1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    





























































































































    Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Research ArticleSpine

  
      

  
      
Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging
  
    	
N.R. Khadem, S. Karimi, K.K. Peck, Y. Yamada, E. Lis, J. Lyo, M. Bilsky, H.A. Vargas and A.I. Holodny

  
    	
American Journal of Neuroradiology December 2012,  33 (11) 2178-2185; DOI: https://doi.org/10.3174/ajnr.A3104 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    1. Yuh  WT, 
    2. Zachar  CK, 
    3. Barloon  TJ, 
    4. et al
    .
Vertebral compression fractures: distinction between benign and malignant causes with MR imaging.
Radiology
1989;
172:
215–18
    PubMedWeb of Science
  2. 2.↵


    1. Baker  LL, 
    2. Goodman  SB, 
    3. Perkash  I, 
    4. et al
    .
Benign versus pathologic compression fractures of vertebral bodies: assessment with conventional spin-echo, chemical-shift, and STIR MR imaging.
Radiology
1990;
174:
495–502
    PubMedWeb of Science
  3. 3.↵


    1. Shih  TT, 
    2. Tsuang  YH, 
    3. Huang  KM, 
    4. et al
    .
Magnetic resonance imaging of vertebral compression fractures.
J Formos Med Assoc
1996;
95:
313–19
    PubMed
  4. 4.↵


    1. Shih  TT, 
    2. Huang  KM, 
    3. Li  YW
    .
Solitary vertebral collapse: distinction between benign and malignant causes using MR patterns.
J Magn Reson Imaging
1999;
9:
635–42
    CrossRefPubMedWeb of Science
  5. 5.↵


    1. Moulopoulos  LA, 
    2. Maris  TG, 
    3. Papanikolaou  N, 
    4. et al
    .
Detection of malignant bone marrow involvement with dynamic contrast-enhanced magnetic resonance imaging.
Ann Oncol
2003;
14:
152–58
    Abstract/FREE Full Text
  6. 6.↵


    1. Montazel  JL, 
    2. Divine  M, 
    3. Lepage  E, 
    4. et al
    .
Normal spinal bone marrow in adults: dynamic gadolinium-enhanced MR imaging.
Radiology
2003;
229:
703–09
    PubMed
  7. 7.↵


    1. Verstraete  KL, 
    2. Van der Woude  HJ, 
    3. Hogendoorn  PC, 
    4. et al
    .
Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: basic principles and clinical applications.
J Magn Reson Imaging
1996;
6:
311–21
    CrossRefPubMed
  8. 8.↵


    1. Chen  WT, 
    2. Shih  TT, 
    3. Chen  RC, 
    4. et al
    .
Blood perfusion of vertebral lesions evaluated with gadolinium-enhanced dynamic MRI: in comparison with compression fracture and metastasis.
J Magn Reson Imaging
2002;
15:
308–14
    CrossRefPubMedWeb of Science
  9. 9.↵


    1. Tokuda  O, 
    2. Hayashi  N, 
    3. Taguchi  K, 
    4. et al
    .
Dynamic contrast-enhanced perfusion MR imaging of diseased vertebrae: analysis of three parameters and the distribution of the time-intensity curve patterns.
Skeletal Radiol
2005;
34:
632–38
    CrossRefPubMedWeb of Science
  10. 10.↵


    1. Pauliah  M, 
    2. Saxena  V, 
    3. Haris  M, 
    4. et al
    .
Improved T(1)-weighted dynamic contrast-enhanced MRI to probe microvascularity and heterogeneity of human glioma.
Magn Reson Imaging
2007;
25:
1292–99
    CrossRefPubMedWeb of Science
  11. 11.↵


    1. Hackländer  T, 
    2. Reichenbach  JR, 
    3. Modder  U
    .
Comparison of cerebral blood volume measurements using the T1 and T2* methods in normal human brains and brain tumors.
J Comput Assist Tomogr
1997;
21:
857–66
    CrossRefPubMed
  12. 12.↵


    1. Baur  A, 
    2. Stabler  A, 
    3. Bartl  R, 
    4. et al
    .
MRI gadolinium enhancement of bone marrow: age-related changes in normals and in diffuse neoplastic infiltration.
Skeletal Radiol
1997;
26:
414–18
    CrossRefPubMed
  13. 13.↵


    1. Bollow  M, 
    2. Knauf  W, 
    3. Korfel  A, 
    4. et al
    .
Initial experience with dynamic MR imaging in evaluation of normal bone marrow versus malignant bone marrow infiltrations in humans.
J Magn Reson Imaging
1997;
7:
241–50
    PubMed
  14. 14.↵


    1. Erlemann  R, 
    2. Reiser  MF, 
    3. Peters  PE, 
    4. et al
    .
Musculoskeletal neoplasms: static and dynamic Gd-DTPA–enhanced MR imaging.
Radiology
1989;
171:
767–73
    PubMedWeb of Science
  15. 15.↵


    1. Verstraete  KL, 
    2. De Deene  Y, 
    3. Roels  H, 
    4. et al
    .
Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging–parametric “first-pass” images depict tissue vascularization and perfusion.
Radiology
1994;
192:
835–43
    PubMedWeb of Science
  16. 16.↵


    1. Hawighorst  H, 
    2. Libicher  M, 
    3. Knopp  MV, 
    4. et al
    .
Evaluation of angiogenesis and perfusion of bone marrow lesions: role of semiquantitative and quantitative dynamic MRI.
J Magn Reson Imaging
1999;
10:
286–94
    CrossRefPubMedWeb of Science
  17. 17.↵


    1. van der Woude  HJ, 
    2. Bloem  JL, 
    3. Verstraete  KL, 
    4. et al
    .
Osteosarcoma and Ewing's sarcoma after neoadjuvant chemotherapy: value of dynamic MR imaging in detecting viable tumor before surgery.
AJR Am J Roentgenol
1995;
165:
593–98
    PubMedWeb of Science
  18. 18.↵


    1. Fletcher  BD, 
    2. Hanna  SL, 
    3. Fairclough  DL, 
    4. et al
    .
Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy.
Radiology
1992;
184:
243–48
    PubMedWeb of Science
  19. 19.↵


    1. Cox  RW
    .
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.
Comput Biomed Res
1996;
29:
162–73
    CrossRefPubMedWeb of Science
  20. 20.↵


    1. Chen  WT, 
    2. Shih  TT, 
    3. Chen  RC, 
    4. et al
    .
Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MR imaging: significance of aging and sex.
Radiology
2001;
220:
213–18
    PubMedWeb of Science
  21. 21.↵


    1. van der Woude  HJ, 
    2. Verstraete  KL, 
    3. Hogendoorn  PC, 
    4. et al
    .
Musculoskeletal tumors: does fast dynamic contrast-enhanced subtraction MR imaging contribute to the characterization?
Radiology
1998;
208:
821–28
    PubMedWeb of Science
  22. 22.↵


    1. Maranzano  E, 
    2. Trippa  F, 
    3. Pacchiarini  D, 
    4. et al
    .
Re-irradiation of brain metastases and metastatic spinal cord compression: clinical practice suggestions.
Tumori
2005;
91:
325–30
    PubMedWeb of Science
  23. 23.↵


    1. Al-Shamy  G, 
    2. Sawaya  R
    .
Management of brain metastases: the indispensable role of surgery.
J Neurooncol
2009;
92:
275–82
    CrossRefPubMed
  24. 24.↵


    1. Ranjan  T, 
    2. Abrey  LE
    .
Current management of metastatic brain disease.
Neurotherapeutics
2009;
6:
598–603
    CrossRefPubMedWeb of Science
  25. 25.↵


    1. Tai  SH, 
    2. Hung  YC, 
    3. Chen  JC, 
    4. et al
    .
A patient with two episodes of thoracic spinal cord compression caused by primary lymphoma and metastatic carcinoma of the prostate, 11 years apart.
Kaohsiung J Med Sci
2010;
26:
506–10
    CrossRefPubMed
  26. 26.↵


    1. Vasudevan  V, 
    2. Cheung  MC, 
    3. Yang  R, 
    4. et al
    .
Pediatric solid tumors and second malignancies: characteristics and survival outcomes.
J Surg Res
2010;
160:
184–89
    CrossRefPubMed
  27. 27.↵


    1. Sharma  SD, 
    2. Upreti  RR, 
    3. Laskar  S, 
    4. et al
    .
Estimation of risk of radiation-induced carcinogenesis in adolescents with nasopharyngeal cancer treated using sliding window IMRT.
Radiother Oncol
2008;
86:
177–81
    CrossRefPubMed
  28. 28.↵


    1. Helissey  C, 
    2. Levy  A, 
    3. Jacob  J, 
    4. et al
    .
External beam radiotherapy in the management of spinal metastases: review of current strategies and perspectives for highly conformal irradiation modalities.
Discov Med
2011;
11:
505–11
    PubMed
  29. 29.↵


    1. Delank  KS, 
    2. Wendtner  C, 
    3. Eich  HT, 
    4. et al
    .
The treatment of spinal metastases.
Dtsch Arztebl Int
2011;
108:
71–79;
quiz 80
    PubMed
  30. 30.↵


    1. Morris  PG, 
    2. Hudis  CA
    .
Personalizing therapy for metastatic breast cancer.
Expert Rev Anticancer Ther
2009;
9:
1223–26
    CrossRefPubMed
  31. 31.↵


    1. Broxterman  HJ, 
    2. Gotink  KJ, 
    3. Verheul  HM
    .
Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib.
Drug Resist Updat
2009;
12:
114–26
    CrossRefPubMed
  32. 32.↵


    1. Griffith  JF, 
    2. Yeung  DK, 
    3. Antonio  GE, 
    4. et al
    .
Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy.
Radiology
2005;
236:
945–51
    PubMedWeb of Science
  33. 33.↵


    1. Griffith  JF, 
    2. Yeung  DK, 
    3. Antonio  GE, 
    4. et al
    .
Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation.
Radiology
2006;
241:
831–38
    CrossRefPubMedWeb of Science
  34. 34.↵


    1. Savvopoulou  V, 
    2. Maris  TG, 
    3. Vlahos  L, 
    4. et al
    .
Differences in perfusion parameters between upper and lower lumbar vertebral segments with dynamic contrast-enhanced MRI (DCE MRI).
Eur Radiol
2008;
18:
1876–83
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging
  
    	
N.R. Khadem, S. Karimi, K.K. Peck, Y. Yamada, E. Lis, J. Lyo, M. Bilsky, H.A. Vargas, A.I. Holodny

  
    	
American Journal of Neuroradiology Dec 2012, 33 (11) 2178-2185; DOI: 10.3174/ajnr.A3104 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement