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<meta name="DC.Title" content="Rest versus Exercise Hemodynamics for Middle Cerebral Artery Aneurysms: A Computational Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1797" />
<meta name="DC.Date" content="2010-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Exercise is an accepted method of improving cardiovascular health; however, the impact of increases in blood flow and heart rate on a cerebral aneurysms is unknown. This study was performed to simulate the changes in hemodynamic conditions within an intracranial aneurysm when a patient exercises.

MATERIALS AND METHODS: Rotational 3D digital subtraction angiograms were used to reconstruct patient-specific geometries of 3 aneurysms located at the bifurcation of the middle cerebral artery. CFD was used to solve for transient flow fields during simulated rest and exercise conditions. Inlet conditions were set by using published transcranial Doppler sonography data for the middle cerebral artery. Velocity fields were analyzed and postprocessed to provide physiologically relevant metrics.

RESULTS: Overall flow patterns were not significantly altered during exercise. Across subjects, during the exercise simulation, time-averaged WSS increased by a mean of 20% (range, 4%–34%), the RRT of a particle in the near-wall flow decreased by a mean of 28% (range, 13%–40%), and time-averaged pressure on the aneurysm wall did not change significantly. In 2 of the aneurysms, there was a 3-fold order-of-magnitude spatial difference in RRT between the aneurysm and surrounding vasculature.

CONCLUSIONS: WSS did not increase significantly during simulated moderate aerobic exercise. While the reduction in RRT during exercise was small in comparison with spatial differences, there may be potential benefits associated with decreased RRT (ie, improved replenishment of nutrients to cells within the aneurysmal tissue).

AR
:   aspect ratio
bpm
:   beats per minute
CFD
:   computational fluid dynamics
EC
:   endothelial cell
max
:   maximum
min
:   minimum
MMP
:   matrix metalloproteinase
OSI
:   oscillatory shear index
PC-MRA
:   phase-contrast MR angiography
PI
:   pulsatility index
Re
:   Reynolds number
RRT
:   relative residence time
SIMPLEC
:   semi-implicit method for pressure-linked equations consistent
T
:   time period
V
:   velocity
WSS
:   wall shear stress" />
<meta name="DC.Contributor" content="T.J. Bowker" />
<meta name="DC.Contributor" content="P.N. Watton" />
<meta name="DC.Contributor" content="P.E. Summers" />
<meta name="DC.Contributor" content="J.V. Byrne" />
<meta name="DC.Contributor" content="Y. Ventikos" />
<meta name="article:published_time" content="2010-02-01" />
<meta name="article:section" content="Interventional" />
<meta name="citation_title" content="Rest versus Exercise Hemodynamics for Middle Cerebral Artery Aneurysms: A Computational Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Exercise is an accepted method of improving cardiovascular health; however, the impact of increases in blood flow and heart rate on a cerebral aneurysms is unknown. This study was performed to simulate the changes in hemodynamic conditions within an intracranial aneurysm when a patient exercises.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Rotational 3D digital subtraction angiograms were used to reconstruct patient-specific geometries of 3 aneurysms located at the bifurcation of the middle cerebral artery. CFD was used to solve for transient flow fields during simulated rest and exercise conditions. Inlet conditions were set by using published transcranial Doppler sonography data for the middle cerebral artery. Velocity fields were analyzed and postprocessed to provide physiologically relevant metrics.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Overall flow patterns were not significantly altered during exercise. Across subjects, during the exercise simulation, time-averaged WSS increased by a mean of 20% (range, 4%–34%), the RRT of a particle in the near-wall flow decreased by a mean of 28% (range, 13%–40%), and time-averaged pressure on the aneurysm wall did not change significantly. In 2 of the aneurysms, there was a 3-fold order-of-magnitude spatial difference in RRT between the aneurysm and surrounding vasculature.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;WSS did not increase significantly during simulated moderate aerobic exercise. While the reduction in RRT during exercise was small in comparison with spatial differences, there may be potential benefits associated with decreased RRT (ie, improved replenishment of nutrients to cells within the aneurysmal tissue).&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=Circulation;citation_author=J. Myers;citation_title=Cardiology patient pages: exercise and cardiovascular health;citation_pages=e2-5;citation_volume=107;citation_year=2003;citation_pmid=12515760;citation_doi=10.1161/01.CIR.0000048890.59383.8D" />
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<meta name="citation_reference" content="citation_journal_title=Journal of Applied Physiology;citation_journal_abbrev=J. Appl. Physiol.;citation_author=DG. Martin;citation_author=EW. Ferguson;citation_author=S. Wigutoff;citation_title=Blood viscosity responses to maximal exercise in endurance-trained and sedentary female subjects;citation_pages=348-353;citation_volume=59;citation_year=1985;citation_issue=2;citation_issn=0021-8987;citation_pmid=4030588" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Exercise is an accepted method of improving cardiovascular health; however, the impact of increases in blood flow and heart rate on a cerebral aneurysms is unknown. This study was performed to simulate the changes in hemodynamic conditions within an intracranial aneurysm when a patient exercises.

MATERIALS AND METHODS: Rotational 3D digital subtraction angiograms were used to reconstruct patient-specific geometries of 3 aneurysms located at the bifurcation of the middle cerebral artery. CFD was used to solve for transient flow fields during simulated rest and exercise conditions. Inlet conditions were set by using published transcranial Doppler sonography data for the middle cerebral artery. Velocity fields were analyzed and postprocessed to provide physiologically relevant metrics.

RESULTS: Overall flow patterns were not significantly altered during exercise. Across subjects, during the exercise simulation, time-averaged WSS increased by a mean of 20% (range, 4%–34%), the RRT of a particle in the near-wall flow decreased by a mean of 28% (range, 13%–40%), and time-averaged pressure on the aneurysm wall did not change significantly. In 2 of the aneurysms, there was a 3-fold order-of-magnitude spatial difference in RRT between the aneurysm and surrounding vasculature.

CONCLUSIONS: WSS did not increase significantly during simulated moderate aerobic exercise. While the reduction in RRT during exercise was small in comparison with spatial differences, there may be potential benefits associated with decreased RRT (ie, improved replenishment of nutrients to cells within the aneurysmal tissue).

AR
:   aspect ratio
bpm
:   beats per minute
CFD
:   computational fluid dynamics
EC
:   endothelial cell
max
:   maximum
min
:   minimum
MMP
:   matrix metalloproteinase
OSI
:   oscillatory shear index
PC-MRA
:   phase-contrast MR angiography
PI
:   pulsatility index
Re
:   Reynolds number
RRT
:   relative residence time
SIMPLEC
:   semi-implicit method for pressure-linked equations consistent
T
:   time period
V
:   velocity
WSS
:   wall shear stress" />
<meta name="og-title" property="og:title" content="Rest versus Exercise Hemodynamics for Middle Cerebral Artery Aneurysms: A Computational Study" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/31/2/317" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Exercise is an accepted method of improving cardiovascular health; however, the impact of increases in blood flow and heart rate on a cerebral aneurysms is unknown. This study was performed to simulate the changes in hemodynamic conditions within an intracranial aneurysm when a patient exercises.

MATERIALS AND METHODS: Rotational 3D digital subtraction angiograms were used to reconstruct patient-specific geometries of 3 aneurysms located at the bifurcation of the middle cerebral artery. CFD was used to solve for transient flow fields during simulated rest and exercise conditions. Inlet conditions were set by using published transcranial Doppler sonography data for the middle cerebral artery. Velocity fields were analyzed and postprocessed to provide physiologically relevant metrics.

RESULTS: Overall flow patterns were not significantly altered during exercise. Across subjects, during the exercise simulation, time-averaged WSS increased by a mean of 20% (range, 4%–34%), the RRT of a particle in the near-wall flow decreased by a mean of 28% (range, 13%–40%), and time-averaged pressure on the aneurysm wall did not change significantly. In 2 of the aneurysms, there was a 3-fold order-of-magnitude spatial difference in RRT between the aneurysm and surrounding vasculature.

CONCLUSIONS: WSS did not increase significantly during simulated moderate aerobic exercise. While the reduction in RRT during exercise was small in comparison with spatial differences, there may be potential benefits associated with decreased RRT (ie, improved replenishment of nutrients to cells within the aneurysmal tissue).

AR
:   aspect ratio
bpm
:   beats per minute
CFD
:   computational fluid dynamics
EC
:   endothelial cell
max
:   maximum
min
:   minimum
MMP
:   matrix metalloproteinase
OSI
:   oscillatory shear index
PC-MRA
:   phase-contrast MR angiography
PI
:   pulsatility index
Re
:   Reynolds number
RRT
:   relative residence time
SIMPLEC
:   semi-implicit method for pressure-linked equations consistent
T
:   time period
V
:   velocity
WSS
:   wall shear stress" />
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<div class="cit ref-cit ref-journal" id="cit-31.2.317.1" data-doi="10.1056/NEJMra052760"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Brisman</span>  <span class="cit-name-given-names">JL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Song</span>  <span class="cit-name-given-names">JK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Newell</span>  <span class="cit-name-given-names">DW</span></span></li></ol><cite>. <span class="cit-article-title">Cerebral aneurysms</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">355</span>:<span class="cit-fpage">928</span>–<span class="cit-lpage">39</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1056/NEJMra052760&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16943405&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000240113100010&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.2" data-doi="10.1161/01.CIR.0000048890.59383.8D"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Myers</span>  <span class="cit-name-given-names">J</span></span></li></ol><cite>. <span class="cit-article-title">Cardiology patient pages: exercise and cardiovascular health</span>. <abbr class="cit-jnl-abbrev">Circulation</abbr> <span class="cit-pub-date">2003</span>;<span class="cit-vol">107</span>:<span class="cit-fpage">e2</span>–<span class="cit-lpage">5</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1161/01.CIR.0000048890.59383.8D&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12515760&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000180366600002&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.3" data-doi="10.1016/S0741-5214(99)70249-1"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Taylor</span>  <span class="cit-name-given-names">CA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hughes</span>  <span class="cit-name-given-names">TJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zarins</span>  <span class="cit-name-given-names">CK</span></span></li></ol><cite>. <span class="cit-article-title">Effect of exercise on hemodynamic conditions in the abdominal aorta</span>. <abbr class="cit-jnl-abbrev">J Vasc Surg</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">29</span>:<span class="cit-fpage">1077</span>–<span class="cit-lpage">89</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S0741-5214(99)70249-1&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10359942&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000080864800023&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.4" data-doi="10.1016/j.cardiores.2006.08.017"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Gupta</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Grande-Allen</span>  <span class="cit-name-given-names">KJ</span></span></li></ol><cite>. <span class="cit-article-title">Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells</span>. <abbr class="cit-jnl-abbrev">Cardiovasc Res</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">72</span>:<span class="cit-fpage">375</span>–<span class="cit-lpage">83</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MTM6ImNhcmRpb3Zhc2NyZXMiO3M6NToicmVzaWQiO3M6ODoiNzIvMy8zNzUiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMzEvMi8zMTcuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.5"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Poulin</span>  <span class="cit-name-given-names">MJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Syed</span>  <span class="cit-name-given-names">RJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Robbins</span>  <span class="cit-name-given-names">PA</span></span></li></ol><cite>. <span class="cit-article-title">Assessments of flow by transcranial Doppler ultrasound in the middle cerebral artery during exercise in humans</span>. <abbr class="cit-jnl-abbrev">J Appl Physiol</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">86</span>:<span class="cit-fpage">1632</span>–<span class="cit-lpage">37</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamFwIjtzOjU6InJlc2lkIjtzOjk6Ijg2LzUvMTYzMiI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zMS8yLzMxNy5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">6.</span><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6. in text" id="ref-6">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.6" data-doi="10.1007/BF00377701"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Moraine</span>  <span class="cit-name-given-names">JJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lamotte</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Berre</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Relationship of middle cerebral artery blood flow velocity to intensity during dynamic exercise in normal subjects</span>. <abbr class="cit-jnl-abbrev">Eur J Appl Physiol Occup Physiol</abbr> <span class="cit-pub-date">1993</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">35</span>–<span class="cit-lpage">38</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/BF00377701&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=8375362&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1993LP08500007&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">7.</span><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7. in text" id="ref-7">↵</a>

<div class="cit ref-cit ref-book" id="cit-31.2.317.7"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Nichols</span>  <span class="cit-name-given-names">WW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">O'Rourke</span>  <span class="cit-name-given-names">MF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">McDonald</span>  <span class="cit-name-given-names">DA</span></span></li></ol><cite>. <span class="cit-source">McDonald's Blood Flow in Arteries: Theoretic, Experimental and Clinical Principles</span>. <span class="cit-publ-loc">London</span>: <span class="cit-publ-name">Hodder Arnold</span>; <span class="cit-pub-date">2005</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">8.</span><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8. in text" id="ref-8">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.8" data-doi="10.1109/TMI.2005.844159"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Cebral</span>  <span class="cit-name-given-names">JR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Castro</span>  <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Appanaboyina</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity</span>. <abbr class="cit-jnl-abbrev">IEEE Trans Med Imaging</abbr> <span class="cit-pub-date">2005</span>;<span class="cit-vol">24</span>:<span class="cit-fpage">457</span>–<span class="cit-lpage">67</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1109/TMI.2005.844159&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15822804&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000228051200005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">9.</span><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9. in text" id="ref-9">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.9"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Perktold</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Peter</span>  <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Resch</span>  <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Pulsatile non-Newtonian blood flow simulation through a bifurcation with an aneurysm</span>. <abbr class="cit-jnl-abbrev">Biorheology</abbr> <span class="cit-pub-date">1989</span>;<span class="cit-vol">26</span>:<span class="cit-fpage">1011</span>–<span class="cit-lpage">30</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=2624892&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1989CE55300004&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">10.</span><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10. in text" id="ref-10">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.10"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Martin</span>  <span class="cit-name-given-names">DG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ferguson</span>  <span class="cit-name-given-names">EW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wigutoff</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Blood viscosity responses to maximal exercise in endurance-trained and sedentary female subjects</span>. <abbr class="cit-jnl-abbrev">J Appl Physiol</abbr> <span class="cit-pub-date">1985</span>;<span class="cit-vol">59</span>:<span class="cit-fpage">348</span>–<span class="cit-lpage">53</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamFwIjtzOjU6InJlc2lkIjtzOjg6IjU5LzIvMzQ4IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzMxLzIvMzE3LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">11.</span><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11. in text" id="ref-11">↵</a>

<div class="cit ref-cit ref-book" id="cit-31.2.317.11"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Patankar</span>  <span class="cit-name-given-names">SV</span></span></li></ol><cite>. <span class="cit-source">Numerical Heat Transfer and Fluid Flow</span>. <span class="cit-publ-loc">London</span>: <span class="cit-publ-name">Hemisphere</span>; <span class="cit-pub-date">1980</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">12.</span><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12. in text" id="ref-12">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.12"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Hellstrom</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fischer-Colbrie</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wahlgren</span>  <span class="cit-name-given-names">NG</span></span>, </li><li><span class="cit-etal">et al.</span></li></ol><cite>
<span class="cit-article-title">Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise</span>. <abbr class="cit-jnl-abbrev">J Appl Physiol</abbr> <span class="cit-pub-date">1996</span>;<span class="cit-vol">81</span>:<span class="cit-fpage">413</span>–<span class="cit-lpage">18</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamFwIjtzOjU6InJlc2lkIjtzOjg6IjgxLzEvNDEzIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzMxLzIvMzE3LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">13.</span><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13. in text" id="ref-13">↵</a>

<div class="cit ref-cit ref-book" id="cit-31.2.317.13"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Gosling</span>  <span class="cit-name-given-names">RG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">King</span>  <span class="cit-name-given-names">DH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Marcus</span>  <span class="cit-name-given-names">AW</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-source">Arteries and Veins: Ultrasound Angiology</span>. <span class="cit-publ-loc">Edinburgh, UK</span>: <span class="cit-publ-name">Churchill Livingstone</span>; <span class="cit-pub-date">1975</span>:<span class="cit-fpage">61</span>–<span class="cit-lpage">75</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">14.</span><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14. in text" id="ref-14">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.14" data-doi="10.1016/0301-5629(85)90003-1"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Ku</span>  <span class="cit-name-given-names">DN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Giddens</span>  <span class="cit-name-given-names">DP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Phillips</span>  <span class="cit-name-given-names">DJ</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Hemodynamics of the normal human carotid bifurcation: in vitro and in vivo studies</span>. <abbr class="cit-jnl-abbrev">Ultrasound Med Biol</abbr> <span class="cit-pub-date">1985</span>;<span class="cit-vol">11</span>:<span class="cit-fpage">13</span>–<span class="cit-lpage">26</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/0301-5629(85)90003-1&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=3160152&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1985AGQ6100002&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">15.</span><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15. in text" id="ref-15">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.15"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Himburg</span>  <span class="cit-name-given-names">HA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Grzybowski</span>  <span class="cit-name-given-names">DM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hazel</span>  <span class="cit-name-given-names">AL</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability</span>. <abbr class="cit-jnl-abbrev">Am J Physiol</abbr> <span class="cit-pub-date">2004</span>;<span class="cit-vol">286</span>:<span class="cit-fpage">H1916</span>–<span class="cit-lpage">22</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">16.</span><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16. in text" id="ref-16">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.16" data-doi="10.1002/jmri.21179"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Hollnagel</span>  <span class="cit-name-given-names">DI</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Summers</span>  <span class="cit-name-given-names">PE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kollias</span>  <span class="cit-name-given-names">SS</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Laser Doppler velocimetry (LDV) and 3D phase-contrast magnetic resonance angiography (PC-MRA) velocity measurements: validation in an anatomically accurate cerebral artery aneurysm model with steady flow</span>. <abbr class="cit-jnl-abbrev">J Magn Reson Imaging</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">26</span>:<span class="cit-fpage">1493</span>–<span class="cit-lpage">505</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/jmri.21179&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=17968887&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div>
</li><li><span class="ref-label">17.</span><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17. in text" id="ref-17">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.17"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Ford</span>  <span class="cit-name-given-names">MD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nikolov</span>  <span class="cit-name-given-names">HN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Milner</span>  <span class="cit-name-given-names">JS</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models</span>. <abbr class="cit-jnl-abbrev">J Biomech Eng</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">130</span>:<span class="cit-comment">021015</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">18.</span><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18. in text" id="ref-18">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.18" data-doi="10.1097/00006123-200103000-00007"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Ujiie</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tamano</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sasaki</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm?</span> <abbr class="cit-jnl-abbrev">Neurosurgery</abbr> <span class="cit-pub-date">2001</span>;<span class="cit-vol">48</span>:<span class="cit-fpage">495</span>–<span class="cit-lpage">502</span>, <span class="cit-comment">discussion 502–03</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/00006123-200103000-00007&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11270538&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000167304000011&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">19.</span><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19. in text" id="ref-19">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.19" data-doi="10.1007/s00234-007-0350-x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Szikora</span>  <span class="cit-name-given-names">I</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Paal</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ugron</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Impact of aneurysmal geometry on intraaneurysmal flow: a computerized flow simulation study</span>. <abbr class="cit-jnl-abbrev">Neuroradiology</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">50</span>:<span class="cit-fpage">411</span>–<span class="cit-lpage">21</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s00234-007-0350-x&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18180916&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div>
</li><li><span class="ref-label">20.</span><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20. in text" id="ref-20">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.20" data-doi="10.1161/01.STR.0000046456.26587.8B"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Tateshima</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Murayama</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Villablanca</span>  <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">In vitro measurement of fluid-induced wall shear stress in unruptured cerebral aneurysms harboring blebs</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2003</span>;<span class="cit-vol">34</span>:<span class="cit-fpage">187</span>–<span class="cit-lpage">92</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjg6IjM0LzEvMTg3IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzMxLzIvMzE3LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">21.</span><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21. in text" id="ref-21">↵</a>

<div class="cit ref-cit ref-confproc" id="cit-31.2.317.21"><div class="cit-metadata"><ol class="cit-ed-list duplicate"><li><span class="cit-ed"><span class="cit-name-surname">Armando</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Xiaoping</span>  <span class="cit-name-given-names">PH</span></span></li></ol><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Cebral</span>  <span class="cit-name-given-names">JR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Radaelli</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Frangi</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Hemodynamics before and after bleb formation in cerebral aneurysms</span>. In: <span class="cit-ed"><span class="cit-name-surname">Armando</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-ed"><span class="cit-name-surname">Xiaoping</span>  <span class="cit-name-given-names">PH</span></span> eds. <span class="cit-conf-name">Proceedings of the Society of Photo-Optical Instrumentation Engineers</span>, <span class="cit-pub-date">2007</span>:<span class="cit-fpage">65112C</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">22.</span><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22. in text" id="ref-22">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.22"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Satoh</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Omi</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ohsako</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Influence of perianeurysmal environment on the deformation and bleb formation of the unruptured cerebral aneurysm: assessment with fusion imaging of 3D MR cisternography and 3D MR angiography</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2005</span>;<span class="cit-vol">26</span>:<span class="cit-fpage">2010</span>–<span class="cit-lpage">18</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo5OiIyNi84LzIwMTAiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMzEvMi8zMTcuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">23.</span><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23. in text" id="ref-23">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.23" data-doi="10.1161/01.STR.0000177877.88925.06"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Shojima</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Oshima</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Takagi</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Role of the bloodstream impacting force and the local pressure elevation in the rupture of cerebral aneurysms</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2005</span>;<span class="cit-vol">36</span>:<span class="cit-fpage">1933</span>–<span class="cit-lpage">38</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjk6IjM2LzkvMTkzMyI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zMS8yLzMxNy5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">24.</span><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24. in text" id="ref-24">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.24"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Fogelholm</span>  <span class="cit-name-given-names">RR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Turjanmaa</span>  <span class="cit-name-given-names">VM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nuutila</span>  <span class="cit-name-given-names">MT</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Diurnal blood pressure variations and onset of subarachnoid haemorrhage: a population-based study</span>. <abbr class="cit-jnl-abbrev">J Hypertens</abbr> <span class="cit-comment">995</span>;<span class="cit-vol">13</span>:<span class="cit-fpage">495</span>–<span class="cit-lpage">98</span>
</cite></div><div class="cit-extra"></div></div>
</li><li><span class="ref-label">25.</span><a class="rev-xref-ref" href="#xref-ref-25-1" title="View reference 25. in text" id="ref-25">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.25"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Haykowsky</span>  <span class="cit-name-given-names">MJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Findlay</span>  <span class="cit-name-given-names">JM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ignaszewski</span>  <span class="cit-name-given-names">AP</span></span></li></ol><cite>. <span class="cit-article-title">Aneurysmal subarachnoid hemorrhage associated with weight training: three case reports</span>. <abbr class="cit-jnl-abbrev">Clin J Sport Med</abbr> <span class="cit-pub-date">1996</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">52</span>–<span class="cit-lpage">55</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=8925367&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1996TL99400011&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">26.</span><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26. in text" id="ref-26">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.26" data-doi="10.1016/j.jstrokecerebrovasdis.2006.09.001"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Matsuda</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Watanabe</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Saito</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Circumstances, activities, and events precipitating aneurysmal subarachnoid hemorrhage</span>. <abbr class="cit-jnl-abbrev">J Stroke Cerebrovasc Dis</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">16</span>:<span class="cit-fpage">25</span>–<span class="cit-lpage">29</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.jstrokecerebrovasdis.2006.09.001&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=17689388&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div>
</li><li><span class="ref-label">27.</span><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27. in text" id="ref-27">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.27" data-doi="10.1016/0002-8703(74)90011-8"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Littler</span>  <span class="cit-name-given-names">WA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Honour</span>  <span class="cit-name-given-names">AJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sleight</span>  <span class="cit-name-given-names">P</span></span></li></ol><cite>. <span class="cit-article-title">Direct arterial pressure, pulse rate, and electrocardiogram during micturition and defecation in unrestricted man</span>. <abbr class="cit-jnl-abbrev">Am Heart J</abbr> <span class="cit-pub-date">1974</span>;<span class="cit-vol">88</span>:<span class="cit-fpage">205</span>–<span class="cit-lpage">10</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/0002-8703(74)90011-8&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=4841221&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1974T875500011&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">28.</span><a class="rev-xref-ref" href="#xref-ref-28-1" title="View reference 28. in text" id="ref-28">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.28" data-doi="10.1161/01.STR.30.7.1396"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kataoka</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Taneda</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Asai</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Structural fragility and inflammatory response of ruptured cerebral aneurysms: a comparative study between ruptured and unruptured cerebral aneurysms</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">30</span>:<span class="cit-fpage">1396</span>–<span class="cit-lpage">401</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjk6IjMwLzcvMTM5NiI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zMS8yLzMxNy5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">29.</span><a class="rev-xref-ref" href="#xref-ref-29-1" title="View reference 29. in text" id="ref-29">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.29" data-doi="10.1146/annurev.fluid.39.050905.110128"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lasheras</span>  <span class="cit-name-given-names">JC</span></span></li></ol><cite>. <span class="cit-article-title">The biomechanics of arterial aneurysms</span>. <abbr class="cit-jnl-abbrev">Ann Rev Fluid Mech</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">39</span>:<span class="cit-fpage">293</span>–<span class="cit-lpage">319</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1146/annurev.fluid.39.050905.110128&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a></div></div>
</li><li><span class="ref-label">30.</span><a class="rev-xref-ref" href="#xref-ref-30-1" title="View reference 30. in text" id="ref-30">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.30" data-doi="10.1152/ajpheart.01047.2006"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Chien</span>  <span class="cit-name-given-names">S</span></span></li></ol><cite>. <span class="cit-article-title">Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell</span>. <abbr class="cit-jnl-abbrev">Am J Physiol Heart Circ Physiol</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">292</span>:<span class="cit-fpage">H1209</span>–<span class="cit-lpage">24</span>. <span class="cit-comment">Epub 2006 Nov 10</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6ODoiYWpwaGVhcnQiO3M6NToicmVzaWQiO3M6MTE6IjI5Mi8zL0gxMjA5IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzMxLzIvMzE3LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">31.</span><a class="rev-xref-ref" href="#xref-ref-31-1" title="View reference 31. in text" id="ref-31">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.31" data-doi="10.1002/jmri.20928"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Ahn</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shin</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tateshima</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Fluid-induced wall shear stress in anthropomorphic brain aneurysm models: MR phase-contrast study at 3 T</span>. <abbr class="cit-jnl-abbrev">J Magn Reson Imaging</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">25</span>:<span class="cit-fpage">1120</span>–<span class="cit-lpage">30</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/jmri.20928&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=17520716&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div>
</li><li><span class="ref-label">32.</span><a class="rev-xref-ref" href="#xref-ref-32-1" title="View reference 32. in text" id="ref-32">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.32" data-doi="10.1161/01.STR.0000144648.89172.0f"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Shojima</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Oshima</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Takagi</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2004</span>;<span class="cit-vol">35</span>:<span class="cit-fpage">2500</span>–<span class="cit-lpage">05</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjEwOiIzNS8xMS8yNTAwIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzMxLzIvMzE3LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">33.</span><a class="rev-xref-ref" href="#xref-ref-33-1" title="View reference 33. in text" id="ref-33">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.33" data-doi="10.1161/STROKEAHA.106.481234"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Meng</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wang</span>  <span class="cit-name-given-names">Z</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hoi</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">38</span>:<span class="cit-fpage">1924</span>–<span class="cit-lpage">31</span>
</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjk6IjM4LzYvMTkyNCI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zMS8yLzMxNy5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div>
</li><li><span class="ref-label">34.</span><a class="rev-xref-ref" href="#xref-ref-34-1" title="View reference 34. in text" id="ref-34">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.34" data-doi="10.1007/s10439-007-9426-3"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Chien</span>  <span class="cit-name-given-names">S</span></span></li></ol><cite>. <span class="cit-article-title">Effects of disturbed flow on endothelial cells</span>. <abbr class="cit-jnl-abbrev">Ann Biomed Eng</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">36</span>:<span class="cit-fpage">554</span>–<span class="cit-lpage">62</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s10439-007-9426-3&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18172767&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000254176000006&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
</li><li><span class="ref-label">35.</span><a class="rev-xref-ref" href="#xref-ref-35-1" title="View reference 35. in text" id="ref-35">↵</a>

<div class="cit ref-cit ref-journal" id="cit-31.2.317.35"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Butty</span>  <span class="cit-name-given-names">VD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gudjonsson</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Buchel</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Residence times and basins of attraction for a realistic right internal carotid artery with two aneurysms</span>. <abbr class="cit-jnl-abbrev">Biorheology</abbr> <span class="cit-pub-date">2002</span>;<span class="cit-vol">39</span>:<span class="cit-fpage">387</span>–<span class="cit-lpage">93</span>
</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=12122257&amp;link_type=MED&amp;atom=%2Fajnr%2F31%2F2%2F317.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000176489600015&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 31</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 2 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Feb 2010 </div></div>
      
      
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      <div class="highwire-cite-title">Rest versus Exercise Hemodynamics for Middle Cerebral Artery Aneurysms: A Computational Study</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.J.</span> <span class="nlm-surname">Bowker</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">P.N.</span> <span class="nlm-surname">Watton</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">P.E.</span> <span class="nlm-surname">Summers</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.V.</span> <span class="nlm-surname">Byrne</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Ventikos</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">317-323; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1797 </span></div>
  
  
  
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