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<meta name="DC.Title" content="Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging" />
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<meta name="DC.Description" content="CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.

ADC
:   apparent diffusion coefficient
CBV
:   cerebral blood volume
CE
:   contrast enhancement
Cho
:   choline
CNS
:   central nervous system
Cr
:   creatine
DWI
:   diffusion-weighted imaging
FA
:   fractional anisotropy
FDG
:   fluorodeoxyglucose
HAART
:   highly active antiretroviral therapy
HIV
:   human immunodeficiency virus
MRI
:   MR imaging
MS
:   multiple sclerosis
NHL
:   non-Hodgkin lymphoma
PCNSL
:   primary CNS lymphoma
PET
:   positron-emission tomography
PML
:   progressive multifocal leukoencephalopathy
rCBV
:   relative cerebral blood volume
SPECT
:   single-photon emission CT
SPET
:   single photon-emission tomography
SWI
:   susceptibility-weighted imaging" />
<meta name="DC.Contributor" content="I.S. Haldorsen" />
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&lt;p&gt;CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.&lt;/p&gt;" />
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<meta name="twitter:title" content="Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging" />
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<meta name="twitter:description" content="CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.

ADC
:   apparent diffusion coefficient
CBV
:   cerebral blood volume
CE
:   contrast enhancement
Cho
:   choline
CNS
:   central nervous system
Cr
:   creatine
DWI
:   diffusion-weighted imaging
FA
:   fractional anisotropy
FDG
:   fluorodeoxyglucose
HAART
:   highly active antiretroviral therapy
HIV
:   human immunodeficiency virus
MRI
:   MR imaging
MS
:   multiple sclerosis
NHL
:   non-Hodgkin lymphoma
PCNSL
:   primary CNS lymphoma
PET
:   positron-emission tomography
PML
:   progressive multifocal leukoencephalopathy
rCBV
:   relative cerebral blood volume
SPECT
:   single-photon emission CT
SPET
:   single photon-emission tomography
SWI
:   susceptibility-weighted imaging" />
<meta name="og-title" property="og:title" content="Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging" />
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<meta name="og-description" property="og:description" content="CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.

ADC
:   apparent diffusion coefficient
CBV
:   cerebral blood volume
CE
:   contrast enhancement
Cho
:   choline
CNS
:   central nervous system
Cr
:   creatine
DWI
:   diffusion-weighted imaging
FA
:   fractional anisotropy
FDG
:   fluorodeoxyglucose
HAART
:   highly active antiretroviral therapy
HIV
:   human immunodeficiency virus
MRI
:   MR imaging
MS
:   multiple sclerosis
NHL
:   non-Hodgkin lymphoma
PCNSL
:   primary CNS lymphoma
PET
:   positron-emission tomography
PML
:   progressive multifocal leukoencephalopathy
rCBV
:   relative cerebral blood volume
SPECT
:   single-photon emission CT
SPET
:   single photon-emission tomography
SWI
:   susceptibility-weighted imaging" />
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<h2>SUMMARY:</h2>
<p id="p-2">CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.</p>
</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">ADC<span class="def-item-dt-sep"></span></dt><dd>apparent diffusion coefficient<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">CBV<span class="def-item-dt-sep"></span></dt><dd>cerebral blood volume<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">CE<span class="def-item-dt-sep"></span></dt><dd>contrast enhancement<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">Cho<span class="def-item-dt-sep"></span></dt><dd>choline<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">CNS<span class="def-item-dt-sep"></span></dt><dd>central nervous system<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">Cr<span class="def-item-dt-sep"></span></dt><dd>creatine<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">DWI<span class="def-item-dt-sep"></span></dt><dd>diffusion-weighted imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">FDG<span class="def-item-dt-sep"></span></dt><dd>fluorodeoxyglucose<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">HAART<span class="def-item-dt-sep"></span></dt><dd>highly active antiretroviral therapy<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">HIV<span class="def-item-dt-sep"></span></dt><dd>human immunodeficiency virus<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">MRI<span class="def-item-dt-sep"></span></dt><dd>MR imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">MS<span class="def-item-dt-sep"></span></dt><dd>multiple sclerosis<span class="def-item-dd-sep"></span></dd><dt id="def-item-14">NHL<span class="def-item-dt-sep"></span></dt><dd>non-Hodgkin lymphoma<span class="def-item-dd-sep"></span></dd><dt id="def-item-15">PCNSL<span class="def-item-dt-sep"></span></dt><dd>primary CNS lymphoma<span class="def-item-dd-sep"></span></dd><dt id="def-item-16">PET<span class="def-item-dt-sep"></span></dt><dd>positron-emission tomography<span class="def-item-dd-sep"></span></dd><dt id="def-item-17">PML<span class="def-item-dt-sep"></span></dt><dd>progressive multifocal leukoencephalopathy<span class="def-item-dd-sep"></span></dd><dt id="def-item-18">rCBV<span class="def-item-dt-sep"></span></dt><dd>relative cerebral blood volume<span class="def-item-dd-sep"></span></dd><dt id="def-item-19">SPECT<span class="def-item-dt-sep"></span></dt><dd>single-photon emission CT<span class="def-item-dd-sep"></span></dd><dt id="def-item-20">SPET<span class="def-item-dt-sep"></span></dt><dd>single photon-emission tomography<span class="def-item-dd-sep"></span></dd><dt id="def-item-21">SWI<span class="def-item-dt-sep"></span></dt><dd>susceptibility-weighted imaging</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/32/6/984.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 32</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jun 2011 </div></div>
      
      
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