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<meta name="DC.Title" content="Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3256" />
<meta name="DC.Date" content="2013-03-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2013 by American Journal of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries.

MATERIALS AND METHODS: Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E1) and perpendicular (E23) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery.

RESULTS: In presurgical measures of the genu of the CC, higher E23 ( P = .018 ) , higher ADC ( P = .026), and lower FA ( P = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E23 ( P = .013 ) , higher ADC ( P = .012), and lower FA ( P = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups.

CONCLUSIONS: We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E23, high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.

CC
:   corpus callosum
CHD
:   congenital heart disease
CPB
:   cardiopulmonary bypass surgery
d-TGA
:   dextrotransposition of the great artery
FA
:   fractional anisotropy
HC
:   healthy controls" />
<meta name="DC.Contributor" content="M. Makki" />
<meta name="DC.Contributor" content="I. Scheer" />
<meta name="DC.Contributor" content="C. Hagmann" />
<meta name="DC.Contributor" content="R. Liamlahi" />
<meta name="DC.Contributor" content="W. Knirsch" />
<meta name="DC.Contributor" content="H. Dave" />
<meta name="DC.Contributor" content="V. Bernet" />
<meta name="DC.Contributor" content="K. Batinic" />
<meta name="DC.Contributor" content="B. Latal" />
<meta name="article:published_time" content="2013-03-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E&lt;sub&gt;1&lt;/sub&gt;) and perpendicular (E&lt;sub&gt;23&lt;/sub&gt;) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;In presurgical measures of the genu of the CC, higher E&lt;sub&gt;23&lt;/sub&gt; (&lt;i&gt;P&lt;/i&gt; = .018&lt;i&gt;)&lt;/i&gt;, higher ADC (&lt;i&gt;P&lt;/i&gt; = .026), and lower FA (&lt;i&gt;P&lt;/i&gt; = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E&lt;sub&gt;23&lt;/sub&gt; (&lt;i&gt;P&lt;/i&gt; = .013&lt;i&gt;)&lt;/i&gt;, higher ADC (&lt;i&gt;P&lt;/i&gt; = .012), and lower FA (&lt;i&gt;P&lt;/i&gt; = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E&lt;sub&gt;23&lt;/sub&gt;, high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.&lt;/p&gt;" />
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<meta name="twitter:title" content="Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries.

MATERIALS AND METHODS: Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E1) and perpendicular (E23) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery.

RESULTS: In presurgical measures of the genu of the CC, higher E23 ( P = .018 ) , higher ADC ( P = .026), and lower FA ( P = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E23 ( P = .013 ) , higher ADC ( P = .012), and lower FA ( P = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups.

CONCLUSIONS: We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E23, high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.

CC
:   corpus callosum
CHD
:   congenital heart disease
CPB
:   cardiopulmonary bypass surgery
d-TGA
:   dextrotransposition of the great artery
FA
:   fractional anisotropy
HC
:   healthy controls" />
<meta name="og-title" property="og:title" content="Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/34/3/634" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries.

MATERIALS AND METHODS: Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E1) and perpendicular (E23) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery.

RESULTS: In presurgical measures of the genu of the CC, higher E23 ( P = .018 ) , higher ADC ( P = .026), and lower FA ( P = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E23 ( P = .013 ) , higher ADC ( P = .012), and lower FA ( P = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups.

CONCLUSIONS: We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E23, high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.

CC
:   corpus callosum
CHD
:   congenital heart disease
CPB
:   cardiopulmonary bypass surgery
d-TGA
:   dextrotransposition of the great artery
FA
:   fractional anisotropy
HC
:   healthy controls" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12276--5" data-node-nid="12276" id="top-node-12276--6186422064" data-pisa="ajnr;34/3/634" data-pisa-master="ajnr;ajnr.A3256" data-apath="/ajnr/34/3/634.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M. Makki</span>, <span class="highwire-citation-author" data-delta="1">I. Scheer</span>, <span class="highwire-citation-author" data-delta="2">C. Hagmann</span>, <span class="highwire-citation-author" data-delta="3">R. Liamlahi</span>, <span class="highwire-citation-author" data-delta="4">W. Knirsch</span>, <span class="highwire-citation-author" data-delta="5">H. Dave</span>, <span class="highwire-citation-author" data-delta="6">V. Bernet</span>, <span class="highwire-citation-author" data-delta="7">K. Batinic</span> and <span class="highwire-citation-author" data-delta="8">B. Latal</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2013,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">634-640; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3256 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12276--6186422064" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M. Makki </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Diagnostic Imaging (M.M., I.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BMakki%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Makki%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BMakki%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">I. Scheer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Diagnostic Imaging (M.M., I.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.%2BScheer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Scheer%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AI.%2BScheer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">C. Hagmann </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Clinic of Neonatology (C.H.), University Hospital of Zurich, Zurich, Switzerland.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BHagmann%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hagmann%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BHagmann%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">R. Liamlahi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Division of Cardiology (R.L., W.K., K.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BLiamlahi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Liamlahi%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BLiamlahi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">W. Knirsch </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Division of Cardiology (R.L., W.K., K.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.%2BKnirsch%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Knirsch%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AW.%2BKnirsch%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">H. Dave </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Congenital Cardiovascular Surgery (H.D.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BDave%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dave%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.%2BDave%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">V. Bernet </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Pediatric Intensive Care and Neonatology (V.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.%2BBernet%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bernet%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AV.%2BBernet%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">K. Batinic </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Division of Cardiology (R.L., W.K., K.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BBatinic%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Batinic%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.%2BBatinic%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">B. 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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries.</p>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E<sub>1</sub>) and perpendicular (E<sub>23</sub>) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery.</p>
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<p id="p-3"><strong>RESULTS:</strong> In presurgical measures of the genu of the CC, higher E<sub>23</sub> (<em>P</em> = .018<em>)</em>, higher ADC (<em>P</em> = .026), and lower FA (<em>P</em> = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E<sub>23</sub> (<em>P</em> = .013<em>)</em>, higher ADC (<em>P</em> = .012), and lower FA (<em>P</em> = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups.</p>
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<p id="p-4"><strong>CONCLUSIONS:</strong> We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E<sub>23</sub>, high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.</p>
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</div><div class="section glossary" id="glossary-1"><h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">CC<span class="def-item-dt-sep"></span></dt><dd>corpus callosum<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">CHD<span class="def-item-dt-sep"></span></dt><dd>congenital heart disease<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">CPB<span class="def-item-dt-sep"></span></dt><dd>cardiopulmonary bypass surgery<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">d-TGA<span class="def-item-dt-sep"></span></dt><dd>dextrotransposition of the great artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">HC<span class="def-item-dt-sep"></span></dt><dd>healthy controls</dd></dl>
</div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2013 by American Journal of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/34/3/634.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 34</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Mar 2013 </div></div>
      
      
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      <div class="highwire-cite-title">Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">634-640; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3256 </span></div>
  
  
  
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      <div class="highwire-cite-title">Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Makki</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Scheer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Hagmann</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Liamlahi</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Knirsch</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Dave</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Bernet</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Batinic</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Latal</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">634-640; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3256 </span></div>
  
  
  
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