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    Perfusion Measurement in Brain Gliomas with Intravoxel Incoherent Motion MRI | American Journal of Neuroradiology  
    


















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleBrain

  
      
Open Access

  
      
Perfusion Measurement in Brain Gliomas with Intravoxel Incoherent Motion MRI
  
    	
C. Federau, R. Meuli, K. O'Brien, P. Maeder and P. Hagmann

  
    	
American Journal of Neuroradiology February 2014,  35 (2) 256-262; DOI: https://doi.org/10.3174/ajnr.A3686 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    The Central Brain Tumor Registry of the United States. http://www.cbtrus.org. Accessed November 11, 2012
  2. 2.↵


    Surveillance, Epidemiology, and End Results (SEER) Program. National Cancer Institute. www.seer.cancer.gov. Accessed November 11, 2012
  3. 3.↵


    1. Aronen  HJ, 
    2. Gazit  IE, 
    3. Louis  DN, 
    4. et al
    . Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191:41–51
    CrossRefPubMedWeb of Science
  4. 4.↵


    1. Law  M, 
    2. Yang  S, 
    3. Wang  H, 
    4. et al
    . Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 2003;24:1989–98
    Abstract/FREE Full Text
  5. 5.↵


    1. Law  M, 
    2. Young  RJ, 
    3. Babb  JS, 
    4. et al
    . Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2008;247:490–98
    CrossRefPubMedWeb of Science
  6. 6.↵


    1. Kumar  V, 
    2. Abbas  AK, 
    3. Aster  JC, 
    4. et al
    . Robbins & Cotran Pathologic Basis of Disease. 7th ed. Paris, France: Elsevier Saunders; 2005
  7. 7.↵


    1. Le Bihan  D, 
    2. Breton  E, 
    3. Lallemand  D, 
    4. et al
    . Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 1988;168:497–505
    PubMedWeb of Science
  8. 8.↵


    1. Stejskal  EO, 
    2. Tanner  JE
    . Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288–92
    CrossRefWeb of Science
  9. 9.↵


    1. Le Bihan  D, 
    2. Turner  R
    . The capillary network: a link between IVIM and classical perfusion. Magn Reson Med 1992;27:171–78
    CrossRefPubMed
  10. 10.↵


    1. Sumi  M, 
    2. Van Cauteren  M, 
    3. Sumi  T, 
    4. et al
    . Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors. Radiology 2012;263:770–77
    CrossRefPubMed
  11. 11.↵


    1. Lemke  A, 
    2. Laun  FB, 
    3. Klauss  M, 
    4. et al
    . Differentiation of pancreas carcinoma from healthy pancreatic tissue using multiple b-values: comparison of apparent diffusion coefficient and intravoxel incoherent motion derived parameters. Invest Radiol 2009;44:769–75
    CrossRefPubMed
  12. 12.↵


    1. Chandarana  H, 
    2. Kang  SK, 
    3. Wong  S, 
    4. et al
    . Diffusion-weighted intravoxel incoherent motion imaging of renal tumors with histopathologic correlation. Invest Radiol 2012;47:688–96
    CrossRefPubMed
  13. 13.↵


    1. Sigmund  EE, 
    2. Cho  GY, 
    3. Kim  S, 
    4. et al
    . Intravoxel incoherent motion imaging of tumor microenvironment in locally advanced breast cancer. Magn Reson Med 2011;65:1437–47
    CrossRefPubMed
  14. 14.↵


    1. Henkelman  RM, 
    2. Neil  JJ, 
    3. Xiang  QS
    . A quantitative interpretation of IVIM measurements of vascular perfusion in the rat brain. Magn Reson Med 1994;32:464–69
    CrossRefPubMedWeb of Science
  15. 15.↵


    1. Turner  R, 
    2. Le Bihan  D, 
    3. Maier  J, 
    4. et al
    . Echo-planar imaging of intravoxel incoherent motion. Radiology 1990;177:407–14
    PubMedWeb of Science
  16. 16.↵


    1. Neil  JJ, 
    2. Bosch  CS, 
    3. Ackerman  JJ
    . An evaluation of the sensitivity of the intravoxel incoherent motion (IVIM) method of blood flow measurement to changes in cerebral blood flow. Magn Reson Med 1994;32:60–65
    CrossRefPubMed
  17. 17.↵


    1. Chenevert  TL, 
    2. Pipe  JG, 
    3. Williams  DM, 
    4. et al
    . Quantitative measurement of tissue perfusion and diffusion in vivo. Magn Reson Med 1991;17:197–212
    CrossRefPubMed
  18. 18.↵


    1. Le Bihan  D, 
    2. Moonen  CT, 
    3. van Zijl  PC, 
    4. et al
    . Measuring random microscopic motion of water in tissues with MR imaging: a cat brain study. J Comput Assist Tomogr 1991;15:19–25
    CrossRefPubMedWeb of Science
  19. 19.↵


    1. Wirestam  R, 
    2. Brockstedt  S, 
    3. Lindgren  A, 
    4. et al
    . The perfusion fraction in volunteers and in patients with ischaemic stroke. Acta Radiol 1997;38:961–64
    FREE Full Text
  20. 20.↵


    1. Federau  C, 
    2. Maeder  P, 
    3. O'Brien  K, 
    4. et al
    . Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging. Radiology 2012;265:874–81
    CrossRefPubMed
  21. 21.↵


    1. Seber  GA, 
    2. Wild  CJ
    . Nonlinear Regression. Hoboken, New Jersey: Wiley-Interscience; 2003
  22. 22.↵


    1. Le Bihan  D, 
    2. Turner  R, 
    3. MacFall  JR
    . Effects of intravoxel incoherent motions (IVIM) in steady-state free precession (SSFP) imaging: applications to molecular diffusion imaging. Magn Reson Med 1989;10:324–37
    CrossRefPubMedWeb of Science
  23. 23.↵


    1. Wirestam  R, 
    2. Borg  M, 
    3. Brockstedt  S, 
    4. et al
    . Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique. Acta Radiol 2001;42:123–28
    FREE Full Text
  24. 24.↵


    1. Andreou  A, 
    2. Koh  DM, 
    3. Collins  DJ, 
    4. et al
    . Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases. Eur Radiol 2013;23:428–34
    CrossRefPubMed
  25. 25.↵


    1. Federau  C, 
    2. O'Brien  K, 
    3. Meuli  R, 
    4. et al
    . Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience. J Magn Reson Imaging 2013. In press
  26. 26.↵


    1. Federau  C, 
    2. O'Brien  K, 
    3. Müller  M, 
    4. et al
    . Pulsatile microvascular perfusion demonstrated in the human brain with intravoxel incoherent motion (IVIM) MRI. In: Proceedings of the 21st Annual Meeting of the International Society for Magnetic Resonance in Medicine, Salt Lake City, Utah. April 20–26, 2013
  27. 27.↵


    1. Sugahara  T, 
    2. Korogi  Y, 
    3. Kochi  M, 
    4. et al
    . Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 1999;9:53–60
    CrossRefPubMedWeb of Science
  28. 28.↵


    1. Higano  S, 
    2. Yun  X, 
    3. Kumabe  T, 
    4. et al
    . Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology 2006;241:839–46
    CrossRefPubMedWeb of Science
  29. 29.↵


    1. Murakami  R, 
    2. Sugahara  T, 
    3. Nakamura  H, 
    4. et al
    . Malignant supratentorial astrocytoma treated with postoperative radiation therapy: prognostic value of pretreatment quantitative diffusion-weighted MR imaging. Radiology 2007;243:493–99
    CrossRefPubMedWeb of Science
  30. 30.↵


    1. Scatliff  JH, 
    2. Radcliffe  WB, 
    3. Pittman  HH, 
    4. et al
    . Vascular structure of glioblastomas. Am J Roentgenol Radium Ther Nuclear Med 1969;105:795–805
    CrossRefPubMed
  31. 31.↵


    1. Jain  RK, 
    2. di Tomaso  E, 
    3. Duda  DG, 
    4. et al
    . Angiogenesis in brain tumours. Nat Rev Neurosci 2007;8:610–22
    PubMedWeb of Science
  32. 32.↵


    1. Calamante  F, 
    2. Gadian  DG, 
    3. Connelly  A
    . Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical use. Stroke 2002;33:1146–51
    Abstract/FREE Full Text
  33. 33.↵


    1. Knutsson  L, 
    2. Stahlberg  F, 
    3. Wirestam  R
    . Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities. MAGMA 2010;23:1–21
    CrossRefPubMed
  34. 34.↵


    1. Petersen  ET, 
    2. Zimine  I, 
    3. Ho  YC, 
    4. et al
    . Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques. Br J Radiol 2006;79:688–701
    Abstract/FREE Full Text
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Perfusion Measurement in Brain Gliomas with Intravoxel Incoherent Motion MRI
  
    	
C. Federau, R. Meuli, K. O'Brien, P. Maeder, P. Hagmann

  
    	
 American Journal of Neuroradiology Feb 2014, 35 (2) 256-262; DOI: 10.3174/ajnr.A3686 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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