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<meta name="DC.Title" content="Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1852" />
<meta name="DC.Date" content="2010-03-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy.

MATERIALS AND METHODS: Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, t tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival.

RESULTS: The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure ( P ≤ .02). The BF and PS were predictive ( P ≤ .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors ( P = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% ( P = .03) and 59%/69% ( P = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch ( P = .01).

CONCLUSIONS: BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.

BF
:   blood flow
BV
:   blood volume
CECT
:   contrast-enhanced CT
MTT
:   mean transit time
N
:   nodal
OS
:   overall survival
PCT
:   perfusion CT
PET
:   positron-emission tomography
PS
:   permeability surface area product
ROC
:   receiver operating characteristic
SCCA
:   squamous cell carcinoma" />
<meta name="DC.Contributor" content="S. Bisdas" />
<meta name="DC.Contributor" content="Z. Rumboldt" />
<meta name="DC.Contributor" content="K. Šurlan-Popovič" />
<meta name="DC.Contributor" content="M. Baghi" />
<meta name="DC.Contributor" content="T.S. Koh" />
<meta name="DC.Contributor" content="T.J. Vogl" />
<meta name="DC.Contributor" content="M.G. Mack" />
<meta name="article:published_time" content="2010-03-01" />
<meta name="article:section" content="Head and Neck" />
<meta name="citation_title" content="Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, &lt;i&gt;t&lt;/i&gt; tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure (&lt;i&gt;P&lt;/i&gt; ≤ .02). The BF and PS were predictive (&lt;i&gt;P&lt;/i&gt; ≤ .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors (&lt;i&gt;P&lt;/i&gt; = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% (&lt;i&gt;P&lt;/i&gt; = .03) and 59%/69% (&lt;i&gt;P&lt;/i&gt; = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch (&lt;i&gt;P&lt;/i&gt; = .01).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.&lt;/p&gt;" />
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<meta name="twitter:title" content="Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy.

MATERIALS AND METHODS: Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, t tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival.

RESULTS: The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure ( P ≤ .02). The BF and PS were predictive ( P ≤ .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors ( P = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% ( P = .03) and 59%/69% ( P = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch ( P = .01).

CONCLUSIONS: BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.

BF
:   blood flow
BV
:   blood volume
CECT
:   contrast-enhanced CT
MTT
:   mean transit time
N
:   nodal
OS
:   overall survival
PCT
:   perfusion CT
PET
:   positron-emission tomography
PS
:   permeability surface area product
ROC
:   receiver operating characteristic
SCCA
:   squamous cell carcinoma" />
<meta name="og-title" property="og:title" content="Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/31/3/576" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy.

MATERIALS AND METHODS: Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, t tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival.

RESULTS: The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure ( P ≤ .02). The BF and PS were predictive ( P ≤ .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors ( P = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% ( P = .03) and 59%/69% ( P = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch ( P = .01).

CONCLUSIONS: BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.

BF
:   blood flow
BV
:   blood volume
CECT
:   contrast-enhanced CT
MTT
:   mean transit time
N
:   nodal
OS
:   overall survival
PCT
:   perfusion CT
PET
:   positron-emission tomography
PS
:   permeability surface area product
ROC
:   receiver operating characteristic
SCCA
:   squamous cell carcinoma" />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Head and Neck</span></span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-series highwire-cite-metadata">F</span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S. Bisdas</span>, <span class="highwire-citation-author" data-delta="1">Z. Rumboldt</span>, <span class="highwire-citation-author" data-delta="2">K. Šurlan-Popovič</span>, <span class="highwire-citation-author" data-delta="3">M. Baghi</span>, <span class="highwire-citation-author" data-delta="4">T.S. Koh</span>, <span class="highwire-citation-author" data-delta="5">T.J. Vogl</span> and <span class="highwire-citation-author" data-delta="6">M.G. Mack</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">576-581; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1852 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9578--6304061852" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S. Bisdas </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BBisdas%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bisdas%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.%2BBisdas%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Z. 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<p id="p-3"><strong>BACKGROUND AND PURPOSE:</strong> PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy.</p>
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<p id="p-4"><strong>MATERIALS AND METHODS:</strong> Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, <em>t</em> tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival.</p>
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<p id="p-5"><strong>RESULTS:</strong> The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure (<em>P</em> ≤ .02). The BF and PS were predictive (<em>P</em> ≤ .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors (<em>P</em> = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% (<em>P</em> = .03) and 59%/69% (<em>P</em> = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch (<em>P</em> = .01).</p>
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<p id="p-6"><strong>CONCLUSIONS:</strong> BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">BF<span class="def-item-dt-sep"></span></dt><dd>blood flow<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">BV<span class="def-item-dt-sep"></span></dt><dd>blood volume<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">CECT<span class="def-item-dt-sep"></span></dt><dd>contrast-enhanced CT<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">MTT<span class="def-item-dt-sep"></span></dt><dd>mean transit time<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">N<span class="def-item-dt-sep"></span></dt><dd>nodal<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">OS<span class="def-item-dt-sep"></span></dt><dd>overall survival<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">PCT<span class="def-item-dt-sep"></span></dt><dd>perfusion CT<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">PET<span class="def-item-dt-sep"></span></dt><dd>positron-emission tomography<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">PS<span class="def-item-dt-sep"></span></dt><dd>permeability surface area product<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">ROC<span class="def-item-dt-sep"></span></dt><dd>receiver operating characteristic<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">SCCA<span class="def-item-dt-sep"></span></dt><dd>squamous cell carcinoma</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/3/576.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">576-581; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1852 </span></div>
  
  
  
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      <div class="highwire-cite-title">Perfusion CT in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Long-Term Predictive Value of Baseline Perfusion CT Measurements</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Bisdas</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Z.</span> <span class="nlm-surname">Rumboldt</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Šurlan-Popovič</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Baghi</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">T.S.</span> <span class="nlm-surname">Koh</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">T.J.</span> <span class="nlm-surname">Vogl</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">M.G.</span> <span class="nlm-surname">Mack</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">576-581; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1852 </span></div>
  
  
  
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