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    MR Imaging Assessment of Tumor Perfusion and 3D Segmented Volume at Baseline, during Treatment, and at Tumor Progression in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticlePediatrics

  
      
Open Access

  
      
MR Imaging Assessment of Tumor Perfusion and 3D Segmented Volume at Baseline, during Treatment, and at Tumor Progression in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
  
    	
J. Sedlacik, A. Winchell, M. Kocak, R.B. Loeffler, A. Broniscer and C.M. Hillenbrand

  
    	
American Journal of Neuroradiology July 2013,  34 (7) 1450-1455; DOI: https://doi.org/10.3174/ajnr.A3421 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
REFERENCES
  1. 1.↵


    1. Broniscer  A, 
    2. Gajjar  A
    . Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. Oncologist 2004;9:197–206
    Abstract/FREE Full Text
  2. 2.↵


    1. Hargrave  D, 
    2. Bartels  U, 
    3. Bouffet  E
    . Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol 2006;7:241–48
    CrossRefPubMedWeb of Science
  3. 3.↵


    1. Broniscer  A, 
    2. Baker  JN, 
    3. Tagen  M, 
    4. et al
    . Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma. J Clin Oncol 2010;28:4762–68
    Abstract/FREE Full Text
  4. 4.↵


    1. Hargrave  D, 
    2. Chuang  N, 
    3. Bouffet  E
    . Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma. J Neurooncol 2008;86:313–19
    CrossRefPubMed
  5. 5.↵


    1. Sedlacik  J, 
    2. Lobel  U, 
    3. Kocak  M, 
    4. et al
    . Attenuation of cerebral venous contrast in susceptibility-weighted imaging of spontaneously breathing pediatric patients sedated with propofol. AJNR Am J Neuroradiol 2010;31:901–06
    Abstract/FREE Full Text
  6. 6.↵


    1. Mugler  JP  III., 
    2. Wald  LL, 
    3. Brookeman  JR
    . T2-weighted 3D spin echo train imaging of the brain at 3 Tesla: Reduced power deposition using low flip-angle refocusing RF pulses. In: Proceedings of the International Society for Magnetic Resonance Imaging; April 21–27, 2001; Glasgow, United Kingdom. Abstract 438
  7. 7.↵


    1. Zhang  Y, 
    2. Brady  M, 
    3. Smith  S
    . Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57
    CrossRefPubMedWeb of Science
  8. 8.↵


    1. Mugler  JP  3rd., 
    2. Brookeman  JR
    . Three-dimensional magnetization-prepared rapid gradient-echo imaging (3D MP RAGE). Magn Reson Med 1990;15:152–57
    CrossRefPubMedWeb of Science
  9. 9.↵


    1. Luh  WM, 
    2. Wong  EC, 
    3. Bandettini  PA, 
    4. et al
    . QUIPS S II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn Reson Med 1999;41:1246–54
    CrossRefPubMedWeb of Science
  10. 10.↵


    1. Thesen  S, 
    2. Heid  O, 
    3. Mueller  E, 
    4. et al
    . Prospective acquisition correction for head motion with image-based tracking for real-time fMRI. Magn Reson Med 2000;44:457–65
    CrossRefPubMedWeb of Science
  11. 11.↵


    1. Lüdemann  L, 
    2. Warmuth  C, 
    3. Plotkin  M, 
    4. et al
    . Brain tumor perfusion: comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and T2* contrast, pulsed arterial spin labeling, and H2(15)O positron emission tomography. Eur J Radiol 2009;70:465–74
    CrossRefPubMed
  12. 12.↵


    1. Wang  J, 
    2. Alsop  DC, 
    3. Li  L, 
    4. et al
    . Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn Reson Med 2002;48:242–54
    CrossRefPubMedWeb of Science
  13. 13.↵


    1. Ostergaard  L, 
    2. Sorensen  AG, 
    3. Kwong  KK, 
    4. et al
    . High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: experimental comparison and preliminary results. Magn Reson Med 1996;36:726–36
    CrossRefPubMedWeb of Science
  14. 14.↵


    1. Ostergaard  L, 
    2. Weisskoff  RM, 
    3. Chesler  DA, 
    4. et al
    . High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med 1996;36:715–25
    CrossRefPubMedWeb of Science
  15. 15.↵


    1. Jenkinson  M, 
    2. Bannister  P, 
    3. Brady  M, 
    4. et al
    . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–41
    CrossRefPubMedWeb of Science
  16. 16.↵


    1. Macdonald  DR, 
    2. Cascino  TL, 
    3. Schold  SC  Jr., 
    4. et al
    . Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 1990;8:1277–80
    Abstract
  17. 17.↵


    1. Poussaint  TY, 
    2. Kocak  M, 
    3. Vajapeyam  S, 
    4. et al
    . MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol 2011;13:417–27
    Abstract/FREE Full Text
  18. 18.↵


    1. Gutmann  R, 
    2. Leunig  M, 
    3. Feyh  J, 
    4. et al
    . Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res 1992;52:1993–95
    Abstract/FREE Full Text
  19. 19.↵


    1. Znati  CA, 
    2. Rosenstein  M, 
    3. Boucher  Y, 
    4. et al
    . Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft. Cancer Res 1996;56:964–68
    Abstract/FREE Full Text
  20. 20.↵


    1. Jain  RK, 
    2. Tong  RT, 
    3. Munn  LL
    . Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res 2007;67:2729–35
    Abstract/FREE Full Text
  21. 21.↵


    1. Sorensen  AG, 
    2. Emblem  KE, 
    3. Polaskova  P, 
    4. et al
    . Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res 2012;72:402–07
    Abstract/FREE Full Text
  22. 22.↵


    1. Law  M, 
    2. Young  RJ, 
    3. Babb  JS, 
    4. et al
    . Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2008;247:490–98
    CrossRefPubMedWeb of Science
  23. 23.↵


    1. Hipp  SJ, 
    2. Steffen-Smith  E, 
    3. Hammoud  D, 
    4. et al
    . Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging. Neuro Oncol 2011;13:904–09
    Abstract/FREE Full Text
  24. 24.↵


    1. Löbel  U, 
    2. Sedlacik  J, 
    3. Reddick  WE, 
    4. et al
    . Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol 2011;32:315–22
    Abstract/FREE Full Text
  25. 25.↵


    1. Young  R, 
    2. Babb  J, 
    3. Law  M, 
    4. et al
    . Comparison of region-of-interest analysis with three different histogram analysis methods in the determination of perfusion metrics in patients with brain gliomas. J Magn Reson Imaging 2007;26:1053–63
    CrossRefPubMed
  26. 26.↵


    1. Günther  M, 
    2. Oshio  K, 
    3. Feinberg  DA
    . Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements. Magn Reson Med 2005;54:491–98
    CrossRefPubMed
  27. 27.↵


    1. Song  R, 
    2. Loeffler  RB, 
    3. Hillenbrand  CM
    . QUIPS S II with window-sliding saturation sequence (Q2WISE). Magn Reson Med 2012;67:1127–32
    CrossRefPubMed
  28. 28.↵


    1. Willats  L, 
    2. Christensen  S, 
    3. Ma  HK, 
    4. et al
    . Validating a local Arterial Input Function method for improved perfusion quantification in stroke. J Cereb Blood Flow Metab 2011;31:2189–98
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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MR Imaging Assessment of Tumor Perfusion and 3D Segmented Volume at Baseline, during Treatment, and at Tumor Progression in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
  
    	
J. Sedlacik, A. Winchell, M. Kocak, R.B. Loeffler, A. Broniscer, C.M. Hillenbrand

  
    	
 American Journal of Neuroradiology Jul 2013, 34 (7) 1450-1455; DOI: 10.3174/ajnr.A3421 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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