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<meta name="twitter:description" content="SUMMARY: The American Journal of Neuroradiology has played a seminal role in the history of vertebral augmentation (VA). Because VA is increasingly being included in the multidisciplinary management of malignant vertebral compression fractures (VCFs), combined therapeutic approaches that include strategies to treat metastatic disease along with the fracture have become appealing options for patients. To that end, we recently investigated the dosimetric feasibility of treating malignant VCFs with radionuclide therapy. The goal would be to provide local control of the systemic disease beyond the pain relief and structural support provided by polymethylmethacrylate cement. The purpose of this article is to propose a methodology for evaluating radionuclides for use in radiation therapy that takes into account a number of factors including radiation characteristics, biochemical effects, production capacity, and safety. The goal of such a methodology is to introduce a systematic approach to selecting radionuclides in designing treatment regimens and future investigations and also to stimulate discussion and experimentation involving new radionuclides that may provide more effective treatments than the current isotopes in widespread use." />
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<meta name="og-description" property="og:description" content="SUMMARY: The American Journal of Neuroradiology has played a seminal role in the history of vertebral augmentation (VA). Because VA is increasingly being included in the multidisciplinary management of malignant vertebral compression fractures (VCFs), combined therapeutic approaches that include strategies to treat metastatic disease along with the fracture have become appealing options for patients. To that end, we recently investigated the dosimetric feasibility of treating malignant VCFs with radionuclide therapy. The goal would be to provide local control of the systemic disease beyond the pain relief and structural support provided by polymethylmethacrylate cement. The purpose of this article is to propose a methodology for evaluating radionuclides for use in radiation therapy that takes into account a number of factors including radiation characteristics, biochemical effects, production capacity, and safety. The goal of such a methodology is to introduce a systematic approach to selecting radionuclides in designing treatment regimens and future investigations and also to stimulate discussion and experimentation involving new radionuclides that may provide more effective treatments than the current isotopes in widespread use." />
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2009,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1824-1829; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1773 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-8369--8874998601" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J.J. Cuaron </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.J.%2BCuaron%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cuaron%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.J.%2BCuaron%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.A. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">J.J. Cuaron</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">J.A. Hirsch</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-3"><span class="name">D.C. Medich</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-4"><span class="name">B.S. Rosenstein</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a><span class="xref-sep">,</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">e</a>, </li><li class="contributor" id="contrib-5"><span class="name">C.B. Martel</span><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">f</a> and </li><li class="last" id="contrib-6"><span class="name">A.E. Hirsch</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Department of Radiation Oncology (J.J.C., A.E.H.), Boston University Medical Center, Boston University School of Medicine, Boston, Mass</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Department of Radiology (J.A.H.), Division of Interventional Neuroradiology, Massachusetts General Hospital, Boston, Mass</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Radiation Laboratory (D.C.M.), University of Massachusetts Lowell, Lowell, Mass</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Departments of Radiation Oncology, Dermatology, and Community and Preventive Medicine (B.S.R.), Mount Sinai School of Medicine, New York, NY</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>e</sup>Department of Radiation Oncology (B.S.R.), New York University School of Medicine, New York, NY</address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>f</sup>Department of Health Physics (C.B.M.), Brigham and Women's Hospital, Boston, Mass.</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Ariel E. Hirsch, MD, <span class="addr-line">Department of Radiation Oncology, Boston University Medical Center, Massachusetts General Hospital, 830 Harrison Ave, Moakley Building-LL, Boston, MA 02118</span>; e-mail: <span class="em-link"><span class="em-addr">Ariel.hirsch{at}bmc.org</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/30/10/1824.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2009, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1824-1829; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1773 </span></div>
  
  
  
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      <div class="highwire-cite-title">A Proposed Methodology to Select Radioisotopes for Use in Radionuclide Therapy</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.J.</span> <span class="nlm-surname">Cuaron</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Hirsch</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">D.C.</span> <span class="nlm-surname">Medich</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">B.S.</span> <span class="nlm-surname">Rosenstein</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">C.B.</span> <span class="nlm-surname">Martel</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.E.</span> <span class="nlm-surname">Hirsch</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2009, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1824-1829; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1773 </span></div>
  
  
  
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