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<meta name="DC.Title" content="How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2635" />
<meta name="DC.Date" content="2011-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Endovascular coiling is a well-established therapy for treating intracranial aneurysms. Nonetheless, postoperative hemodynamic changes induced by this therapy remain not fully understood. The purpose of this work is to assess the influence of coil configuration and packing density on intra-aneurysmal hemodynamics.

MATERIALS AND METHODS: Three 3D rotational angiography images of 3 intracranial aneurysms before and after endovascular coiling were used. For each aneurysm, a 3D representation of the vasculature was obtained after the segmentation of the images. Afterward, a virtual coiling technique was used to treat the aneurysm geometries with coil models. The aneurysms were coiled with 5 packing densities, and each was generated by using 3 coil configurations. Computational fluid dynamics analyses were carried out in both untreated and treated aneurysm geometries. Statistical tests were performed to evaluate the relative effect of coil configuration on local hemodynamics.

RESULTS: The intra-aneurysmal blood flow velocity and wall shear stress were diminished as packing density increased. Aneurysmal flow velocity was reduced &gt;50% due to the first inserted coils (packing density &lt;12%) but with a high dependency on coil configuration. Nonsignificant differences ( P &gt; .01) were found in the hemodynamics due to coil configuration for high packing densities (near 30%). A damping effect was observed on the intra-aneurysmal blood flow waveform after coiling.

CONCLUSIONS: Intra-aneurysmal hemodynamics are altered by coils. Coil configuration might reduce its influence on intra-aneurysmal hemodynamics as the packing density increases until an insignificant influence could be achieved for high packing densities.

3DRA
:   3D rotational angiography
ANOVA
:   analysis of variance
CFD
:   computational fluid dynamics
DSA
:   digital subtraction angiography
WSS
:   wall shear stress" />
<meta name="DC.Contributor" content="H.G. Morales" />
<meta name="DC.Contributor" content="M. Kim" />
<meta name="DC.Contributor" content="E.E. Vivas" />
<meta name="DC.Contributor" content="M.-C. Villa-Uriol" />
<meta name="DC.Contributor" content="I. Larrabide" />
<meta name="DC.Contributor" content="T. Sola" />
<meta name="DC.Contributor" content="L. Guimaraens" />
<meta name="DC.Contributor" content="A.F. Frangi" />
<meta name="article:published_time" content="2011-11-01" />
<meta name="article:section" content="Interventional" />
<meta name="citation_title" content="How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Endovascular coiling is a well-established therapy for treating intracranial aneurysms. Nonetheless, postoperative hemodynamic changes induced by this therapy remain not fully understood. The purpose of this work is to assess the influence of coil configuration and packing density on intra-aneurysmal hemodynamics.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Three 3D rotational angiography images of 3 intracranial aneurysms before and after endovascular coiling were used. For each aneurysm, a 3D representation of the vasculature was obtained after the segmentation of the images. Afterward, a virtual coiling technique was used to treat the aneurysm geometries with coil models. The aneurysms were coiled with 5 packing densities, and each was generated by using 3 coil configurations. Computational fluid dynamics analyses were carried out in both untreated and treated aneurysm geometries. Statistical tests were performed to evaluate the relative effect of coil configuration on local hemodynamics.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The intra-aneurysmal blood flow velocity and wall shear stress were diminished as packing density increased. Aneurysmal flow velocity was reduced &amp;gt;50% due to the first inserted coils (packing density &amp;lt;12%) but with a high dependency on coil configuration. Nonsignificant differences (&lt;i&gt;P&lt;/i&gt; &amp;gt; .01) were found in the hemodynamics due to coil configuration for high packing densities (near 30%). A damping effect was observed on the intra-aneurysmal blood flow waveform after coiling.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Intra-aneurysmal hemodynamics are altered by coils. Coil configuration might reduce its influence on intra-aneurysmal hemodynamics as the packing density increases until an insignificant influence could be achieved for high packing densities.&lt;/p&gt;" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Endovascular coiling is a well-established therapy for treating intracranial aneurysms. Nonetheless, postoperative hemodynamic changes induced by this therapy remain not fully understood. The purpose of this work is to assess the influence of coil configuration and packing density on intra-aneurysmal hemodynamics.

MATERIALS AND METHODS: Three 3D rotational angiography images of 3 intracranial aneurysms before and after endovascular coiling were used. For each aneurysm, a 3D representation of the vasculature was obtained after the segmentation of the images. Afterward, a virtual coiling technique was used to treat the aneurysm geometries with coil models. The aneurysms were coiled with 5 packing densities, and each was generated by using 3 coil configurations. Computational fluid dynamics analyses were carried out in both untreated and treated aneurysm geometries. Statistical tests were performed to evaluate the relative effect of coil configuration on local hemodynamics.

RESULTS: The intra-aneurysmal blood flow velocity and wall shear stress were diminished as packing density increased. Aneurysmal flow velocity was reduced &gt;50% due to the first inserted coils (packing density &lt;12%) but with a high dependency on coil configuration. Nonsignificant differences ( P &gt; .01) were found in the hemodynamics due to coil configuration for high packing densities (near 30%). A damping effect was observed on the intra-aneurysmal blood flow waveform after coiling.

CONCLUSIONS: Intra-aneurysmal hemodynamics are altered by coils. Coil configuration might reduce its influence on intra-aneurysmal hemodynamics as the packing density increases until an insignificant influence could be achieved for high packing densities.

3DRA
:   3D rotational angiography
ANOVA
:   analysis of variance
CFD
:   computational fluid dynamics
DSA
:   digital subtraction angiography
WSS
:   wall shear stress" />
<meta name="og-title" property="og:title" content="How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/32/10/1935" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Endovascular coiling is a well-established therapy for treating intracranial aneurysms. Nonetheless, postoperative hemodynamic changes induced by this therapy remain not fully understood. The purpose of this work is to assess the influence of coil configuration and packing density on intra-aneurysmal hemodynamics.

MATERIALS AND METHODS: Three 3D rotational angiography images of 3 intracranial aneurysms before and after endovascular coiling were used. For each aneurysm, a 3D representation of the vasculature was obtained after the segmentation of the images. Afterward, a virtual coiling technique was used to treat the aneurysm geometries with coil models. The aneurysms were coiled with 5 packing densities, and each was generated by using 3 coil configurations. Computational fluid dynamics analyses were carried out in both untreated and treated aneurysm geometries. Statistical tests were performed to evaluate the relative effect of coil configuration on local hemodynamics.

RESULTS: The intra-aneurysmal blood flow velocity and wall shear stress were diminished as packing density increased. Aneurysmal flow velocity was reduced &gt;50% due to the first inserted coils (packing density &lt;12%) but with a high dependency on coil configuration. Nonsignificant differences ( P &gt; .01) were found in the hemodynamics due to coil configuration for high packing densities (near 30%). A damping effect was observed on the intra-aneurysmal blood flow waveform after coiling.

CONCLUSIONS: Intra-aneurysmal hemodynamics are altered by coils. Coil configuration might reduce its influence on intra-aneurysmal hemodynamics as the packing density increases until an insignificant influence could be achieved for high packing densities.

3DRA
:   3D rotational angiography
ANOVA
:   analysis of variance
CFD
:   computational fluid dynamics
DSA
:   digital subtraction angiography
WSS
:   wall shear stress" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node11656--7" data-node-nid="11656" id="top-node-11656--81851682976" data-pisa="ajnr;32/10/1935" data-pisa-master="ajnr;ajnr.A2635" data-apath="/ajnr/32/10/1935.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H.G. Morales</span>, <span class="highwire-citation-author" data-delta="1">M. Kim</span>, <span class="highwire-citation-author" data-delta="2">E.E. Vivas</span>, <span class="highwire-citation-author" data-delta="3">M.-C. Villa-Uriol</span>, <span class="highwire-citation-author" data-delta="4">I. Larrabide</span>, <span class="highwire-citation-author" data-delta="5">T. Sola</span>, <span class="highwire-citation-author" data-delta="6">L. Guimaraens</span> and <span class="highwire-citation-author" data-delta="7">A.F. Frangi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2011,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1935-1941; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2635 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11656--81851682976" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H.G. Morales </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.G.%2BMorales%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Morales%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.G.%2BMorales%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M. 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Villa-Uriol </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.-C.%2BVilla-Uriol%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Villa-Uriol%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.-C.%2BVilla-Uriol%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">I. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">H.G. Morales</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">M. Kim</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">E.E. Vivas</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-4"><span class="name">M.-C. Villa-Uriol</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-5"><span class="name">I. Larrabide</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-6"><span class="name">T. Sola</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-7"><span class="name">L. Guimaraens</span><a id="xref-aff-3-3" class="xref-aff" href="#aff-3">c</a> and </li><li class="last" id="contrib-8"><span class="name">A.F. Frangi</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-3" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Center for Computational Imaging &amp; Simulation Technologies in Biomedicine (H.G.M., M.K., M.-C.V.-U., I.L., A.F.F.), Information &amp; Communication Technologies Department, Universitat Pompeu Fabra, Barcelona, Spain</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Networking Center on Biomedical Research (CIBER-BBN) (H.G.M., M.K., M.-C.V.-U., I.L., A.F.F.), Barcelona, Spain</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Neuroangiografía Terapéutica J. J. Merland (E.E.V., T.S., L.G.), Hospital General de Catalunya, San Cugat del Valles, Spain</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Institució Catalana de Recerca i Estudis Avançats (A.F.F.), Barcelona, Spain.</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Alejandro F. Frangi, <span class="addr-line">Center for Computational Imaging &amp; Simulation Technologies in Biomedicine (CISTIB), Information &amp; Communications Technologies Department, Universitat Pompeu Fabra, c/Roc Boronat 138-E08018 Barcelona, Spain</span>; e-mail: <span class="em-link"><span class="em-addr">frangi{at}upf.edu</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/32/10/1935.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-article-citation highwire-citation-type-highwire-article cite-tool-node11656--3" data-node-nid="11656" id="citation-node-11656--42074567546" data-pisa="ajnr;32/10/1935" data-pisa-master="ajnr;ajnr.A2635" data-apath="/ajnr/32/10/1935.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard clearfix">
  
  
  
  
      <div class="highwire-cite-title">How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.G.</span> <span class="nlm-surname">Morales</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">E.E.</span> <span class="nlm-surname">Vivas</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.-C.</span> <span class="nlm-surname">Villa-Uriol</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Larrabide</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Sola</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Guimaraens</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A.F.</span> <span class="nlm-surname">Frangi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1935-1941; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2635 </span></div>
  
  
  
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      <div class="highwire-cite-title">How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.G.</span> <span class="nlm-surname">Morales</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">E.E.</span> <span class="nlm-surname">Vivas</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.-C.</span> <span class="nlm-surname">Villa-Uriol</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Larrabide</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Sola</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Guimaraens</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A.F.</span> <span class="nlm-surname">Frangi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1935-1941; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2635 </span></div>
  
  
  
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