surname">O’Donnell</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Cullen</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Ding</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Pickup</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Wolfe</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Poptani</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">308-313; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0791 </span></div>
  
  
  
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