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<meta name="DC.Title" content="Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3583" />
<meta name="DC.Date" content="2014-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2014 by American Journal of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

MATERIALS AND METHODS: A total of 43 first-contact, drug-naïve, patients with schizophrenia and 17 age-matched control participants were studied. All participants underwent T1-weighted MR imaging and DTI scans. Voxel-based morphometry and tract-based spatial statistics were used to compare GM volumes and WM DTI metrics between groups. MR imaging measures were correlated with the duration of the untreated psychosis and the clinical positive and negative symptoms.

RESULTS: Compared with control participants, patients with schizophrenia showed smaller volumes of the temporal, parietal, and occipital GM, and a pattern of decreased mean diffusivity and increased fractional anisotropy in the brain stem and cerebellum bilaterally, interhemispheric and cortico-cortical connections bilaterally, and right anterior and posterior limb of the internal capsule. In patients, decreased mean diffusivity and increased fractional anisotropy in several brain regions were related to a longer duration of the untreated psychosis and the severity of positive symptoms.

CONCLUSIONS: First-contact, drug-naïve, patients with schizophrenia present with volumetric and DTI changes, which correlated with their clinical features. This study increases our knowledge on the neural networks involved in the pathophysiologic mechanisms of schizophrenia.

DARTEL
:   Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra
DUP
:   duration of the untreated psychosis
FA
:   fractional anisotropy
MD
:   mean diffusivity
PANSS
:   Positive and Negative Syndrome Scales
MNI
:   Montreal Neurological Institute
TBSS
:   tract-based spatial statistics" />
<meta name="DC.Contributor" content="M. Filippi" />
<meta name="DC.Contributor" content="E. Canu" />
<meta name="DC.Contributor" content="R. Gasparotti" />
<meta name="DC.Contributor" content="F. Agosta" />
<meta name="DC.Contributor" content="P. Valsecchi" />
<meta name="DC.Contributor" content="G. Lodoli" />
<meta name="DC.Contributor" content="A. Galluzzo" />
<meta name="DC.Contributor" content="G. Comi" />
<meta name="DC.Contributor" content="E. Sacchetti" />
<meta name="article:published_time" content="2014-01-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A total of 43 first-contact, drug-naïve, patients with schizophrenia and 17 age-matched control participants were studied. All participants underwent T1-weighted MR imaging and DTI scans. Voxel-based morphometry and tract-based spatial statistics were used to compare GM volumes and WM DTI metrics between groups. MR imaging measures were correlated with the duration of the untreated psychosis and the clinical positive and negative symptoms.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Compared with control participants, patients with schizophrenia showed smaller volumes of the temporal, parietal, and occipital GM, and a pattern of decreased mean diffusivity and increased fractional anisotropy in the brain stem and cerebellum bilaterally, interhemispheric and cortico-cortical connections bilaterally, and right anterior and posterior limb of the internal capsule. In patients, decreased mean diffusivity and increased fractional anisotropy in several brain regions were related to a longer duration of the untreated psychosis and the severity of positive symptoms.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;First-contact, drug-naïve, patients with schizophrenia present with volumetric and DTI changes, which correlated with their clinical features. This study increases our knowledge on the neural networks involved in the pathophysiologic mechanisms of schizophrenia.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author_institution" content="aFrom the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience" />
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<meta name="citation_author_institution" content="cDepartment of Diagnostic Imaging (R.G., G.L.), Neuroradiology Unit, Brescia University School of Medicine, Spedali Civili, Brescia, Italy" />
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<meta name="citation_author_institution" content="aFrom the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience" />
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<meta name="citation_reference" content="citation_journal_title=Journal of psychiatric research;citation_journal_abbrev=J Psychiatr Res;citation_author=BD. Peters;citation_author=J. Blaas;citation_author=L. de Haan;citation_title=Diffusion tensor imaging in the early phase of schizophrenia: what have we learned?;citation_pages=993-1004;citation_volume=44;citation_year=2010;citation_issue=15;citation_pmid=20554292;citation_doi=10.1016/j.jpsychires.2010.05.003" />
<meta name="citation_reference" content="citation_journal_abbrev=Curr Top Behav Neurosci;citation_author=JJ. Levitt;citation_author=L. Bobrow;citation_author=D. Lucia;citation_title=A selective review of volumetric and morphometric imaging in schizophrenia.;citation_pages=243-281;citation_volume=4;citation_year=2010;citation_pmid=21312403;citation_doi=10.1007/7854_2010_53" />
<meta name="citation_reference" content="citation_journal_title=Schizophrenia research;citation_journal_abbrev=Schizophr Res;citation_author=I. Ellison-Wright;citation_author=E. Bullmore;citation_title=Meta-analysis of diffusion tensor imaging studies in schizophrenia.;citation_pages=3-10;citation_volume=108;citation_year=2009;citation_issue=1-3;citation_pmid=19128945;citation_doi=10.1016/j.schres.2008.11.021" />
<meta name="citation_reference" content="citation_journal_title=Psychological medicine;citation_journal_abbrev=Psychol Med;citation_author=V. Cheung;citation_author=C. Cheung;citation_author=GM. McAlonan;citation_title=A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia.;citation_pages=877-885;citation_volume=38;citation_year=2008;citation_issue=6;citation_pmid=17949516" />
<meta name="citation_reference" content="citation_journal_title=Psychological medicine;citation_journal_abbrev=Psychol Med;citation_author=V. Cheung;citation_author=CP. Chiu;citation_author=CW. Law;citation_title=Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia.;citation_pages=1709-1719;citation_volume=41;citation_year=2011;citation_issue=8;citation_pmid=20809999;citation_doi=10.1017/S003329171000156X" />
<meta name="citation_reference" content="citation_journal_title=Schizophrenia research;citation_journal_abbrev=Schizophr Res;citation_author=R. Gasparotti;citation_author=P. Valsecchi;citation_author=F. Carletti;citation_title=Reduced fractional anisotropy of corpus callosum in first-contact, antipsychotic drug-naive patients with schizophrenia.;citation_pages=41-48;citation_volume=108;citation_year=2009;citation_issue=1-3;citation_pmid=19103476;citation_doi=10.1016/j.schres.2008.11.015" />
<meta name="citation_reference" content="citation_journal_title=Neuroscience letters;citation_journal_abbrev=Neurosci Lett;citation_author=W. Guo;citation_author=F. Liu;citation_author=Z. Liu;citation_title=Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia.;citation_pages=5-9;citation_volume=531;citation_year=2012;citation_issue=1;citation_pmid=23022507;citation_doi=10.1016/j.neulet.2012.09.033" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=R. Pérez-Iglesias;citation_author=D. Tordesillas-Gutiérrez;citation_author=GJ. Barker;citation_title=White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging;citation_pages=199-204;citation_volume=49;citation_year=2010;citation_pmid=19619664;citation_doi=10.1016/j.neuroimage.2009.07.016" />
<meta name="citation_reference" content="citation_journal_title=Academic radiology;citation_journal_abbrev=Acad Radiol;citation_author=LQ. Zou;citation_author=JX. Xie;citation_author=HS. Yuan;citation_title=Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia.;citation_pages=285-289;citation_volume=15;citation_year=2008;citation_issue=3;citation_pmid=18280926;citation_doi=10.1016/j.acra.2007.09.026" />
<meta name="citation_reference" content="citation_journal_title=Neuropsychopharmacology :  official publication of the American College of Neuropsychopharmacology;citation_journal_abbrev=Neuropsychopharmacology;citation_author=PR. Szeszko;citation_author=DG. Robinson;citation_author=M. Ashtari;citation_title=Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia.;citation_pages=976-984;citation_volume=33;citation_year=2008;citation_issue=5;citation_pmid=17581532;citation_doi=10.1038/sj.npp.1301480" />
<meta name="citation_reference" content="citation_journal_title=Journal of psychiatric research;citation_journal_abbrev=J Psychiatr Res;citation_author=MF. Folstein;citation_author=SE. Folstein;citation_author=PR. McHugh;citation_title=&amp;quot;Mini-mental state&amp;quot;. A practical method for grading the cognitive state of patients for the clinician.;citation_pages=189-198;citation_volume=12;citation_year=1975;citation_issue=3;citation_pmid=1202204;citation_doi=10.1016/0022-3956(75)90026-6" />
<meta name="citation_reference" content="citation_title=WAIS-R Manual. Wechsler Adult Intelligence Scale Revised;citation_author=D. Wechsler;citation_year=1981" />
<meta name="citation_reference" content="citation_title=Diagnostic and Statistical Manual of Mental Disorders (DSM-IV);citation_year=1994" />
<meta name="citation_reference" content="citation_journal_title=Brain, behavior, and immunity;citation_journal_abbrev=Brain Behav Immun;citation_author=E. Sacchetti;citation_author=L. Bocchio-Chiavetto;citation_author=P. Valsecchi;citation_title=-G308A tumor necrosis factor alpha functional polymorphism and schizophrenia risk: meta-analysis plus association study.;citation_pages=450-457;citation_volume=21;citation_year=2007;citation_issue=4;citation_pmid=17234379;citation_doi=10.1016/j.bbi.2006.11.009" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Psychiatry;citation_journal_abbrev=Am. J. Psychiatry;citation_author=TJ. Craig;citation_author=EJ. Bromet;citation_author=S. Fennig;citation_title=Is There an Association Between Duration of Untreated Psychosis and 24-Month Clinical Outcome in a First-Admission Series?;citation_pages=60-66;citation_volume=157;citation_year=2000;citation_issue=1;citation_issn=0002-953X;citation_pmid=10618014" />
<meta name="citation_reference" content="citation_journal_title=Schizophr Bull;citation_author=SR. Kay;citation_author=A. Fiszbein;citation_author=LA. Opler;citation_title=The positive and negative syndrome scale (PANSS) for schizophrenia;citation_volume=13;citation_year=1987;citation_pmid=3616518;citation_doi=10.1093/schbul/13.2.261" />
<meta name="citation_reference" content="citation_journal_title=Human brain mapping;citation_journal_abbrev=Hum Brain Mapp;citation_author=TE. Nichols;citation_author=AP. Holmes;citation_title=Nonparametric permutation tests for functional neuroimaging: a primer with examples.;citation_pages=1-25;citation_volume=15;citation_year=2002;citation_issue=1;citation_pmid=11747097;citation_doi=10.1002/hbm.1058" />
<meta name="citation_reference" content="citation_journal_title=Molecular psychiatry;citation_journal_abbrev=Mol Psychiatry;citation_author=GM. Innocenti;citation_author=F. Ansermet;citation_author=J. Parnas;citation_title=Schizophrenia, neurodevelopment and corpus callosum.;citation_pages=261-274;citation_volume=8;citation_year=2003;citation_issue=3;citation_pmid=12660799;citation_doi=10.1038/sj.mp.4001205" />
<meta name="citation_reference" content="citation_journal_abbrev=Curr Opin Psychiatry;citation_author=M. Kyriakopoulos;citation_author=S. Frangou;citation_title=Recent diffusion tensor imaging findings in early stages of schizophrenia.;citation_pages=168-176;citation_volume=22;citation_year=2009;citation_issue=2;citation_pmid=19553871;citation_doi=10.1097/YCO.0b013e328325aa23" />
<meta name="citation_reference" content="citation_journal_title=Brain research bulletin;citation_journal_abbrev=Brain Res Bull;citation_author=N. Uranova;citation_author=D. Orlovskaya;citation_author=O. Vikhreva;citation_title=Electron microscopy of oligodendroglia in severe mental illness.;citation_pages=597-610;citation_volume=55;citation_year=2001;citation_issue=5;citation_pmid=11576756;citation_doi=10.1016/S0361-9230(01)00528-7" />
<meta name="citation_reference" content="citation_journal_title=European archives of psychiatry and clinical neuroscience;citation_journal_abbrev=Eur Arch Psychiatry Clin Neurosci;citation_author=K. Koch;citation_author=G. Wagner;citation_author=R. Dahnke;citation_title=Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia.;citation_pages=419-426;citation_volume=260;citation_year=2010;citation_issue=5;citation_pmid=19915989;citation_doi=10.1007/s00406-009-0087-0" />
<meta name="citation_reference" content="citation_journal_title=Neuroreport;citation_journal_abbrev=Neuroreport;citation_author=Z. Sun;citation_author=F. Wang;citation_author=L. Cui;citation_title=Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study.;citation_pages=1833-1836;citation_volume=14;citation_year=2003;citation_issue=14;citation_pmid=14534430;citation_doi=10.1097/00001756-200310060-00015" />
<meta name="citation_reference" content="citation_journal_title=Neurobiology of disease;citation_journal_abbrev=Neurobiol Dis;citation_author=A. Federspiel;citation_author=S. Begre;citation_author=C. Kiefer;citation_title=Alterations of white matter connectivity in first episode schizophrenia.;citation_pages=702-709;citation_volume=22;citation_year=2006;citation_issue=3;citation_pmid=16624566;citation_doi=10.1016/j.nbd.2006.01.015" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Psychiatry;citation_journal_abbrev=Am. J. Psychiatry;citation_author=SA. Chance;citation_author=JR. Highley;citation_author=MM. Esiri;citation_title=Fiber Content of the Fornix in Schizophrenia: Lack of Evidence for a Primary Limbic Encephalopathy;citation_pages=1720-1724;citation_volume=156;citation_year=1999;citation_issue=11;citation_issn=0002-953X;citation_pmid=10553734" />
<meta name="citation_reference" content="citation_journal_title=International review of neurobiology;citation_journal_abbrev=Int Rev Neurobiol;citation_author=O. Guillin;citation_author=A. Abi-Dargham;citation_author=M. Laruelle;citation_title=Neurobiology of dopamine in schizophrenia.;citation_pages=1-39;citation_volume=78;citation_year=2007;citation_pmid=17349856" />
<meta name="citation_reference" content="citation_journal_title=Archives of General Psychiatry;citation_journal_abbrev=Arch Gen Psychiatry;citation_author=D. Hubl;citation_author=T. Koenig;citation_author=W. Strik;citation_title=Pathways That Make Voices: White Matter Changes in Auditory Hallucinations;citation_pages=658-668;citation_volume=61;citation_year=2004;citation_issue=7;citation_issn=0003-990X;citation_pmid=15237078;citation_doi=10.1001/archpsyc.61.7.658" />
<meta name="citation_reference" content="citation_journal_title=The British Journal of Psychiatry;citation_journal_abbrev=Br. J. Psychiatry;citation_author=SS. Shergill;citation_author=MJ. Brammer;citation_author=R. Fukuda;citation_title=Engagement of brain areas implicated in processing inner speech in people with auditory hallucinations;citation_pages=525-531;citation_volume=182;citation_year=2003;citation_issue=6;citation_issn=0007-1250;citation_pmid=12777344;citation_doi=10.1192/bjp.182.6.525" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=JH. Seok;citation_author=HJ. Park;citation_author=JW. Chun;citation_title=White matter abnormalities associated with auditory hallucinations in schizophrenia: a combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging.;citation_pages=93-104;citation_volume=156;citation_year=2007;citation_issue=2;citation_pmid=17884391;citation_doi=10.1016/j.pscychresns.2007.02.002" />
<meta name="citation_reference" content="citation_journal_title=Biophysical Journal;citation_journal_abbrev=Biophys. J;citation_author=PJ. Basser;citation_author=J. Mattiello;citation_author=D. LeBihan;citation_title=MR diffusion tensor spectroscopy and imaging.;citation_pages=259-267;citation_volume=66;citation_year=1994;citation_issue=1;citation_issn=0006-3495;citation_pmid=8130344;citation_doi=10.1016/S0006-3495(94)80775-1" />
<meta name="citation_reference" content="citation_journal_title=NMR in biomedicine;citation_journal_abbrev=NMR Biomed;citation_author=C. Beaulieu;citation_title=The basis of anisotropic water diffusion in the nervous system - a technical review.;citation_pages=435-455;citation_volume=15;citation_year=2002;citation_issue=7-8;citation_pmid=12489094;citation_doi=10.1002/nbm.782" />
<meta name="citation_reference" content="citation_journal_title=NeuroImage;citation_journal_abbrev=Neuroimage;citation_author=SK. Song;citation_author=SW. Sun;citation_author=MJ. Ramsbottom;citation_title=Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water.;citation_pages=1429-1436;citation_volume=17;citation_year=2002;citation_issue=3;citation_pmid=12414282;citation_doi=10.1006/nimg.2002.1267" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=CA. Wheeler-Kingshott;citation_author=M. Cercignani;citation_title=About &quot;axial&quot; and &quot;radial&quot; diffusivities.;citation_pages=1255-1260;citation_volume=61;citation_year=2009;citation_issue=5;citation_pmid=19253405;citation_doi=10.1002/mrm.21965" />
<meta name="citation_reference" content="citation_journal_title=Schizophrenia research;citation_journal_abbrev=Schizophr Res;citation_author=E. Bora;citation_author=A. Fornito;citation_author=J. Radua;citation_title=Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis.;citation_pages=46-57;citation_volume=127;citation_year=2011;citation_issue=1-3;citation_pmid=21300524;citation_doi=10.1016/j.schres.2010.12.020" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=E. Di Rosa;citation_author=TJ. Crow;citation_author=MA. Walker;citation_title=Reduced neuron density, enlarged minicolumn spacing and altered ageing effects in fusiform cortex in schizophrenia.;citation_pages=102-115;citation_volume=166;citation_year=2009;citation_issue=2-3;citation_pmid=19250686;citation_doi=10.1016/j.psychres.2008.04.007" />
<meta name="citation_reference" content="citation_journal_title=Neuron;citation_journal_abbrev=Neuron;citation_author=P. Vuilleumier;citation_author=JL. Armony;citation_author=J. Driver;citation_title=Effects of attention and emotion on face processing in the human brain: an event-related fMRI study.;citation_pages=829-841;citation_volume=30;citation_year=2001;citation_issue=3;citation_pmid=11430815;citation_doi=10.1016/S0896-6273(01)00328-2" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=PA. Thomann;citation_author=M. Roebel;citation_author=V. Dos Santos;citation_title=Cerebellar substructures and neurological soft signs in first-episode schizophrenia.;citation_pages=83-87;citation_volume=173;citation_year=2009;citation_issue=2;citation_pmid=19540731;citation_doi=10.1016/j.pscychresns.2008.07.006" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_author=A. Tavano;citation_author=R. Grasso;citation_author=C. Gagliardi;citation_title=Disorders of cognitive and affective development in cerebellar malformations;citation_volume=130;citation_year=2007;citation_pmid=17872929;citation_doi=10.1093/brain/awm201" />
<meta name="citation_reference" content="citation_journal_title=Trends in cognitive sciences;citation_journal_abbrev=Trends Cogn Sci;citation_author=SJ. Blakemore;citation_author=DM. Wolpert;citation_author=CD. Frith;citation_title=Abnormalities in the awareness of action.;citation_pages=237-242;citation_volume=6;citation_year=2002;citation_issue=6;citation_pmid=12039604;citation_doi=10.1016/S1364-6613(02)01907-1" />
<meta name="citation_reference" content="citation_journal_title=Lancet;citation_journal_abbrev=Lancet;citation_author=C. Pantelis;citation_author=D. Velakoulis;citation_author=PD. McGorry;citation_title=Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.;citation_pages=281-288;citation_volume=361;citation_year=2003;citation_issue=9354;citation_pmid=12559861;citation_doi=10.1016/S0140-6736(03)12323-9" />
<meta name="citation_reference" content="citation_journal_title=Psychopharmacology bulletin;citation_journal_abbrev=Psychopharmacol Bull;citation_author=BD. Peters;citation_author=L. de Haan;citation_author=EJ. Vlieger;citation_title=Recent-onset schizophrenia and adolescent cannabis use: MRI evidence for structural hyperconnectivity?;citation_pages=75-88;citation_volume=42;citation_year=2009;citation_issue=2;citation_pmid=19629024" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=N. Dekker;citation_author=N. Schmitz;citation_author=BD. Peters;citation_title=Cannabis use and callosal white matter structure and integrity in recent-onset schizophrenia.;citation_pages=51-56;citation_volume=181;citation_year=2010;citation_issue=1;citation_pmid=19962862;citation_doi=10.1016/j.pscychresns.2009.06.003" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=S. Bava;citation_author=LR. Frank;citation_author=T. McQueeny;citation_title=Altered white matter microstructure in adolescent substance users.;citation_pages=228-237;citation_volume=173;citation_year=2009;citation_issue=3;citation_pmid=19699064;citation_doi=10.1016/j.pscychresns.2009.04.005" />
<meta name="citation_reference" content="citation_journal_title=Alcoholism, clinical and experimental research;citation_journal_abbrev=Alcohol Clin Exp Res;citation_author=MD. De Bellis;citation_author=E. Van Voorhees;citation_author=SR. Hooper;citation_title=Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders.;citation_pages=395-404;citation_volume=32;citation_year=2008;citation_issue=3;citation_pmid=18241319;citation_doi=10.1111/j.1530-0277.2007.00603.x" />
<meta name="citation_reference" content="citation_journal_title=The European journal of neuroscience;citation_journal_abbrev=Eur J Neurosci;citation_author=A. Arévalo-Martín;citation_author=D. García-Ovejero;citation_author=A. Rubio-Araiz;citation_title=Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post-natal rats through cannabinoid receptor 1 and cannabinoid receptor 2.;citation_pages=1548-1559;citation_volume=26;citation_year=2007;citation_issue=6;citation_pmid=17880390;citation_doi=10.1111/j.1460-9568.2007.05782.x" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=DC. Alexander;citation_author=GJ. Barker;citation_author=SR. Arridge;citation_title=Detection and modeling of non-Gaussian apparent diffusion coefficient profiles in human brain data.;citation_pages=331-340;citation_volume=48;citation_year=2002;citation_issue=2;citation_pmid=12210942;citation_doi=10.1002/mrm.10209" />
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<meta name="citation_reference" content="citation_title=Permutation, Parametric, and Bootstrap Tests of Hypotheses;citation_author=PI. Good;citation_year=2005" />
<meta name="twitter:title" content="Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

MATERIALS AND METHODS: A total of 43 first-contact, drug-naïve, patients with schizophrenia and 17 age-matched control participants were studied. All participants underwent T1-weighted MR imaging and DTI scans. Voxel-based morphometry and tract-based spatial statistics were used to compare GM volumes and WM DTI metrics between groups. MR imaging measures were correlated with the duration of the untreated psychosis and the clinical positive and negative symptoms.

RESULTS: Compared with control participants, patients with schizophrenia showed smaller volumes of the temporal, parietal, and occipital GM, and a pattern of decreased mean diffusivity and increased fractional anisotropy in the brain stem and cerebellum bilaterally, interhemispheric and cortico-cortical connections bilaterally, and right anterior and posterior limb of the internal capsule. In patients, decreased mean diffusivity and increased fractional anisotropy in several brain regions were related to a longer duration of the untreated psychosis and the severity of positive symptoms.

CONCLUSIONS: First-contact, drug-naïve, patients with schizophrenia present with volumetric and DTI changes, which correlated with their clinical features. This study increases our knowledge on the neural networks involved in the pathophysiologic mechanisms of schizophrenia.

DARTEL
:   Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra
DUP
:   duration of the untreated psychosis
FA
:   fractional anisotropy
MD
:   mean diffusivity
PANSS
:   Positive and Negative Syndrome Scales
MNI
:   Montreal Neurological Institute
TBSS
:   tract-based spatial statistics" />
<meta name="og-title" property="og:title" content="Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/35/1/30" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

MATERIALS AND METHODS: A total of 43 first-contact, drug-naïve, patients with schizophrenia and 17 age-matched control participants were studied. All participants underwent T1-weighted MR imaging and DTI scans. Voxel-based morphometry and tract-based spatial statistics were used to compare GM volumes and WM DTI metrics between groups. MR imaging measures were correlated with the duration of the untreated psychosis and the clinical positive and negative symptoms.

RESULTS: Compared with control participants, patients with schizophrenia showed smaller volumes of the temporal, parietal, and occipital GM, and a pattern of decreased mean diffusivity and increased fractional anisotropy in the brain stem and cerebellum bilaterally, interhemispheric and cortico-cortical connections bilaterally, and right anterior and posterior limb of the internal capsule. In patients, decreased mean diffusivity and increased fractional anisotropy in several brain regions were related to a longer duration of the untreated psychosis and the severity of positive symptoms.

CONCLUSIONS: First-contact, drug-naïve, patients with schizophrenia present with volumetric and DTI changes, which correlated with their clinical features. This study increases our knowledge on the neural networks involved in the pathophysiologic mechanisms of schizophrenia.

DARTEL
:   Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra
DUP
:   duration of the untreated psychosis
FA
:   fractional anisotropy
MD
:   mean diffusivity
PANSS
:   Positive and Negative Syndrome Scales
MNI
:   Montreal Neurological Institute
TBSS
:   tract-based spatial statistics" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12748--5" data-node-nid="12748" id="top-node-12748--6882044241" data-pisa="ajnr;35/1/30" data-pisa-master="ajnr;ajnr.A3583" data-apath="/ajnr/35/1/30.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M. Filippi</span>, <span class="highwire-citation-author" data-delta="1">E. Canu</span>, <span class="highwire-citation-author" data-delta="2">R. Gasparotti</span>, <span class="highwire-citation-author" data-delta="3">F. Agosta</span>, <span class="highwire-citation-author" data-delta="4">P. Valsecchi</span>, <span class="highwire-citation-author" data-delta="5">G. Lodoli</span>, <span class="highwire-citation-author" data-delta="6">A. Galluzzo</span>, <span class="highwire-citation-author" data-delta="7">G. Comi</span> and <span class="highwire-citation-author" data-delta="8">E. Sacchetti</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2014,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">30-37; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3583 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12748--6882044241" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M. Filippi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology (M.F., G.C.) San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BFilippi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Filippi%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BFilippi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E. Canu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BCanu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Canu%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BCanu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">R. Gasparotti </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Diagnostic Imaging (R.G., G.L.), Neuroradiology Unit, Brescia University School of Medicine, Spedali Civili, Brescia, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BGasparotti%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gasparotti%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BGasparotti%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">F. Agosta </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BAgosta%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Agosta%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BAgosta%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">P. Valsecchi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Mental Health (P.V., A.G., E.S.), Spedali Civili, Brescia, Italy</div><div class='author-affiliation'><span class='nlm-sup'>e</span>University Psychiatric Unit (P.V., E.S.), Brescia University School of Medicine, Brescia, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BValsecchi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Valsecchi%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.%2BValsecchi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">G. Lodoli </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Diagnostic Imaging (R.G., G.L.), Neuroradiology Unit, Brescia University School of Medicine, Spedali Civili, Brescia, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BLodoli%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lodoli%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BLodoli%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">A. Galluzzo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Mental Health (P.V., A.G., E.S.), Spedali Civili, Brescia, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BGalluzzo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Galluzzo%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BGalluzzo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">G. Comi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology (M.F., G.C.) San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BComi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Comi%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BComi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">E. Sacchetti </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Mental Health (P.V., A.G., E.S.), Spedali Civili, Brescia, Italy</div><div class='author-affiliation'><span class='nlm-sup'>e</span>University Psychiatric Unit (P.V., E.S.), Brescia University School of Medicine, Brescia, Italy</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Centre on Behavioural and Neurodegenerative Disorders (E.S.), Brescia University and EULO, Brescia, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BSacchetti%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sacchetti%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BSacchetti%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.</p>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> A total of 43 first-contact, drug-naïve, patients with schizophrenia and 17 age-matched control participants were studied. All participants underwent T1-weighted MR imaging and DTI scans. Voxel-based morphometry and tract-based spatial statistics were used to compare GM volumes and WM DTI metrics between groups. MR imaging measures were correlated with the duration of the untreated psychosis and the clinical positive and negative symptoms.</p>
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<p id="p-3"><strong>RESULTS:</strong> Compared with control participants, patients with schizophrenia showed smaller volumes of the temporal, parietal, and occipital GM, and a pattern of decreased mean diffusivity and increased fractional anisotropy in the brain stem and cerebellum bilaterally, interhemispheric and cortico-cortical connections bilaterally, and right anterior and posterior limb of the internal capsule. In patients, decreased mean diffusivity and increased fractional anisotropy in several brain regions were related to a longer duration of the untreated psychosis and the severity of positive symptoms.</p>
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<p id="p-4"><strong>CONCLUSIONS:</strong> First-contact, drug-naïve, patients with schizophrenia present with volumetric and DTI changes, which correlated with their clinical features. This study increases our knowledge on the neural networks involved in the pathophysiologic mechanisms of schizophrenia.</p>
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</div><div class="section glossary" id="glossary-1"><h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">DARTEL<span class="def-item-dt-sep"></span></dt><dd>Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">DUP<span class="def-item-dt-sep"></span></dt><dd>duration of the untreated psychosis<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">MD<span class="def-item-dt-sep"></span></dt><dd>mean diffusivity<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">PANSS<span class="def-item-dt-sep"></span></dt><dd>Positive and Negative Syndrome Scales<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">MNI<span class="def-item-dt-sep"></span></dt><dd>Montreal Neurological Institute<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">TBSS<span class="def-item-dt-sep"></span></dt><dd>tract-based spatial statistics</dd></dl>
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2014, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">30-37; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3583 </span></div>
  
  
  
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