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<meta name="DC.Title" content="Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3553" />
<meta name="DC.Date" content="2013-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2013 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Along with cortical abnormalities, white matter microstructural changes such as axonal loss and myelin breakdown are implicated in the pathogenesis of Alzheimer disease. Recently, a white matter model was introduced that relates non-Gaussian diffusional kurtosis imaging metrics to characteristics of white matter tract integrity, including the axonal water fraction, the intra-axonal diffusivity, and the extra-axonal axial and radial diffusivities.

MATERIALS AND METHODS: This study reports these white matter tract integrity metrics in subjects with amnestic mild cognitive impairment ( n = 12), Alzheimer disease ( n = 14), and age-matched healthy controls ( n = 15) in an effort to investigate their sensitivity, diagnostic accuracy, and associations with white matter changes through the course of Alzheimer disease.

RESULTS: With tract-based spatial statistics and region-of-interest analyses, increased diffusivity in the extra-axonal space (extra-axonal axial and radial diffusivities) in several white matter tracts sensitively and accurately discriminated healthy controls from those with amnestic mild cognitive impairment (area under the receiver operating characteristic curve = 0.82–0.95), while widespread decreased axonal water fraction discriminated amnestic mild cognitive impairment from Alzheimer disease (area under the receiver operating characteristic curve = 0.84). Additionally, these white matter tract integrity metrics in the body of the corpus callosum were strongly correlated with processing speed in amnestic mild cognitive impairment ( r = |0.80–0.82|, P &lt; .001).

CONCLUSIONS: These findings have implications for the course and spatial progression of white matter degeneration in Alzheimer disease, suggest the mechanisms by which these changes occur, and demonstrate the viability of these white matter tract integrity metrics as potential neuroimaging biomarkers of the earliest stages of Alzheimer disease and disease progression.

AD
:   Alzheimer disease
aMCI
:   amnestic mild cognitive impairment
AWF
:   axonal water fraction
CPS
:   composite processing speed
DKI
:   diffusional kurtosis imaging
FA
:   fractional anisotropy
NC
:   healthy controls
TBSS
:   tract-based spatial statistics
WMTI
:   white matter tract integrity" />
<meta name="DC.Contributor" content="E. Fieremans" />
<meta name="DC.Contributor" content="A. Benitez" />
<meta name="DC.Contributor" content="J.H. Jensen" />
<meta name="DC.Contributor" content="M.F. Falangola" />
<meta name="DC.Contributor" content="A. Tabesh" />
<meta name="DC.Contributor" content="R.L. Deardorff" />
<meta name="DC.Contributor" content="M.V.S. Spampinato" />
<meta name="DC.Contributor" content="J.S. Babb" />
<meta name="DC.Contributor" content="D.S. Novikov" />
<meta name="DC.Contributor" content="S.H. Ferris" />
<meta name="DC.Contributor" content="J.A. Helpern" />
<meta name="article:published_time" content="2013-11-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Along with cortical abnormalities, white matter microstructural changes such as axonal loss and myelin breakdown are implicated in the pathogenesis of Alzheimer disease. Recently, a white matter model was introduced that relates non-Gaussian diffusional kurtosis imaging metrics to characteristics of white matter tract integrity, including the axonal water fraction, the intra-axonal diffusivity, and the extra-axonal axial and radial diffusivities.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This study reports these white matter tract integrity metrics in subjects with amnestic mild cognitive impairment (&lt;i&gt;n&lt;/i&gt; = 12), Alzheimer disease (&lt;i&gt;n&lt;/i&gt; = 14), and age-matched healthy controls (&lt;i&gt;n&lt;/i&gt; = 15) in an effort to investigate their sensitivity, diagnostic accuracy, and associations with white matter changes through the course of Alzheimer disease.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;With tract-based spatial statistics and region-of-interest analyses, increased diffusivity in the extra-axonal space (extra-axonal axial and radial diffusivities) in several white matter tracts sensitively and accurately discriminated healthy controls from those with amnestic mild cognitive impairment (area under the receiver operating characteristic curve = 0.82–0.95), while widespread decreased axonal water fraction discriminated amnestic mild cognitive impairment from Alzheimer disease (area under the receiver operating characteristic curve = 0.84). Additionally, these white matter tract integrity metrics in the body of the corpus callosum were strongly correlated with processing speed in amnestic mild cognitive impairment (&lt;i&gt;r&lt;/i&gt; = |0.80–0.82|, &lt;i&gt;P&lt;/i&gt; &amp;lt; .001).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;These findings have implications for the course and spatial progression of white matter degeneration in Alzheimer disease, suggest the mechanisms by which these changes occur, and demonstrate the viability of these white matter tract integrity metrics as potential neuroimaging biomarkers of the earliest stages of Alzheimer disease and disease progression.&lt;/p&gt;" />
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<meta name="twitter:title" content="Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Along with cortical abnormalities, white matter microstructural changes such as axonal loss and myelin breakdown are implicated in the pathogenesis of Alzheimer disease. Recently, a white matter model was introduced that relates non-Gaussian diffusional kurtosis imaging metrics to characteristics of white matter tract integrity, including the axonal water fraction, the intra-axonal diffusivity, and the extra-axonal axial and radial diffusivities.

MATERIALS AND METHODS: This study reports these white matter tract integrity metrics in subjects with amnestic mild cognitive impairment ( n = 12), Alzheimer disease ( n = 14), and age-matched healthy controls ( n = 15) in an effort to investigate their sensitivity, diagnostic accuracy, and associations with white matter changes through the course of Alzheimer disease.

RESULTS: With tract-based spatial statistics and region-of-interest analyses, increased diffusivity in the extra-axonal space (extra-axonal axial and radial diffusivities) in several white matter tracts sensitively and accurately discriminated healthy controls from those with amnestic mild cognitive impairment (area under the receiver operating characteristic curve = 0.82–0.95), while widespread decreased axonal water fraction discriminated amnestic mild cognitive impairment from Alzheimer disease (area under the receiver operating characteristic curve = 0.84). Additionally, these white matter tract integrity metrics in the body of the corpus callosum were strongly correlated with processing speed in amnestic mild cognitive impairment ( r = |0.80–0.82|, P &lt; .001).

CONCLUSIONS: These findings have implications for the course and spatial progression of white matter degeneration in Alzheimer disease, suggest the mechanisms by which these changes occur, and demonstrate the viability of these white matter tract integrity metrics as potential neuroimaging biomarkers of the earliest stages of Alzheimer disease and disease progression.

AD
:   Alzheimer disease
aMCI
:   amnestic mild cognitive impairment
AWF
:   axonal water fraction
CPS
:   composite processing speed
DKI
:   diffusional kurtosis imaging
FA
:   fractional anisotropy
NC
:   healthy controls
TBSS
:   tract-based spatial statistics
WMTI
:   white matter tract integrity" />
<meta name="og-title" property="og:title" content="Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/34/11/2105" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Along with cortical abnormalities, white matter microstructural changes such as axonal loss and myelin breakdown are implicated in the pathogenesis of Alzheimer disease. Recently, a white matter model was introduced that relates non-Gaussian diffusional kurtosis imaging metrics to characteristics of white matter tract integrity, including the axonal water fraction, the intra-axonal diffusivity, and the extra-axonal axial and radial diffusivities.

MATERIALS AND METHODS: This study reports these white matter tract integrity metrics in subjects with amnestic mild cognitive impairment ( n = 12), Alzheimer disease ( n = 14), and age-matched healthy controls ( n = 15) in an effort to investigate their sensitivity, diagnostic accuracy, and associations with white matter changes through the course of Alzheimer disease.

RESULTS: With tract-based spatial statistics and region-of-interest analyses, increased diffusivity in the extra-axonal space (extra-axonal axial and radial diffusivities) in several white matter tracts sensitively and accurately discriminated healthy controls from those with amnestic mild cognitive impairment (area under the receiver operating characteristic curve = 0.82–0.95), while widespread decreased axonal water fraction discriminated amnestic mild cognitive impairment from Alzheimer disease (area under the receiver operating characteristic curve = 0.84). Additionally, these white matter tract integrity metrics in the body of the corpus callosum were strongly correlated with processing speed in amnestic mild cognitive impairment ( r = |0.80–0.82|, P &lt; .001).

CONCLUSIONS: These findings have implications for the course and spatial progression of white matter degeneration in Alzheimer disease, suggest the mechanisms by which these changes occur, and demonstrate the viability of these white matter tract integrity metrics as potential neuroimaging biomarkers of the earliest stages of Alzheimer disease and disease progression.

AD
:   Alzheimer disease
aMCI
:   amnestic mild cognitive impairment
AWF
:   axonal water fraction
CPS
:   composite processing speed
DKI
:   diffusional kurtosis imaging
FA
:   fractional anisotropy
NC
:   healthy controls
TBSS
:   tract-based spatial statistics
WMTI
:   white matter tract integrity" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12697--5" data-node-nid="12697" id="top-node-12697--6566170065" data-pisa="ajnr;34/11/2105" data-pisa-master="ajnr;ajnr.A3553" data-apath="/ajnr/34/11/2105.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">E. Fieremans</span>, <span class="highwire-citation-author" data-delta="1">A. Benitez</span>, <span class="highwire-citation-author" data-delta="2">J.H. Jensen</span>, <span class="highwire-citation-author" data-delta="3">M.F. Falangola</span>, <span class="highwire-citation-author" data-delta="4">A. Tabesh</span>, <span class="highwire-citation-author" data-delta="5">R.L. Deardorff</span>, <span class="highwire-citation-author" data-delta="6">M.V.S. Spampinato</span>, <span class="highwire-citation-author" data-delta="7">J.S. Babb</span>, <span class="highwire-citation-author" data-delta="8">D.S. Novikov</span>, <span class="highwire-citation-author" data-delta="9">S.H. Ferris</span> and <span class="highwire-citation-author" data-delta="10">J.A. Helpern</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2013,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2105-2112; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3553 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12697--6566170065" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">E. Fieremans </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (E.F., J.S.B., D.S.N.), Center for Biomedical Imaging</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BFieremans%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fieremans%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BFieremans%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A. Benitez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BBenitez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Benitez%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BBenitez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">J.H. Jensen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.H.%2BJensen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jensen%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.H.%2BJensen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M.F. Falangola </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurosciences (M.F.F., J.A.H.), Medical University of South Carolina, Charleston, South Carolina.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.F.%2BFalangola%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Falangola%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.F.%2BFalangola%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">A. Tabesh </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BTabesh%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tabesh%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BTabesh%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">R.L. Deardorff </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.L.%2BDeardorff%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Deardorff%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.L.%2BDeardorff%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">M.V.S. Spampinato </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.V.S.%2BSpampinato%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Spampinato%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.V.S.%2BSpampinato%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">J.S. Babb </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (E.F., J.S.B., D.S.N.), Center for Biomedical Imaging</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.S.%2BBabb%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Babb%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.S.%2BBabb%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">D.S. Novikov </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (E.F., J.S.B., D.S.N.), Center for Biomedical Imaging</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.S.%2BNovikov%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Novikov%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.S.%2BNovikov%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">S.H. Ferris </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Psychiatry (S.H.F.) and Alzheimer's Disease Center, New York University School of Medicine, New York, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.H.%2BFerris%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ferris%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.H.%2BFerris%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">J.A. Helpern </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology and Radiological Science (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Biomedical Imaging (A.B., J.H.J., M.F.F., A.T., R.L.D., M.V.S.S., J.A.H.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurosciences (M.F.F., J.A.H.), Medical University of South Carolina, Charleston, South Carolina.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.A.%2BHelpern%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Helpern%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.A.%2BHelpern%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2>REFERENCES</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a>

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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 34</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 11 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 2013 </div></div>
      
      
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      <div class="highwire-cite-title">Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Fieremans</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Benitez</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Jensen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.F.</span> <span class="nlm-surname">Falangola</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tabesh</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">R.L.</span> <span class="nlm-surname">Deardorff</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">M.V.S.</span> <span class="nlm-surname">Spampinato</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">J.S.</span> <span class="nlm-surname">Babb</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">D.S.</span> <span class="nlm-surname">Novikov</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.H.</span> <span class="nlm-surname">Ferris</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Helpern</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2105-2112; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3553 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Fieremans</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Benitez</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Jensen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.F.</span> <span class="nlm-surname">Falangola</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tabesh</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">R.L.</span> <span class="nlm-surname">Deardorff</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">M.V.S.</span> <span class="nlm-surname">Spampinato</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">J.S.</span> <span class="nlm-surname">Babb</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">D.S.</span> <span class="nlm-surname">Novikov</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.H.</span> <span class="nlm-surname">Ferris</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Helpern</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2105-2112; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3553 </span></div>
  
  
  
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