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<meta name="DC.Title" content="Regional Gray Matter Atrophy in Patients with Parkinson Disease and Freezing of Gait" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3066" />
<meta name="DC.Date" content="2012-10-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: FOG is a troublesome symptom of PD. Despite growing evidence suggesting that FOG in PD may be associated with cognitive dysfunction, the relationship between regional brain atrophy and FOG has been poorly investigated.

MATERIALS AND METHODS: Optimized VBM was applied to 3T brain MR images of 24 patients with PD and 12 HC. Patients were classified as either FOG− or FOG+ ( n = 12) based on their responses to a validated FOG Questionnaire and clinical observation. All patients with PD also underwent a detailed neuropsychological evaluation.

RESULTS: The VBM analysis in patients with FOG+ showed a reduced GM volume in the left cuneus, precuneus, lingual gyrus, and posterior cingulate cortex compared with both patients with FOG− and HC. We did not detect any significant change of GM volume when comparing HC versus all patients with PD (FOG− and FOG+). FOG clinical severity was significantly correlated with GM loss in posterior cortical regions. Finally, patients with FOG+ scored lower on tests of frontal lobe function.

CONCLUSIONS: Our findings provide the first evidence that the development of FOG in patients with PD is associated with posterior GM atrophy, which may play a role in the complex pathophysiology of this disabling symptom.

18F
:   fluorine 18
FOG
:   freezing of gait
FOG-Q
:   FOG Questionnaire
FWE
:   family-wise error
GM
:   gray matter
HC
:   healthy controls
PD
:   Parkinson disease
RCPM
:   Raven's Colored Progressive Matrices 
UPDRS
:   Unified Parkinson's Disease Rating Scale
VBM
:   voxel-based morphometry" />
<meta name="DC.Contributor" content="A. Tessitore" />
<meta name="DC.Contributor" content="M. Amboni" />
<meta name="DC.Contributor" content="G. Cirillo" />
<meta name="DC.Contributor" content="D. Corbo" />
<meta name="DC.Contributor" content="M. Picillo" />
<meta name="DC.Contributor" content="A. Russo" />
<meta name="DC.Contributor" content="C. Vitale" />
<meta name="DC.Contributor" content="G. Santangelo" />
<meta name="DC.Contributor" content="R. Erro" />
<meta name="DC.Contributor" content="M. Cirillo" />
<meta name="DC.Contributor" content="F. Esposito" />
<meta name="DC.Contributor" content="P. Barone" />
<meta name="DC.Contributor" content="G. Tedeschi" />
<meta name="article:published_time" content="2012-10-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Regional Gray Matter Atrophy in Patients with Parkinson Disease and Freezing of Gait" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;FOG is a troublesome symptom of PD. Despite growing evidence suggesting that FOG in PD may be associated with cognitive dysfunction, the relationship between regional brain atrophy and FOG has been poorly investigated.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Optimized VBM was applied to 3T brain MR images of 24 patients with PD and 12 HC. Patients were classified as either FOG− or FOG+ (&lt;i&gt;n&lt;/i&gt; = 12) based on their responses to a validated FOG Questionnaire and clinical observation. All patients with PD also underwent a detailed neuropsychological evaluation.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The VBM analysis in patients with FOG+ showed a reduced GM volume in the left cuneus, precuneus, lingual gyrus, and posterior cingulate cortex compared with both patients with FOG− and HC. We did not detect any significant change of GM volume when comparing HC versus all patients with PD (FOG− and FOG+). FOG clinical severity was significantly correlated with GM loss in posterior cortical regions. Finally, patients with FOG+ scored lower on tests of frontal lobe function.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Our findings provide the first evidence that the development of FOG in patients with PD is associated with posterior GM atrophy, which may play a role in the complex pathophysiology of this disabling symptom.&lt;/p&gt;" />
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<meta name="twitter:title" content="Regional Gray Matter Atrophy in Patients with Parkinson Disease and Freezing of Gait" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/33/9.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: FOG is a troublesome symptom of PD. Despite growing evidence suggesting that FOG in PD may be associated with cognitive dysfunction, the relationship between regional brain atrophy and FOG has been poorly investigated.

MATERIALS AND METHODS: Optimized VBM was applied to 3T brain MR images of 24 patients with PD and 12 HC. Patients were classified as either FOG− or FOG+ ( n = 12) based on their responses to a validated FOG Questionnaire and clinical observation. All patients with PD also underwent a detailed neuropsychological evaluation.

RESULTS: The VBM analysis in patients with FOG+ showed a reduced GM volume in the left cuneus, precuneus, lingual gyrus, and posterior cingulate cortex compared with both patients with FOG− and HC. We did not detect any significant change of GM volume when comparing HC versus all patients with PD (FOG− and FOG+). FOG clinical severity was significantly correlated with GM loss in posterior cortical regions. Finally, patients with FOG+ scored lower on tests of frontal lobe function.

CONCLUSIONS: Our findings provide the first evidence that the development of FOG in patients with PD is associated with posterior GM atrophy, which may play a role in the complex pathophysiology of this disabling symptom.

18F
:   fluorine 18
FOG
:   freezing of gait
FOG-Q
:   FOG Questionnaire
FWE
:   family-wise error
GM
:   gray matter
HC
:   healthy controls
PD
:   Parkinson disease
RCPM
:   Raven's Colored Progressive Matrices 
UPDRS
:   Unified Parkinson's Disease Rating Scale
VBM
:   voxel-based morphometry" />
<meta name="og-title" property="og:title" content="Regional Gray Matter Atrophy in Patients with Parkinson Disease and Freezing of Gait" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/33/9/1804" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: FOG is a troublesome symptom of PD. Despite growing evidence suggesting that FOG in PD may be associated with cognitive dysfunction, the relationship between regional brain atrophy and FOG has been poorly investigated.

MATERIALS AND METHODS: Optimized VBM was applied to 3T brain MR images of 24 patients with PD and 12 HC. Patients were classified as either FOG− or FOG+ ( n = 12) based on their responses to a validated FOG Questionnaire and clinical observation. All patients with PD also underwent a detailed neuropsychological evaluation.

RESULTS: The VBM analysis in patients with FOG+ showed a reduced GM volume in the left cuneus, precuneus, lingual gyrus, and posterior cingulate cortex compared with both patients with FOG− and HC. We did not detect any significant change of GM volume when comparing HC versus all patients with PD (FOG− and FOG+). FOG clinical severity was significantly correlated with GM loss in posterior cortical regions. Finally, patients with FOG+ scored lower on tests of frontal lobe function.

CONCLUSIONS: Our findings provide the first evidence that the development of FOG in patients with PD is associated with posterior GM atrophy, which may play a role in the complex pathophysiology of this disabling symptom.

18F
:   fluorine 18
FOG
:   freezing of gait
FOG-Q
:   FOG Questionnaire
FWE
:   family-wise error
GM
:   gray matter
HC
:   healthy controls
PD
:   Parkinson disease
RCPM
:   Raven's Colored Progressive Matrices 
UPDRS
:   Unified Parkinson's Disease Rating Scale
VBM
:   voxel-based morphometry" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12089--5" data-node-nid="12089" id="top-node-12089--61840286288" data-pisa="ajnr;33/9/1804" data-pisa-master="ajnr;ajnr.A3066" data-apath="/ajnr/33/9/1804.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Regional Gray Matter Atrophy in Patients with Parkinson Disease and Freezing of Gait</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A. Tessitore</span>, <span class="highwire-citation-author" data-delta="1">M. Amboni</span>, <span class="highwire-citation-author" data-delta="2">G. Cirillo</span>, <span class="highwire-citation-author" data-delta="3">D. Corbo</span>, <span class="highwire-citation-author" data-delta="4">M. Picillo</span>, <span class="highwire-citation-author" data-delta="5">A. Russo</span>, <span class="highwire-citation-author" data-delta="6">C. Vitale</span>, <span class="highwire-citation-author" data-delta="7">G. Santangelo</span>, <span class="highwire-citation-author" data-delta="8">R. Erro</span>, <span class="highwire-citation-author" data-delta="9">M. Cirillo</span>, <span class="highwire-citation-author" data-delta="10">F. Esposito</span>, <span class="highwire-citation-author" data-delta="11">P. Barone</span> and <span class="highwire-citation-author" data-delta="12">G. Tedeschi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2012,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1804-1809; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3066 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12089--61840286288" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A. Tessitore </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurological Sciences (A.T., G.C., A.R., M.C., G.T.), Second University of Naples, Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BTessitore%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tessitore%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BTessitore%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M. Amboni </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Institute for Diagnosis and Care “Hermitage Capodimonte” (M.A., D.C., A.R., G.T.), Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BAmboni%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Amboni%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BAmboni%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">G. Cirillo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurological Sciences (A.T., G.C., A.R., M.C., G.T.), Second University of Naples, Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BCirillo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cirillo%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BCirillo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">D. Corbo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Institute for Diagnosis and Care “Hermitage Capodimonte” (M.A., D.C., A.R., G.T.), Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BCorbo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Corbo%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.%2BCorbo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">M. Picillo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BPicillo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Picillo%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BPicillo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">A. Russo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurological Sciences (A.T., G.C., A.R., M.C., G.T.), Second University of Naples, Naples, Italy</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Institute for Diagnosis and Care “Hermitage Capodimonte” (M.A., D.C., A.R., G.T.), Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BRusso%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Russo%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BRusso%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">C. Vitale </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div><div class='author-affiliation'><span class='nlm-sup'>e</span>University of Naples “Parthenope” (C.V.), Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BVitale%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vitale%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BVitale%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">G. Santangelo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Neuropsychology Laboratory (G.S.), Department of Psychology, Second University of Naples, Caserta, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BSantangelo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Santangelo%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BSantangelo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">R. Erro </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BErro%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Erro%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BErro%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">M. Cirillo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurological Sciences (A.T., G.C., A.R., M.C., G.T.), Second University of Naples, Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BCirillo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cirillo%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BCirillo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">F. Esposito </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BEsposito%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Esposito%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BEsposito%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">P. Barone </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Medicine and Surgery (P.B.), University of Salerno, Salerno, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BBarone%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Barone%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.%2BBarone%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">G. Tedeschi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neurological Sciences (A.T., G.C., A.R., M.C., G.T.), Second University of Naples, Naples, Italy</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Institute for Diagnosis and Care “Hermitage Capodimonte” (M.A., D.C., A.R., G.T.), Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BTedeschi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tedeschi%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BTedeschi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12089" data-node-nid="12089" id="node-12089--2765647884" data-pisa="ajnr;33/9/1804" data-pisa-master="ajnr;ajnr.A3066" data-apath="/ajnr/33/9/1804.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-highwire-article-info clearfix">
  
  
  
  
  
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">vol. 33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">no. 9 </span><span  class="highwire-cite-metadata-page-string highwire-cite-metadata">1804-1809 </span></div>
  
  
  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">A. Tessitore</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">M. Amboni</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-3"><span class="name">G. Cirillo</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">D. Corbo</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-5"><span class="name">M. Picillo</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-6"><span class="name">A. Russo</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-3-3" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-7"><span class="name">C. Vitale</span><a id="xref-aff-2-3" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">e</a>, </li><li class="contributor" id="contrib-8"><span class="name">G. Santangelo</span><a id="xref-aff-2-4" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">f</a>, </li><li class="contributor" id="contrib-9"><span class="name">R. Erro</span><a id="xref-aff-2-5" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-10"><span class="name">M. Cirillo</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-11"><span class="name">F. Esposito</span><a id="xref-aff-2-6" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-12"><span class="name">P. Barone</span><a id="xref-aff-2-7" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a> and </li><li class="last" id="contrib-13"><span class="name">G. Tedeschi</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-3-4" class="xref-aff" href="#aff-3">c</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Department of Neurological Sciences (A.T., G.C., A.R., M.C., G.T.), Second University of Naples, Naples, Italy</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Department of Neurological Sciences (M.A., M.P., C.V., G.S., R.E., F.E., P.B.), University “Federico II,” Naples, Italy</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Institute for Diagnosis and Care “Hermitage Capodimonte” (M.A., D.C., A.R., G.T.), Naples, Italy</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Department of Medicine and Surgery (P.B.), University of Salerno, Salerno, Italy</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>e</sup>University of Naples “Parthenope” (C.V.), Naples, Italy</address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>f</sup>Neuropsychology Laboratory (G.S.), Department of Psychology, Second University of Naples, Caserta, Italy.</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Gioacchino Tedeschi, MD, <span class="addr-line">Division of Neurology, University of Naples, SUN, Piazza Miraglia 2-I-80138, Naples, Italy</span>; e-mail: <span class="em-link"><span class="em-addr">tessitorealessandro{at}libero.it</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/33/9/1804.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tessitore</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Amboni</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Cirillo</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Corbo</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Picillo</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Russo</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Vitale</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Santangelo</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Erro</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Cirillo</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Esposito</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Barone</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Tedeschi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2012, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1804-1809; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3066 </span></div>
  
  
  
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      <div class="highwire-cite-title">Regional Gray Matter Atrophy in Patients with Parkinson Disease and Freezing of Gait</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tessitore</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Amboni</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Cirillo</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Corbo</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Picillo</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Russo</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Vitale</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Santangelo</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Erro</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Cirillo</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Esposito</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Barone</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Tedeschi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2012, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1804-1809; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3066 </span></div>
  
  
  
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