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<meta name="DC.Title" content="Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4083" />
<meta name="DC.Date" content="2015-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2015 by American Journal of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function.

MATERIALS AND METHODS: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4–15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation.

RESULTS: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale ( r = −0.87, P = .003, n = 9) and the posterior limb of the internal capsule ( r = −0.68, P = .04, n = 9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming ( r = −0.71, P = .05, n = 8).

CONCLUSIONS: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

ACS
:   anterior centrum semiovale
HII
:   hypoxic-ischemic injury
HVx
:   hemoglobin volume index
IQR
:   interquartile ranges
NIRS
:   near-infrared spectroscopy
MAP
:   mean arterial blood pressure
MAPOPT
:   optimal MAP
PCS
:   posterior centrum semiovale
PLIC
:   posterior limb of the internal capsule
PP
:   putamen and globus pallidus" />
<meta name="DC.Contributor" content="A. Tekes" />
<meta name="DC.Contributor" content="A. Poretti" />
<meta name="DC.Contributor" content="M.M. Scheurkogel" />
<meta name="DC.Contributor" content="T.A.G.M. Huisman" />
<meta name="DC.Contributor" content="J.A. Howlett" />
<meta name="DC.Contributor" content="E. Alqahtani" />
<meta name="DC.Contributor" content="J.-H. Lee" />
<meta name="DC.Contributor" content="C. Parkinson" />
<meta name="DC.Contributor" content="K. Shapiro" />
<meta name="DC.Contributor" content="S.-E. Chung" />
<meta name="DC.Contributor" content="J.M. Jennings" />
<meta name="DC.Contributor" content="M.M. Gilmore" />
<meta name="DC.Contributor" content="C.W. Hogue" />
<meta name="DC.Contributor" content="L.J. Martin" />
<meta name="DC.Contributor" content="R.C. Koehler" />
<meta name="DC.Contributor" content="F.J. Northington" />
<meta name="DC.Contributor" content="J.K. Lee" />
<meta name="article:published_time" content="2015-01-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4–15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale (&lt;i&gt;r&lt;/i&gt; = −0.87, &lt;i&gt;P&lt;/i&gt; = .003, &lt;i&gt;n&lt;/i&gt; = 9) and the posterior limb of the internal capsule (&lt;i&gt;r&lt;/i&gt; = −0.68, &lt;i&gt;P&lt;/i&gt; = .04, &lt;i&gt;n&lt;/i&gt; = 9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming (&lt;i&gt;r&lt;/i&gt; = −0.71, &lt;i&gt;P&lt;/i&gt; = .05, &lt;i&gt;n&lt;/i&gt; = 8).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.&lt;/p&gt;" />
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<meta name="twitter:title" content="Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function.

MATERIALS AND METHODS: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4–15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation.

RESULTS: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale ( r = −0.87, P = .003, n = 9) and the posterior limb of the internal capsule ( r = −0.68, P = .04, n = 9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming ( r = −0.71, P = .05, n = 8).

CONCLUSIONS: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

ACS
:   anterior centrum semiovale
HII
:   hypoxic-ischemic injury
HVx
:   hemoglobin volume index
IQR
:   interquartile ranges
NIRS
:   near-infrared spectroscopy
MAP
:   mean arterial blood pressure
MAPOPT
:   optimal MAP
PCS
:   posterior centrum semiovale
PLIC
:   posterior limb of the internal capsule
PP
:   putamen and globus pallidus" />
<meta name="og-title" property="og:title" content="Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/36/1/188" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function.

MATERIALS AND METHODS: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4–15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation.

RESULTS: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale ( r = −0.87, P = .003, n = 9) and the posterior limb of the internal capsule ( r = −0.68, P = .04, n = 9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming ( r = −0.71, P = .05, n = 8).

CONCLUSIONS: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

ACS
:   anterior centrum semiovale
HII
:   hypoxic-ischemic injury
HVx
:   hemoglobin volume index
IQR
:   interquartile ranges
NIRS
:   near-infrared spectroscopy
MAP
:   mean arterial blood pressure
MAPOPT
:   optimal MAP
PCS
:   posterior centrum semiovale
PLIC
:   posterior limb of the internal capsule
PP
:   putamen and globus pallidus" />
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    <title>Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury | American Journal of Neuroradiology</title>  
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node13838--7" data-node-nid="13838" id="top-node-13838--81384969911" data-pisa="ajnr;36/1/188" data-pisa-master="ajnr;ajnr.A4083" data-apath="/ajnr/36/1/188.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A. Tekes</span>, <span class="highwire-citation-author" data-delta="1">A. Poretti</span>, <span class="highwire-citation-author" data-delta="2">M.M. Scheurkogel</span>, <span class="highwire-citation-author" data-delta="3">T.A.G.M. Huisman</span>, <span class="highwire-citation-author" data-delta="4">J.A. Howlett</span>, <span class="highwire-citation-author" data-delta="5">E. Alqahtani</span>, <span class="highwire-citation-author" data-delta="6">J.-H. Lee</span>, <span class="highwire-citation-author" data-delta="7">C. Parkinson</span>, <span class="highwire-citation-author" data-delta="8">K. Shapiro</span>, <span class="highwire-citation-author" data-delta="9">S.-E. Chung</span>, <span class="highwire-citation-author" data-delta="10">J.M. Jennings</span>, <span class="highwire-citation-author" data-delta="11">M.M. Gilmore</span>, <span class="highwire-citation-author" data-delta="12">C.W. Hogue</span>, <span class="highwire-citation-author" data-delta="13">L.J. Martin</span>, <span class="highwire-citation-author" data-delta="14">R.C. Koehler</span>, <span class="highwire-citation-author" data-delta="15">F.J. Northington</span> and <span class="highwire-citation-author" data-delta="16">J.K. Lee</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2015,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">188-193; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4083 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13838--81384969911" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A. Tekes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BTekes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tekes%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BTekes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A. Poretti </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BPoretti%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Poretti%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BPoretti%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">M.M. Scheurkogel </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.M.%2BScheurkogel%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Scheurkogel%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.M.%2BScheurkogel%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">T.A.G.M. Huisman </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.A.G.M.%2BHuisman%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Huisman%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AT.A.G.M.%2BHuisman%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">J.A. 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Alqahtani </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BAlqahtani%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Alqahtani%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BAlqahtani%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">J.-H. 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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">vol. 36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">no. 1 </span><span  class="highwire-cite-metadata-page-string highwire-cite-metadata">188-193 </span></div>
  
  
  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">A. Tekes</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-2"><span class="name">A. Poretti</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-3"><span class="name">M.M. Scheurkogel</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">T.A.G.M. Huisman</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-3" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-5"><span class="name">J.A. Howlett</span><a id="xref-aff-2-4" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-6"><span class="name">E. Alqahtani</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-7"><span class="name">J.-H. Lee</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a>, </li><li class="contributor" id="contrib-8"><span class="name">C. Parkinson</span><a id="xref-aff-2-5" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-9"><span class="name">K. Shapiro</span><a id="xref-aff-2-6" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-3-3" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-10"><span class="name">S.-E. Chung</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">e</a><span class="xref-sep">,</span><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">f</a>, </li><li class="contributor" id="contrib-11"><span class="name">J.M. Jennings</span><a id="xref-aff-5-2" class="xref-aff" href="#aff-5">e</a><span class="xref-sep">,</span><a id="xref-aff-6-2" class="xref-aff" href="#aff-6">f</a>, </li><li class="contributor" id="contrib-12"><span class="name">M.M. Gilmore</span><a id="xref-aff-2-7" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-3-4" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-13"><span class="name">C.W. Hogue</span><a id="xref-aff-4-2" class="xref-aff" href="#aff-4">d</a>, </li><li class="contributor" id="contrib-14"><span class="name">L.J. Martin</span><a id="xref-aff-7-1" class="xref-aff" href="#aff-7">g</a>, </li><li class="contributor" id="contrib-15"><span class="name">R.C. Koehler</span><a id="xref-aff-4-3" class="xref-aff" href="#aff-4">d</a>, </li><li class="contributor" id="contrib-16"><span class="name">F.J. Northington</span><a id="xref-aff-2-8" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-3-5" class="xref-aff" href="#aff-3">c</a> and </li><li class="last" id="contrib-17"><span class="name">J.K. Lee</span><a id="xref-aff-2-9" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-6-3" class="xref-aff" href="#aff-6">f</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.)</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Division of Neonatology, (J.A.H., C.P., K.S., M.M.G., F.J.N.), Department of Pediatrics</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Department of Anesthesiology and Critical Care Medicine (J.-H.L., C.W.H., R.C.K.)</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>e</sup>Division of General Pediatrics and Adolescent Medicine (S.-E.C., J.M.J.), Department of Pediatrics</address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>f</sup>Center for Child and Community Health Research (S.-E.C., J.M.J., J.K.L.)</address></li><li class="aff"><a id="aff-7" name="aff-7"></a><address><sup>g</sup>Division of Neuropathology (L.J.M.), Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Aylin Tekes, MD, <span class="addr-line">Division of Pediatric Radiology and Section of Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed 4th floor, Room 4155, Baltimore, MD 21205</span>; e-mail: <span class="em-link"><span class="em-addr">atekes1{at}jhmi.edu</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/36/1/188.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tekes</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Poretti</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Scheurkogel</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">T.A.G.M.</span> <span class="nlm-surname">Huisman</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Howlett</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Alqahtani</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.-H.</span> <span class="nlm-surname">Lee</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Parkinson</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Shapiro</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.-E.</span> <span class="nlm-surname">Chung</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">J.M.</span> <span class="nlm-surname">Jennings</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Gilmore</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">C.W.</span> <span class="nlm-surname">Hogue</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">L.J.</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">R.C.</span> <span class="nlm-surname">Koehler</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">F.J.</span> <span class="nlm-surname">Northington</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">J.K.</span> <span class="nlm-surname">Lee</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2015, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">188-193; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4083 </span></div>
  
  
  
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      <div class="highwire-cite-title">Apparent Diffusion Coefficient Scalars Correlate with Near-Infrared Spectroscopy Markers of Cerebrovascular Autoregulation in Neonates Cooled for Perinatal Hypoxic-Ischemic Injury</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tekes</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Poretti</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Scheurkogel</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">T.A.G.M.</span> <span class="nlm-surname">Huisman</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Howlett</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Alqahtani</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.-H.</span> <span class="nlm-surname">Lee</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Parkinson</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Shapiro</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.-E.</span> <span class="nlm-surname">Chung</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">J.M.</span> <span class="nlm-surname">Jennings</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Gilmore</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">C.W.</span> <span class="nlm-surname">Hogue</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">L.J.</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">R.C.</span> <span class="nlm-surname">Koehler</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">F.J.</span> <span class="nlm-surname">Northington</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">J.K.</span> <span class="nlm-surname">Lee</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2015, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">188-193; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4083 </span></div>
  
  
  
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