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AF
:   arcuate fasciculus
ASFNR
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BOLD
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CPT
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CPU
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CSM
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DTI
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DTT
:   diffusion tensor tractography
EPI
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FA
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FDA
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fMRI
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GLM
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MEG
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PACS
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QC
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RAM
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SPM
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TL
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TLE
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Wada
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<meta name="citation_reference" content="citation_journal_title=Proc Natl Acad Sci U S A;citation_author=D. Saur;citation_author=BW. Kreher;citation_author=S. Schnell;citation_title=Ventral and dorsal pathways for language;citation_volume=105;citation_year=2008;citation_pmid=19004769;citation_doi=10.1073/pnas.0805234105" />
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<meta name="twitter:title" content="The Evolution of Clinical Functional Imaging during the Past 2 Decades and Its Current Impact on Neurosurgical Planning" />
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<meta name="twitter:description" content="SUMMARY: BOLD fMRI has, during the past decade, made a major transition from a purely research imaging technique to a viable clinical technique used primarily for presurgical planning in patients with brain tumors and other resectable brain lesions. This review article briefly examines the history and evolution of clinical functional imaging, with particular emphasis on how the use of BOLD fMRI for neurosurgical planning has changed during the past 2 decades. Even more important, this article describes the many published studies during that same period that have examined the overall clinical impact that BOLD and DTI have made on surgical planning.

AF
:   arcuate fasciculus
ASFNR
:   American Society of Functional Neuroradiology
BOLD
:   blood oxygen level–dependent
CPT
:   current procedural terminology
CPU
:   central processing unit
CSM
:   intraoperative cortical stimulation mapping
DTI
:   diffusion tensor imaging
DTT
:   diffusion tensor tractography
EPI
:   echo-planar imaging
FA
:   fractional anisotropy
FDA
:   US Food and Drug Administration
fMRI
:   functional MR imaging
GLM
:   general linear model
MEG
:   magnetoencephalography
PACS
:   picture archiving and communication system
QC
:   quality control
RAM
:   random access memory
SPM
:   Statistical Parametric Mapping
TL
:   temporal lobe
TLE
:   temporal lobe epilepsy
Wada
:   intracarotid sodium amobarbital test" />
<meta name="og-title" property="og:title" content="The Evolution of Clinical Functional Imaging during the Past 2 Decades and Its Current Impact on Neurosurgical Planning" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/31/2/219" />
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<meta name="og-description" property="og:description" content="SUMMARY: BOLD fMRI has, during the past decade, made a major transition from a purely research imaging technique to a viable clinical technique used primarily for presurgical planning in patients with brain tumors and other resectable brain lesions. This review article briefly examines the history and evolution of clinical functional imaging, with particular emphasis on how the use of BOLD fMRI for neurosurgical planning has changed during the past 2 decades. Even more important, this article describes the many published studies during that same period that have examined the overall clinical impact that BOLD and DTI have made on surgical planning.

AF
:   arcuate fasciculus
ASFNR
:   American Society of Functional Neuroradiology
BOLD
:   blood oxygen level–dependent
CPT
:   current procedural terminology
CPU
:   central processing unit
CSM
:   intraoperative cortical stimulation mapping
DTI
:   diffusion tensor imaging
DTT
:   diffusion tensor tractography
EPI
:   echo-planar imaging
FA
:   fractional anisotropy
FDA
:   US Food and Drug Administration
fMRI
:   functional MR imaging
GLM
:   general linear model
MEG
:   magnetoencephalography
PACS
:   picture archiving and communication system
QC
:   quality control
RAM
:   random access memory
SPM
:   Statistical Parametric Mapping
TL
:   temporal lobe
TLE
:   temporal lobe epilepsy
Wada
:   intracarotid sodium amobarbital test" />
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">219-225; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1845 </span></div>
  
  
  
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