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    Association between Carotid Artery Plaque Type and Cerebral Microbleeds | American Journal of Neuroradiology  
    

















    





























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleExtracranial Vascular

  
      

  
      
Association between Carotid Artery Plaque Type and Cerebral Microbleeds
  
    	
L. Saba, R. Montisci, E. Raz, R. Sanfilippo, J.S. Suri and M. Piga

  
    	
American Journal of Neuroradiology December 2012,  33 (11) 2144-2150; DOI: https://doi.org/10.3174/ajnr.A3133 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    1. Werring  DJ, 
    2. Coward  LJ, 
    3. Losseff  NA, 
    4. et al
    .
Cerebral microbleeds are common in ischemic stroke but rare in TIA.
Neurology 2005;65:1914–18
    Abstract/FREE Full Text
  2. 2.↵


    1. Fazekas  F, 
    2. Kleinert  R, 
    3. Roob  G, 
    4. et al
    .
Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds.
AJNR Am J Neuroradiol 1999;20:637–42
    Abstract/FREE Full Text
  3. 3.↵


    1. Atlas  SW, 
    2. Mark  AS, 
    3. Grossman  RI, 
    4. et al
    .
Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T: comparison with spin-echo imaging and clinical applications.
Radiology 1988;168:803–07
    PubMedWeb of Science
  4. 4.↵


    1. Werring  DJ, 
    2. Frazer  DW, 
    3. Coward  LJ, 
    4. et al
    .
Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI.
Brain 2004;127:2265–75
    Abstract/FREE Full Text
  5. 5.↵


    1. Leblanc  R, 
    2. Haddad  G, 
    3. Robitaille  Y.
    .
Cerebral hemorrhage from amyloid angiopathy and coronary thrombolysis.
Neurosurgery 1992;31:586–90
    PubMedWeb of Science
  6. 6.↵


    1. Wong  KS, 
    2. Chan  YL, 
    3. Liu  JY, 
    4. et al
    .
Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages.
Neurology 2003;60:511–13
    Abstract/FREE Full Text
  7. 7.↵


    1. Naka  H, 
    2. Nomura  E, 
    3. Wakabayashi  S, 
    4. et al
    .
Frequency of asymptomatic microbleeds on T2*-weighted MR images of patients with recurrent stroke: association with combination of stroke subtypes and leukoaraiosis.
AJNR Am J Neuroradiol 2004;25:714–19
    Abstract/FREE Full Text
  8. 8.↵


    1. Imaizumi  T, 
    2. Horita  Y, 
    3. Hashimoto  Y, 
    4. et al
    .
Dotlike hemosiderin spots on T2*-weighted magnetic resonance imaging as a predictor of stroke recurrence: a prospective study.
J Neurosurg 2004;101:915–20
    CrossRefPubMedWeb of Science
  9. 9.↵


    1. Bos  D, 
    2. Ikram  MA, 
    3. Elias-Smale  SE, 
    4. et al
    .
Calcification in major vessel beds relates to vascular brain disease.
Arterioscler Thromb Vasc Biol 2011;31:2331–37
    Abstract/FREE Full Text
  10. 10.↵


    1. Naghavi  M, 
    2. Libby  P, 
    3. Falk  E, 
    4. et al
    .
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.
Circulation 2003;108:1772–78
    Abstract/FREE Full Text
  11. 11.↵


    1. Wintermark  M, 
    2. Jawadi  SS, 
    3. Rapp  JH, 
    4. et al
    .
High-resolution CT imaging of carotid artery atherosclerotic plaques.
AJNR Am J Neuroradiol 2008;29:875–82
    Abstract/FREE Full Text
  12. 12.↵


    1. Saba  L, 
    2. Montisci  R, 
    3. Sanfilippo  R, 
    4. et al
    .
Multidetector row CT of the brain and carotid artery: a correlative analysis.
Clin Radiol 2009;64:767–78
    CrossRefPubMed
  13. 13.↵


    1. Moody  AR, 
    2. Murphy  RE, 
    3. Morgan  PS, 
    4. et al
    .
Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia.
Circulation 2003;107:3047–52
    Abstract/FREE Full Text
  14. 14.↵


    1. Suri  JS, 
    2. Kathuria  C, 
    3. Molinari  F
    1. Saba  L
    . 
CT imaging in the carotid artery. 
In: 

Suri  JS, 
Kathuria  C, 
Molinari  F, eds. 
Atherosclerosis Disease Management. 
New York: 
Springer-Verlag, 2010: 333–76
  15. 15.↵


    1. Rozie  S, 
    2. de Weert  TT, 
    3. de Monyé  C, 
    4. et al
    .
Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors.
Eur Radiol 2009;19:2294–301
    CrossRefPubMed
  16. 16.↵


    1. Saba  L, 
    2. Sanfilippo  R, 
    3. Pascalis  L, 
    4. et al
    .
Carotid artery abnormalities and leukoaraiosis in elderly patients: evaluation with MDCT.
AJR Am J Roentgenol 2009;192:W63–70
  17. 17.↵


    1. Saba  L, 
    2. Mallarini  G.
    .
Fissured fibrous cap of vulnerable carotid plaques and symptomaticity: are they correlated? Preliminary results by using multi-detector-row CT angiography.
Cerebrovasc Dis 2009;27:322–27
    CrossRefPubMed
  18. 18.↵


    1. Saba  L, 
    2. Mallarini  G.
    .
Window settings for the study of calcified carotid plaques with multidetector CT angiography.
AJNR Am J Neuroradiol 2009;30:1445–50
    Abstract/FREE Full Text
  19. 19.↵


    1. Wintermark  M, 
    2. Arora  S, 
    3. Tong  E, 
    4. et al
    .
Carotid plaque computed tomography imaging in stroke and nonstroke patients.
Ann Neurol 2008;64:149–57
    CrossRefPubMed
  20. 20.↵


    1. de Weert  TT, 
    2. Ouhlous  M, 
    3. Meijering  E, 
    4. et al
    .
In vivo characterization and quantification of atherosclerotic carotid plaque components with multidetector computed tomography and histopathological correlation.
Arterioscler Thromb Vasc Biol 2006;26:2366–72
    Abstract/FREE Full Text
  21. 21.↵


    1. de Weert  TT, 
    2. Ouhlous  M, 
    3. Zondervan  PE, 
    4. et al
    .
In vitro characterization of atherosclerotic carotid plaque with multidetector computed tomography and histopathological correlation.
Eur Radiol 2005;15:1906–14
    CrossRefPubMed
  22. 22.↵


    1. Saba  L, 
    2. Pascalis  L, 
    3. Sanfilippo  R, 
    4. et al
    .
Carotid artery wall thickness and leukoaraiosis: preliminary results using multidetector row CT angiography.
AJNR Am J Neuroradiol 2011;32:955–61
    Abstract/FREE Full Text
  23. 23.↵


    1. Saba  L, 
    2. Sanfilippo  R, 
    3. Anzidei  M, 
    4. et al
    .
Stenosis Asymmetry Index (SAI) between symptomatic and asymptomatic patients in the analysis of carotid arteries. A study using CT angiography.
Eur J Radiol 2012;81:77–82
    CrossRefPubMed
  24. 24.↵


    1. Saba  L, 
    2. Sanfilippo  R, 
    3. Montisci  R, 
    4. et al
    . 
Carotid artery wall thickness using CT: inter- and intraobserver agreement analysis. 
AJNR Am J Neuroradiol 2012 March 1 [Epub ahead of print]
  25. 25.↵


    1. Fure  B, 
    2. Wyller  TB, 
    3. Thommessen  B.
    .
TOAST criteria applied in acute ischemic stroke.
Acta Neurol Scand 2005;112:254–58
    CrossRefPubMed
  26. 26.↵


    1. Saba  L, 
    2. Mallarini  G.
    .
Carotid plaque enhancement and symptom correlations: an evaluation by using multidetector row CT angiography.
AJNR Am J Neuroradiol 2011;32:1919–25
    Abstract/FREE Full Text
  27. 27.↵


    1. Roob  G, 
    2. Schmidt  R, 
    3. Kapeller  P, 
    4. et al
    .
MRI evidence of past cerebral microbleeds in a healthy elderly population.
Neurology 1999;52:991–94
    Abstract/FREE Full Text
  28. 28.↵


    1. Kinoshita  T, 
    2. Okudera  T, 
    3. Tamura  H, 
    4. et al
    .
Assessment of lacunar hemorrhage associated with hypertensive stroke by echo-planar gradient-echo T2*-weighted MRI.
Stroke 2000;31:1646–50
    Abstract/FREE Full Text
  29. 29.↵


    1. Alemany  M, 
    2. Stenborg  A, 
    3. Terent  A, 
    4. et al
    .
Coexistence of microhemorrhages and acute spontaneous brain hemorrhage: correlation with signs of microangiopathy and clinical data.
Radiology 2006;238:240–47
    PubMedWeb of Science
  30. 30.↵


    1. Vernooij  MW, 
    2. Ikram  MA, 
    3. Wielopolski  PA, 
    4. et al
    .
Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection.
Radiology 2008;248:272–77
    CrossRefPubMedWeb of Science
  31. 31.↵


    1. Jeerakathil  T, 
    2. Wolf  PA, 
    3. Beiser  A, 
    4. et al
    .
Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study.
Stroke 2004;35:1831–35
    Abstract/FREE Full Text
  32. 32.↵


    1. Hachinski  V, 
    2. Iadecola  C, 
    3. Petersen  RC, 
    4. et al
    .
National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards.
Stroke 2006;37:2220–41
    Abstract/FREE Full Text
  33. 33.↵


    1. Staals  J, 
    2. van Oostenbrugge  RJ, 
    3. Knottnerus  IL, 
    4. et al
    .
Brain microbleeds relate to higher ambulatory blood pressure levels in first-ever lacunar stroke patients.
Stroke 2009;40:3264–68
    Abstract/FREE Full Text
  34. 34.↵


    1. Lee  SH, 
    2. Bae  HJ, 
    3. Yoon  BW, 
    4. et al
    .
Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions.
Stroke 2002;33:2845–49
    Abstract/FREE Full Text
  35. 35.↵


    1. Saba  L, 
    2. Mallarini  G.
    .
MDCTA of carotid plaque degree of stenosis: evaluation of interobserver agreement.
AJR Am J Roentgenol 2008;190:W41–46
    CrossRef
  36. 36.↵


    1. Landis  JR, 
    2. Koch  GG.
    .
The measurement of observer agreement for categorical data.
Biometrics 1977;33:159–74
    CrossRefPubMedWeb of Science
  37. 37.↵


    1. Vernooij  MW, 
    2. van der Lugt  LA, 
    3. Ikram  MA, 
    4. et al
    .
Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study.
Neurology 2008;70:1208–14
    Abstract/FREE Full Text
  38. 38.↵


    1. Pantoni  L.
    .
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.
Lancet Neurol 2010;9:689–701
    CrossRefPubMedWeb of Science
  39. 39.↵


    1. Cordonnier  C, 
    2. Al-Shahi  SR, 
    3. Wardlaw  J.
    .
Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting.
Brain 2007;130:1988–2003
    Abstract/FREE Full Text
  40. 40.↵


    1. Poels  MM, 
    2. Ikram  MA, 
    3. van der Lugt  A, 
    4. et al
    .
Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study.
Stroke 2011;42:656–61
    Abstract/FREE Full Text
  41. 41.↵


    1. Ovbiagele  B, 
    2. Saver  JL, 
    3. Sanossian  N, 
    4. et al
    .
Predictors of cerebral microbleeds in acute ischemic stroke and TIA patients.
Cerebrovasc Dis 2006;22:378–83
    CrossRefPubMed
  42. 42.↵


    1. Gregoire  SM, 
    2. Chaudhary  UJ, 
    3. Brown  MM, 
    4. et al
    .
The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds.
Neurology 2009;73:1759–66
    Abstract/FREE Full Text
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Association between Carotid Artery Plaque Type and Cerebral Microbleeds
  
    	
L. Saba, R. Montisci, E. Raz, R. Sanfilippo, J.S. Suri, M. Piga

  
    	
American Journal of Neuroradiology Dec 2012, 33 (11) 2144-2150; DOI: 10.3174/ajnr.A3133 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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