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<meta name="HW.identifier" content="/ajnr/35/10/1897.atom" />
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<meta name="DC.Title" content="Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3996" />
<meta name="DC.Date" content="2014-10-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2014 by American Journal of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: MRA is widely accepted as a noninvasive diagnostic tool for the detection of intracranial aneurysms, but detection is still a challenging task with rather low detection rates. Our aim was to examine the performance of a computer-aided diagnosis algorithm for detecting intracranial aneurysms on MRA in a clinical setting.

MATERIALS AND METHODS: Aneurysm detectability was evaluated retrospectively in 48 subjects with and without computer-aided diagnosis by 6 readers using a clinical 3D viewing system. Aneurysms ranged from 1.1 to 6.0 mm (mean = 3.12 mm, median = 2.50 mm). We conducted a multireader, multicase, double-crossover design, free-response, observer-performance study on sets of images from different MRA scanners by using DSA as the reference standard. Jackknife alternative free-response operating characteristic curve analysis with the figure of merit was used.

RESULTS: For all readers combined, the mean figure of merit improved from 0.655 to 0.759, indicating a change in the figure of merit attributable to computer-aided diagnosis of 0.10 (95% CI, 0.03–0.18), which was statistically significant ( F 1,47 = 7.00, P = .011). Five of the 6 radiologists had improved performance with computer-aided diagnosis, primarily due to increased sensitivity.

CONCLUSIONS: In conditions similar to clinical practice, using computer-aided diagnosis significantly improved radiologists' detection of intracranial DSA-confirmed aneurysms of ≤6 mm.

CAD
:   computer-aided diagnosis
FOM
:   figure of merit" />
<meta name="DC.Contributor" content="I.L. Štep̌án-Buksakowska" />
<meta name="DC.Contributor" content="J.M. Accurso" />
<meta name="DC.Contributor" content="F.E. Diehn" />
<meta name="DC.Contributor" content="J. Huston" />
<meta name="DC.Contributor" content="T.J. Kaufmann" />
<meta name="DC.Contributor" content="P.H. Luetmer" />
<meta name="DC.Contributor" content="C.P. Wood" />
<meta name="DC.Contributor" content="X. Yang" />
<meta name="DC.Contributor" content="D.J. Blezek" />
<meta name="DC.Contributor" content="R. Carter" />
<meta name="DC.Contributor" content="C. Hagen" />
<meta name="DC.Contributor" content="D. Hořínek" />
<meta name="DC.Contributor" content="A. Hejčl" />
<meta name="DC.Contributor" content="M. Roček" />
<meta name="DC.Contributor" content="B.J. Erickson" />
<meta name="article:published_time" content="2014-10-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;MRA is widely accepted as a noninvasive diagnostic tool for the detection of intracranial aneurysms, but detection is still a challenging task with rather low detection rates. Our aim was to examine the performance of a computer-aided diagnosis algorithm for detecting intracranial aneurysms on MRA in a clinical setting.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Aneurysm detectability was evaluated retrospectively in 48 subjects with and without computer-aided diagnosis by 6 readers using a clinical 3D viewing system. Aneurysms ranged from 1.1 to 6.0 mm (mean = 3.12 mm, median = 2.50 mm). We conducted a multireader, multicase, double-crossover design, free-response, observer-performance study on sets of images from different MRA scanners by using DSA as the reference standard. Jackknife alternative free-response operating characteristic curve analysis with the figure of merit was used.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;For all readers combined, the mean figure of merit improved from 0.655 to 0.759, indicating a change in the figure of merit attributable to computer-aided diagnosis of 0.10 (95% CI, 0.03–0.18), which was statistically significant (&lt;i&gt;F&lt;/i&gt;&lt;sub&gt;1,47&lt;/sub&gt; = 7.00, &lt;i&gt;P&lt;/i&gt; = .011). Five of the 6 radiologists had improved performance with computer-aided diagnosis, primarily due to increased sensitivity.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;In conditions similar to clinical practice, using computer-aided diagnosis significantly improved radiologists9 detection of intracranial DSA-confirmed aneurysms of ≤6 mm.&lt;/p&gt;" />
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<meta name="twitter:title" content="Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting" />
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<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/35/10.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: MRA is widely accepted as a noninvasive diagnostic tool for the detection of intracranial aneurysms, but detection is still a challenging task with rather low detection rates. Our aim was to examine the performance of a computer-aided diagnosis algorithm for detecting intracranial aneurysms on MRA in a clinical setting.

MATERIALS AND METHODS: Aneurysm detectability was evaluated retrospectively in 48 subjects with and without computer-aided diagnosis by 6 readers using a clinical 3D viewing system. Aneurysms ranged from 1.1 to 6.0 mm (mean = 3.12 mm, median = 2.50 mm). We conducted a multireader, multicase, double-crossover design, free-response, observer-performance study on sets of images from different MRA scanners by using DSA as the reference standard. Jackknife alternative free-response operating characteristic curve analysis with the figure of merit was used.

RESULTS: For all readers combined, the mean figure of merit improved from 0.655 to 0.759, indicating a change in the figure of merit attributable to computer-aided diagnosis of 0.10 (95% CI, 0.03–0.18), which was statistically significant ( F 1,47 = 7.00, P = .011). Five of the 6 radiologists had improved performance with computer-aided diagnosis, primarily due to increased sensitivity.

CONCLUSIONS: In conditions similar to clinical practice, using computer-aided diagnosis significantly improved radiologists' detection of intracranial DSA-confirmed aneurysms of ≤6 mm.

CAD
:   computer-aided diagnosis
FOM
:   figure of merit" />
<meta name="og-title" property="og:title" content="Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/35/10/1897" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: MRA is widely accepted as a noninvasive diagnostic tool for the detection of intracranial aneurysms, but detection is still a challenging task with rather low detection rates. Our aim was to examine the performance of a computer-aided diagnosis algorithm for detecting intracranial aneurysms on MRA in a clinical setting.

MATERIALS AND METHODS: Aneurysm detectability was evaluated retrospectively in 48 subjects with and without computer-aided diagnosis by 6 readers using a clinical 3D viewing system. Aneurysms ranged from 1.1 to 6.0 mm (mean = 3.12 mm, median = 2.50 mm). We conducted a multireader, multicase, double-crossover design, free-response, observer-performance study on sets of images from different MRA scanners by using DSA as the reference standard. Jackknife alternative free-response operating characteristic curve analysis with the figure of merit was used.

RESULTS: For all readers combined, the mean figure of merit improved from 0.655 to 0.759, indicating a change in the figure of merit attributable to computer-aided diagnosis of 0.10 (95% CI, 0.03–0.18), which was statistically significant ( F 1,47 = 7.00, P = .011). Five of the 6 radiologists had improved performance with computer-aided diagnosis, primarily due to increased sensitivity.

CONCLUSIONS: In conditions similar to clinical practice, using computer-aided diagnosis significantly improved radiologists' detection of intracranial DSA-confirmed aneurysms of ≤6 mm.

CAD
:   computer-aided diagnosis
FOM
:   figure of merit" />
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      <h1 class="highwire-cite-title" id="page-title">Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">I.L. Štep̌án-Buksakowska</span>, <span class="highwire-citation-author" data-delta="1">J.M. Accurso</span>, <span class="highwire-citation-author" data-delta="2">F.E. Diehn</span>, <span class="highwire-citation-author" data-delta="3">J. Huston</span>, <span class="highwire-citation-author" data-delta="4">T.J. Kaufmann</span>, <span class="highwire-citation-author" data-delta="5">P.H. Luetmer</span>, <span class="highwire-citation-author" data-delta="6">C.P. Wood</span>, <span class="highwire-citation-author" data-delta="7">X. Yang</span>, <span class="highwire-citation-author" data-delta="8">D.J. Blezek</span>, <span class="highwire-citation-author" data-delta="9">R. Carter</span>, <span class="highwire-citation-author" data-delta="10">C. Hagen</span>, <span class="highwire-citation-author" data-delta="11">D. Hořínek</span>, <span class="highwire-citation-author" data-delta="12">A. Hejčl</span>, <span class="highwire-citation-author" data-delta="13">M. Roček</span> and <span class="highwire-citation-author" data-delta="14">B.J. Erickson</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2014,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1897-1902; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3996 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13762--21043413953" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">I.L. Štep̌án-Buksakowska </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.L.Š.-B., F.E.D., J.H., T.J.K., P.H.L., C.P.W., B.J.E.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>International Clinical Research Center (I.L.Š.-B., D.H., A.H.), St. Anne's University Hospital Brno, Brno, Czech Republic</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Radiology (I.L.Š.-B., M.R.), Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.L.%2B%C5%A0tep%CC%8C%C3%A1n-Buksakowska%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=%C5%A0tep%CC%8C%C3%A1n-Buksakowska%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AI.L.%2B%25C5%25A0tep%25CC%258C%25C3%25A1n-Buksakowska%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.M. Accurso </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Radiology (J.M.A.), Mayo Clinic, Jacksonville, Florida</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.M.%2BAccurso%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Accurso%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.M.%2BAccurso%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">F.E. Diehn </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.L.Š.-B., F.E.D., J.H., T.J.K., P.H.L., C.P.W., B.J.E.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.E.%2BDiehn%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Diehn%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.E.%2BDiehn%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J. Huston </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.L.Š.-B., F.E.D., J.H., T.J.K., P.H.L., C.P.W., B.J.E.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BHuston%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Huston%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2BHuston%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">T.J. Kaufmann </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.L.Š.-B., F.E.D., J.H., T.J.K., P.H.L., C.P.W., B.J.E.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.J.%2BKaufmann%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kaufmann%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AT.J.%2BKaufmann%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">P.H. Luetmer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.L.Š.-B., F.E.D., J.H., T.J.K., P.H.L., C.P.W., B.J.E.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.H.%2BLuetmer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Luetmer%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.H.%2BLuetmer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">C.P. Wood </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.L.Š.-B., F.E.D., J.H., T.J.K., P.H.L., C.P.W., B.J.E.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.P.%2BWood%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wood%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.P.%2BWood%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">X. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">REFERENCES</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a>

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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 35</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 2014 </div></div>
      
      
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      <div class="highwire-cite-title">Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">I.L.</span> <span class="nlm-surname">Štep̌án-Buksakowska</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.M.</span> <span class="nlm-surname">Accurso</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.E.</span> <span class="nlm-surname">Diehn</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Huston</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">T.J.</span> <span class="nlm-surname">Kaufmann</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">P.H.</span> <span class="nlm-surname">Luetmer</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.P.</span> <span class="nlm-surname">Wood</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">X.</span> <span class="nlm-surname">Yang</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">D.J.</span> <span class="nlm-surname">Blezek</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Carter</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Hagen</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Hořínek</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Hejčl</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Roček</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">B.J.</span> <span class="nlm-surname">Erickson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2014, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1897-1902; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3996 </span></div>
  
  
  
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node13762--3" data-node-nid="13762" id="share-node-13762--41339763287" data-pisa="ajnr;35/10/1897" data-pisa-master="ajnr;ajnr.A3996" data-apath="/ajnr/35/10/1897.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard clearfix">
  
  
  
  
      <div class="highwire-cite-title">Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">I.L.</span> <span class="nlm-surname">Štep̌án-Buksakowska</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.M.</span> <span class="nlm-surname">Accurso</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.E.</span> <span class="nlm-surname">Diehn</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Huston</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">T.J.</span> <span class="nlm-surname">Kaufmann</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">P.H.</span> <span class="nlm-surname">Luetmer</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.P.</span> <span class="nlm-surname">Wood</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">X.</span> <span class="nlm-surname">Yang</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">D.J.</span> <span class="nlm-surname">Blezek</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Carter</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Hagen</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Hořínek</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Hejčl</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Roček</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">B.J.</span> <span class="nlm-surname">Erickson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2014, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1897-1902; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3996 </span></div>
  
  
  
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