Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

H. Zhao; C. Zheng; G. Feng; Y. Zhao; H. Liang; H. Wu; G. Zhou; B. Liang; Y. Wang; X. Xia

doi:10.3174/ajnr.A3177

References

1.↵
1. Pollak JS,
2. White RI Jr.
. The use of cyanoacrylate adhesives in peripheral embolization. J Vasc Interv Radiol 2001;12:907–13
PubMed
2.↵
1. Loffroy R,
2. Guiu B,
3. Cercueil JP,
4. et al
. Endovascular therapeutic embolisation: an overview of occluding agents and their effects on embolised tissues. Curr Vasc Pharmacol 2009;7:250–63
CrossRef PubMed
3.↵
1. Lewandowski RJ,
2. Geschwind JF,
3. Liapi E,
4. et al
. Transcatheter intra-arterial therapies: rationale and overview. Radiology 2011;259:641–57
CrossRef PubMed
4.↵
1. Jordan O,
2. Doelker E,
3. Rufenacht DA
. Biomaterials used in injectable implants (liquid embolics) for percutaneous filling of vascular spaces. Cardiovasc Intervent Radiol 2005;28:561–69
CrossRef PubMed
5.↵
1. Bakar B,
2. Oruckaptan HH,
3. Hazer BD,
4. et al
. Evaluation of the toxicity of Onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research. Neuroradiology 2010;52:125–34
CrossRef PubMed
6.↵
1. Zhou YM,
2. Ishikawa A,
3. Okahashi R,
4. et al
. Deposition transfection technology using a DNA complex with a thermoresponsive cationic star polymer. J Control Release 2007;123:239–46
CrossRef PubMed Web of Science
7.↵
1. Sabnis A,
2. Wadajkar AS,
3. Aswath P,
4. et al
. Factorial analyses of photopolymerizable thermoresponsive composite hydrogels for protein delivery. Nanomedicine 2009;5:305–15
CrossRef PubMed
8.↵
1. Wang Q,
2. Zhao YB,
3. Yang YJ,
4. et al
. Thermosensitive phase behavior and drug release of in situ gelable poly (N-isopropylacrylamide-co-acrylamide) microgels. Colloid Polym Sci 2007;285:515–21
CrossRef
9.↵
1. Klouda L,
2. Mikos AG
. Thermoresponsive hydrogels in biomedical applications. Eur J Pharm Biopharm 2008;68:34–45
CrossRef PubMed Web of Science
10.↵
1. Matsumaru Y,
2. Hyodo A,
3. Nose T,
4. et al
. Application of thermosensitive polymers as a new embolic material for intravascular neurosurgery. J Biomater Sci Polym Ed 1996;7:795–804
CrossRef PubMed
11.↵
1. Raymond J,
2. Metcalfe A,
3. Salazkin I,
4. et al
. Temporary vascular occlusion with poloxamer 407. Biomaterials 2004;25:3983–89
CrossRef PubMed
12.↵
1. Li X,
2. Liu W,
3. Ye G,
4. et al
. Thermosensitive N-isopropylacrylamide-N-propylacrylamide-vinyl pyrrolidone terpolymers: synthesis, characterization and preliminary application as embolic agents. Biomaterials 2005;26:7002–11
CrossRef PubMed
13.↵
1. Zhao Y,
2. Zheng C,
3. Wang Q,
4. et al
. Permanent and peripheral embolization: temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogel as a novel blood-vessel-embolic material in the interventional therapy of liver tumors. Adv Funct Mater 2011;21:2035–42
CrossRef
14.↵
1. Senturk C,
2. Cakir V,
3. Yorukoglu K,
4. et al
. Looking for the ideal particle: an experimental embolization study. Cardiovasc Intervent Radiol 2010;33:336–45
CrossRef PubMed
15.↵
1. Kwak BK,
2. Shim HJ,
3. Han SM,
4. et al
. Chitin-based embolic materials in the renal artery of rabbits: pathologic evaluation of an absorbable particulate agent. Radiology 2005;236:151–58
CrossRef PubMed
16.↵
1. Kónya A,
2. Van Pelt CS,
3. Wright KC
. Ethiodized oil-ethanol capillary embolization in rabbit kidneys: temporal histopathologic findings. Radiology 2004;232:147–53
PubMed
17.↵
1. Sadato A,
2. Wakhloo AK,
3. Hopkins LN
. Effects of a mixture of a low concentration of n-butylcyanoacrylate and ethiodol on tissue reactions and the permanence of arterial occlusion after embolization. Neurosurgery 2000;47:1197–203; discussion 1204–05
CrossRef PubMed Web of Science
18.↵
1. Klisch J,
2. Yin L,
3. Requejo F,
4. et al
. Liquid 2-poly-hydroxyethyl-methacrylate embolization of experimental arteriovenous malformations: feasibility study. AJNR Am J Neuroradiol 2002;23:422–29
Abstract/FREE Full Text
19.↵
1. Schwartz RS,
2. Huber KC,
3. Murphy JG,
4. et al
. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol 1992;19:267–74
CrossRef PubMed Web of Science
20.↵
1. Laurent A,
2. Wassef M,
3. Namur J,
4. et al
. Recanalization and particle exclusion after embolization of uterine arteries in sheep: a long-term study. Fertil Steril 2009;91:884–92
CrossRef PubMed
21.↵
1. Gobin YP,
2. Vinuela F,
3. Vinters HV,
4. et al
. Embolization with radiopaque microbeads of polyacrylonitrile hydrogel: evaluation in swine. Radiology 2000;214:113–19
CrossRef PubMed Web of Science
22.↵
1. Kai Y,
2. Hamada J,
3. Morioka M,
4. et al
. The utility of the microcrystalline cellulose sphere as a particulate embolic agent: an experimental study. AJNR Am J Neuroradiol 2000;21:1160–63
Abstract/FREE Full Text
23.↵
1. Arakawa H,
2. Murayama Y,
3. Davis CR,
4. et al
. Endovascular embolization of the swine rete mirabile with Eudragit-E 100 polymer. AJNR Am J Neuroradiol 2007;28:1191–96
Abstract/FREE Full Text
24.↵
1. de Luis E,
2. Bilbao JI,
3. de Ciercoles JA,
4. et al
. In vivo evaluation of a new embolic spherical particle (HepaSphere) in a kidney animal model. Cardiovasc Intervent Radiol 2008;31:367–76
CrossRef PubMed
25.↵
1. Vinters HV,
2. Lundie MJ,
3. Kaufmann JC
. Long-term pathological follow-up of cerebral arteriovenous malformations treated by embolization with bucrylate. N Engl J Med 1986;314:477–83
PubMed Web of Science
26.↵
1. Germano IM,
2. Davis RL,
3. Wilson CB,
4. et al
. Histopathological follow-up study of 66 cerebral arteriovenous malformations after therapeutic embolization with polyvinyl alcohol. J Neurosurg 1992;76:607–14
PubMed
27.↵
1. Bilbao JI,
2. de Luis E,
3. Garcia de Jalon JA,
4. et al
. Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol 2008;19:1625–38
CrossRef PubMed
28.↵
1. Chaloupka JC,
2. Vinuela F,
3. Vinters HV,
4. et al
. Technical feasibility and histopathologic studies of ethylene vinyl copolymer (EVAL) using a swine endovascular embolization model. AJNR Am J Neuroradiol 1994;15:1107–15
Abstract/FREE Full Text
29.↵
1. Murayama Y,
2. Vinuela F,
3. Ulhoa A,
4. et al
. Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile. Neurosurgery 1998;43:1164–75
CrossRef PubMed Web of Science
30.↵
1. Takao H,
2. Murayama Y,
3. Yuki I,
4. et al
. Endovascular treatment of experimental aneurysms using a combination of thermoreversible gelation polymer and protection devices: feasibility study. Neurosurgery 2009;65:601–09; discussion 609
CrossRef PubMed Web of Science

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An injectable shear-thinning biomaterial for endovascular embolization

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Show more INTERVENTIONAL

[1] 1.↵
Pollak JS,
White RI Jr.
. The use of cyanoacrylate adhesives in peripheral embolization. J Vasc Interv Radiol 2001;12:907–13
PubMed

[2] Pollak JS,

[3] White RI Jr.

[4] 2.↵
Loffroy R,
Guiu B,
Cercueil JP,
et al
. Endovascular therapeutic embolisation: an overview of occluding agents and their effects on embolised tissues. Curr Vasc Pharmacol 2009;7:250–63
CrossRef PubMed

[5] Loffroy R,

[6] Guiu B,

[7] Cercueil JP,

[8] et al

[9] 3.↵
Lewandowski RJ,
Geschwind JF,
Liapi E,
et al
. Transcatheter intra-arterial therapies: rationale and overview. Radiology 2011;259:641–57
CrossRef PubMed

[10] Lewandowski RJ,

[11] Geschwind JF,

[12] Liapi E,

[13] et al

[14] 4.↵
Jordan O,
Doelker E,
Rufenacht DA
. Biomaterials used in injectable implants (liquid embolics) for percutaneous filling of vascular spaces. Cardiovasc Intervent Radiol 2005;28:561–69
CrossRef PubMed

[15] Jordan O,

[16] Doelker E,

[17] Rufenacht DA

[18] 5.↵
Bakar B,
Oruckaptan HH,
Hazer BD,
et al
. Evaluation of the toxicity of Onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research. Neuroradiology 2010;52:125–34
CrossRef PubMed

[19] Bakar B,

[20] Oruckaptan HH,

[21] Hazer BD,

[22] et al

[23] 6.↵
Zhou YM,
Ishikawa A,
Okahashi R,
et al
. Deposition transfection technology using a DNA complex with a thermoresponsive cationic star polymer. J Control Release 2007;123:239–46
CrossRef PubMed Web of Science

[24] Zhou YM,

[25] Ishikawa A,

[26] Okahashi R,

[27] et al

[28] 7.↵
Sabnis A,
Wadajkar AS,
Aswath P,
et al
. Factorial analyses of photopolymerizable thermoresponsive composite hydrogels for protein delivery. Nanomedicine 2009;5:305–15
CrossRef PubMed

[29] Sabnis A,

[30] Wadajkar AS,

[31] Aswath P,

[32] et al

[33] 8.↵
Wang Q,
Zhao YB,
Yang YJ,
et al
. Thermosensitive phase behavior and drug release of in situ gelable poly (N-isopropylacrylamide-co-acrylamide) microgels. Colloid Polym Sci 2007;285:515–21
CrossRef

[34] Wang Q,

[35] Zhao YB,

[36] Yang YJ,

[37] et al

[38] 9.↵
Klouda L,
Mikos AG
. Thermoresponsive hydrogels in biomedical applications. Eur J Pharm Biopharm 2008;68:34–45
CrossRef PubMed Web of Science

[39] Klouda L,

[40] Mikos AG

[41] 10.↵
Matsumaru Y,
Hyodo A,
Nose T,
et al
. Application of thermosensitive polymers as a new embolic material for intravascular neurosurgery. J Biomater Sci Polym Ed 1996;7:795–804
CrossRef PubMed

[42] Matsumaru Y,

[43] Hyodo A,

[44] Nose T,

[45] et al

[46] 11.↵
Raymond J,
Metcalfe A,
Salazkin I,
et al
. Temporary vascular occlusion with poloxamer 407. Biomaterials 2004;25:3983–89
CrossRef PubMed

[47] Raymond J,

[48] Metcalfe A,

[49] Salazkin I,

[50] et al

[51] 12.↵
Li X,
Liu W,
Ye G,
et al
. Thermosensitive N-isopropylacrylamide-N-propylacrylamide-vinyl pyrrolidone terpolymers: synthesis, characterization and preliminary application as embolic agents. Biomaterials 2005;26:7002–11
CrossRef PubMed

[52] Li X,

[53] Liu W,

[54] Ye G,

[55] et al

[56] 13.↵
Zhao Y,
Zheng C,
Wang Q,
et al
. Permanent and peripheral embolization: temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogel as a novel blood-vessel-embolic material in the interventional therapy of liver tumors. Adv Funct Mater 2011;21:2035–42
CrossRef

[57] Zhao Y,

[58] Zheng C,

[59] Wang Q,

[60] et al

[61] 14.↵
Senturk C,
Cakir V,
Yorukoglu K,
et al
. Looking for the ideal particle: an experimental embolization study. Cardiovasc Intervent Radiol 2010;33:336–45
CrossRef PubMed

[62] Senturk C,

[63] Cakir V,

[64] Yorukoglu K,

[65] et al

[66] 15.↵
Kwak BK,
Shim HJ,
Han SM,
et al
. Chitin-based embolic materials in the renal artery of rabbits: pathologic evaluation of an absorbable particulate agent. Radiology 2005;236:151–58
CrossRef PubMed

[67] Kwak BK,

[68] Shim HJ,

[69] Han SM,

[70] et al

[71] 16.↵
Kónya A,
Van Pelt CS,
Wright KC
. Ethiodized oil-ethanol capillary embolization in rabbit kidneys: temporal histopathologic findings. Radiology 2004;232:147–53
PubMed

[72] Kónya A,

[73] Van Pelt CS,

[74] Wright KC

[75] 17.↵
Sadato A,
Wakhloo AK,
Hopkins LN
. Effects of a mixture of a low concentration of n-butylcyanoacrylate and ethiodol on tissue reactions and the permanence of arterial occlusion after embolization. Neurosurgery 2000;47:1197–203; discussion 1204–05
CrossRef PubMed Web of Science

[76] Sadato A,

[77] Wakhloo AK,

[78] Hopkins LN

[79] 18.↵
Klisch J,
Yin L,
Requejo F,
et al
. Liquid 2-poly-hydroxyethyl-methacrylate embolization of experimental arteriovenous malformations: feasibility study. AJNR Am J Neuroradiol 2002;23:422–29
Abstract/FREE Full Text

[80] Klisch J,

[81] Yin L,

[82] Requejo F,

[83] et al

[84] 19.↵
Schwartz RS,
Huber KC,
Murphy JG,
et al
. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol 1992;19:267–74
CrossRef PubMed Web of Science

[85] Schwartz RS,

[86] Huber KC,

[87] Murphy JG,

[88] et al

[89] 20.↵
Laurent A,
Wassef M,
Namur J,
et al
. Recanalization and particle exclusion after embolization of uterine arteries in sheep: a long-term study. Fertil Steril 2009;91:884–92
CrossRef PubMed

[90] Laurent A,

[91] Wassef M,

[92] Namur J,

[93] et al

[94] 21.↵
Gobin YP,
Vinuela F,
Vinters HV,
et al
. Embolization with radiopaque microbeads of polyacrylonitrile hydrogel: evaluation in swine. Radiology 2000;214:113–19
CrossRef PubMed Web of Science

[95] Gobin YP,

[96] Vinuela F,

[97] Vinters HV,

[98] et al

[99] 22.↵
Kai Y,
Hamada J,
Morioka M,
et al
. The utility of the microcrystalline cellulose sphere as a particulate embolic agent: an experimental study. AJNR Am J Neuroradiol 2000;21:1160–63
Abstract/FREE Full Text

[100] Kai Y,

[101] Hamada J,

[102] Morioka M,

[103] et al

[104] 23.↵
Arakawa H,
Murayama Y,
Davis CR,
et al
. Endovascular embolization of the swine rete mirabile with Eudragit-E 100 polymer. AJNR Am J Neuroradiol 2007;28:1191–96
Abstract/FREE Full Text

[105] Arakawa H,

[106] Murayama Y,

[107] Davis CR,

[108] et al

[109] 24.↵
de Luis E,
Bilbao JI,
de Ciercoles JA,
et al
. In vivo evaluation of a new embolic spherical particle (HepaSphere) in a kidney animal model. Cardiovasc Intervent Radiol 2008;31:367–76
CrossRef PubMed

[110] de Luis E,

[111] Bilbao JI,

[112] de Ciercoles JA,

[113] et al

[114] 25.↵
Vinters HV,
Lundie MJ,
Kaufmann JC
. Long-term pathological follow-up of cerebral arteriovenous malformations treated by embolization with bucrylate. N Engl J Med 1986;314:477–83
PubMed Web of Science

[115] Vinters HV,

[116] Lundie MJ,

[117] Kaufmann JC

[118] 26.↵
Germano IM,
Davis RL,
Wilson CB,
et al
. Histopathological follow-up study of 66 cerebral arteriovenous malformations after therapeutic embolization with polyvinyl alcohol. J Neurosurg 1992;76:607–14
PubMed

[119] Germano IM,

[120] Davis RL,

[121] Wilson CB,

[122] et al

[123] 27.↵
Bilbao JI,
de Luis E,
Garcia de Jalon JA,
et al
. Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol 2008;19:1625–38
CrossRef PubMed

[124] Bilbao JI,

[125] de Luis E,

[126] Garcia de Jalon JA,

[127] et al

[128] 28.↵
Chaloupka JC,
Vinuela F,
Vinters HV,
et al
. Technical feasibility and histopathologic studies of ethylene vinyl copolymer (EVAL) using a swine endovascular embolization model. AJNR Am J Neuroradiol 1994;15:1107–15
Abstract/FREE Full Text

[129] Chaloupka JC,

[130] Vinuela F,

[131] Vinters HV,

[132] et al

[133] 29.↵
Murayama Y,
Vinuela F,
Ulhoa A,
et al
. Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile. Neurosurgery 1998;43:1164–75
CrossRef PubMed Web of Science

[134] Murayama Y,

[135] Vinuela F,

[136] Ulhoa A,

[137] et al

[138] 30.↵
Takao H,
Murayama Y,
Yuki I,
et al
. Endovascular treatment of experimental aneurysms using a combination of thermoreversible gelation polymer and protection devices: feasibility study. Neurosurgery 2009;65:601–09; discussion 609
CrossRef PubMed Web of Science

[139] Takao H,

[140] Murayama Y,

[141] Yuki I,

[142] et al

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Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

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Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

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