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<meta name="DC.Title" content="Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2237" />
<meta name="DC.Date" content="2011-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: SBO is a life-threatening infection that may have radiologic features similar to those of the neoplastic processes. The purpose of this study was to evaluate the DWI findings in SBO to facilitate the differential diagnosis.

MATERIALS AND METHODS: The MR imaging findings of 9 patients with SBO were retrospectively evaluated and compared with MR imaging studies from 9 patients with NPC, 9 with lymphoma, and 9 with metastatic disease of the skull base. ADC measurements were performed from the ADCST and the ADCNST in all 4 groups.

RESULTS: The mean ADCST values were 1.26 ± 0.19 × 10−3 mm2/s for SBO, 0.74 ± 0.18 × 10−3 mm2/s for NPC, 0.59 ± 0.11 × 10−3 mm2/s for lymphoma, and 0.99 ± 0.34 × 10−3 mm2/s for metastatic disease, respectively. The mean ADC value of SBO was significantly higher than those of NPC and lymphoma ( P &lt; .0001). There was no significant difference for the comparison of SBO and metastatic lesions. When an ADC value equal to or higher than 1.08 × 10−3 mm2/s was used to rule out lymphoma and NPC, the accuracy was 96%.

CONCLUSIONS: Although SBO is a relatively rare condition, its differential diagnosis from neoplastic processes of the skull base is essential to start appropriate treatment promptly. ADC values may help to distinguish patients with SBO from those with malignant lesions.

ADC
:   apparent diffusion coefficient
ADCNST
:   ADC value of the normal-appearing soft tissue
ADCPONS
:   ADC value of the central pons
ADCST
:   ADC value of the affected soft tissue
DWI
:   diffusion-weighted imaging
Dx
:   diagnosis
EAC
:   external auditory canal
Lym
:   lymphoma
Met
:   metastatic lesions
NPC
:   nasopharyngeal carcinoma
SBO
:   skull base osteomyelitis
SCC
:   squamous cell carcinoma
SE
:   spin-echo" />
<meta name="DC.Contributor" content="B. Ozgen" />
<meta name="DC.Contributor" content="K.K. Oguz" />
<meta name="DC.Contributor" content="A. Cila" />
<meta name="article:published_time" content="2011-01-01" />
<meta name="article:section" content="Head and Neck" />
<meta name="citation_title" content="Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;SBO is a life-threatening infection that may have radiologic features similar to those of the neoplastic processes. The purpose of this study was to evaluate the DWI findings in SBO to facilitate the differential diagnosis.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;The MR imaging findings of 9 patients with SBO were retrospectively evaluated and compared with MR imaging studies from 9 patients with NPC, 9 with lymphoma, and 9 with metastatic disease of the skull base. ADC measurements were performed from the ADC&lt;sub&gt;ST&lt;/sub&gt; and the ADC&lt;sub&gt;NST&lt;/sub&gt; in all 4 groups.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The mean ADC&lt;sub&gt;ST&lt;/sub&gt; values were 1.26 ± 0.19 × 10&lt;sup&gt;−3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s for SBO, 0.74 ± 0.18 × 10&lt;sup&gt;−3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s for NPC, 0.59 ± 0.11 × 10&lt;sup&gt;−3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s for lymphoma, and 0.99 ± 0.34 × 10&lt;sup&gt;−3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s for metastatic disease, respectively. The mean ADC value of SBO was significantly higher than those of NPC and lymphoma (&lt;i&gt;P&lt;/i&gt; &amp;lt; .0001). There was no significant difference for the comparison of SBO and metastatic lesions. When an ADC value equal to or higher than 1.08 × 10&lt;sup&gt;−3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s was used to rule out lymphoma and NPC, the accuracy was 96%.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Although SBO is a relatively rare condition, its differential diagnosis from neoplastic processes of the skull base is essential to start appropriate treatment promptly. ADC values may help to distinguish patients with SBO from those with malignant lesions.&lt;/p&gt;" />
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<meta name="twitter:title" content="Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/32/1.cover.gif" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: SBO is a life-threatening infection that may have radiologic features similar to those of the neoplastic processes. The purpose of this study was to evaluate the DWI findings in SBO to facilitate the differential diagnosis.

MATERIALS AND METHODS: The MR imaging findings of 9 patients with SBO were retrospectively evaluated and compared with MR imaging studies from 9 patients with NPC, 9 with lymphoma, and 9 with metastatic disease of the skull base. ADC measurements were performed from the ADCST and the ADCNST in all 4 groups.

RESULTS: The mean ADCST values were 1.26 ± 0.19 × 10−3 mm2/s for SBO, 0.74 ± 0.18 × 10−3 mm2/s for NPC, 0.59 ± 0.11 × 10−3 mm2/s for lymphoma, and 0.99 ± 0.34 × 10−3 mm2/s for metastatic disease, respectively. The mean ADC value of SBO was significantly higher than those of NPC and lymphoma ( P &lt; .0001). There was no significant difference for the comparison of SBO and metastatic lesions. When an ADC value equal to or higher than 1.08 × 10−3 mm2/s was used to rule out lymphoma and NPC, the accuracy was 96%.

CONCLUSIONS: Although SBO is a relatively rare condition, its differential diagnosis from neoplastic processes of the skull base is essential to start appropriate treatment promptly. ADC values may help to distinguish patients with SBO from those with malignant lesions.

ADC
:   apparent diffusion coefficient
ADCNST
:   ADC value of the normal-appearing soft tissue
ADCPONS
:   ADC value of the central pons
ADCST
:   ADC value of the affected soft tissue
DWI
:   diffusion-weighted imaging
Dx
:   diagnosis
EAC
:   external auditory canal
Lym
:   lymphoma
Met
:   metastatic lesions
NPC
:   nasopharyngeal carcinoma
SBO
:   skull base osteomyelitis
SCC
:   squamous cell carcinoma
SE
:   spin-echo" />
<meta name="og-title" property="og:title" content="Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/32/1/179" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: SBO is a life-threatening infection that may have radiologic features similar to those of the neoplastic processes. The purpose of this study was to evaluate the DWI findings in SBO to facilitate the differential diagnosis.

MATERIALS AND METHODS: The MR imaging findings of 9 patients with SBO were retrospectively evaluated and compared with MR imaging studies from 9 patients with NPC, 9 with lymphoma, and 9 with metastatic disease of the skull base. ADC measurements were performed from the ADCST and the ADCNST in all 4 groups.

RESULTS: The mean ADCST values were 1.26 ± 0.19 × 10−3 mm2/s for SBO, 0.74 ± 0.18 × 10−3 mm2/s for NPC, 0.59 ± 0.11 × 10−3 mm2/s for lymphoma, and 0.99 ± 0.34 × 10−3 mm2/s for metastatic disease, respectively. The mean ADC value of SBO was significantly higher than those of NPC and lymphoma ( P &lt; .0001). There was no significant difference for the comparison of SBO and metastatic lesions. When an ADC value equal to or higher than 1.08 × 10−3 mm2/s was used to rule out lymphoma and NPC, the accuracy was 96%.

CONCLUSIONS: Although SBO is a relatively rare condition, its differential diagnosis from neoplastic processes of the skull base is essential to start appropriate treatment promptly. ADC values may help to distinguish patients with SBO from those with malignant lesions.

ADC
:   apparent diffusion coefficient
ADCNST
:   ADC value of the normal-appearing soft tissue
ADCPONS
:   ADC value of the central pons
ADCST
:   ADC value of the affected soft tissue
DWI
:   diffusion-weighted imaging
Dx
:   diagnosis
EAC
:   external auditory canal
Lym
:   lymphoma
Met
:   metastatic lesions
NPC
:   nasopharyngeal carcinoma
SBO
:   skull base osteomyelitis
SCC
:   squamous cell carcinoma
SE
:   spin-echo" />
<meta name="og-type" property="og:type" content="article" />
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<script>window.dataLayer = window.dataLayer || [];window.dataLayer.push({"page":{"hwTitle":"Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy","hwUrl":"http://ajnr-stage2.stage.highwire.org/content/32/1/179","hwPath":"/content/32/1/179/tab-article-info","hwType":"journal page"},"user":{"hwMemberID":"","hwLoggedIntoInstitutionID":"","hwLoggedIntoInstitution":"","hwAccessUsageTerms":"guest","hwRegisteredUser":"no","hwHasFullTextAccess":"yes","hwEntitled":"no"},"content":{"hwIssueDate":"2011-01-01","hwIssueDateTime":"2011-01-01 00:00:00","hwPublicationDate":"2011-01-13","hwPublicationDateTime":"2011-01-13 08:01:41","hwNlmArticleType":"research-article","hwDOI":"10.3174/ajnr.A2237","hwAuthors":"B. Ozgen,K.K. Oguz,A. Cila","hwContributors":"","hwIsEarlyRelease":"no","hwEissn":"1936-959X","hwPissn":"0195-6108","hwVolume":"32","hwIssue":"1","hwArticleType":"Head and Neck","hwTabView":"main_tab","hwViewType":"full","hwAccessType":"Free","hwOpenAccess":"no","hwFreeAccess":"yes","hwTaxonomy":"","hwCorpusCode":"ajnr","hwType":"article","hwSubtitle":null,"hwOverline":null,"hwPisaId":"ajnr;32/1/179","hwFirstPage":"179","hwLastPage":"184","hwIsLatestVersion":"yes","hwIsCurrentIssue":"no","hwIsOpenIssue":"no","hwHasFullText":"yes","hwHasPDF":"yes","hwParentTitle":"American Journal of Neuroradiology: 32 (1)","hwElectronicPubDate":"2011-01-13","hwElectronicPubDateTime":"2011-01-13 08:01:41"}});
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">B. Ozgen</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">K.K. Oguz</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a> and </li><li class="last" id="contrib-3"><span class="name">A. Cila</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Department of Radiology, Hacettepe University, Ankara, Turkey.</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Burce Ozgen, MD, 
<span class="addr-line">Department of Radiology, Hacettepe University, Faculty of Medicine, Sihhiye, Ankara, 06100 Turkey</span>; e-mail: <span class="em-link"><span class="em-addr">burce{at}hacettepe.edu.tr</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/32/1/179.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Diffusion MR Imaging Features of Skull Base Osteomyelitis Compared with Skull Base Malignancy</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Ozgen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.K.</span> <span class="nlm-surname">Oguz</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Cila</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">179-184; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2237 </span></div>
  
  
  
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