1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    











































































































    Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Research ArticleBRAIN

  
      

  
      
Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease
  
    	
T. Yoshiura, A. Hiwatashi, K. Yamashita, Y. Ohyagi, A. Monji, Y. Takayama, E. Nagao, H. Kamano, T. Noguchi and H. Honda

  
    	
American Journal of Neuroradiology August 2009,  30 (7) 1388-1393; DOI: https://doi.org/10.3174/ajnr.A1562 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. ↵
    Johnson KA, Mueller ST, Walshe TM, et al. Cerebral perfusion imaging in Alzheimer's disease: use of single photon emission computed tomography and iofetamine hydrochloride I 123. Arch Neurol 1987;44:165–68
    CrossRefPubMedWeb of Science
  2. ↵
    Ishii K, Sasaki M, Yamaji S, et al. Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography. Eur J Nucl Med 1997;24:670–73
    PubMed
  3. ↵
    Matsuda H. Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT. J Nucl Med 2007;48:1289–300
    Abstract/FREE Full Text
  4. ↵
    Hirao K, Ohnishi T, Matsuda H, et al. Functional interactions between entorhinal cortex and posterior cingulate cortex at the very early stage of Alzheimer's disease using brain perfusion single-photon emission computed tomography. Nucl Med Commun 2006;27:151–66
    CrossRefPubMedWeb of Science
  5. ↵
    Nagata K, Sato M, Satoh Y, et al. Hemodynamic aspects of Alzheimer's disease. Ann NY Acad Sci 2002;977:391–402
    CrossRefPubMed
  6. ↵
    Detre JA, Leigh JS, Williams DS, et al. Perfusion imaging. Magn Reson Med 1992;23:37–45
    CrossRefPubMedWeb of Science
  7. ↵
    Alsop DC, Detre JA, Grossman M. Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging. Ann Neurol 2000;47:93–100
    CrossRefPubMedWeb of Science
  8. ↵
    Johnson NA, Jahng G-H, Welner MW, et al. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology 2005;234:851–59
    CrossRefPubMedWeb of Science
  9. ↵
    Kane I, Carpenter T, Chappell F, et al. Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect of lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. Stroke 2007;38:3158–64
    Abstract/FREE Full Text
  10. ↵
    Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98
    CrossRefPubMedWeb of Science
  11. ↵
    Petersen ET, Lim T, Golay X. Model-free arterial spin labeling quantification approach for perfusion MRI. Magn Reson Med 2006;55:219–32
    CrossRefPubMed
  12. ↵
    Look DC, Locker DR. Time saving in measurement of NMR and EPR relaxation times. Rev Sci Instrum 1970;41:250–51
    CrossRef
  13. ↵
    Canny J. A computational approach to edge-detection. IEEE Trans Pattern Anal Machine Intell 1986;8:679–98
    CrossRef
  14. ↵
    Powers WJ, Grubb RL, Raichle ME. Physiological responses to focal cerebral ischemia in humans. Ann Neurol 1984;16:546–52
    CrossRefPubMedWeb of Science
  15. ↵
    De Reuck J, Decoo D, Hasenbroekx MC, et al. Acetazolamide vasoreactivity in vascular dementia: a positron emission tomographic study. Eur Neurol 1999;41:31–36
    CrossRefPubMed
  16. ↵
    Bonte FJ, Devous MD Sr, Reisch JS, et al. The effect of acetazolamide on regional cerebral blood flow in patients with Alzheimer's disease or stroke as measured by single-photon emission computed tomography. Invest Radiol 1989;24:99–103
    CrossRefPubMed
  17. Knap WH, Dannenberg C, Marschall B, et al. Changes in local cerebral blood flow by neuroactivation and vasoactivation in patients with impaired cognitive function. Eur J Nucl Med 1996;23:878–88
    CrossRefPubMed
  18. ↵
    Pávics L, Grünwald F, Reichmann K, et al. Regional cerebral blood flow single-photon emission tomography with 99mTc-HMPAO and the acetazolamide test in the evaluation of vascular and Alzheimer's dementia. Eur J Nucl Med 1999;26:239–45
    CrossRefPubMed
  19. ↵
    Meyer JS, Shirai T, Akiyama H. Neuroimaging for differentiating vascular from Alzheimer's dementias. Cerebrovasc Brain Metab Rev 1996;8:1–10
    PubMed
  20. ↵
    Puls I, Hauck K, Demuth K, et al. Diagnostic impact of cerebral transit time in the identification of microangiopathy in dementia: a transcranial ultrasound study. Stroke 1999;30:2291–95
    Abstract/FREE Full Text
  21. ↵
    Hendrikse J, Petersen ET, van Laar PJ, et al. Cerebral border zones between distal end branches of intracranial arteries: MR imaging. Radiology 2008;246:572–80. Epub 2007 Nov 30
    CrossRefPubMedWeb of Science
  22. ↵
    Bokkers RP, van Laar PJ, van de Ven KC, et al. Arterial spin labeling MR imaging measurements of timing parameters in patients with a carotid artery occlusion. AJNR Am J Neuroradiol 2008;29:1698–703
    Abstract/FREE Full Text
  23. ↵
    Wang J, Alsop DC, Song HK, et al. Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magn Reson Med 2003;50:599–607
    CrossRefPubMedWeb of Science
  24. ↵
    Brookes MJ, Morris PG, Gowland PA, et al. Noninvasive measurement of arterial cerebral blood volume using Look-Locker EPI and arterial spin labeling. Magn Reson Med 2007;58:41–54
    CrossRefPubMed
  25. ↵
    Jahng G-H, Song E, Zhu X-P, et al. Human brain: reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging. Radiology 2005;234:909–16
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease
  
    	
T. Yoshiura, A. Hiwatashi, K. Yamashita, Y. Ohyagi, A. Monji, Y. Takayama, E. Nagao, H. Kamano, T. Noguchi, H. Honda

  
    	
American Journal of Neuroradiology Aug 2009, 30 (7) 1388-1393; DOI: 10.3174/ajnr.A1562 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement