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    MR Imaging–Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies | American Journal of Neuroradiology  
    

















    





























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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MR Imaging–Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies
  
    	
L. Altabella, F. Zoratto, W. Adriani and R. Canese

  
    	
American Journal of Neuroradiology June 2014,  35 (6 suppl) S55-S63; DOI: https://doi.org/10.3174/ajnr.A3843 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    1. Oades  RD
    . Frontal, temporal and lateralized brain function in children with attention-deficit hyperactivity disorder: a psychophysiological and neuropsychological viewpoint on development. Behav Brain Res 1998;94:83–95
    CrossRefPubMedWeb of Science
  2. 2.↵


    1. Castellanos  FX, 
    2. Sonuga-Barke  EJ, 
    3. Milham  MP, 
    4. et al
    . Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci 2006;10:117–23
    CrossRefPubMedWeb of Science
  3. 3.↵


    1. Sonuga-Barke  EJ
    . Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry 2005;57:1231–38
    CrossRefPubMedWeb of Science
  4. 4.↵


    1. Casey  BJ, 
    2. Durston  S
    . From behavior to cognition to the brain and back: what have we learned from functional imaging studies of attention deficit hyperactivity disorder? Am J Psychiatry 2006;163:957–60
    CrossRefPubMedWeb of Science
  5. 5.↵


    1. Sagvolden  T, 
    2. Aase  H, 
    3. Zeiner  P, 
    4. et al
    . Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder. Behav Brain Res 1998;94:61–71
    CrossRefPubMedWeb of Science
  6. 6.↵


    1. Accardo  P, 
    2. Blondis  TA
    . What's all the fuss about Ritalin? J Pediatr 2001;138:6–9
    CrossRefPubMedWeb of Science
  7. 7.↵


    1. Scheffler  RM, 
    2. Hinshaw  SP, 
    3. Modrek  S, 
    4. et al
    . The global market for ADHD medications. Health Aff (Millwood) 2007;26:450–57
    Abstract/FREE Full Text
  8. 8.↵


    1. Altabella  L, 
    2. Strolin  S, 
    3. Villani  N, 
    4. et al
    . Magnetic resonance imaging and spectroscopy in the study in ADHD syndrome: a short review. Biophysics and Bioeng Letters 2011;4:23–34
  9. 9.↵


    1. Bush  G
    . Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder. Biol Psychiatry 2011;69:1160–67
    CrossRefPubMedWeb of Science
  10. 10.↵


    1. Hart  H, 
    2. Radua  J, 
    3. Mataix-Cols  D, 
    4. et al
    . Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD). Neurosci Biobehav Rev 2012;36:2248–56
    CrossRefPubMed
  11. 11.↵


    1. de Graaf  RA
    . In Vivo NMR Spectroscopy: Principles and Techniques. Chichester, UK: John Wiley; 2008
  12. 12.↵


    1. Posse  S, 
    2. Otazo  R, 
    3. Dager  SR, 
    4. et al
    . MR spectroscopic imaging: principles and recent advances. J Magn Reson Imaging 2013;37:1301–25
    CrossRefPubMed
  13. 13.↵


    1. Canese  R, 
    2. Pisanu  ME, 
    3. Mezzanzanica  D, 
    4. et al
    . Characterisation of in vivo ovarian cancer models by quantitative 1H magnetic resonance spectroscopy and diffusion-weighted imaging. NMR Biomed 2012;25:632–42
    CrossRefPubMed
  14. 14.↵


    1. Scheidegger  O, 
    2. Wingeier  K, 
    3. Stefan  D, 
    4. et al
    . Optimized quantitative magnetic resonance spectroscopy for clinical routine. Magn Reson Med 2013;70:25–32
    CrossRefPubMed
  15. 15.↵


    1. Puts  NA, 
    2. Edden  RA
    . In vivo magnetic resonance spectroscopy of GABA: a methodological review. Prog Nucl Magn Reson Spectrosc 2012;60:29–41
    CrossRefPubMed
  16. 16.↵


    1. Blüml  S, 
    2. Wisnowski  JL, 
    3. Nelson  MD  Jr., 
    4. et al
    . Metabolic maturation of the human brain from birth through adolescence: insights from in vivo magnetic resonance spectroscopy. Cereb Cortex 2013;23:2944–55
    Abstract/FREE Full Text
  17. 17.↵


    1. Horská  A, 
    2. Kaufmann  WE, 
    3. Brant  LJ, 
    4. et al
    . In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging 2002;15:137–43
    CrossRefPubMedWeb of Science
  18. 18.↵


    1. Vyas  NS, 
    2. Patel  NH, 
    3. Herscovitch  P, 
    4. et al
    . Recent developments in neurochemical imaging in schizophrenia: an update. Curr Med Chem 2013;20:351–56
    PubMed
  19. 19.↵


    1. Kraguljac  NV, 
    2. Reid  M, 
    3. White  D, 
    4. et al
    . Neurometabolites in schizophrenia and bipolar disorder: a systematic review and meta-analysis. Psychiatry Res 2012;203:111–25
    CrossRefPubMedWeb of Science
  20. 20.↵


    1. Baruth  JM, 
    2. Wall  CA, 
    3. Patterson  MC, 
    4. et al
    . Proton magnetic resonance spectroscopy as a probe into the pathophysiology of autism spectrum disorders (ASD): a review. Autism Res 2013;6:119–33
    CrossRefPubMedWeb of Science
  21. 21.↵


    1. Biederman  J, 
    2. Faraone  SV
    . Attention-deficit hyperactivity disorder. Lancet 2005;366:237–48
    CrossRefPubMedWeb of Science
  22. 22.↵


    1. van der Staay  FJ
    . Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy. Brain Res Rev 2006;52:131–59
    CrossRefPubMed
  23. 23.↵


    1. Shaywitz  BA, 
    2. Yager  RD, 
    3. Klopper  JH
    . Selective brain dopamine depletion in developing rats: an experimental model of minimal brain dysfunction. Science 1976;191:305–08
    Abstract/FREE Full Text
  24. 24.↵


    1. Fan  X, 
    2. Bruno  KJ, 
    3. Hess  EJ
    . Rodent models of ADHD. Curr Top Behav Neurosci 2012;9:273–300
    PubMed
  25. 25.↵


    1. Adriani  W, 
    2. Boyer  F, 
    3. Gioiosa  L, 
    4. et al
    . Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens. Neuroscience 2009;159:47–58
    CrossRefPubMedWeb of Science
  26. 26.↵


    1. Adriani  W, 
    2. Boyer  F, 
    3. Leo  D, 
    4. et al
    . Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens. Int J Neuropsychopharmacol 2010;13:1329–42
    Abstract/FREE Full Text
  27. 27.↵


    1. Adriani  W, 
    2. Zoratto  F, 
    3. Laviola  G
    . Brain processes in discounting: consequences of adolescent methylphenidate exposure. Curr Top Behav Neurosci 2012;9:113–43
    PubMed
  28. 28.↵


    1. Adriani  W, 
    2. Canese  R, 
    3. Podo  F, 
    4. et al
    . 1H MRS-detectable metabolic brain changes and reduced impulsive behavior in adult rats exposed to methylphenidate during adolescence. Neurotoxicol Teratol 2007;29:116–25
    CrossRefPubMedWeb of Science
  29. 29.↵


    1. Adriani  W, 
    2. Leo  D, 
    3. Greco  D, 
    4. et al
    . Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression. Neuropsychopharmacology 2006;31:1946–56
    CrossRefPubMedWeb of Science
  30. 30.↵


    1. Perlov  E, 
    2. Philipsen  A, 
    3. Matthies  S, 
    4. et al
    . Spectroscopic findings in attention-deficit/hyperactivity disorder: review and meta-analysis. World J Biol Psychiatry 2009;10:355–65
    CrossRefPubMedWeb of Science
  31. 31.↵


    1. Hammerness  P, 
    2. Biederman  J, 
    3. Petty  C, 
    4. et al
    . Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot study. CNS Neurosci Ther 2012;18:34–40
    CrossRefPubMed
  32. 32.↵


    1. Arcos-Burgos  M, 
    2. Londono  AC, 
    3. Pineda  DA, 
    4. et al
    . Analysis of brain metabolism by proton magnetic resonance spectroscopy (1H-MRS) in attention-deficit/hyperactivity disorder suggests a generalized differential ontogenic pattern from controls. Atten Defic Hyperact Disord 2012;4:205–12
    CrossRefPubMed
  33. 33.↵


    1. Krain  AL, 
    2. Castellanos  FX
    . Brain development and ADHD. Clin Psychol Rev 2006;26:433–44
    CrossRefPubMedWeb of Science
  34. 34.↵


    1. Tafazoli  S, 
    2. O'Neill  J, 
    3. Bejjani  A, 
    4. et al
    . 1H MRSI of middle frontal gyrus in pediatric ADHD. J Psychiatr Res 2013;47:505–12
    CrossRefPubMed
  35. 35.↵


    1. Soliva  JC, 
    2. Moreno  A, 
    3. Fauquet  J, 
    4. et al
    . Cerebellar neurometabolite abnormalities in pediatric attention/deficit hyperactivity disorder: a proton MR spectroscopic study. Neurosci Lett 2010;470:60–64
    CrossRefPubMed
  36. 36.↵


    1. Provencher  SW
    . Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672–79
    CrossRefPubMedWeb of Science
  37. 37.↵


    1. Provencher  SW
    . Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001;14:260–64
    CrossRefPubMedWeb of Science
  38. 38.↵


    1. Carrey  NJ, 
    2. MacMaster  FP, 
    3. Gaudet  L, 
    4. et al
    . Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2007;17:11–17
    CrossRefPubMedWeb of Science
  39. 39.↵


    1. Yang  P, 
    2. Wu  MT, 
    3. Dung  SS, 
    4. et al
    . Short-TE proton magnetic resonance spectroscopy investigation in adolescents with attention-deficit hyperactivity disorder. Psychiatry Res 2010;181:199–203
    CrossRefPubMed
  40. 40.↵


    1. Hesslinger  B, 
    2. Thiel  T, 
    3. Tebartz van Elst  L, 
    4. et al
    . Attention-deficit disorder in adults with or without hyperactivity: where is the difference? A study in humans using short echo (1)H-magnetic resonance spectroscopy. Neurosci Lett 2001;304:117–19
    CrossRefPubMedWeb of Science
  41. 41.↵


    1. Edden  RA, 
    2. Crocetti  D, 
    3. Zhu  H, 
    4. et al
    . Reduced GABA concentration in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2012;69:750–53
    CrossRefPubMedWeb of Science
  42. 42.↵


    1. Stanley  JA, 
    2. Kipp  H, 
    3. Greisenegger  E, 
    4. et al
    . Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy study. Arch Gen Psychiatry 2008;65:1419–28
    CrossRefPubMedWeb of Science
  43. 43.↵


    1. Stanley  JA, 
    2. Kipp  H, 
    3. Greisenegger  E, 
    4. et al
    . Regionally specific alterations in membrane phospholipids in children with ADHD: an in vivo 31P spectroscopy study. Psychiatry Res 2006;148:217–21
    CrossRefPubMedWeb of Science
  44. 44.↵


    1. Colla  M, 
    2. Ende  G, 
    3. Alm  B, 
    4. et al
    . Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times. J Psychiatr Res 2008;42:587–95
    CrossRefPubMed
  45. 45.↵


    1. Perlov  E, 
    2. Philipsen  A, 
    3. Hesslinger  B, 
    4. et al
    . Reduced cingulate glutamate/glutamine-to-creatine ratios in adult patients with attention deficit/hyperactivity disorder: a magnet resonance spectroscopy study. J Psychiatr Res 2007;41:934–41
    CrossRefPubMedWeb of Science
  46. 46.↵


    1. Dramsdahl  M, 
    2. Ersland  L, 
    3. Plessen  KJ, 
    4. et al
    . Adults with attention-deficit/hyperactivity disorder: a brain magnetic resonance spectroscopy study. Front Psychiatry 2011;2:65
    PubMed
  47. 47.↵


    1. Kronenberg  G, 
    2. Ende  G, 
    3. Alm  B, 
    4. et al
    . Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate: a spectroscopic test-retest study in adult ADHD. Eur Arch Psychiatry Clin Neurosci 2008;258:446–50
    CrossRefPubMed
  48. 48.↵


    1. Perlov  E, 
    2. Tebarzt van Elst  L, 
    3. Buechert  M, 
    4. et al
    . H(1)-MR-spectroscopy of cerebellum in adult attention deficit/hyperactivity disorder. J Psychiatr Res 2010;44:938–43
    CrossRefPubMed
  49. 49.↵


    1. Yin  HH, 
    2. Knowlton  BJ, 
    3. Balleine  BW
    . Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. Eur J Neurosci 2004;19:181–89
    CrossRefPubMedWeb of Science
  50. 50.↵


    1. Cardinal  RN, 
    2. Winstanley  CA, 
    3. Robbins  TW, 
    4. et al
    . Limbic corticostriatal systems and delayed reinforcement. Ann N Y Acad Sci 2004;1021:33–50
    CrossRefPubMedWeb of Science
  51. 51.↵


    1. Bjork  JM, 
    2. Knutson  B, 
    3. Fong  GW, 
    4. et al
    . Incentive-elicited brain activation in adolescents: similarities and differences from young adults. J Neurosci 2004;24:1793–802
    Abstract/FREE Full Text
  52. 52.↵


    1. Dalley  JW, 
    2. Cardinal  RN, 
    3. Robbins  TW
    . Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 2004;28:771–84
    CrossRefPubMedWeb of Science
  53. 53.↵


    1. Arnsten  AF
    . Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction. CNS Drugs 2009;23(suppl 1):33–41
    CrossRefPubMedWeb of Science
  54. 54.↵


    1. Seamans  JK, 
    2. Lapish  CC, 
    3. Durstewitz  D
    . Comparing the prefrontal cortex of rats and primates: insights from electrophysiology. Neurotox Res 2008;14:249–62
    CrossRefPubMedWeb of Science
  55. 55.↵


    1. Ridderinkhof  KR, 
    2. van den Wildenberg  WP, 
    3. Segalowitz  SJ, 
    4. et al
    . Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning. Brain Cogn 2004;56:129–40
    CrossRefPubMedWeb of Science
  56. 56.↵


    1. Frodl  T, 
    2. Skokauskas  N
    . Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatr Scand 2012;125:114–26
    CrossRefPubMedWeb of Science
  57. 57.↵


    1. Hoerst  M, 
    2. Weber-Fahr  W, 
    3. Tunc-Skarka  N, 
    4. et al
    . Correlation of glutamate levels in the anterior cingulate cortex with self-reported impulsivity in patients with borderline personality disorder and healthy controls. Arch Gen Psychiatry 2010;67:946–54
    CrossRefPubMedWeb of Science
  58. 58.↵


    1. Carlsson  ML
    . On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:5–26
    CrossRefPubMed
  59. 59.↵


    1. Todd  RD, 
    2. Botteron  KN
    . Is attention-deficit/hyperactivity disorder an energy deficiency syndrome? Biol Psychiatry 2001;50:151–58
    CrossRefPubMed
  60. 60.↵


    1. Silveri  MM, 
    2. Sneider  JT, 
    3. Crowley  DJ, 
    4. et al
    . Frontal lobe gamma-aminobutyric acid levels during adolescence: associations with impulsivity and response inhibition. Biol Psychiatry 2013;74:296–304
    CrossRefPubMed
  61. 61.↵


    1. Dautry  C, 
    2. Vaufrey  F, 
    3. Brouillet  E, 
    4. et al
    . Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid. J Cereb Blood Flow Metab 2000;20:789–99
    CrossRefPubMedWeb of Science
  62. 62.↵


    1. Fagundes  AO, 
    2. Rezin  GT, 
    3. Zanette  F, 
    4. et al
    . Chronic administration of methylphenidate activates mitochondrial respiratory chain in brain of young rats. Int J Dev Neurosci 2007;25:47–51
    CrossRefPubMed
  63. 63.↵


    1. De Stefano  N, 
    2. Filippi  M
    . MR spectroscopy in multiple sclerosis. J Neuroimaging 2007;17(suppl 1):31S–35S
    CrossRefPubMedWeb of Science
  64. 64.↵


    1. Gujar  SK, 
    2. Maheshwari  S, 
    3. Bjorkman-Burtscher  I, 
    4. et al
    . Magnetic resonance spectroscopy. J Neuroophthalmol 2005;25:217–26
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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MR Imaging–Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies
  
    	
L. Altabella, F. Zoratto, W. Adriani, R. Canese

  
    	
 American Journal of Neuroradiology Jun 2014, 35 (6 suppl) S55-S63; DOI: 10.3174/ajnr.A3843 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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