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    Tactile Sensory and Pain Networks in the Human Spinal Cord and Brain Stem Mapped by Means of Functional MR Imaging | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleFunctional

  
      
Open Access

  
      
Tactile Sensory and Pain Networks in the Human Spinal Cord and Brain Stem Mapped by Means of Functional MR Imaging
  
    	
N.F. Ghazni, C.M. Cahill and P.W. Stroman

  
    	
American Journal of Neuroradiology April 2010,  31 (4) 661-667; DOI: https://doi.org/10.3174/ajnr.A1909 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    1. Meyer  R, 
    2. Ringkamp  M, 
    3. Campbell  J, 
    4. et al
    . Peripheral Mechanisms of Cutaneous Nociception. Philadelphia: Elsevier/Churchill Livingstone; 2006
  2. 2.↵


    1. Creac’h  C, 
    2. Henry  P, 
    3. Caille  JM, 
    4. et al
    . Functional MR imaging analysis of pain-related brain activation after acute mechanical stimulation. AJNR Am J Neuroradiol 2000; 21: 1402–06
    Abstract/FREE Full Text
  3. 3.↵


    1. Hansson  T, 
    2. Brismar  T
    . Tactile stimulation of the hand causes bilateral cortical activation: a functional magnetic resonance study in humans. Neurosci Lett 1999; 271: 29–32
    CrossRefPubMedWeb of Science
  4. 4.↵


    1. Blatow  M, 
    2. Nennig  E, 
    3. Durst  A, 
    4. et al
    . fMRI reflects functional connectivity of human somatosensory cortex. Neuroimage 2007; 37: 927–36
    CrossRefPubMedWeb of Science
  5. 5.↵


    1. Dunckley  P, 
    2. Wise  RG, 
    3. Fairhurst  M, 
    4. et al
    . A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J Neurosci 2005; 25: 7333–41
    Abstract/FREE Full Text
  6. 6.↵


    1. Fairhurst  M, 
    2. Wiech  K, 
    3. Dunckley  P, 
    4. et al
    . Anticipatory brainstem activity predicts neural processing of pain in humans. Pain 2007; 128: 101–10
    CrossRefPubMedWeb of Science
  7. 7.↵


    1. Govers  N, 
    2. Beghin  J, 
    3. Van Goethem  JW, 
    4. et al
    . Functional MRI of the cervical spinal cord on 1.5 T with fingertapping: to what extent is it feasible? Neuroradiology 2007; 49: 73–81
    CrossRefPubMed
  8. 8.↵


    1. Madi  S, 
    2. Flanders  AE, 
    3. Vinitski  S, 
    4. et al
    . Functional MR imaging of the human cervical spinal cord. AJNR Am J Neuroradiol 2001; 22: 1768–74
    Abstract/FREE Full Text
  9. 9.↵


    1. Stracke  CP, 
    2. Pettersson  LG, 
    3. Schoth  F, 
    4. et al
    . Interneuronal systems of the cervical spinal cord assessed with BOLD imaging at 1.5 T. Neuroradiology 2005; 47: 127–33
    CrossRefPubMedWeb of Science
  10. 10.↵


    1. Yoshizawa  T, 
    2. Nose  T, 
    3. Moore  GJ, 
    4. et al
    . Functional magnetic resonance imaging of motor activation in the human cervical spinal cord. Neuroimage 1996; 4: 174–82
    CrossRefPubMedWeb of Science
  11. 11.↵


    1. Komisaruk  BR, 
    2. Mosier  KM, 
    3. Liu  WC, 
    4. et al
    . Functional localization of brainstem and cervical spinal cord nuclei in humans with fMRI. AJNR Am J Neuroradiol 2002; 23: 609–17
    Abstract/FREE Full Text
  12. 12.↵


    1. Stroman  PW, 
    2. Kornelsen  J, 
    3. Bergman  A, 
    4. et al
    . Noninvasive assessment of the injured human spinal cord by means of functional magnetic resonance imaging. Spinal Cord 2004; 42: 59–66
    CrossRefPubMedWeb of Science
  13. 13.↵


    1. Stroman  PW, 
    2. Kornelsen  J, 
    3. Lawrence  J, 
    4. et al
    . Functional magnetic resonance imaging based on SEEP contrast: response function and anatomical specificity. Magn Reson Imaging 2005; 23: 843–50
    CrossRefPubMed
  14. 14.↵


    1. Stroman  PW, 
    2. Krause  V, 
    3. Malisza  KL, 
    4. et al
    . Characterization of contrast changes in functional MRI of the human spinal cord at 1.5 T. Magn Reson Imaging 2001; 19: 833–38
    CrossRefPubMedWeb of Science
  15. 15.↵


    1. Stroman  PW
    . Magnetic resonance imaging of neuronal function in the spinal cord: spinal FMRI. Clin Med Res 2005; 3: 146–56
    Abstract/FREE Full Text
  16. 16.↵


    1. Agosta  F, 
    2. Valsasina  P, 
    3. Caputo  D, 
    4. et al
    . Tactile-associated fMRI recruitment of the cervical cord in healthy subjects. Hum Brain Mapp 2009; 30: 340–45
    CrossRefPubMedWeb of Science
  17. 17.↵


    1. Stroman  PW
    . Discrimination of errors from neuronal activity in functional MRI of the human spinal cord by means of general linear model analysis. Magn Reson Med 2006; 56: 452–56
    CrossRefPubMedWeb of Science
  18. 18.↵


    1. Stroman  PW, 
    2. Kornelsen  J, 
    3. Lawrence  J
    . An improved method for spinal functional MRI with large volume coverage of the spinal cord. J Magn Reson Imaging 2005; 21: 520–26
    CrossRefPubMedWeb of Science
  19. 19.↵


    1. Stroman  PW, 
    2. Tomanek  B, 
    3. Krause  V, 
    4. et al
    . Mapping of neuronal function in the healthy and injured human spinal cord with spinal fMRI. Neuroimage 2002; 17: 1854–60
    CrossRefPubMedWeb of Science
  20. 20.↵


    1. Field  MJ, 
    2. Bramwell  S, 
    3. Hughes  J, 
    4. et al
    . Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones? Pain 1999; 83: 303–11
    CrossRefPubMedWeb of Science
  21. 21.↵


    1. Rainville  P, 
    2. Feine  JS, 
    3. Bushnell  MC, 
    4. et al
    . A psychophysical comparison of sensory and affective responses to four modalities of experimental pain. Somatosens Mot Res 1992; 9: 265–77
    PubMedWeb of Science
  22. 22.↵


    1. Stroman  PW, 
    2. Figley  CR, 
    3. Cahill  CM
    . Spatial normalization, bulk motion correction and coregistration for functional magnetic resonance imaging of the human cervical spinal cord and brainstem. Magn Reson Imaging 2008; 26: 809–14
    CrossRefPubMed
  23. 23.↵


    1. Figley  CR, 
    2. Stroman  PW
    . Investigation of human cervical and upper thoracic spinal cord motion: implications for imaging spinal cord structure and function. Magn Reson Med 2007; 58: 185–89
    CrossRefPubMed
  24. 24.↵


    1. McGonigle  DJ, 
    2. Howseman  AM, 
    3. Athwal  BS, 
    4. et al
    . Variability in fMRI: an examination of intersession differences. Neuroimage 2000; 11: 708–34
    CrossRefPubMedWeb of Science
  25. 25.↵


    1. Friston  KJ, 
    2. Ashburner  JT, 
    3. Kiebel  SJ
    . Random Effects Analysis. London: Academic Press; 2007
  26. 26.↵


    1. DeArmond  SJ, 
    2. Dewey  MM, 
    3. Fusco  MM
    . Structure of the Human Brain: A Photographic Atlas. New York: Oxford University Press; 1974
  27. 27.↵


    1. Tamraz  JC, 
    2. Comair  YG
    . The brainstem and cerebellum. In: Atlas of Regional Anatomy of the Brain using MRI. New York: Springer; 2006: 227–55
  28. 28.↵


    1. Kimberley  TJ, 
    2. Lewis  SM
    . Understanding neuroimaging. Phys Ther 2007; 87: 670–83
    Abstract/FREE Full Text
  29. 29.↵


    1. Leitch  J, 
    2. Cahill  CM, 
    3. Ghazni  N, 
    4. et al
    . Spinal cord and brainstem activation in carpal tunnel syndrome patients in response to noxious stimuli: a spinal fMRI study. Proceedings of the International Society for Magnetic Resonance in Medicine 17th Annual Meeting, April 18–24, 2009; Honolulu, Hawaii
  30. 30.↵


    1. Stroman  PW
    . Spinal fMRI investigation of human spinal cord function over a range of innocuous thermal sensory stimuli and study-related emotional influences. Magn Reson Imaging 2009; 10: 1333–46
  31. 31.↵


    1. Ochoa  JL, 
    2. Yarnitsky  D
    . Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 1993; 33: 465–72
    CrossRefPubMedWeb of Science
  32. 32.↵


    1. Yezierski  RP, 
    2. Wilcox  TK, 
    3. Willis  WD
    . The effects of serotonin antagonists on the inhibition of primate spinothalamic tract cells produced by stimulation in nucleus raphe magnus or periaqueductal gray. J Pharmacol Exp Ther 1982; 220: 266–77
    Abstract/FREE Full Text
  33. 33.↵


    1. Besson  JM
    . The neurobiology of pain. Lancet 1999; 353: 1610–15
    CrossRefPubMedWeb of Science
  34. 34.↵


    1. Willis  WD, 
    2. Westlund  KN
    . Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol 1997; 14: 2–31
    PubMedWeb of Science
  35. 35.↵


    1. Gardner  E, 
    2. Marin  J, 
    3. Jessel  T
    . The Bodily Senses. New York: McGraw-Hill; 2000
  36. 36.↵


    1. Kennedy  PR
    . Corticospinal, rubrospinal and rubro-olivary projections: a unifying hypothesis. Trends Neurosci 1990; 13: 474–79
    CrossRefPubMedWeb of Science
  37. 37.↵


    1. Baumeister  AA, 
    2. Anticich  TG, 
    3. Hawkins  MF, 
    4. et al
    . Evidence that the substantia nigra is a component of the endogenous pain suppression system in the rat. Brain Res 1988; 447: 116–21
    CrossRefPubMedWeb of Science
  38. 38.↵


    1. Sotres-Bayon  F, 
    2. Torres-Lopez  E, 
    3. Lopez-Avila  A, 
    4. et al
    . Lesion and electrical stimulation of the ventral tegmental area modify persistent nociceptive behavior in the rat. Brain Res 2001; 898: 342–49
    CrossRefPubMed
  39. 39.↵


    1. Fields  HL, 
    2. Basbaum  AI, 
    3. Heinricher  MM
    . Central Nervous System Mechanisms of Pain Modulation. Philadelphia: Elsevier/Churchill Livingstone; 2006
  40. 40.↵


    1. Monhemius  R, 
    2. Green  DL, 
    3. Roberts  MH, 
    4. et al
    . Periaqueductal grey mediated inhibition of responses to noxious stimulation is dynamically activated in a rat model of neuropathic pain. Neurosci Lett 2001; 298: 70–74
    CrossRefPubMedWeb of Science
  41. 41.↵


    1. Sillery  E, 
    2. Bittar  RG, 
    3. Robson  MD, 
    4. et al
    . Connectivity of the human periventricular-periaqueductal gray region. J Neurosurg 2005; 103: 1030–34
    PubMedWeb of Science
  42. 42.↵


    1. Waters  AJ, 
    2. Lumb  BM
    . Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs. Pain 2008; 134: 32–40
    CrossRefPubMedWeb of Science
  43. 43.↵


    1. Logothetis  NK, 
    2. Pauls  J, 
    3. Augath  M, 
    4. et al
    . Neurophysiological investigation of the basis of the fMRI signal. Nature 2001; 412: 150–57
    CrossRefPubMed
  44. 44.↵


    1. Menon  RS, 
    2. Ogawa  S, 
    3. Kim  SG, 
    4. et al
    . Functional brain mapping using magnetic resonance imaging: signal changes accompanying visual stimulation. Invest Radiol 1992; 27 (suppl 2): S47–53
    CrossRefPubMedWeb of Science
  45. 45.↵


    1. Ogawa  S, 
    2. Tank  DW, 
    3. Menon  R, 
    4. et al
    . Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 1992; 89: 5951–55
    Abstract/FREE Full Text
  46. 46.↵


    1. McKiernan  KA, 
    2. Kaufman  JN, 
    3. Kucera-Thompson  J, 
    4. et al
    . A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. J Cogn Neurosci 2003; 15: 394–408
    CrossRefPubMedWeb of Science
  47. 47.↵


    1. Liu  WC, 
    2. Feldman  SC, 
    3. Cook  DB, 
    4. et al
    . fMRI study of acupuncture-induced periaqueductal gray activity in humans. Neuroreport 2004; 15: 1937–40
    CrossRefPubMedWeb of Science
  48. 48.↵


    1. Maihofner  C, 
    2. Neundorfer  B, 
    3. Stefan  H, 
    4. et al
    . Cortical processing of brush-evoked allodynia. Neuroreport 2003; 14: 785–89
    CrossRefPubMed
  49. 49.↵


    1. Schweinhardt  P, 
    2. Glynn  C, 
    3. Brooks  J, 
    4. et al
    . An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage 2006; 32: 256–65
    CrossRefPubMedWeb of Science
  50. 50.↵


    1. Witting  N, 
    2. Kupers  RC, 
    3. Svensson  P, 
    4. et al
    . A PET activation study of brush-evoked allodynia in patients with nerve injury pain. Pain 2006; 120: 145–54
    CrossRefPubMedWeb of Science
  51. 51.↵


    1. Witting  N, 
    2. Kupers  RC, 
    3. Svensson  P, 
    4. et al
    . Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology 2001; 57: 1817–24
    CrossRef
  52. 52.↵


    1. Peyron  R, 
    2. Schneider  F, 
    3. Faillenot  I, 
    4. et al
    . An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology 2004; 63: 1838–46
    CrossRef
  53. 53.↵


    1. Kiernan  JA, 
    2. Barr  ML
    . Barr's The Human Nervous System: An Anatomical Viewpoint. Philadelphia: Lippincott-Raven; 1998
  54. 54.↵


    1. Willis  WD, 
    2. Coggeshall  RE
    . Structure of the dorsal horn. In: Sensory Mechanisms of the Spinal Cord 2nd ed. New York: Plenum Press; 1991: 155–84
  55. 55.↵


    1. Carpenter  MB
    . Core Text of Neuroanatomy. Baltimore: Williams & Wilkins; 1991
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Tactile Sensory and Pain Networks in the Human Spinal Cord and Brain Stem Mapped by Means of Functional MR Imaging
  
    	
N.F. Ghazni, C.M. Cahill, P.W. Stroman

  
    	
 American Journal of Neuroradiology Apr 2010, 31 (4) 661-667; DOI: 10.3174/ajnr.A1909 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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