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<meta name="HW.identifier" content="/ajnr/34/11/2144.atom" />
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<meta name="DC.Language" content="en" />
<meta name="DC.Title" content="Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3569" />
<meta name="DC.Date" content="2013-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2013 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: It has been demonstrated that increased levels of iron in the brain occur with aging. In this study we investigated the nature of the association between age and SWI-filtered phase values, indicative of iron content, in the subcortical deep gray matter of healthy individuals.

MATERIALS AND METHODS: A total of 210 healthy individuals (men: n = 89, women: n = 121), mean age, 39.8 years (standard deviation = 15.5; range = 6–76 years), were imaged on a 3T scanner. Mean MRI phase, mean phase of low-phase voxels, and normalized volumes were determined for total subcortical deep gray matter, caudate, putamen, globus pallidus, thalamus, pulvinar nucleus, hippocampus, amygdala, nucleus accumbens, red nucleus, and substantia nigra. Linear and nonlinear regression models were used to explore the relationship between phase and volume measures, and aging.

RESULTS: Mean phase values of subcortical deep gray matter structures showed a quadratic relationship, with individuals in late middle age (40–59 years) having the lowest mean phase values, followed by a reversal of this trend in the elderly. In contrast, mean phase of low-phase voxel measurements showed strong negative linear relationships with aging. Significantly lower phase values were detected in women compared with men ( P &lt; .001), whereas no sex differences were observed for mean phase of low-phase voxels. Normalized volume measurements were also linearly related to aging, and women showed smaller normalized volumes of subcortical deep gray matter structures than men ( P &lt; .001). Lower mean phase of low-phase voxels was related to decreased volume measures.

CONCLUSIONS: A strong association between phase (quadratic effect; phase decreases are followed by increases), mean phase of low-phase voxels (linear effect), volume (linear effect), and age was observed. Low phase was related to brain atrophy.

SDGM
:   subcortical deep gray matter
MP-LPV
:   mean phase of low-phase voxels
NC
:   neocortex" />
<meta name="DC.Contributor" content="J. Hagemeier" />
<meta name="DC.Contributor" content="M.G. Dwyer" />
<meta name="DC.Contributor" content="N. Bergsland" />
<meta name="DC.Contributor" content="F. Schweser" />
<meta name="DC.Contributor" content="C.R. Magnano" />
<meta name="DC.Contributor" content="M. Heininen-Brown" />
<meta name="DC.Contributor" content="D.P. Ramasamy" />
<meta name="DC.Contributor" content="E. Carl" />
<meta name="DC.Contributor" content="C. Kennedy" />
<meta name="DC.Contributor" content="R. Melia" />
<meta name="DC.Contributor" content="P. Polak" />
<meta name="DC.Contributor" content="A. Deistung" />
<meta name="DC.Contributor" content="J.J.G. Geurts" />
<meta name="DC.Contributor" content="J.R. Reichenbach" />
<meta name="DC.Contributor" content="R. Zivadinov" />
<meta name="article:published_time" content="2013-11-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;It has been demonstrated that increased levels of iron in the brain occur with aging. In this study we investigated the nature of the association between age and SWI-filtered phase values, indicative of iron content, in the subcortical deep gray matter of healthy individuals.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A total of 210 healthy individuals (men: &lt;i&gt;n&lt;/i&gt; = 89, women: &lt;i&gt;n&lt;/i&gt; = 121), mean age, 39.8 years (standard deviation = 15.5; range = 6–76 years), were imaged on a 3T scanner. Mean MRI phase, mean phase of low-phase voxels, and normalized volumes were determined for total subcortical deep gray matter, caudate, putamen, globus pallidus, thalamus, pulvinar nucleus, hippocampus, amygdala, nucleus accumbens, red nucleus, and substantia nigra. Linear and nonlinear regression models were used to explore the relationship between phase and volume measures, and aging.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Mean phase values of subcortical deep gray matter structures showed a quadratic relationship, with individuals in late middle age (40–59 years) having the lowest mean phase values, followed by a reversal of this trend in the elderly. In contrast, mean phase of low-phase voxel measurements showed strong negative linear relationships with aging. Significantly lower phase values were detected in women compared with men (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001), whereas no sex differences were observed for mean phase of low-phase voxels. Normalized volume measurements were also linearly related to aging, and women showed smaller normalized volumes of subcortical deep gray matter structures than men (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001). Lower mean phase of low-phase voxels was related to decreased volume measures.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;A strong association between phase (quadratic effect; phase decreases are followed by increases), mean phase of low-phase voxels (linear effect), volume (linear effect), and age was observed. Low phase was related to brain atrophy.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2013/11/01" />
<meta name="citation_mjid" content="ajnr;34/11/2144" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A3569" />
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<meta name="citation_volume" content="34" />
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<meta name="citation_firstpage" content="2144" />
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<meta name="citation_author" content="J. Hagemeier" />
<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
<meta name="citation_author" content="M.G. Dwyer" />
<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
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<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
<meta name="citation_author" content="F. Schweser" />
<meta name="citation_author_institution" content="bMedical Physics Group (F.S., A.D., J.R.R.), Institute of Diagnostic and Interventional Radiology I, Jena University Hospital–Friedrich Schiller University, Jena, Germany" />
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<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
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<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
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<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
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<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
<meta name="citation_author" content="C. Kennedy" />
<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
<meta name="citation_author" content="R. Melia" />
<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
<meta name="citation_author" content="P. Polak" />
<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
<meta name="citation_author" content="A. Deistung" />
<meta name="citation_author_institution" content="bMedical Physics Group (F.S., A.D., J.R.R.), Institute of Diagnostic and Interventional Radiology I, Jena University Hospital–Friedrich Schiller University, Jena, Germany" />
<meta name="citation_author" content="J.J.G. Geurts" />
<meta name="citation_author_institution" content="cDepartment of Anatomy and Neurosciences (J.J.G.G.), Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands." />
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<meta name="citation_author_institution" content="bMedical Physics Group (F.S., A.D., J.R.R.), Institute of Diagnostic and Interventional Radiology I, Jena University Hospital–Friedrich Schiller University, Jena, Germany" />
<meta name="citation_author" content="R. Zivadinov" />
<meta name="citation_author_institution" content="aFrom the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York" />
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<meta name="twitter:title" content="Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/34/11.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: It has been demonstrated that increased levels of iron in the brain occur with aging. In this study we investigated the nature of the association between age and SWI-filtered phase values, indicative of iron content, in the subcortical deep gray matter of healthy individuals.

MATERIALS AND METHODS: A total of 210 healthy individuals (men: n = 89, women: n = 121), mean age, 39.8 years (standard deviation = 15.5; range = 6–76 years), were imaged on a 3T scanner. Mean MRI phase, mean phase of low-phase voxels, and normalized volumes were determined for total subcortical deep gray matter, caudate, putamen, globus pallidus, thalamus, pulvinar nucleus, hippocampus, amygdala, nucleus accumbens, red nucleus, and substantia nigra. Linear and nonlinear regression models were used to explore the relationship between phase and volume measures, and aging.

RESULTS: Mean phase values of subcortical deep gray matter structures showed a quadratic relationship, with individuals in late middle age (40–59 years) having the lowest mean phase values, followed by a reversal of this trend in the elderly. In contrast, mean phase of low-phase voxel measurements showed strong negative linear relationships with aging. Significantly lower phase values were detected in women compared with men ( P &lt; .001), whereas no sex differences were observed for mean phase of low-phase voxels. Normalized volume measurements were also linearly related to aging, and women showed smaller normalized volumes of subcortical deep gray matter structures than men ( P &lt; .001). Lower mean phase of low-phase voxels was related to decreased volume measures.

CONCLUSIONS: A strong association between phase (quadratic effect; phase decreases are followed by increases), mean phase of low-phase voxels (linear effect), volume (linear effect), and age was observed. Low phase was related to brain atrophy.

SDGM
:   subcortical deep gray matter
MP-LPV
:   mean phase of low-phase voxels
NC
:   neocortex" />
<meta name="og-title" property="og:title" content="Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/34/11/2144" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: It has been demonstrated that increased levels of iron in the brain occur with aging. In this study we investigated the nature of the association between age and SWI-filtered phase values, indicative of iron content, in the subcortical deep gray matter of healthy individuals.

MATERIALS AND METHODS: A total of 210 healthy individuals (men: n = 89, women: n = 121), mean age, 39.8 years (standard deviation = 15.5; range = 6–76 years), were imaged on a 3T scanner. Mean MRI phase, mean phase of low-phase voxels, and normalized volumes were determined for total subcortical deep gray matter, caudate, putamen, globus pallidus, thalamus, pulvinar nucleus, hippocampus, amygdala, nucleus accumbens, red nucleus, and substantia nigra. Linear and nonlinear regression models were used to explore the relationship between phase and volume measures, and aging.

RESULTS: Mean phase values of subcortical deep gray matter structures showed a quadratic relationship, with individuals in late middle age (40–59 years) having the lowest mean phase values, followed by a reversal of this trend in the elderly. In contrast, mean phase of low-phase voxel measurements showed strong negative linear relationships with aging. Significantly lower phase values were detected in women compared with men ( P &lt; .001), whereas no sex differences were observed for mean phase of low-phase voxels. Normalized volume measurements were also linearly related to aging, and women showed smaller normalized volumes of subcortical deep gray matter structures than men ( P &lt; .001). Lower mean phase of low-phase voxels was related to decreased volume measures.

CONCLUSIONS: A strong association between phase (quadratic effect; phase decreases are followed by increases), mean phase of low-phase voxels (linear effect), volume (linear effect), and age was observed. Low phase was related to brain atrophy.

SDGM
:   subcortical deep gray matter
MP-LPV
:   mean phase of low-phase voxels
NC
:   neocortex" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12699--5" data-node-nid="12699" id="top-node-12699--61708318631" data-pisa="ajnr;34/11/2144" data-pisa-master="ajnr;ajnr.A3569" data-apath="/ajnr/34/11/2144.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J. Hagemeier</span>, <span class="highwire-citation-author" data-delta="1">M.G. Dwyer</span>, <span class="highwire-citation-author" data-delta="2">N. Bergsland</span>, <span class="highwire-citation-author" data-delta="3">F. Schweser</span>, <span class="highwire-citation-author" data-delta="4">C.R. Magnano</span>, <span class="highwire-citation-author" data-delta="5">M. Heininen-Brown</span>, <span class="highwire-citation-author" data-delta="6">D.P. Ramasamy</span>, <span class="highwire-citation-author" data-delta="7">E. Carl</span>, <span class="highwire-citation-author" data-delta="8">C. Kennedy</span>, <span class="highwire-citation-author" data-delta="9">R. Melia</span>, <span class="highwire-citation-author" data-delta="10">P. Polak</span>, <span class="highwire-citation-author" data-delta="11">A. Deistung</span>, <span class="highwire-citation-author" data-delta="12">J.J.G. Geurts</span>, <span class="highwire-citation-author" data-delta="13">J.R. Reichenbach</span> and <span class="highwire-citation-author" data-delta="14">R. Zivadinov</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2013,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2144-2151; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3569 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12699--61708318631" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J. Hagemeier </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BHagemeier%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hagemeier%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2BHagemeier%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M.G. Dwyer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.G.%2BDwyer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dwyer%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.G.%2BDwyer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">N. Bergsland </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BBergsland%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bergsland%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AN.%2BBergsland%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">F. Schweser </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Medical Physics Group (F.S., A.D., J.R.R.), Institute of Diagnostic and Interventional Radiology I, Jena University Hospital–Friedrich Schiller University, Jena, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BSchweser%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Schweser%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BSchweser%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">C.R. Magnano </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.R.%2BMagnano%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Magnano%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.R.%2BMagnano%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M. Heininen-Brown </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BHeininen-Brown%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Heininen-Brown%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BHeininen-Brown%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">D.P. Ramasamy </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.P.%2BRamasamy%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ramasamy%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.P.%2BRamasamy%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">E. Carl </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BCarl%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Carl%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BCarl%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">C. Kennedy </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BKennedy%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kennedy%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BKennedy%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">R. Melia </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BMelia%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Melia%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BMelia%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">P. Polak </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Buffalo Neuroimaging Analysis Center (J.H., M.G.D., N.B., C.R.M., M.H.-B., D.P.R., E.C., C.K., R.M., P.P., R.Z.), Department of Neurology, University at Buffalo, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BPolak%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Polak%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.%2BPolak%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">A. Deistung </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Medical Physics Group (F.S., A.D., J.R.R.), Institute of Diagnostic and Interventional Radiology I, Jena University Hospital–Friedrich Schiller University, Jena, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BDeistung%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Deistung%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BDeistung%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">J.J.G. 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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Hagemeier</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.G.</span> <span class="nlm-surname">Dwyer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Bergsland</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Schweser</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">C.R.</span> <span class="nlm-surname">Magnano</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Heininen-Brown</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">D.P.</span> <span class="nlm-surname">Ramasamy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Carl</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Kennedy</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Melia</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Polak</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Deistung</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">J.J.G.</span> <span class="nlm-surname">Geurts</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">J.R.</span> <span class="nlm-surname">Reichenbach</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Zivadinov</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2144-2151; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3569 </span></div>
  
  
  
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      <div class="highwire-cite-title">Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Hagemeier</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.G.</span> <span class="nlm-surname">Dwyer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Bergsland</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Schweser</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">C.R.</span> <span class="nlm-surname">Magnano</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Heininen-Brown</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">D.P.</span> <span class="nlm-surname">Ramasamy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Carl</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Kennedy</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Melia</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Polak</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Deistung</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">J.J.G.</span> <span class="nlm-surname">Geurts</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">J.R.</span> <span class="nlm-surname">Reichenbach</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Zivadinov</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2144-2151; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3569 </span></div>
  
  
  
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