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    A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleBrain

  
      
Open Access

  
      
A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis
  
    	
G. Carrara, C. Carapelli, F. Venturi, M.M. Ferraris, L. Lequio, A. Chiò, A. Calvo, S. Sirgiovanni, A. Cistaro and M.C. Valentini

  
    	
American Journal of Neuroradiology April 2012,  33 (4) 733-739; DOI: https://doi.org/10.3174/ajnr.A2855 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    1. Brownell  B, 
    2. Oppenheimer  DR, 
    3. Hughes  JT
    . The central nervous system in motor neurone disease. J Neurol Neurosurg Psychiatry 1970;33: 338–57
    Abstract/FREE Full Text
  2. 2.↵


    1. Davidson  CD
    . Amyotrophic lateral sclerosis: origin and extent of the upper motor neuron lesion. Arch Neurol 1941;46: 1039–56
  3. 3.↵


    1. Chancellor  AM, 
    2. Slattery  JM, 
    3. Fraser  H, 
    4. et al
    . The prognosis of adult-onset motor neuron disease: a prospective study based on the Scottish Motor Neuron Disease Register. J Neurol 1993;240: 339–46
    CrossRefPubMedWeb of Science
  4. 4.↵


    1. Worms  PM
    . The epidemiology of motor neuron diseases: a review of recent studies. J Neurol Sci 2001;191: 3–9
    CrossRefPubMedWeb of Science
  5. 5.↵


    1. Logroscino  G, 
    2. Traynor  BJ, 
    3. Hardiman  O, 
    4. et al.
    , 
for EURALS. 
Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry 2008;79: 6–11
    Abstract/FREE Full Text
  6. 6.↵


    1. Chiò  A, 
    2. Mora  G, 
    3. Calvo  A, 
    4. et al
    . Epidemiology of ALS in Italy: a 10-year prospective population-based study. Neurology, 
2009;72: 725–31
    Abstract/FREE Full Text
  7. 7.↵


    1. Wijesekera  LC, 
    2. Leigh  PN
    . Amyotrophic lateral sclerosis. Orphanet J Rare Dis 2009;4:
3
  8. 8.↵


    1. Cheung  G, 
    2. Gawel  MJ, 
    3. Cooper  PW, 
    4. et al
    . Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. Radiology 1995;194: 263–70
    PubMedWeb of Science
  9. 9.↵


    1. Hofmann  E, 
    2. Ochs  G, 
    3. Pelzl  A, 
    4. et al
    . The corticospinal tract in amyotrophic lateral sclerosis. Neuroradiology 1998;40: 71–75
    CrossRefPubMedWeb of Science
  10. 10.↵


    1. Goodin  DS, 
    2. Rowley  HA, 
    3. Olney  RK
    . Magnetic resonance imaging in amyotrophic lateral sclerosis. Ann Neurol 1988;23: 418–20
    CrossRefPubMedWeb of Science
  11. 11.↵


    1. Bowen  BC, 
    2. Pattany  PM, 
    3. Bradley  WG, 
    4. et al
    . MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2000;21: 647–58
    Abstract/FREE Full Text
  12. 12.↵


    1. Zhang  L, 
    2. Ulug  AM, 
    3. Zimmerman  RD, 
    4. et al
    . The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis. J Magn Reson Imaging 2003;17: 521–27
    CrossRefPubMed
  13. 13.↵


    1. Hecht  MJ, 
    2. Fellner  F, 
    3. Fellner  C, 
    4. et al
    . MRI-FLAIR images of the head show corticospinal tract alterations in ALS patients more frequently than T2-, T1- and proton-density weighted images. J Neurol Sci 2001;186: 37–44
    CrossRefPubMedWeb of Science
  14. 14.↵


    1. Ngai  S, 
    2. Tang  YM, 
    3. Du  L, 
    4. et al
    . Hyperintensity of the precentral gyral subcortical white matter and hypointensity of the precentral gyrus on fluid-attenuated inversion recovery: variation with age and implications for the diagnosis of amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2007;28: 250–54
    Abstract/FREE Full Text
  15. 15.↵


    1. Oba  H, 
    2. Araki  T, 
    3. Ohtomo  K, 
    4. et al
    . Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology 1993;189: 843–46
    PubMedWeb of Science
  16. 16.↵


    1. Waragai  M
    . MRI and clinical features in amyotrophic lateral sclerosis. Neuroradiology 1997;39: 847–51
    CrossRefPubMedWeb of Science
  17. 17.↵


    1. Hecht  MJ, 
    2. Fellner  F, 
    3. Fellner  C, 
    4. et al
    . Hyperintense and hypointense MRI signals of the precentral gyrus and corticospinal tract in ALS: a follow-up examination including FLAIR images. J Neurol Sci 2002;199: 59–65
    CrossRefPubMed
  18. 18.↵


    1. Da Rocha  AJ, 
    2. Oliveira  ASB, 
    3. Fonseca  RB, 
    4. et al
    . Detection of corticospinal tract compromise in amyotrophic lateral sclerosis with brain MR imaging: relevance of the T1-weighted spin-echo magnetization transfer contrast sequence. AJNR Am J Neuroradiol 2004;25: 1509–15
    Abstract/FREE Full Text
  19. 19.↵


    1. Kato  Y, 
    2. Matsumura  K, 
    3. Kinosoda  Y, 
    4. et al
    . Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements. AJNR Am J Neuroradiol 1997;18: 1541–47
    Abstract
  20. 20.↵


    1. Tanabe  JL, 
    2. Vermathen  M, 
    3. Miller  R, 
    4. et al
    . Reduced MTR in the corticospinal tract and normal T2 in amyotrophic lateral sclerosis. Magn Reson Imaging 1998;16: 1163–68
    CrossRefPubMedWeb of Science
  21. 21.↵


    1. Grossman  RI
    . Magnetization transfer in multiple sclerosis. Ann Neurol 1994;36: S97–99
    CrossRefPubMedWeb of Science
  22. 22.↵


    1. Cosottini  M, 
    2. Pesaresi  I, 
    3. Piazza  S, 
    4. et al
    . Magnetization transfer imaging demonstrates a distributed pattern of microstructural changes of the cerebral cortex in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2011;32: 704–08
    Abstract/FREE Full Text
  23. 23.↵


    1. Basser  PJ, 
    2. Mattiello  J, 
    3. LeBihan  D
    . MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66: 259–67
    CrossRefPubMedWeb of Science
  24. 24.↵


    1. Pierpaoli  P, 
    2. Basser  P
    . Toward a quantitive assessment of diffusion anisotropy. Magn Reson Med 1996;36: 893–906
    CrossRefPubMedWeb of Science
  25. 25.↵


    1. Beaulieu  C, 
    2. Does  MD, 
    3. Snyder  RE, 
    4. et al
    . Changes in water diffusion due to Wallerian degeneration in peripheral nerve. Magn Reson Med 1996;36: 627–31
    CrossRefPubMedWeb of Science
  26. 26.↵


    1. Smith  SM, 
    2. Jenkinson  M, 
    3. Johansen-Berg  H, 
    4. et al
    . Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31: 1487–505
    CrossRefPubMedWeb of Science
  27. 27.↵


    1. Ellis  CM, 
    2. Simmons  A, 
    3. Jones  DK, 
    4. et al
    . Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology 1999;53: 1051–58
    Abstract/FREE Full Text
  28. 28.↵


    1. Sach  M, 
    2. Winkler  G, 
    3. Glauche  V, 
    4. et al
    . Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. Brain 2004;127: 340–50
    Abstract/FREE Full Text
  29. 29.↵


    1. Graham  JM, 
    2. Papadakis  N, 
    3. Evans  J, 
    4. et al
    . Diffusion tensor imaging for the assessment of upper motor neuron integrity in ALS. Neurology 2004;63: 2111–19
    Abstract/FREE Full Text
  30. 30.↵


    1. Karlsborg  M, 
    2. Rosenbaum  S, 
    3. Wiegell  M, 
    4. et al
    . Corticospinal tract degeneration and possible pathogenesis in ALS evaluated by MR diffusion tensor imaging. Amyotroph Lateral Scler Other Mot Neuron Disord 2004;5: 136–40
  31. 31.↵


    1. Hong  YH, 
    2. Lee  KW, 
    3. Sung  JJ, 
    4. et al
    . Diffusion tensor MRI as a diagnostic tool of upper motor neuron involvement in amyotrophic lateral sclerosis. J Neurol Sci 2004;227: 73–78
    CrossRefPubMedWeb of Science
  32. 32.↵


    1. Cosottini  M, 
    2. Giannelli  M, 
    3. Siciliano  G, 
    4. et al
    . Diffusion-tensor MR imaging of corticospinal tract in amyotrophic lateral sclerosis and progressive muscular atrophy. Radiology 2005;237: 258–64
    CrossRefPubMedWeb of Science
  33. 33.↵


    1. Thivard  L, 
    2. Pradat  PF, 
    3. Lehericy  S, 
    4. et al
    . Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability. J Neurol Neurosurg Psychiatry 2007;78: 889–92
    Abstract/FREE Full Text
  34. 34.↵


    1. Wong  JC, 
    2. Concha  L, 
    3. Beaulieu  C, 
    4. et al
    . Spatial profiling of the corticospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging. J Neuroimaging 2007;17: 234–40
    CrossRefPubMedWeb of Science
  35. 35.↵


    1. Sage  CA, 
    2. Peeters  RR, 
    3. Gorner  A, 
    4. et al
    . Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Neuroimage 2007;34: 486–99
    CrossRefPubMedWeb of Science
  36. 36.↵


    1. Iwata  NK, 
    2. Aoki  S, 
    3. Okabe  S, 
    4. et al
    . Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation. Neurology 2008;70: 528–32
    Abstract/FREE Full Text
  37. 37.↵


    1. Ciccarelli  O, 
    2. Behrens  TE, 
    3. Johansen-Berg  H, 
    4. et al
    . Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics. Hum Brain Mapp 2009;30: 615–24
    CrossRefPubMedWeb of Science
  38. 38.↵


    1. Sage  CA, 
    2. Van Hecke  W, 
    3. Peeters  R, 
    4. et al
    . Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: revisited. Hum Brain Mapp 2009;30: 3657–75
    CrossRefPubMedWeb of Science
  39. 39.↵


    1. Metwalli  NS, 
    2. Benatar  M, 
    3. Nair  G, 
    4. et al
    . Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis. Brain Res 2010;1348: 156–64
    CrossRefPubMedWeb of Science
  40. 40.↵


    1. Agosta  F, 
    2. Pagani  E, 
    3. Rocca  MA, 
    4. et al
    . Voxel-based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability. Hum Brain Mapp 2007;28: 1430–38
    CrossRefPubMedWeb of Science
  41. 41.↵


    1. Brooks  BR, 
    2. Miller  RG, 
    3. Swash  M, 
    4. et al
    . El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000;1: 293–99
    CrossRefPubMedWeb of Science
  42. 42.↵


    1. Chiò  A, 
    2. Calvo  A, 
    3. Moglia  C, 
    4. et al
    . Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study. J Neurol Neurosurg Psychiatry 2011;82: 740–46. 
Epub 2011 Mar 14
    Abstract/FREE Full Text
  43. 43.↵


    1. Smith  SM, 
    2. Jenkinson  M, 
    3. Woolrich  MW, 
    4. et al
    . Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23: S208–19
    CrossRefPubMedWeb of Science
  44. 44.↵


    1. Smith  SM, 
    2. Johansen-Berg, 
    3. Jenkinson  M, 
    4. et al
    . Acquisition and voxelwise analysis of multi-subject diffusion data with tract-based spatial statistics. Nat Protoc 2007;2: 499–503
    CrossRefPubMedWeb of Science
  45. 45.↵


    1. Rueckert  D, 
    2. Sonoda  LI, 
    3. Hayes  C, 
    4. et al
    . Non rigid registration using free-form deformations: application to breast MR images. IEEE Trans Med Imaging 1999;18: 712–21
    CrossRefPubMedWeb of Science
  46. 46.↵


    1. Nichols  TE, 
    2. Holmes  AP
    . Non parametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 2002;15: 1–25
    CrossRefPubMedWeb of Science
  47. 47.↵


    1. Mori  S, 
    2. Oishi  K, 
    3. Jiang  H, 
    4. et al
    . Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 2008;40: 570–82
    CrossRefPubMedWeb of Science
  48. 48.↵


    1. Okamoto  K, 
    2. Hirai  S, 
    3. Shoji  M, 
    4. et al
    . Axonal swelling in the corticospinal tract in amyotrophic lateral sclerosis. Acta Neuropathol 1990;80: 222–26
    CrossRefPubMed
  49. 49.↵


    1. Mirowitz  S, 
    2. Sartor  K, 
    3. Gado  M, 
    4. et al
    . Focal signal intensity variations in the posterior limb of the internal capsule: normal MR findings and distinction from pathologic findings. Radiology 1989;172: 535–39
    PubMed
  50. 50.↵


    1. De Kerviler  E, 
    2. Cuenod  C, 
    3. Clement  O, 
    4. et al
    . What is bright in T1 MRI scans. J Radiol 1998;79: 117–26
    PubMed
  51. 51.↵


    1. Bartels  C, 
    2. Mertens  N, 
    3. Hofer  S, 
    4. et al
    . Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system. Neuromuscul Disord 2008;18: 398–407
    CrossRefPubMedWeb of Science
  52. 52.↵


    1. Filippini  N, 
    2. Douaud  G, 
    3. Mackay  CE, 
    4. et al
    . Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology 2010;75: 1645–52
    Abstract/FREE Full Text
  53. 53.↵


    1. Farina  L, 
    2. Bizzi  A, 
    3. Finocchiaro  G, 
    4. et al
    . MR imaging and proton MR spectroscopy in adult Krabbe disease. AJNR Am J Neuroradiol 2000;21: 1478–82
    Abstract/FREE Full Text
  54. 54.↵


    1. Meyer  B, 
    2. Röricht  S, 
    3. Gräfin von Einsiedel  H, 
    4. et al
    . Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain 1995;118: 429–40
    Abstract/FREE Full Text
  55. 55.↵


    1. Karandreas  N, 
    2. Papadopoulou  M, 
    3. Kokotis  P, 
    4. et al
    . Impaired interhemispheric inhibition in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2007;8: 112–18
    CrossRefPubMed
  56. 56.↵


    1. Riad  SM, 
    2. Hathout  H, 
    3. Huang  JC
    . High T2 signal in primary lateral sclerosis supports the topographic distribution of fibers in the corpus callosum: assessing disease in the primary motor segment. AJNR Am J Neuroradiol 2011;32: E61–64
    Abstract/FREE Full Text
  57. 57.↵


    1. Unrath  A, 
    2. Muller  HP, 
    3. Riecker  A, 
    4. et al
    . Whole brain-based analysis of regional white matter tract alterations in rare motor neuron diseases by diffusion tensor imaging. Hum Brain Mapp 2010;31: 1727–40
    PubMedWeb of Science
  58. 58.↵


    1. Hudson  AJ, 
    2. Kiernan  JA, 
    3. Munoz  DG, 
    4. et al
    . Clinicopathological features of primary lateral sclerosis are different from amyotrophic lateral sclerosis. Brain Res Bull 1993;30: 359–64
    CrossRefPubMedWeb of Science
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis
  
    	
G. Carrara, C. Carapelli, F. Venturi, M.M. Ferraris, L. Lequio, A. Chiò, A. Calvo, S. Sirgiovanni, A. Cistaro, M.C. Valentini

  
    	
 American Journal of Neuroradiology Apr 2012, 33 (4) 733-739; DOI: 10.3174/ajnr.A2855 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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