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<meta name="DC.Title" content="Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0903" />
<meta name="DC.Date" content="2008-04-01" />
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<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: We investigated the relationship between tumor blood-flow measurement based on perfusion imaging by arterial spin-labeling (ASL-PI) and histopathologic findings in brain tumors.

MATERIALS AND METHODS: We used ASL-PI to examine 35 patients with brain tumors, including 11 gliomas, 9 meningiomas, 9 schwannomas, 1 diffuse large B-cell lymphoma, 4 hemangioblastomas, and 1 metastatic brain tumor. As an index of tumor perfusion, the relative signal intensity (SI) of each tumor (%Signal intensity) was determined as a percentage of the maximal SI within the tumor per averaged SI within normal cerebral gray matter on ASL-PI. Relative vascular attenuation (%Vessel) was determined as the total microvessel area per the entire tissue area on CD-34–immunostained histopathologic specimens. MIB1 indices of gliomas were also calculated. The differences in %Signal intensity among different histopathologic types and between high- and low-grade gliomas were compared. In addition, the correlations between %Signal intensity and %Vessel or MIB1 index were evaluated in gliomas.

RESULTS: Statistically significant differences in %Signal intensity were observed between hemangioblastomas versus gliomas ( P &lt; .005), meningiomas ( P &lt; .05), and schwannomas ( P &lt; .005). Among gliomas, %Signal intensity was significantly higher for high-grade than for low-grade tumors ( P &lt; .05). Correlation analyses revealed significant positive correlations between %Signal intensity and %Vessel in 35 patients, including all 6 histopathologic types ( rs = 0.782, P &lt; .00005) and in gliomas ( rs = 0.773, P &lt; .05). In addition, in gliomas, %Signal intensity and MIB1 index were significantly positively correlated ( rs = 0.700, P &lt; .05).

CONCLUSION: ASL-PI may predict histopathologic vascular densities of brain tumors and may be useful in distinguishing between high- and low-grade gliomas and in differentiating hemangioblastomas from other brain tumors." />
<meta name="DC.Contributor" content="T. Noguchi" />
<meta name="DC.Contributor" content="T. Yoshiura" />
<meta name="DC.Contributor" content="A. Hiwatashi" />
<meta name="DC.Contributor" content="O. Togao" />
<meta name="DC.Contributor" content="K. Yamashita" />
<meta name="DC.Contributor" content="E. Nagao" />
<meta name="DC.Contributor" content="T. Shono" />
<meta name="DC.Contributor" content="M. Mizoguchi" />
<meta name="DC.Contributor" content="S. Nagata" />
<meta name="DC.Contributor" content="T. Sasaki" />
<meta name="DC.Contributor" content="S.O. Suzuki" />
<meta name="DC.Contributor" content="T. Iwaki" />
<meta name="DC.Contributor" content="K. Kobayashi" />
<meta name="DC.Contributor" content="F. Mihara" />
<meta name="DC.Contributor" content="H. Honda" />
<meta name="article:published_time" content="2008-04-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; We investigated the relationship between tumor blood-flow measurement based on perfusion imaging by arterial spin-labeling (ASL-PI) and histopathologic findings in brain tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; We used ASL-PI to examine 35 patients with brain tumors, including 11 gliomas, 9 meningiomas, 9 schwannomas, 1 diffuse large B-cell lymphoma, 4 hemangioblastomas, and 1 metastatic brain tumor. As an index of tumor perfusion, the relative signal intensity (SI) of each tumor (%Signal intensity) was determined as a percentage of the maximal SI within the tumor per averaged SI within normal cerebral gray matter on ASL-PI. Relative vascular attenuation (%Vessel) was determined as the total microvessel area per the entire tissue area on CD-34–immunostained histopathologic specimens. MIB1 indices of gliomas were also calculated. The differences in %Signal intensity among different histopathologic types and between high- and low-grade gliomas were compared. In addition, the correlations between %Signal intensity and %Vessel or MIB1 index were evaluated in gliomas.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Statistically significant differences in %Signal intensity were observed between hemangioblastomas versus gliomas (&lt;i&gt;P&lt;/i&gt; &amp;lt; .005), meningiomas (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05), and schwannomas (&lt;i&gt;P&lt;/i&gt; &amp;lt; .005). Among gliomas, %Signal intensity was significantly higher for high-grade than for low-grade tumors (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05). Correlation analyses revealed significant positive correlations between %Signal intensity and %Vessel in 35 patients, including all 6 histopathologic types (&lt;i&gt;rs&lt;/i&gt; = 0.782, &lt;i&gt;P&lt;/i&gt; &amp;lt; .00005) and in gliomas (&lt;i&gt;rs&lt;/i&gt; = 0.773, &lt;i&gt;P&lt;/i&gt; &amp;lt; .05). In addition, in gliomas, %Signal intensity and MIB1 index were significantly positively correlated (&lt;i&gt;rs&lt;/i&gt; = 0.700, &lt;i&gt;P&lt;/i&gt; &amp;lt; .05).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; ASL-PI may predict histopathologic vascular densities of brain tumors and may be useful in distinguishing between high- and low-grade gliomas and in differentiating hemangioblastomas from other brain tumors.&lt;/p&gt;" />
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<meta name="twitter:title" content="Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: We investigated the relationship between tumor blood-flow measurement based on perfusion imaging by arterial spin-labeling (ASL-PI) and histopathologic findings in brain tumors.

MATERIALS AND METHODS: We used ASL-PI to examine 35 patients with brain tumors, including 11 gliomas, 9 meningiomas, 9 schwannomas, 1 diffuse large B-cell lymphoma, 4 hemangioblastomas, and 1 metastatic brain tumor. As an index of tumor perfusion, the relative signal intensity (SI) of each tumor (%Signal intensity) was determined as a percentage of the maximal SI within the tumor per averaged SI within normal cerebral gray matter on ASL-PI. Relative vascular attenuation (%Vessel) was determined as the total microvessel area per the entire tissue area on CD-34–immunostained histopathologic specimens. MIB1 indices of gliomas were also calculated. The differences in %Signal intensity among different histopathologic types and between high- and low-grade gliomas were compared. In addition, the correlations between %Signal intensity and %Vessel or MIB1 index were evaluated in gliomas.

RESULTS: Statistically significant differences in %Signal intensity were observed between hemangioblastomas versus gliomas ( P &lt; .005), meningiomas ( P &lt; .05), and schwannomas ( P &lt; .005). Among gliomas, %Signal intensity was significantly higher for high-grade than for low-grade tumors ( P &lt; .05). Correlation analyses revealed significant positive correlations between %Signal intensity and %Vessel in 35 patients, including all 6 histopathologic types ( rs = 0.782, P &lt; .00005) and in gliomas ( rs = 0.773, P &lt; .05). In addition, in gliomas, %Signal intensity and MIB1 index were significantly positively correlated ( rs = 0.700, P &lt; .05).

CONCLUSION: ASL-PI may predict histopathologic vascular densities of brain tumors and may be useful in distinguishing between high- and low-grade gliomas and in differentiating hemangioblastomas from other brain tumors." />
<meta name="og-title" property="og:title" content="Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: We investigated the relationship between tumor blood-flow measurement based on perfusion imaging by arterial spin-labeling (ASL-PI) and histopathologic findings in brain tumors.

MATERIALS AND METHODS: We used ASL-PI to examine 35 patients with brain tumors, including 11 gliomas, 9 meningiomas, 9 schwannomas, 1 diffuse large B-cell lymphoma, 4 hemangioblastomas, and 1 metastatic brain tumor. As an index of tumor perfusion, the relative signal intensity (SI) of each tumor (%Signal intensity) was determined as a percentage of the maximal SI within the tumor per averaged SI within normal cerebral gray matter on ASL-PI. Relative vascular attenuation (%Vessel) was determined as the total microvessel area per the entire tissue area on CD-34–immunostained histopathologic specimens. MIB1 indices of gliomas were also calculated. The differences in %Signal intensity among different histopathologic types and between high- and low-grade gliomas were compared. In addition, the correlations between %Signal intensity and %Vessel or MIB1 index were evaluated in gliomas.

RESULTS: Statistically significant differences in %Signal intensity were observed between hemangioblastomas versus gliomas ( P &lt; .005), meningiomas ( P &lt; .05), and schwannomas ( P &lt; .005). Among gliomas, %Signal intensity was significantly higher for high-grade than for low-grade tumors ( P &lt; .05). Correlation analyses revealed significant positive correlations between %Signal intensity and %Vessel in 35 patients, including all 6 histopathologic types ( rs = 0.782, P &lt; .00005) and in gliomas ( rs = 0.773, P &lt; .05). In addition, in gliomas, %Signal intensity and MIB1 index were significantly positively correlated ( rs = 0.700, P &lt; .05).

CONCLUSION: ASL-PI may predict histopathologic vascular densities of brain tumors and may be useful in distinguishing between high- and low-grade gliomas and in differentiating hemangioblastomas from other brain tumors." />
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      <h1 class="highwire-cite-title" id="page-title">Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">T. Noguchi</span>, <span class="highwire-citation-author" data-delta="1">T. Yoshiura</span>, <span class="highwire-citation-author" data-delta="2">A. Hiwatashi</span>, <span class="highwire-citation-author" data-delta="3">O. Togao</span>, <span class="highwire-citation-author" data-delta="4">K. Yamashita</span>, <span class="highwire-citation-author" data-delta="5">E. Nagao</span>, <span class="highwire-citation-author" data-delta="6">T. Shono</span>, <span class="highwire-citation-author" data-delta="7">M. Mizoguchi</span>, <span class="highwire-citation-author" data-delta="8">S. Nagata</span>, <span class="highwire-citation-author" data-delta="9">T. Sasaki</span>, <span class="highwire-citation-author" data-delta="10">S.O. Suzuki</span>, <span class="highwire-citation-author" data-delta="11">T. Iwaki</span>, <span class="highwire-citation-author" data-delta="12">K. Kobayashi</span>, <span class="highwire-citation-author" data-delta="13">F. Mihara</span> and <span class="highwire-citation-author" data-delta="14">H. Honda</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2008,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">688-693; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0903 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-8188--6643827629" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">T. Noguchi </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.%2BNoguchi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Noguchi%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AT.%2BNoguchi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">T. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.1" data-doi="10.1161/01.STR.31.3.680"><div class="cit-metadata"><cite>Chalela JA, Alsop DC, Gonzalez-Atavales JB, et al. <strong>Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling.</strong> <span class="cit-source">Stroke</span> <span class="cit-pub-date">2000</span>;<span class="cit-vol">31</span>:<span class="cit-fpage">680</span>–87</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjg6IjMxLzMvNjgwIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzI5LzQvNjg4LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><div class="cit ref-cit ref-other no-rev-xref" id="cit-29.4.688.2" data-doi="10.1002/jmri.20382"><div class="cit-metadata"><cite>Kimura H, Kado H, Koshimoto Y, et al. <strong>Multislice continuous arterial spin-labeled perfusion MRI in patients with chronic occlusive cerebrovascular disease: a correlative study with CO2 PET validation.</strong> <span class="cit-source">J Magn Reson Imaging</span> <span class="cit-pub-date">2005</span>;<span class="cit-vol">22</span>:<span class="cit-fpage">189</span>–98</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/jmri.20382&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16028241&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000230812900003&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3 in text" id="ref-3">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.3"><div class="cit-metadata"><cite>Detre JA, Alsop DC, Vives LR, et al. <strong>Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease.</strong> <span class="cit-source">Neurology</span> <span class="cit-pub-date">1998</span>;<span class="cit-vol">50</span>:<span class="cit-fpage">633</span>–41</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6IjUwLzMvNjMzIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzI5LzQvNjg4LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4 in text" id="ref-4">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.4" data-doi="10.1002/1531-8249(200001)47:1&lt;93::AID-ANA15&gt;3.0.CO;2-8"><div class="cit-metadata"><cite>Alsop DC, Detre JA, Grossman M. <strong>Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging.</strong> <span class="cit-source">Ann Neurol</span> <span class="cit-pub-date">2000</span>;<span class="cit-vol">47</span>:<span class="cit-fpage">93</span>–100</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/1531-8249(200001)47:1&lt;93::AID-ANA15&gt;3.0.CO;2-8&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10632106&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000084636800014&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5 in text" id="ref-5">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.5" data-doi="10.1212/01.wnl.0000238163.71349.78"><div class="cit-metadata"><cite>Du AT, Jahng GH, Hayasaka S, et al. <strong>Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI.</strong> <span class="cit-source">Neurology</span> <span class="cit-pub-date">2006</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">1215</span>–20</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjk6IjY3LzcvMTIxNSI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8yOS80LzY4OC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6 in text" id="ref-6">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.6" data-doi="10.1002/1522-2594(200103)45:3&lt;431::AID-MRM1056&gt;3.0.CO;2-E"><div class="cit-metadata"><cite>Liu HL, Kochunov P, Hou J, et al. <strong>Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR-HASTE: comparison with H215O PET measurements.</strong> <span class="cit-source">Magn Reson Med</span> <span class="cit-pub-date">2001</span>;<span class="cit-vol">45</span>:<span class="cit-fpage">431</span>–35</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/1522-2594(200103)45:3&lt;431::AID-MRM1056&gt;3.0.CO;2-E&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11241700&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000167163800012&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7 in text" id="ref-7">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.7"><div class="cit-metadata"><cite>Wolf RL, Alsop DC, Levy-Reis I, et al. <strong>Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging.</strong> <span class="cit-source">AJNR Am J Neuroradiol</span> <span class="cit-pub-date">2001</span>;<span class="cit-vol">22</span>:<span class="cit-fpage">1334</span>–41</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo5OiIyMi83LzEzMzQiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMjkvNC82ODguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8 in text" id="ref-8">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.8" data-doi="10.1097/01.rli.0000119195.50515.04"><div class="cit-metadata"><cite>Weber MA, Thilmann C, Lichy MP, et al. <strong>Assessment of irradiated brain metastases by means of arterial spin-labeling and dynamic susceptibility-weighted contrast-enhanced perfusion MRI: initial results.</strong> <span class="cit-source">Invest Radiol</span> <span class="cit-pub-date">2004</span>;<span class="cit-vol">39</span>:<span class="cit-fpage">277</span>–87</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/01.rli.0000119195.50515.04&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15087722&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9 in text" id="ref-9">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.9" data-doi="10.1212/01.wnl.0000219767.49705.9c"><div class="cit-metadata"><cite>Weber MA, Zoubaa S, Schlieter M, et al. <strong>Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors.</strong> <span class="cit-source">Neurology</span> <span class="cit-pub-date">2006</span>;<span class="cit-vol">66</span>:<span class="cit-fpage">1899</span>–906</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjEwOiI2Ni8xMi8xODk5IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzI5LzQvNjg4LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10 in text" id="ref-10">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.10" data-doi="10.1148/radiol.2282020409"><div class="cit-metadata"><cite>Warmuth C, Gunther M, Zimmer C. <strong>Quantification of blood flow in brain tumors: comparison of arterial spin-labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging.</strong> <span class="cit-source">Radiology</span> <span class="cit-pub-date">2003</span>;<span class="cit-vol">228</span>:<span class="cit-fpage">523</span>–32</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiol.2282020409&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12819338&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000184381100034&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11 in text" id="ref-11">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.11" data-doi="10.1002/jmri.20415"><div class="cit-metadata"><cite>Wolf RL, Wang J, Wang S, et al. <strong>Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla.</strong> <span class="cit-source">J Magn Reson Imaging</span> <span class="cit-pub-date">2005</span>;<span class="cit-vol">22</span>:<span class="cit-fpage">475</span>–82</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/jmri.20415&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16161080&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12 in text" id="ref-12">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.12"><div class="cit-metadata"><cite>Gaa J, Warach S, Wen P, et al. <strong>Noninvasive perfusion imaging of human brain tumors with EPISTAR.</strong> <span class="cit-source">Eur Radiol</span> <span class="cit-pub-date">1996</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">518</span>–22</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=8798035&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13 in text" id="ref-13">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.13"><div class="cit-metadata"><cite>Kimura H, Takeuchi H, Koshimoto Y, et al. <strong>Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features.</strong> <span class="cit-source">AJNR Am J Neuroradiol</span> <span class="cit-pub-date">2006</span>;<span class="cit-vol">27</span>:<span class="cit-fpage">85</span>–93</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo3OiIyNy8xLzg1IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzI5LzQvNjg4LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14 in text" id="ref-14">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.14"><div class="cit-metadata"><cite>Louis DN, Ohgaki H, Wiestler OD, et al. <span class="cit-source">WHO Classification of Tumours of the Central Nervous System: Histological and Genetic Typing of Human Tumours.</span> Lyon, France: IARC PRESS;<span class="cit-pub-date">2007</span></cite></div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15 in text" id="ref-15">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.15" data-doi="10.1002/(SICI)1522-2594(199906)41:6&lt;1246::AID-MRM22&gt;3.0.CO;2-N"><div class="cit-metadata"><cite>Luh WM, Wong EC, Bandettini PA, et al. <strong>QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling.</strong> <span class="cit-source">Magn Reson Med</span> <span class="cit-pub-date">1999</span>;<span class="cit-vol">41</span>:<span class="cit-fpage">1246</span>–54</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/(SICI)1522-2594(199906)41:6&lt;1246::AID-MRM22&gt;3.0.CO;2-N&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10371458&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000081422500022&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16 in text" id="ref-16">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.16" data-doi="10.2463/mrms.6.91"><div class="cit-metadata"><cite>Noguchi T, Yoshiura T, Hiwatashi A, et al. <strong>Quantitative perfusion imaging with pulsed arterial spin labeling: a phantom study.</strong> <span class="cit-source">Magn Reson Med Sci</span> <span class="cit-pub-date">2007</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">91</span>–97</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.2463/mrms.6.91&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=17690539&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17 in text" id="ref-17">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.17" data-doi="10.1002/mrm.10180"><div class="cit-metadata"><cite>Parkes LM, Tofts PS. <strong>Improved accuracy of human cerebral blood perfusion measurements using arterial spin labeling: accounting for capillary water permeability.</strong> <span class="cit-source">Magn Reson Med</span> <span class="cit-pub-date">2002</span>;<span class="cit-vol">48</span>:<span class="cit-fpage">27</span>–41</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.10180&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12111929&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18 in text" id="ref-18">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.18" data-doi="10.1002/mrm.20023"><div class="cit-metadata"><cite>Parkes LM, Rashid W, Chard DT, et al. <strong>Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects.</strong> <span class="cit-source">Magn Reson Med</span> <span class="cit-pub-date">2004</span>;<span class="cit-vol">51</span>:<span class="cit-fpage">736</span>–43</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.20023&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15065246&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000220557200012&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19 in text" id="ref-19">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.19" data-doi="10.1002/nbm.1075"><div class="cit-metadata"><cite>Donahue MJ, Lu H, Jones CK, et al. <strong>An account of the discrepancy between MRI and PET cerebral blood flow measures: a high-field MRI investigation.</strong> <span class="cit-source">NMR Biomed</span> <span class="cit-pub-date">2006</span>;<span class="cit-vol">19</span>:<span class="cit-fpage">1043</span>–54</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/nbm.1075&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16948114&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20 in text" id="ref-20">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.20" data-doi="10.1002/1522-2594(200009)44:3&lt;450::AID-MRM16&gt;3.0.CO;2-0"><div class="cit-metadata"><cite>Ye FQ, Berman KF, Ellmore T, et al. <strong>H215O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans.</strong> <span class="cit-source">Magn Reson Med</span> <span class="cit-pub-date">2000</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">450</span>–56</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/1522-2594(200009)44:3&lt;450::AID-MRM16&gt;3.0.CO;2-0&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10975898&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000089093200016&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21 in text" id="ref-21">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.21"><div class="cit-metadata"><cite>Abdulrauf SL, Edvardsen K, Ho KL, et al. <strong>Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma.</strong> <span class="cit-source">J Neurosurg</span> <span class="cit-pub-date">1998</span>;<span class="cit-vol">88</span>:<span class="cit-fpage">513</span>–20</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=9488306&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000072133800013&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22 in text" id="ref-22">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.22" data-doi="10.1002/(SICI)1097-0142(19960115)77:2&lt;362::AID-CNCR20&gt;3.0.CO;2-Z"><div class="cit-metadata"><cite>Leon SP, Folkerth RD, Black PM. <strong>Microvessel density is a prognostic indicator for patients with astroglial brain tumors.</strong> <span class="cit-source">Cancer</span> <span class="cit-pub-date">1996</span>;<span class="cit-vol">77</span>:<span class="cit-fpage">362</span>–72</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/(SICI)1097-0142(19960115)77:2&lt;362::AID-CNCR20&gt;3.0.CO;2-Z&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=8625246&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1996TR25600020&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23 in text" id="ref-23">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.23" data-doi="10.1046/j.1365-2990.2002.00367.x"><div class="cit-metadata"><cite>Korkolopoulou P, Patsouris E, Kavantzas N, et al. <strong>Prognostic implications of microvessel morphometry in diffuse astrocytic neoplasms.</strong> <span class="cit-source">Neuropathol Appl Neurobiol</span> <span class="cit-pub-date">2002</span>;<span class="cit-vol">28</span>:<span class="cit-fpage">57</span>–66</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1046/j.1365-2990.2002.00367.x&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11849564&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24 in text" id="ref-24">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.24"><div class="cit-metadata"><cite>Gerdes J, Lemke H, Baisch H, et al. <strong>Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.</strong> <span class="cit-source">J Immunol</span> <span class="cit-pub-date">1984</span>;<span class="cit-vol">133</span>:<span class="cit-fpage">1710</span>–15</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6ODoiamltbXVub2wiO3M6NToicmVzaWQiO3M6MTA6IjEzMy80LzE3MTAiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMjkvNC82ODguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><div class="cit ref-cit ref-other no-rev-xref" id="cit-29.4.688.25"><div class="cit-metadata"><cite>Ellis PA, Makris A, Burton SA, et al. <strong>Comparison of MIB-1 proliferation index with S-phase fraction in human breast carcinomas.</strong> <span class="cit-source">Br J Cancer</span> <span class="cit-pub-date">1996</span>;<span class="cit-vol">73</span>:<span class="cit-fpage">640</span>–43</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=8605100&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1996TV82700015&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26 in text" id="ref-26">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.26" data-doi="10.1002/path.1711680404"><div class="cit-metadata"><cite>Cattoretti G, Becker MH, Key G, et al. <strong>Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections.</strong> <span class="cit-source">J Pathol</span> <span class="cit-pub-date">1992</span>;<span class="cit-vol">168</span>:<span class="cit-fpage">357</span>–63</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/path.1711680404&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=1484317&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1992KE99600003&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27 in text" id="ref-27">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.27" data-doi="10.1097/00000478-198609000-00003"><div class="cit-metadata"><cite>Burger PC, Shibata T, Kleihues P. <strong>The use of the monoclonal antibody Ki-67 in the identification of proliferating cells: application to surgical neuropathology.</strong> <span class="cit-source">Am J Surg Pathol</span> <span class="cit-pub-date">1986</span>;<span class="cit-vol">10</span>:<span class="cit-fpage">611</span>–17</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/00000478-198609000-00003&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=2428262&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1986D830200003&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-28-1" title="View reference 28 in text" id="ref-28">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.688.28"><div class="cit-metadata"><cite>Ho VB, Smirniotopoulos JG, Murphy FM, et al. <strong>Radiologic-pathologic correlation: hemangioblastoma.</strong> <span class="cit-source">AJNR Am J Neuroradiol</span> <span class="cit-pub-date">1992</span>;<span class="cit-vol">13</span>:<span class="cit-fpage">1343</span>–52</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6MzoiUERGIjtzOjExOiJqb3VybmFsQ29kZSI7czo0OiJham5yIjtzOjU6InJlc2lkIjtzOjk6IjEzLzUvMTM0MyI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8yOS80LzY4OC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-29-1" title="View reference 29 in text" id="ref-29">↵</a><div 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data-doi="10.1016/S0150-9861(05)83159-1"><div class="cit-metadata"><cite>Wintermark M, Sesay M, Barbier E, et al. <strong>Comparative overview of brain perfusion imaging techniques.</strong> <span class="cit-source">J Neuroradiol</span> <span class="cit-pub-date">2005</span>;<span class="cit-vol">32</span>:<span class="cit-fpage">294</span>–314</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S0150-9861(05)83159-1&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16424829&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F688.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000234433400002&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 29</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 4 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">April 2008 </div></div>
      
      
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      <div class="highwire-cite-title">Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Noguchi</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Yoshiura</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Hiwatashi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">O.</span> <span class="nlm-surname">Togao</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Yamashita</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Nagao</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Shono</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Mizoguchi</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Nagata</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Sasaki</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">S.O.</span> <span class="nlm-surname">Suzuki</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Iwaki</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Kobayashi</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Mihara</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Honda</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">688-693; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0903 </span></div>
  
  
  
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      <div class="highwire-cite-title">Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Noguchi</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Yoshiura</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Hiwatashi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">O.</span> <span class="nlm-surname">Togao</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Yamashita</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Nagao</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Shono</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Mizoguchi</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Nagata</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Sasaki</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">S.O.</span> <span class="nlm-surname">Suzuki</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Iwaki</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Kobayashi</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Mihara</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Honda</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">688-693; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0903 </span></div>
  
  
  
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