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<meta name="DC.Title" content="MR T1-Weighted Inversion Recovery Imaging in Detecting Brain Metastases: Could It Replace T1-Weighted Spin-Echo Imaging?" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0907" />
<meta name="DC.Date" content="2008-04-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: T1-weighted inversion recovery (T1IR) imaging demonstrates higher brain tissue contrast and is more sensitive to contrast enhancement than T1-weighted spin-echo (T1SE) imaging. However, the effectiveness of the 2 imaging sequences in detecting brain metastases has not been studied. The objective of this report was to determine which sequence should be used for detecting brain metastases by comparing the effectiveness of T1IR imaging with that of T1SE imaging.

Materials and METHODS: Thirty-one patients with brain metastases underwent T1SE and T1IR with and without intravenous gadopentetate dimeglumine. T1SE and T1IR images were compared for the number of metastases, degree of contrast enhancement, volume and contrast-to-enhancement ratio (CER) of tumors, and contrast ratio (CR) of tumor to white matter (WM), tumor to gray matter (GM), and tumor to CSF.

RESULTS: There were 352 metastases in 31 patients, among which 2 patients with 5 metastases were demonstrated only on postenhanced T1SE images. Pre-enhanced and postenhanced T1SE images detected 162 and 350 lesions, respectively, whereas pre-enhanced and postenhanced T1IR images only discovered 94 and 233 lesions. The degree of tumor contrast enhancement was higher on T1IR images than on T1SE images, whereas no difference in the CER of tumors was found between the 2 sequences. Before enhancement, all of the CRs on T1IR images were higher than on T1SE images. After contrast enhancement, CRs of tumor to WM and tumor to GM were higher on T1SE images than on T1IR images. On the contrary, the CR of tumor to CSF was higher on T1IR images than on T1SE images. Tumor volumes were 5.6 ± 7.0 cm3 on postenhanced T1SE images and 5.5 ± 7.0 cm3 on postenhanced T1IR images, and no significant difference was found between the 2 groups.

CONCLUSION: T1SE, but not T1IR, should be used as T1-weighted imaging in detecting brain metastases, because T1SE imaging has a greater sensitivity than T1IR imaging both before and after contrast material administration." />
<meta name="DC.Contributor" content="Y.-F. Qian" />
<meta name="DC.Contributor" content="C.-L. Yu" />
<meta name="DC.Contributor" content="C. Zhang" />
<meta name="DC.Contributor" content="Y.-Q. Yu" />
<meta name="article:published_time" content="2008-04-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="MR T1-Weighted Inversion Recovery Imaging in Detecting Brain Metastases: Could It Replace T1-Weighted Spin-Echo Imaging?" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; T1-weighted inversion recovery (T1IR) imaging demonstrates higher brain tissue contrast and is more sensitive to contrast enhancement than T1-weighted spin-echo (T1SE) imaging. However, the effectiveness of the 2 imaging sequences in detecting brain metastases has not been studied. The objective of this report was to determine which sequence should be used for detecting brain metastases by comparing the effectiveness of T1IR imaging with that of T1SE imaging.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Materials and METHODS:&lt;/b&gt; Thirty-one patients with brain metastases underwent T1SE and T1IR with and without intravenous gadopentetate dimeglumine. T1SE and T1IR images were compared for the number of metastases, degree of contrast enhancement, volume and contrast-to-enhancement ratio (CER) of tumors, and contrast ratio (CR) of tumor to white matter (WM), tumor to gray matter (GM), and tumor to CSF.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; There were 352 metastases in 31 patients, among which 2 patients with 5 metastases were demonstrated only on postenhanced T1SE images. Pre-enhanced and postenhanced T1SE images detected 162 and 350 lesions, respectively, whereas pre-enhanced and postenhanced T1IR images only discovered 94 and 233 lesions. The degree of tumor contrast enhancement was higher on T1IR images than on T1SE images, whereas no difference in the CER of tumors was found between the 2 sequences. Before enhancement, all of the CRs on T1IR images were higher than on T1SE images. After contrast enhancement, CRs of tumor to WM and tumor to GM were higher on T1SE images than on T1IR images. On the contrary, the CR of tumor to CSF was higher on T1IR images than on T1SE images. Tumor volumes were 5.6 ± 7.0 cm&lt;sup&gt;3&lt;/sup&gt; on postenhanced T1SE images and 5.5 ± 7.0 cm&lt;sup&gt;3&lt;/sup&gt; on postenhanced T1IR images, and no significant difference was found between the 2 groups.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; T1SE, but not T1IR, should be used as T1-weighted imaging in detecting brain metastases, because T1SE imaging has a greater sensitivity than T1IR imaging both before and after contrast material administration.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="twitter:title" content="MR T1-Weighted Inversion Recovery Imaging in Detecting Brain Metastases: Could It Replace T1-Weighted Spin-Echo Imaging?" />
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<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/29/4.cover.gif" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: T1-weighted inversion recovery (T1IR) imaging demonstrates higher brain tissue contrast and is more sensitive to contrast enhancement than T1-weighted spin-echo (T1SE) imaging. However, the effectiveness of the 2 imaging sequences in detecting brain metastases has not been studied. The objective of this report was to determine which sequence should be used for detecting brain metastases by comparing the effectiveness of T1IR imaging with that of T1SE imaging.

Materials and METHODS: Thirty-one patients with brain metastases underwent T1SE and T1IR with and without intravenous gadopentetate dimeglumine. T1SE and T1IR images were compared for the number of metastases, degree of contrast enhancement, volume and contrast-to-enhancement ratio (CER) of tumors, and contrast ratio (CR) of tumor to white matter (WM), tumor to gray matter (GM), and tumor to CSF.

RESULTS: There were 352 metastases in 31 patients, among which 2 patients with 5 metastases were demonstrated only on postenhanced T1SE images. Pre-enhanced and postenhanced T1SE images detected 162 and 350 lesions, respectively, whereas pre-enhanced and postenhanced T1IR images only discovered 94 and 233 lesions. The degree of tumor contrast enhancement was higher on T1IR images than on T1SE images, whereas no difference in the CER of tumors was found between the 2 sequences. Before enhancement, all of the CRs on T1IR images were higher than on T1SE images. After contrast enhancement, CRs of tumor to WM and tumor to GM were higher on T1SE images than on T1IR images. On the contrary, the CR of tumor to CSF was higher on T1IR images than on T1SE images. Tumor volumes were 5.6 ± 7.0 cm3 on postenhanced T1SE images and 5.5 ± 7.0 cm3 on postenhanced T1IR images, and no significant difference was found between the 2 groups.

CONCLUSION: T1SE, but not T1IR, should be used as T1-weighted imaging in detecting brain metastases, because T1SE imaging has a greater sensitivity than T1IR imaging both before and after contrast material administration." />
<meta name="og-title" property="og:title" content="MR T1-Weighted Inversion Recovery Imaging in Detecting Brain Metastases: Could It Replace T1-Weighted Spin-Echo Imaging?" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: T1-weighted inversion recovery (T1IR) imaging demonstrates higher brain tissue contrast and is more sensitive to contrast enhancement than T1-weighted spin-echo (T1SE) imaging. However, the effectiveness of the 2 imaging sequences in detecting brain metastases has not been studied. The objective of this report was to determine which sequence should be used for detecting brain metastases by comparing the effectiveness of T1IR imaging with that of T1SE imaging.

Materials and METHODS: Thirty-one patients with brain metastases underwent T1SE and T1IR with and without intravenous gadopentetate dimeglumine. T1SE and T1IR images were compared for the number of metastases, degree of contrast enhancement, volume and contrast-to-enhancement ratio (CER) of tumors, and contrast ratio (CR) of tumor to white matter (WM), tumor to gray matter (GM), and tumor to CSF.

RESULTS: There were 352 metastases in 31 patients, among which 2 patients with 5 metastases were demonstrated only on postenhanced T1SE images. Pre-enhanced and postenhanced T1SE images detected 162 and 350 lesions, respectively, whereas pre-enhanced and postenhanced T1IR images only discovered 94 and 233 lesions. The degree of tumor contrast enhancement was higher on T1IR images than on T1SE images, whereas no difference in the CER of tumors was found between the 2 sequences. Before enhancement, all of the CRs on T1IR images were higher than on T1SE images. After contrast enhancement, CRs of tumor to WM and tumor to GM were higher on T1SE images than on T1IR images. On the contrary, the CR of tumor to CSF was higher on T1IR images than on T1SE images. Tumor volumes were 5.6 ± 7.0 cm3 on postenhanced T1SE images and 5.5 ± 7.0 cm3 on postenhanced T1IR images, and no significant difference was found between the 2 groups.

CONCLUSION: T1SE, but not T1IR, should be used as T1-weighted imaging in detecting brain metastases, because T1SE imaging has a greater sensitivity than T1IR imaging both before and after contrast material administration." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node8163--5" data-node-nid="8163" id="top-node-8163--6922729877" data-pisa="ajnr;29/4/701" data-pisa-master="ajnr;ajnr.A0907" data-apath="/ajnr/29/4/701.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">MR T1-Weighted Inversion Recovery Imaging in Detecting Brain Metastases: Could It Replace T1-Weighted Spin-Echo Imaging?</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Y.-F. Qian</span>, <span class="highwire-citation-author" data-delta="1">C.-L. Yu</span>, <span class="highwire-citation-author" data-delta="2">C. Zhang</span> and <span class="highwire-citation-author" data-delta="3">Y.-Q. Yu</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2008,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">701-704; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0907 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-8163--6922729877" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Y.-F. Qian </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.-F.%2BQian%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Qian%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AY.-F.%2BQian%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C.-L. Yu </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.-L.%2BYu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Yu%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.-L.%2BYu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">C. Zhang </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BZhang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhang%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BZhang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Y.-Q. Yu </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.-Q.%2BYu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Yu%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AY.-Q.%2BYu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.701.1" data-doi="10.1378/chest.115.3.714"><div class="cit-metadata"><cite>Yokoi K, Kamiva N, Matsuquma H, et al. <strong>Detection of brain metastasis in potentially operable non-small cell lung cancer: a comparison of CT and MRI.</strong> <span class="cit-source">Chest</span> <span class="cit-pub-date">1999</span>;<span class="cit-vol">115</span>:<span class="cit-fpage">714</span>–19</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1378/chest.115.3.714&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a 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cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8 in text" id="ref-8">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.701.8" data-doi="10.1097/01.rct.0000166636.85918.3d"><div class="cit-metadata"><cite>Fischbach F, Bruhn H, Pech M, et al. <strong>Efficacy of contrast medium use for neuroimaging at 3.0 T: utility of IR-FSE compared to other T1-weighted pulse sequences.</strong> <span class="cit-source">J Comput Assist Tomogr</span> <span class="cit-pub-date">2005</span>;<span class="cit-vol">29</span>:<span class="cit-fpage">499</span>–505</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/01.rct.0000166636.85918.3d&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16012308&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F701.atom" 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class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10 in text" id="ref-10">↵</a><div class="cit ref-cit ref-other" id="cit-29.4.701.10"><div class="cit-metadata"><cite>Essig M, Knopp MV, Schoenberg SO, et al. <strong>Cerebral gliomas and metastases: assessment with contrast enhanced FAST fluid-attenuated inversion-recovery MR imaging.</strong> <span class="cit-source">Radiology</span> <span class="cit-pub-date">1999</span>;<span class="cit-vol">210</span>:<span class="cit-fpage">551</span>–57</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10207443&amp;link_type=MED&amp;atom=%2Fajnr%2F29%2F4%2F701.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 29</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 4 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">April 2008 </div></div>
      
      
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">701-704; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0907 </span></div>
  
  
  
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      <div class="highwire-cite-title">MR T1-Weighted Inversion Recovery Imaging in Detecting Brain Metastases: Could It Replace T1-Weighted Spin-Echo Imaging?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Y.-F.</span> <span class="nlm-surname">Qian</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">C.-L.</span> <span class="nlm-surname">Yu</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Y.-Q.</span> <span class="nlm-surname">Yu</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">701-704; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0907 </span></div>
  
  
  
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