Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

M.F. Covington; S.S. Chin; A.G. Osborn

doi:10.3174/ajnr.A2717

Abstract

BACKGROUND AND PURPOSE: Pituicytoma, SCO, and GCT are poorly understood entities with confusing nomenclature and undetermined imaging characteristics. Our purpose was to confirm published cases of pituicytoma, SCO, and GCT with the newest 2007 World Health Organization criteria and elucidate imaging findings that distinguish these tumors from common entities such as pituitary adenoma.

MATERIALS AND METHODS: A literature search identified 145 published cases (81 GCTs, 48 pituicytomas, and 16 SCOs). Case diagnoses were blindly reviewed by a neuropathologist according to the latest WHO criteria, resulting in 112 pathologically documented cases (64 GCTs, 35 pituicytomas, and 13 SCOs). Imaging illustrations from proved cases were reviewed to determine location, configuration, attenuation and signal intensity, and enhancement characteristics.

RESULTS: Only pituicytomas presented as purely intrasellar lesions (7/33). Most GCTs were purely suprasellar (28/45). All SCOs were both intra- and suprasellar (13/13). Twenty-five percent of pituicytomas (6/22) and GCTs (7/30) appeared separate from the pituitary gland. All SCOs were infiltrating. Seventy-nine percent of entities appeared isointense to brain on T1-weighted image (34/43). Seventy-four percent of pituicytomas enhanced homogeneously (14/19). Twelve of 23 GCTs and 5/7 SCOs enhanced heterogeneously. Most GCTs were hyperattenuated to brain on CT (18/20). Eleven of 13 cases enhanced homogeneously. Visual disturbances were common symptoms for all entities (67/112). Diabetes insipidus was rare (4/112).

CONCLUSIONS: Pituicytoma may be considered for purely intrasellar masses that are clearly separate from the pituitary gland. GCT should receive consideration for purely suprasellar lesions that are hyperattenuated to brain on CT. SCO should be considered for infiltrating pituitary masses with a mixed intra- and suprasellar location. A history of diabetes insipidus helps to exclude these tumors.

ABBREVIATIONS

DI: diabetes insipidus
GCT: granular cell tumor
SCO: spindle cell oncocytoma

Primary nonadenomatous pituitary gland tumors are rare, poorly understood entities with confusing nomenclature. The 2007 WHO Classification of Tumors of the Central Nervous System clarified and redefined criteria for pituicytoma, codifying it as a separate diagnostic entity distinct from GCT of the neurohypophysis.¹ The 2007 update also added a new entity—SCO—to the spectrum of nonadenomatous sellar neoplasms.² The purpose of our study was to apply the new World Health Organization (WHO) criteria to published cases and elucidate imaging findings that might distinguish these rare neoplasms from each other as well as more common lesions such as pituitary adenoma and lymphocytic hypophysitis.

Materials and Methods

A comprehensive literature search of English and non-English studies by using PubMed and Google Scholar was completed between September and October 2010 to identify all previously published cases of pituicytoma, SCO, and neurohypophyseal GCT. To include all names assigned to these tumors over past decades, the following keywords were used in the search: pituicytoma, spindle cell oncocytoma, granular cell tumor, infundibuloma, “choristoma”, granular cell myoblastoma, Abriksossoff tumor, and pilocytic astrocytoma.

Search results were screened by the primary author to include only those tumors involving the sellar and suprasellar region (eg, most GCTs involve extracranial sites such as the tongue and esophagus³; pilocytic astrocytoma—previously used synonymously for what is now termed pituicytoma—typically does not involve the infundibulum or pituitary gland⁴). This search identified 145 potential cases (81 GCTs, 48 pituicytomas, and 16 SCOs).

Full-text articles of each report were obtained. The radiologic and histologic images from each article were compiled into electronic databases by the primary author. Captions or other identifying text accompanying each image were removed to facilitate blinded case review.

The histologic image data base was reviewed by a board-certified neuropathologist (S.S.C.) who was blinded as to tumor entity and instructed to classify each case, if possible, as pituicytoma, GCT, or SCO in accordance with the latest 2007 WHO criteria. For cases in which provided histologic images were insufficient to meet WHO criteria, all available written descriptions of the study's pathologic diagnoses were provided. This included descriptions of histology, immunohistochemistry, and ultrastructure. After review of this information, the neuropathologist was again asked whether sufficient WHO criteria were met to classify the case definitively. Any cases that could not be assigned to 1 of our 3 entities based on histology, written reports, or both were recorded as unclassifiable and eliminated from further consideration.

The review process resulted in 112 pathologically documented cases in total from 65 articles (64 GCTs,^{3,5⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓–44} 35 pituicytomas^{4,45⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓–63} and 13 SCOs^{64⇓⇓⇓⇓⇓–70}). Histologic images were of too poor quality to analyze in 7 cases that were received through interlibrary loan (3 GCTs, 2 pituicytomas, and 2 SCOs), and these were marked as unclassifiable along with 33 additional cases. In no case was a tumor reassigned from 1 entity (eg, pituicytoma) to another (eg, SCO or GCT). Most articles were published in pathology, neurosurgery, or other clinically oriented journals. Only 5 articles were published in radiology journals.

Of the 112 pathologically documented cases, only 58 (30 GCTs, 22 pituicytomas, and 6 SCOs) contained CT images, MR images, or both. Original MR images were available for 19 cases of pituicytoma, 7 cases of SCO, and 24 cases of GCT. T1WI was available for 15 pituicytomas, 4 SCOs, and 24 GCTs. T2WI was available for 8 pituicytomas and 17 GCTs. Results of postcontrast scans were available for 19 pituicytomas, 7 SCOs, and 23 GCTs.

Information regarding CT signal intensity characteristics were available for only GCTs (n = 20). Results of CT enhancement patterns were available in 13 of these cases.

Original CT and MR images were compiled into a database and reviewed by a senior neuroradiologist (A.G.O.). Findings including location (suprasellar/infundibulum, intrasellar/pituitary gland, or both), configuration (round or infiltrating and separation from the pituitary gland), attenuation and signal intensity, and enhancement characteristics were tabulated.

Finally, M.F.C. extrapolated the age, sex, and clinical symptoms at presentation from each pathologically documented case.

Results

Location

Pituicytoma was the only tumor that ever presented as a purely intrasellar lesion (7/33) (Table 1). Most pituicytomas were either suprasellar (13/33) or combined intra- and suprasellar lesions (13/33). GCTs were either suprasellar (28/45) or both intra- and suprasellar (17/45). No SCOs were purely intra- or suprasellar; all SCOs were both intra- and suprasellar (13/13).

View this table:

Table 1:

Anatomic location for cases of pituicytoma, SCO, and GCT

Separation from Pituitary Gland

Only 25% each of pituicytomas (6/22) and GCTs (7/30) could be clearly separated from the pituitary gland. Seventy-five percent of all tumor entities were infiltrating and could not be separated from the underlying pituitary gland (39/52).

Imaging Findings

Signal intensity characteristics and enhancement patterns from CT imaging were available for only the GCTs. Eighteen of 20 were hyperattenuated compared with brain on noncontrast CT. Postcontrast scans were available in 13/20 cases. Eighty-four percent (11/13) enhanced homogeneously. One tumor (8%) enhanced inhomogeneously and 1 tumor showed no enhancement after contrast administration.

Forty-three cases had 1 or more MR images illustrated (Table 2). T1WI was available in all 43 cases. Seventy-nine percent of all entities, regardless of tumor type, appeared isointense compared with cortex on T1WI (34/43). T2WI was available in only 25 cases. Pituicytomas were generally hyperintense on T2WI compared with gray matter (6/8), whereas GCTs were predominately isointense (10/17). No confirmed cases of SCO had published images of T2-weighted scans.

View this table:

Table 2:

MR signal characteristics for pituicytoma, SCO, and GCT

Contrast-enhanced T1WI was available for review in 49 cases. Seventy-four percent of pituicytomas enhanced homogeneously (14/19); the remainder showed heterogeneous enhancement (5/19). Enhancement patterns for the other 2 entities were mixed (12/23 GCTs and 5/7 SCOs demonstrated heterogeneous enhancement, whereas the remainder enhanced homogeneously).

Clinical Findings

Visual disturbances (eg, bitemporal hemianopsia, decreased visual acuity) were the most common presenting symptom for all entities (67/112; Table 3). With pituicytomas, the next most common presenting symptoms were headache (10/35), hypopituitarism (9/35), fatigue (8/35), and decreased libido (7/35). For SCO, hypopituitarism was the next most common symptom (6/13) followed by headache (4/13). For GCT, the next most common symptoms were headache (21/64), amenorrhea (12/64), fatigue (8/64), and memory loss (7/64).

View this table:

Table 3:

Presenting symptoms for pituicytoma, SCO, and GCT

DI was especially uncommon with these tumors. Only 1 pathologically documented case of pituicytoma⁵⁶ and 3 cases of GCT^36,39,44 had DI. Similarly, increased levels of prolactin were reported for only 1 case of pituicytoma,⁵⁵ 2 cases of SCO,^64,70 and 4 cases of GCT.^11,17,22,31 Galactorrhea was reported only in 1 case of GCT.¹¹

Sex

The male:female ratio was 18:17 (51.4% male) for pituicytoma, 5:8 (61.5% female) for SCO, and 22:42 (65.5% female) for GCT.

Age

The average age at diagnosis was 50.3 years for pituicytoma, 59.4 years for SCO, and 49.2 years for GCT.

Discussion

Pituicytoma, SCO, and GCT of the neurohypophysis are rare, poorly understood neoplasms of the sellar region. Pituicytoma has an especially notable history of frequently changing nomenclature and shifting diagnostic criteria.⁶² Synonyms for pituicytoma over past decades have included choristoma, granular cell myoblastoma, infundibuloma, pilocytic astrocytoma, and even granular cell tumor. Not until the 2007 edition of the WHO Classification of Tumors of the Central Nervous System was pituicytoma designated as a distinct diagnostic entity, separate from GCT. The 2007 edition also added SCO as a new distinct entity in the differential diagnosis of sellar neoplasms.

Given their striking similarities on imaging to other much more common lesions such as pituitary adenoma, the preoperative diagnosis of pituicytoma, SCO, and GCT has been problematic. The inability to distinguish these lesions from entities such as pituitary adenoma is important because these tumors, unlike pituitary adenomas, tend to be very vascular and are prone to heavy bleeding during surgical resection.^5,52,65 This has often resulted in the need to stabilize the patient, abort the surgery, and consider reoperation at a later date, potentially after embolization of tumor vasculature.⁶² If reoperation does not occur, symptomatic recurrence is common.⁸

Detecting clues that might establish the preoperative diagnosis of these entities has been problematic due to the exceptional rarity of these tumors. No single institution is likely to see more than a handful of these tumors over the course of several decades. The literature consists mostly of single case reports and a few very small case series. Therefore, only a retrospective meta-analysis of all published cases could potentially detect meaningful differential diagnostic information.

In addition, considering these entities' history of frequently changing and often overlapping nomenclature, confirmation of published case diagnoses by a board-certified neuropathologist by using the new 2007 WHO criteria was a necessary prerequisite to imaging analysis. Confirming the precise histologic diagnosis in each case has allowed us to determine that all cases included in our meta-analysis do indeed represent true cases of pituicytoma, SCO, or GCT.

Major limitations of our study include dependence on the often-limited information provided for the figures, images, and text as included in each original case report or case series. Less than 10% of cases were published in the radiology literature. Precise delineation of imaging parameters were universally absent from nonradiology journals and were present in only 2 of the 5 radiology manuscripts used in our imaging analysis. We did not have access to any of the original patient scans for review or comparison to published reports.

Pituicytoma

The definitive histologic description of pituicytoma⁴⁶ and the subsequent acceptance of pituicytoma as a distinct tumor entity were only recently established. Given the lack of known clinical and imaging findings specific to pituicytoma, these tumors are typically diagnosed preoperatively as pituitary adenoma.⁴⁷ Attempted resection of these presumed adenomas often results in unexpected heavy intraoperative bleeding, subtotal resection, and a high risk of symptomatic tumor recurrence.⁶²

Our study identifies specific imaging findings (Fig 1) that could permit a neuroradiologist to make the preoperative diagnosis of pituicytoma in selected cases. Although a minority of pituicytomas will present in this manner, the diagnosis might be suggested if imaging shows a mass that is purely intrasellar and clearly separate from the pituitary gland. We found no similar presentation in any of our pathologically documented cases of SCO or GCT. Such a presentation also would be rare for pituitary adenoma, lymphocytic hypophysitis, or physiologic pituitary hyperplasia.⁷¹

Fig 1.

Pituicytoma. Sagittal T1WI image (A) and coronal T1WI postcontrast scan (B) show a rounded suprasellar mass that is clearly separate from the pituitary gland. (From Gibbs WN, Monuki ES, Linskey ME et al. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol 2006:27:1639–42. Used with permission.)

Patients with pituicytoma almost never present with diabetes insipidus, galactorrhea, or prolactinemia. When these symptoms are present, more common diagnoses such as pituitary adenoma or lymphocytic hypophysitis are likely. Instead, to support the diagnosis of pituicytoma, the radiologist should look for a classic history of visual disturbance, headache, or both.

Spindle Cell Oncocytoma

SCO (Fig 2) was first described in 2002 by Roncaroli et al⁶⁹ in their series of 5 cases. Only 16 total cases have been reported in the literature. Of these, we were able to confirm the histopathology of 13 cases. The remaining 3 cases were marked as unclassifiable due to the poor quality of images received through interlibrary loan.

Fig 2.

Spindle cell oncocytoma. Coronal T1WI (A) demonstrates a mixed intra- and suprasellar infiltrating pituitary lesion. Coronal T1-postcontrast scan (B) reveals a heterogeneous pattern of enhancement. Sagittal T1WI (C) shows enlargement of the anterior pituitary by the infiltrating mass and displacement of the unaffected neurohypophysis. (From Vajtai I, Sahli R, Kappeler A. Spindle cell oncocytoma of the adenohypophysis: report of a case with a 16-year follow-up. Pathol Res Pract 2006:202:745–50. Used with permission.)

Our analysis of pathologically documented cases of SCO was limited by the small number of imaging studies available in the published literature. However, all 13 cases of the pathologically documented SCO presented as combined intra- and suprasellar lesions. Thus it is unlikely that a lesion presenting as a purely intra- or suprasellar mass on imaging is a SCO.

SCOs arise from the adenohypophysis whereas pituicytoma and GCT derive from the neurohypophysis.^69,70 Therefore, if imaging localizes a tumor to the neurohypophysis, the diagnosis of SCO may be excluded. Moreover, all cases of SCO were infiltrating and none could be seen separately from the pituitary gland itself. It is therefore not possible to distinguish SCOs from more common lesions such as pituitary adenoma or lymphocytic hypophysitis on the basis of imaging features alone.

SCO typically presents with visual disturbance, panhypopituitarism, and headache. From our analysis, the incidence of panhypopituitarism seems to be more common with SCO than either pituicytoma or GCT. This discrepancy may possibly be explained by SCO's exclusive derivation from the adenohypophysis. There are no reported cases of SCO presenting with DI.

We could identify no specific imaging or clinical findings that allowed us to suspect the preoperative diagnosis of SCO. In contrast, there are imaging and clinical clues that help exclude SCO when present. These include a mass that clearly arises from the neurohypophysis or masses that are exclusively either intra- or suprasellar on imaging studies. Individuals presenting with a pituitary mass and concomitant diabetes insipidus are unlikely to have a SCO.

Granular Cell Tumor

Boyce and Beadles⁷² first described GCT (Fig 3) as a distinct neurohypophyseal tumor in 1893. Many GCTs are asymptomatic and consist of small nests of tumor cells that do not have any space-occupying effects.⁷ Such tumor cell nests are common in the general population. Necropsy of 200 pituitary glands found GCT nests in 5.7% of cases,¹² and analysis of 1364 pituitary glands identified GCT nests in 6.45% of cases.⁷³

Fig 3.

Granular cell tumor. T1-weighted postcontrast scan (A) demonstrates a large suprasellar mass with a heterogeneous pattern of enhancement that is clearly separate from the pituitary gland. Contrast-enhanced axial CT (B) shows a large mass with heterogeneous enhancement that is hyperattenuated compared with brain. (From Buhl R, Hugo HH, Hempelmann RG et al. Granular-cell tumor: a rare suprasellar mass. Neuroradiology 2001:43:309–12. Used with permission.)

As first reported in 1951,⁴² these tumor cell nests may enlarge over time and become clinically symptomatic, usually in middle-aged or older adults.²² To date, symptomatic GCT of the neurohypophysis has been described in 81 cases, 64 of which we could confirm on histopathologic review.

Our analysis shows that GCT is almost always hyperattenuated to brain on CT and usually demonstrates a homogeneous pattern of enhancement. Most GCTs are entirely suprasellar in location. None of our 64 pathologically documented cases presented as a purely intrasellar mass. Therefore, GCT should be excluded from the differential diagnosis of purely intrasellar lesions.

Clinical findings for GCT are nonspecific and most commonly include visual disturbance, headache, and amenorrhea. Similar to our other entities, DI, prolactinemia, and galactorrhea are uncommon presenting features of GCT.

The diagnosis of GCT should be considered for purely suprasellar masses that are hyperattenuated compared with brain on CT and enhance homogeneously. MR imaging offers few clues that raise preoperative suspicion for GCT. On MR imaging, GCT tends to be isointense on both T1WI and T2WI. The pattern of enhancement for GCTs is equally heterogeneous or homogeneous after gadolinium administration.

Conclusions

Pituicytoma, SCO, and GCT represent rare but important differential diagnostic considerations of sellar and suprasellar lesions. The preoperative diagnosis of these tumors has been difficult owing to a lack of specific imaging and clinical findings. From our analysis, we have identified imaging and clinical clues that make the potential preoperative diagnosis of these entities possible (Fig 4). A diagnosis of pituicytoma may be considered for masses that are purely intrasellar and clearly separate from the pituitary gland on imaging. GCT should receive diagnostic consideration for lesions that are hyperattenuated compared with brain on noncontrast CT and of a purely suprasellar location. SCO should be considered only for infiltrating pituitary masses with a mixed intra- and suprasellar location. Neither pituicytoma, SCO, nor GCT should be highly considered for patients who present with DI, prolactinemia, or galactorrhea. Instead, these rare tumors most often present with visual disturbance and headache.

Fig 4.

Key diagnostic considerations for pituicytoma, SCO, and GCT.

Footnotes

Paper previously presented in part at: Annual Meeting of the American Society of Neuroradiology, June 6–9, 2011; Seattle, Washington.
Disclosures: Anne G. Osborn. Ownership Interest: Amirsys, Amirsys Publishing, Details: shareholder; Other Financial Relationships: Amirsys Publishing, Details: CEO.

References

1.↵
1. Louis DN,
2. Ohgaki H,
3. Weistler OD,
4. et al
. WHO Classification of Tumours of the Central Nervous System, 4th ed. Lyon, France: IARC Press; 2007:309
2.↵
1. Fuller GN,
2. Scheithauer BW
. The 2007 revised World Health Organization (WHO) classification of tumours of the central nervous system: newly codified entities. Brain Pathol 2007;17:304–07
CrossRef PubMed
3.↵
1. Kobayashi TK,
2. Bamba M,
3. Oka H
. Granular cell tumour of the neurohypophysis on cytological squash preparations. Cytopathology 2006;17:153–54
CrossRef PubMed
4.↵
1. Katsuta T,
2. Inoue T,
3. Nakagaki H,
4. et al
. Distinctions between pituicytoma and ordinary pilocytic astrocytoma: case report. J Neurosurg 2003;98:404–06
CrossRef PubMed
5.↵
1. Aquilina K,
2. Kamel M,
3. Kalimuthu SG,
4. et al
. Granular cell tumour of the neurohypophysis: a rare sellar tumour with specific radiological and operative features. Br J Neurosurg 2006;20:51–54
CrossRef PubMed
6.↵
1. Becker DH,
2. Wilson CB
. Symptomatic parasellar granular cell tumors. Neurosurgery 1981;8:173–80
CrossRef PubMed
7.↵
1. Boucher-Schwarz HG,
2. Fries G,
3. Bornemann A,
4. et al
. Suprasellar granular cell tumor. Neurosurgery 1992;31:751–54
CrossRef PubMed
8.↵
1. Buhl R,
2. Hugo HH,
3. Hempelmann RG,
4. et al
. Granular-cell tumour: a rare suprasellar mass. Neuroradiology 2001;43:309–12
CrossRef PubMed
9.↵
1. Burston J,
2. John R,
3. Spencer H
. “Myoblastoma” of the neurohypophysis. J Pathol Bacteriol 1962;83:455–61
CrossRef PubMed
10.↵
1. Cohen-Gadol AA,
2. Pichelmann MA,
3. Link MJ,
4. et al
. Granular cell tumor of the sellar and suprasellar region: clinicopathologic study of 11 cases and literature review. Mayo Clin Proc 2003;78:567–73
CrossRef PubMed
11.↵
1. Cusick JF,
2. Ho KC,
3. Hagen TC,
4. et al
. Granular-cell pituicytoma associated with multiple endocrine neoplasia type 2. J Neurosurg 1982;56:594–96
CrossRef PubMed
12.↵
1. Doron Y,
2. Behar A,
3. Beller AJ
. Granular-cell “myoblastoma” of the neurohypophysis. J Neurosurg 1965;22:95–99
CrossRef PubMed
13.↵
1. Benites Filho PR,
2. Sakamoto D,
3. Machuca TN,
4. et al
. Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation. Virchows Arch 2005;447:649–52
CrossRef PubMed
14.↵
1. Glazer N,
2. Hauser H,
3. Slade H
. Granular cell tumor of the neurohypophysis. Am J Roentgenol Radium Ther Nucl Med 1956;76:324–26
PubMed
15.↵
1. Graziani N,
2. Dufour H,
3. Figarella-Branger D,
4. et al
. Suprasellar granular-cell tumour, presenting with intraventricular haemorrhage. Br J Neurosurg 1995;9:97–102
CrossRef PubMed
16.↵
1. Harland WA
. Granular-cell myoblastoma of the hypophyseal stalk. Cancer 1953;6:1134–38
CrossRef PubMed
17.↵
1. Higuchi M,
2. Tsuji M,
3. Ikeda H
. Symptomatic hypophyseal granular cell tumour: endocrinological and clinicopathological analysis. Br J Neurosurg 1997;11:582–86
CrossRef PubMed
18.↵
1. Jenevein EP
. A neurohypophysial tumor originating from pituicytes. Am J Clin Pathol 1964;41:522–26
PubMed
19.↵
1. Ji CH,
2. Teng MM,
3. Chang T
. Granular cell tumour of the neurohypophysis. Neuroradiology 1995;37:451–52
CrossRef PubMed
20.↵
1. Kasashima S,
2. Oda Y,
3. Nozaki J,
4. et al
. A case of atypical granular cell tumor of the neurohypophysis. Pathol Int 2000;50:568–73
CrossRef PubMed
21.↵
1. Lafitte C,
2. Aesch B,
3. Henry-Lebras F
. Granular cell tumor of the pituitary stalk. Case report. J Neurosurg 1994;80:1103–07
CrossRef PubMed
22.↵
1. Lee CC,
2. Liu CH,
3. Wei CP,
4. et al
. Symptomatic granular cell tumor of the neurohypophysis. J Formos Med Assoc 2004;103:58–62
PubMed
23.↵
1. Lima A,
2. Antunes L,
3. Tome F
. Pituicytoma or granular-cell myoblastoma of the pituitary gland? Report of a case. J Neurosurg 1960;17:778–82
CrossRef PubMed
24.↵
1. Liwnicz BH,
2. Liwnicz RG,
3. Huff JS
. Giant granular cell tumor of the suprasellar area: immunocytochemical and electron microscopic studies. Neurosurgery 1984;15:246–51
CrossRef PubMed
25.↵
1. Losa M,
2. Saeger W,
3. Mortini P
. Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. Case report. J Neurosurg 2000;93:121–26
PubMed
26.↵
1. Moriyama E,
2. Matsumoto Y,
3. Meguro T,
4. et al
. Suprasellar granular cell tumor. Neurol Med Chir (Tokyo) 1996;36:237–40
CrossRef PubMed
27.↵
1. Mumert ML,
2. Walsh MT,
3. Chin SS
. Cystic granular cell tumor mimicking Rathke cleft cyst. J Neurosurg 2011;114:325–28
CrossRef PubMed
28.↵
1. Nishio S,
2. Takeshita I,
3. Yoshimoto K,
4. et al
. Granular cell tumor of the pituitary stalk. Clin Neurol Neurosurg 1998;100:144–47
CrossRef PubMed
29.↵
1. Nishioka H,
2. Ii K,
3. Llena JF,
4. et al
. Immunohistochemical study of granular cell tumors of the neurohypophysis. Virchows Arch B Cell Pathol Incl Mol Pathol 1991;60:413–17
CrossRef PubMed
30.↵
1. Policarpio-Nicolas ML,
2. Le BH,
3. Mandell JW,
4. et al
. Granular cell tumor of the neurohypophysis: report of a case with intraoperative cytologic diagnosis. Diagn Cytopathol 2008;36:58–63
CrossRef PubMed
31.↵
1. Popovic V,
2. Pekic S,
3. Skender-Gazibara M,
4. et al
. A large sellar granular cell tumor in a 21-year-old woman. Endocr Pathol 2007;18:91–94
CrossRef PubMed
32.↵
1. Radhakrishnan W,
2. Misra BK,
3. Rout D
. Granular cell tumour (choristoma) of the neurohypophysis—a report of two cases. Indian J Pathol Microbiol 1997;40:71–74
PubMed
33.↵
1. Rhee JS,
2. Wackym PA,
3. Hague K,
4. et al
. Granular cell tumor of the pituitary fossa. Ann Otol Rhinol Laryngol 2002;111:754–58
Abstract/FREE Full Text
34.↵
1. Satyamurti S,
2. Huntington HW
. Granular cell myoblastoma of the pituitary. Case report. J Neurosurg 1972;37:483–86
CrossRef PubMed
35.↵
1. Schaller B,
2. Kirsch E,
3. Tolnay M,
4. et al
. Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 1998;42:166–71
CrossRef PubMed
36.↵
1. Schlachter LB,
2. Tindall GT,
3. Pearl GS
. Granular cell tumor of the pituitary gland associated with diabetes insipidus. Neurosurgery 1980;6:418–21
CrossRef PubMed
37.↵
1. Shuangshoti S,
2. Chantra K,
3. Navalitloha Y,
4. et al
. Atypical granular cell tumor of the neurohypophysis: a case report with review of the literature. J Med Assoc Thai 1998;81:641–46
PubMed
38.↵
1. Symon L,
2. Burston J,
3. Gonz JC
. Granular cell myoblastoma of the neurohypophysis: report of two cases. J Neurosurg 1971;35:82–89
CrossRef PubMed
39.↵
1. Talerman A,
2. Dawson-Butterworth K
. Granular-cell myoblastoma of the pituitary. Postgrad Med J 1966;42:216–18
FREE Full Text
40.↵
1. Ulrich J,
2. Landolt A,
3. Benini A
. Granular-cell tumor of the third ventricle of the brain. Clinical findings, light and electron microscopy. Acta Neuropathol 1974;26:215–23
41.↵
1. Vaquero J,
2. Leunda G,
3. Cabezudo JM
. Granular pituicytomas of the pituitary stalk. Acta Neurochir (Wien) 1981;59:209–15
CrossRef PubMed
42.↵
1. Luthy F,
2. Klingler M
. The tumoret tumor of the posterior pituitary lobe. Schweiz Z Pathol Bakteriol 1951;14:721–29
PubMed
43.↵
1. Waller RR,
2. Riley FC,
3. Sundt TM
. A rare cause of the chiasmal syndrome. Arch Ophthalmol 1972;88:269–72
CrossRef PubMed
44.↵
1. Wilkinson MD,
2. Fulham MJ,
3. Besser M
. Neuroimaging findings in a suprasellar granular cell tumor. J Comput Assist Tomogr 2003;27:26–29
CrossRef PubMed
45.↵
1. Benveniste RJ,
2. Purohit D,
3. Byun H
. Pituicyotma presenting with spontaneous hemorrhage. Pituitary 2006;9:53–58
CrossRef PubMed
46.↵
1. Brat DJ,
2. Scheithauer BW,
3. Staugaitis SM,
4. et al
. Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol 2000;24:362–68
CrossRef PubMed
47.↵
1. Hammoud DA,
2. Munter FM,
3. Brat DJ,
4. et al
. Magnetic resonance imaging features of pituicytomas: analysis of 10 cases. J Comput Assist Tomogr 2010;34:757–61
CrossRef PubMed
48.↵
1. Cenacchi G,
2. Giovenali P,
3. Castrioto C,
4. et al
. Pituicytoma: ultrastructural evidence of a possible origin from folliculo-stellate cells of the adenohypophysis. Ultrastruct Pathol 2001;25:309–12
CrossRef PubMed
49.↵
1. Chen KT
. Crush cytology of pituicytoma. Diagn Cytopathol 2005;33:255–57
CrossRef PubMed
50.↵
1. Figarella-Branger D,
2. Dufour H,
3. Fernandez C,
4. et al
. Pituicytomas, a misdiagnosed benign tumor of the neurohypophysis: report of three cases. Acta Neuropathol 2002;104:313–19
PubMed
51.↵
1. Furtado SV,
2. Ghosal N,
3. Venkatesh PK,
4. et al
. Diagnostic and clinical implications of pituicytoma. J Clin Neurosci 2010;17:938–43
CrossRef PubMed
52.↵
1. Gibbs WN,
2. Monuki ES,
3. Linskey ME,
4. et al
. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol 2006;27:1639–42
Abstract/FREE Full Text
53.↵
1. Hurley TR,
2. D'Angelo CM,
3. Clasen RA,
4. et al
. Magnetic resonance imaging and pathological analysis of a pituicytoma: case report. Neurosurgery 1994;35:314–17
PubMed
54.↵
1. Kowalski RJ,
2. Prayson RA,
3. Mayberg MR
. Pituicytoma. Ann Diagn Pathol 2004;8:290–94
CrossRef PubMed
55.↵
1. Nakasu Y,
2. Nakasu S,
3. Saito A
. Pituicytoma: two case reports. Neurol Med Chir (Tokyo) 2006;46:152–56
CrossRef PubMed
56.↵
1. Phillips JJ,
2. Misra A,
3. Feuerstein BG,
4. et al
. Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization. Arch Pathol Lab Med 2010;134:1063–69
PubMed
57.↵
1. Schultz AB,
2. Brat DJ,
3. Oyesiku NM,
4. et al
. Intrasellar pituicytoma in a patient with other endocrine neoplasms. Arch Pathol Lab Med 2001;125:527–30
PubMed
58.↵
1. Shah B,
2. Lipper MH,
3. Laws ER,
4. et al
. Posterior pituitary astrocytoma: a rare tumor of the neurohypophysis: a case report. AJNR Am J Neuroradiol 2005;26:1858–61
Abstract/FREE Full Text
59.↵
1. Takei H,
2. Goodman JC,
3. Tanaka S,
4. et al
. Pituicytoma incidentally found at autopsy. Pathol Int 2005;55:745–49
CrossRef PubMed
60.↵
1. Thiryayi WA,
2. Gnanalingham KK,
3. Reid H,
4. et al
. Pituicytoma: a misdiagnosed benign tumour of the posterior pituitary. Br J Neurosurg 2007;21:47–48
CrossRef PubMed
61.↵
1. Ulm AJ,
2. Yachnis AT,
3. Brat DJ,
4. et al
. Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery 2004;54:753–57
PubMed
62.↵
1. Wolfe SQ,
2. Bruce J,
3. Morcos JJ
. Pituicytoma: case report. Neurosurgery 2008;63:E173–74
CrossRef PubMed
63.↵
1. Zhi L,
2. Yang L,
3. Quan H,
4. et al
. Pituicytoma presenting with atypical histological features. Pathology 2009;41:505–09
CrossRef PubMed
64.↵
1. Borges MR,
2. Lillehei KO,
3. Kleinschmidt-Demasters BK
. Spindle cell oncocytoma with late recurrence and unique neuroimaging characteristics due to recurrent subclinical intratumoral bleeding. J Neurooncol 2011;101:145–54
CrossRef PubMed
65.↵
1. Borota OC,
2. Schethauer BW,
3. Fougner SL,
4. et al
. Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. Clin Neuropathol 2009;28:91–95
PubMed
66.↵
1. Coire CI,
2. Horvath E,
3. Smyth HS,
4. et al
. Rapidly recurring folliculostellate cell tumor of the adenohypophysis with the morphology of a spindle cell oncocytoma: case report with electron microscopic studies. Clin Neuropathol 2009;28:303–08
PubMed
67.↵
1. Dahiya S,
2. Sarkar C,
3. Hedley-Whyte ET,
4. et al
. Spindle cell oncocytoma of the adenohypophysis: report of two cases. Acta Neuropathol 2005;110:97–99
CrossRef PubMed
68.↵
1. Kloub O,
2. Perry A,
3. Tu PH,
4. et al
. Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases. Am J Surg Pathol 2005;29:247–53
CrossRef PubMed
69.↵
1. Roncaroli F,
2. Scheithauer BW,
3. Cenacchi G,
4. et al
. ‘Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol 2002;26:1048–55
CrossRef PubMed
70.↵
1. Vajtai I,
2. Sahli R,
3. Kappeler A
. Spindle cell oncocytoma of the adenohypophysis: report of a case with a 16-year follow-up. Pathol Res Pract 2006;202:745–50
CrossRef PubMed
71.↵
1. Osborn AG,
2. Salzman KL,
3. Barkovich AJ
. Diagnostic Imaging. Brain, 2nd ed. Salt Lake City: Amirsys Publishing; 2010:II:24–27, II:42–45
72.↵
1. Boyce R,
2. Beadles CF
. A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol Bacteriol 1893;1:359–83
CrossRef
73.↵
1. Luse SA,
2. Kernohan JW
. Granular-cell tumors of the stalk and posterior lobe of the pituitary gland. Cancer 1955;8:616–22
CrossRef PubMed

Received February 10, 2011.
Accepted after revision April 28, 2011.

View Abstract

In this issue

Download PDF

Email Article

Citation Tools

Purchase

Cited By...

The New World Health Organization Classification of Central Nervous System Tumors: What Can the Neuroradiologist Really Say?

More in this TOC Section

Show more BRAIN

[1] 1.↵
Louis DN,
Ohgaki H,
Weistler OD,
et al
. WHO Classification of Tumours of the Central Nervous System, 4th ed. Lyon, France: IARC Press; 2007:309

[2] Louis DN,

[3] Ohgaki H,

[4] Weistler OD,

[5] et al

[6] 2.↵
Fuller GN,
Scheithauer BW
. The 2007 revised World Health Organization (WHO) classification of tumours of the central nervous system: newly codified entities. Brain Pathol 2007;17:304–07
CrossRef PubMed

[7] Fuller GN,

[8] Scheithauer BW

[9] 3.↵
Kobayashi TK,
Bamba M,
Oka H
. Granular cell tumour of the neurohypophysis on cytological squash preparations. Cytopathology 2006;17:153–54
CrossRef PubMed

[10] Kobayashi TK,

[11] Bamba M,

[12] Oka H

[13] 4.↵
Katsuta T,
Inoue T,
Nakagaki H,
et al
. Distinctions between pituicytoma and ordinary pilocytic astrocytoma: case report. J Neurosurg 2003;98:404–06
CrossRef PubMed

[14] Katsuta T,

[15] Inoue T,

[16] Nakagaki H,

[17] et al

[18] 5.↵
Aquilina K,
Kamel M,
Kalimuthu SG,
et al
. Granular cell tumour of the neurohypophysis: a rare sellar tumour with specific radiological and operative features. Br J Neurosurg 2006;20:51–54
CrossRef PubMed

[19] Aquilina K,

[20] Kamel M,

[21] Kalimuthu SG,

[22] et al

[23] 6.↵
Becker DH,
Wilson CB
. Symptomatic parasellar granular cell tumors. Neurosurgery 1981;8:173–80
CrossRef PubMed

[24] Becker DH,

[25] Wilson CB

[26] 7.↵
Boucher-Schwarz HG,
Fries G,
Bornemann A,
et al
. Suprasellar granular cell tumor. Neurosurgery 1992;31:751–54
CrossRef PubMed

[27] Boucher-Schwarz HG,

[28] Fries G,

[29] Bornemann A,

[30] et al

[31] 8.↵
Buhl R,
Hugo HH,
Hempelmann RG,
et al
. Granular-cell tumour: a rare suprasellar mass. Neuroradiology 2001;43:309–12
CrossRef PubMed

[32] Buhl R,

[33] Hugo HH,

[34] Hempelmann RG,

[35] et al

[36] 9.↵
Burston J,
John R,
Spencer H
. “Myoblastoma” of the neurohypophysis. J Pathol Bacteriol 1962;83:455–61
CrossRef PubMed

[37] Burston J,

[38] John R,

[39] Spencer H

[40] 10.↵
Cohen-Gadol AA,
Pichelmann MA,
Link MJ,
et al
. Granular cell tumor of the sellar and suprasellar region: clinicopathologic study of 11 cases and literature review. Mayo Clin Proc 2003;78:567–73
CrossRef PubMed

[41] Cohen-Gadol AA,

[42] Pichelmann MA,

[43] Link MJ,

[44] et al

[45] 11.↵
Cusick JF,
Ho KC,
Hagen TC,
et al
. Granular-cell pituicytoma associated with multiple endocrine neoplasia type 2. J Neurosurg 1982;56:594–96
CrossRef PubMed

[46] Cusick JF,

[47] Ho KC,

[48] Hagen TC,

[49] et al

[50] 12.↵
Doron Y,
Behar A,
Beller AJ
. Granular-cell “myoblastoma” of the neurohypophysis. J Neurosurg 1965;22:95–99
CrossRef PubMed

[51] Doron Y,

[52] Behar A,

[53] Beller AJ

[54] 13.↵
Benites Filho PR,
Sakamoto D,
Machuca TN,
et al
. Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation. Virchows Arch 2005;447:649–52
CrossRef PubMed

[55] Benites Filho PR,

[56] Sakamoto D,

[57] Machuca TN,

[58] et al

[59] 14.↵
Glazer N,
Hauser H,
Slade H
. Granular cell tumor of the neurohypophysis. Am J Roentgenol Radium Ther Nucl Med 1956;76:324–26
PubMed

[60] Glazer N,

[61] Hauser H,

[62] Slade H

[63] 15.↵
Graziani N,
Dufour H,
Figarella-Branger D,
et al
. Suprasellar granular-cell tumour, presenting with intraventricular haemorrhage. Br J Neurosurg 1995;9:97–102
CrossRef PubMed

[64] Graziani N,

[65] Dufour H,

[66] Figarella-Branger D,

[67] et al

[68] 16.↵
Harland WA
. Granular-cell myoblastoma of the hypophyseal stalk. Cancer 1953;6:1134–38
CrossRef PubMed

[69] Harland WA

[70] 17.↵
Higuchi M,
Tsuji M,
Ikeda H
. Symptomatic hypophyseal granular cell tumour: endocrinological and clinicopathological analysis. Br J Neurosurg 1997;11:582–86
CrossRef PubMed

[71] Higuchi M,

[72] Tsuji M,

[73] Ikeda H

[74] 18.↵
Jenevein EP
. A neurohypophysial tumor originating from pituicytes. Am J Clin Pathol 1964;41:522–26
PubMed

[75] Jenevein EP

[76] 19.↵
Ji CH,
Teng MM,
Chang T
. Granular cell tumour of the neurohypophysis. Neuroradiology 1995;37:451–52
CrossRef PubMed

[77] Ji CH,

[78] Teng MM,

[79] Chang T

[80] 20.↵
Kasashima S,
Oda Y,
Nozaki J,
et al
. A case of atypical granular cell tumor of the neurohypophysis. Pathol Int 2000;50:568–73
CrossRef PubMed

[81] Kasashima S,

[82] Oda Y,

[83] Nozaki J,

[84] et al

[85] 21.↵
Lafitte C,
Aesch B,
Henry-Lebras F
. Granular cell tumor of the pituitary stalk. Case report. J Neurosurg 1994;80:1103–07
CrossRef PubMed

[86] Lafitte C,

[87] Aesch B,

[88] Henry-Lebras F

[89] 22.↵
Lee CC,
Liu CH,
Wei CP,
et al
. Symptomatic granular cell tumor of the neurohypophysis. J Formos Med Assoc 2004;103:58–62
PubMed

[90] Lee CC,

[91] Liu CH,

[92] Wei CP,

[93] et al

[94] 23.↵
Lima A,
Antunes L,
Tome F
. Pituicytoma or granular-cell myoblastoma of the pituitary gland? Report of a case. J Neurosurg 1960;17:778–82
CrossRef PubMed

[95] Lima A,

[96] Antunes L,

[97] Tome F

[98] 24.↵
Liwnicz BH,
Liwnicz RG,
Huff JS
. Giant granular cell tumor of the suprasellar area: immunocytochemical and electron microscopic studies. Neurosurgery 1984;15:246–51
CrossRef PubMed

[99] Liwnicz BH,

[100] Liwnicz RG,

[101] Huff JS

[102] 25.↵
Losa M,
Saeger W,
Mortini P
. Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. Case report. J Neurosurg 2000;93:121–26
PubMed

[103] Losa M,

[104] Saeger W,

[105] Mortini P

[106] 26.↵
Moriyama E,
Matsumoto Y,
Meguro T,
et al
. Suprasellar granular cell tumor. Neurol Med Chir (Tokyo) 1996;36:237–40
CrossRef PubMed

[107] Moriyama E,

[108] Matsumoto Y,

[109] Meguro T,

[110] et al

[111] 27.↵
Mumert ML,
Walsh MT,
Chin SS
. Cystic granular cell tumor mimicking Rathke cleft cyst. J Neurosurg 2011;114:325–28
CrossRef PubMed

[112] Mumert ML,

[113] Walsh MT,

[114] Chin SS

[115] 28.↵
Nishio S,
Takeshita I,
Yoshimoto K,
et al
. Granular cell tumor of the pituitary stalk. Clin Neurol Neurosurg 1998;100:144–47
CrossRef PubMed

[116] Nishio S,

[117] Takeshita I,

[118] Yoshimoto K,

[119] et al

[120] 29.↵
Nishioka H,
Ii K,
Llena JF,
et al
. Immunohistochemical study of granular cell tumors of the neurohypophysis. Virchows Arch B Cell Pathol Incl Mol Pathol 1991;60:413–17
CrossRef PubMed

[121] Nishioka H,

[122] Ii K,

[123] Llena JF,

[124] et al

[125] 30.↵
Policarpio-Nicolas ML,
Le BH,
Mandell JW,
et al
. Granular cell tumor of the neurohypophysis: report of a case with intraoperative cytologic diagnosis. Diagn Cytopathol 2008;36:58–63
CrossRef PubMed

[126] Policarpio-Nicolas ML,

[127] Le BH,

[128] Mandell JW,

[129] et al

[130] 31.↵
Popovic V,
Pekic S,
Skender-Gazibara M,
et al
. A large sellar granular cell tumor in a 21-year-old woman. Endocr Pathol 2007;18:91–94
CrossRef PubMed

[131] Popovic V,

[132] Pekic S,

[133] Skender-Gazibara M,

[134] et al

[135] 32.↵
Radhakrishnan W,
Misra BK,
Rout D
. Granular cell tumour (choristoma) of the neurohypophysis—a report of two cases. Indian J Pathol Microbiol 1997;40:71–74
PubMed

[136] Radhakrishnan W,

[137] Misra BK,

[138] Rout D

[139] 33.↵
Rhee JS,
Wackym PA,
Hague K,
et al
. Granular cell tumor of the pituitary fossa. Ann Otol Rhinol Laryngol 2002;111:754–58
Abstract/FREE Full Text

[140] Rhee JS,

[141] Wackym PA,

[142] Hague K,

[143] et al

[144] 34.↵
Satyamurti S,
Huntington HW
. Granular cell myoblastoma of the pituitary. Case report. J Neurosurg 1972;37:483–86
CrossRef PubMed

[145] Satyamurti S,

[146] Huntington HW

[147] 35.↵
Schaller B,
Kirsch E,
Tolnay M,
et al
. Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 1998;42:166–71
CrossRef PubMed

[148] Schaller B,

[149] Kirsch E,

[150] Tolnay M,

[151] et al

[152] 36.↵
Schlachter LB,
Tindall GT,
Pearl GS
. Granular cell tumor of the pituitary gland associated with diabetes insipidus. Neurosurgery 1980;6:418–21
CrossRef PubMed

[153] Schlachter LB,

[154] Tindall GT,

[155] Pearl GS

[156] 37.↵
Shuangshoti S,
Chantra K,
Navalitloha Y,
et al
. Atypical granular cell tumor of the neurohypophysis: a case report with review of the literature. J Med Assoc Thai 1998;81:641–46
PubMed

[157] Shuangshoti S,

[158] Chantra K,

[159] Navalitloha Y,

[160] et al

[161] 38.↵
Symon L,
Burston J,
Gonz JC
. Granular cell myoblastoma of the neurohypophysis: report of two cases. J Neurosurg 1971;35:82–89
CrossRef PubMed

[162] Symon L,

[163] Burston J,

[164] Gonz JC

[165] 39.↵
Talerman A,
Dawson-Butterworth K
. Granular-cell myoblastoma of the pituitary. Postgrad Med J 1966;42:216–18
FREE Full Text

[166] Talerman A,

[167] Dawson-Butterworth K

[168] 40.↵
Ulrich J,
Landolt A,
Benini A
. Granular-cell tumor of the third ventricle of the brain. Clinical findings, light and electron microscopy. Acta Neuropathol 1974;26:215–23

[169] Ulrich J,

[170] Landolt A,

[171] Benini A

[172] 41.↵
Vaquero J,
Leunda G,
Cabezudo JM
. Granular pituicytomas of the pituitary stalk. Acta Neurochir (Wien) 1981;59:209–15
CrossRef PubMed

[173] Vaquero J,

[174] Leunda G,

[175] Cabezudo JM

[176] 42.↵
Luthy F,
Klingler M
. The tumoret tumor of the posterior pituitary lobe. Schweiz Z Pathol Bakteriol 1951;14:721–29
PubMed

[177] Luthy F,

[178] Klingler M

[179] 43.↵
Waller RR,
Riley FC,
Sundt TM
. A rare cause of the chiasmal syndrome. Arch Ophthalmol 1972;88:269–72
CrossRef PubMed

[180] Waller RR,

[181] Riley FC,

[182] Sundt TM

[183] 44.↵
Wilkinson MD,
Fulham MJ,
Besser M
. Neuroimaging findings in a suprasellar granular cell tumor. J Comput Assist Tomogr 2003;27:26–29
CrossRef PubMed

[184] Wilkinson MD,

[185] Fulham MJ,

[186] Besser M

[187] 45.↵
Benveniste RJ,
Purohit D,
Byun H
. Pituicyotma presenting with spontaneous hemorrhage. Pituitary 2006;9:53–58
CrossRef PubMed

[188] Benveniste RJ,

[189] Purohit D,

[190] Byun H

[191] 46.↵
Brat DJ,
Scheithauer BW,
Staugaitis SM,
et al
. Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol 2000;24:362–68
CrossRef PubMed

[192] Brat DJ,

[193] Scheithauer BW,

[194] Staugaitis SM,

[195] et al

[196] 47.↵
Hammoud DA,
Munter FM,
Brat DJ,
et al
. Magnetic resonance imaging features of pituicytomas: analysis of 10 cases. J Comput Assist Tomogr 2010;34:757–61
CrossRef PubMed

[197] Hammoud DA,

[198] Munter FM,

[199] Brat DJ,

[200] et al

[201] 48.↵
Cenacchi G,
Giovenali P,
Castrioto C,
et al
. Pituicytoma: ultrastructural evidence of a possible origin from folliculo-stellate cells of the adenohypophysis. Ultrastruct Pathol 2001;25:309–12
CrossRef PubMed

[202] Cenacchi G,

[203] Giovenali P,

[204] Castrioto C,

[205] et al

[206] 49.↵
Chen KT
. Crush cytology of pituicytoma. Diagn Cytopathol 2005;33:255–57
CrossRef PubMed

[207] Chen KT

[208] 50.↵
Figarella-Branger D,
Dufour H,
Fernandez C,
et al
. Pituicytomas, a misdiagnosed benign tumor of the neurohypophysis: report of three cases. Acta Neuropathol 2002;104:313–19
PubMed

[209] Figarella-Branger D,

[210] Dufour H,

[211] Fernandez C,

[212] et al

[213] 51.↵
Furtado SV,
Ghosal N,
Venkatesh PK,
et al
. Diagnostic and clinical implications of pituicytoma. J Clin Neurosci 2010;17:938–43
CrossRef PubMed

[214] Furtado SV,

[215] Ghosal N,

[216] Venkatesh PK,

[217] et al

[218] 52.↵
Gibbs WN,
Monuki ES,
Linskey ME,
et al
. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol 2006;27:1639–42
Abstract/FREE Full Text

[219] Gibbs WN,

[220] Monuki ES,

[221] Linskey ME,

[222] et al

[223] 53.↵
Hurley TR,
D'Angelo CM,
Clasen RA,
et al
. Magnetic resonance imaging and pathological analysis of a pituicytoma: case report. Neurosurgery 1994;35:314–17
PubMed

[224] Hurley TR,

[225] D'Angelo CM,

[226] Clasen RA,

[227] et al

[228] 54.↵
Kowalski RJ,
Prayson RA,
Mayberg MR
. Pituicytoma. Ann Diagn Pathol 2004;8:290–94
CrossRef PubMed

[229] Kowalski RJ,

[230] Prayson RA,

[231] Mayberg MR

[232] 55.↵
Nakasu Y,
Nakasu S,
Saito A
. Pituicytoma: two case reports. Neurol Med Chir (Tokyo) 2006;46:152–56
CrossRef PubMed

[233] Nakasu Y,

[234] Nakasu S,

[235] Saito A

[236] 56.↵
Phillips JJ,
Misra A,
Feuerstein BG,
et al
. Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization. Arch Pathol Lab Med 2010;134:1063–69
PubMed

[237] Phillips JJ,

[238] Misra A,

[239] Feuerstein BG,

[240] et al

[241] 57.↵
Schultz AB,
Brat DJ,
Oyesiku NM,
et al
. Intrasellar pituicytoma in a patient with other endocrine neoplasms. Arch Pathol Lab Med 2001;125:527–30
PubMed

[242] Schultz AB,

[243] Brat DJ,

[244] Oyesiku NM,

[245] et al

[246] 58.↵
Shah B,
Lipper MH,
Laws ER,
et al
. Posterior pituitary astrocytoma: a rare tumor of the neurohypophysis: a case report. AJNR Am J Neuroradiol 2005;26:1858–61
Abstract/FREE Full Text

[247] Shah B,

[248] Lipper MH,

[249] Laws ER,

[250] et al

[251] 59.↵
Takei H,
Goodman JC,
Tanaka S,
et al
. Pituicytoma incidentally found at autopsy. Pathol Int 2005;55:745–49
CrossRef PubMed

[252] Takei H,

[253] Goodman JC,

[254] Tanaka S,

[255] et al

[256] 60.↵
Thiryayi WA,
Gnanalingham KK,
Reid H,
et al
. Pituicytoma: a misdiagnosed benign tumour of the posterior pituitary. Br J Neurosurg 2007;21:47–48
CrossRef PubMed

[257] Thiryayi WA,

[258] Gnanalingham KK,

[259] Reid H,

[260] et al

[261] 61.↵
Ulm AJ,
Yachnis AT,
Brat DJ,
et al
. Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery 2004;54:753–57
PubMed

[262] Ulm AJ,

[263] Yachnis AT,

[264] Brat DJ,

[265] et al

[266] 62.↵
Wolfe SQ,
Bruce J,
Morcos JJ
. Pituicytoma: case report. Neurosurgery 2008;63:E173–74
CrossRef PubMed

[267] Wolfe SQ,

[268] Bruce J,

[269] Morcos JJ

[270] 63.↵
Zhi L,
Yang L,
Quan H,
et al
. Pituicytoma presenting with atypical histological features. Pathology 2009;41:505–09
CrossRef PubMed

[271] Zhi L,

[272] Yang L,

[273] Quan H,

[274] et al

[275] 64.↵
Borges MR,
Lillehei KO,
Kleinschmidt-Demasters BK
. Spindle cell oncocytoma with late recurrence and unique neuroimaging characteristics due to recurrent subclinical intratumoral bleeding. J Neurooncol 2011;101:145–54
CrossRef PubMed

[276] Borges MR,

[277] Lillehei KO,

[278] Kleinschmidt-Demasters BK

[279] 65.↵
Borota OC,
Schethauer BW,
Fougner SL,
et al
. Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. Clin Neuropathol 2009;28:91–95
PubMed

[280] Borota OC,

[281] Schethauer BW,

[282] Fougner SL,

[283] et al

[284] 66.↵
Coire CI,
Horvath E,
Smyth HS,
et al
. Rapidly recurring folliculostellate cell tumor of the adenohypophysis with the morphology of a spindle cell oncocytoma: case report with electron microscopic studies. Clin Neuropathol 2009;28:303–08
PubMed

[285] Coire CI,

[286] Horvath E,

[287] Smyth HS,

[288] et al

[289] 67.↵
Dahiya S,
Sarkar C,
Hedley-Whyte ET,
et al
. Spindle cell oncocytoma of the adenohypophysis: report of two cases. Acta Neuropathol 2005;110:97–99
CrossRef PubMed

[290] Dahiya S,

[291] Sarkar C,

[292] Hedley-Whyte ET,

[293] et al

[294] 68.↵
Kloub O,
Perry A,
Tu PH,
et al
. Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases. Am J Surg Pathol 2005;29:247–53
CrossRef PubMed

[295] Kloub O,

[296] Perry A,

[297] Tu PH,

[298] et al

[299] 69.↵
Roncaroli F,
Scheithauer BW,
Cenacchi G,
et al
. ‘Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol 2002;26:1048–55
CrossRef PubMed

[300] Roncaroli F,

[301] Scheithauer BW,

[302] Cenacchi G,

[303] et al

[304] 70.↵
Vajtai I,
Sahli R,
Kappeler A
. Spindle cell oncocytoma of the adenohypophysis: report of a case with a 16-year follow-up. Pathol Res Pract 2006;202:745–50
CrossRef PubMed

[305] Vajtai I,

[306] Sahli R,

[307] Kappeler A

[308] 71.↵
Osborn AG,
Salzman KL,
Barkovich AJ
. Diagnostic Imaging. Brain, 2nd ed. Salt Lake City: Amirsys Publishing; 2010:II:24–27, II:42–45

[309] Osborn AG,

[310] Salzman KL,

[311] Barkovich AJ

[312] 72.↵
Boyce R,
Beadles CF
. A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol Bacteriol 1893;1:359–83
CrossRef

[313] Boyce R,

[314] Beadles CF

[315] 73.↵
Luse SA,
Kernohan JW
. Granular-cell tumors of the stalk and posterior lobe of the pituitary gland. Cancer 1955;8:616–22
CrossRef PubMed

[316] Luse SA,

[317] Kernohan JW

Main menu

User menu

Search

American Journal of Neuroradiology

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

Abstract

ABBREVIATIONS

Materials and Methods

Results

Location

Separation from Pituitary Gland

Imaging Findings

Clinical Findings

Sex

Age

Discussion

Pituicytoma

Spindle Cell Oncocytoma

Granular Cell Tumor

Conclusions

Footnotes

References

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

News and Updates

Resources

Opportunities

American Society of Neuroradiology

Main menu

User menu

Search

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

Abstract

ABBREVIATIONS

Materials and Methods

Results

Location

Separation from Pituitary Gland

Imaging Findings

Clinical Findings

Sex

Age

Discussion

Pituicytoma

Spindle Cell Oncocytoma

Granular Cell Tumor

Conclusions

Footnotes

References

In this issue

Citation Manager Formats

Jump to section

Related Articles

Cited By...

More in this TOC Section

Similar Articles

News and Updates

Resources

Opportunities

American Society of Neuroradiology