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<meta name="DC.Title" content="White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4828" />
<meta name="DC.Date" content="2016-10-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2016 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: White matter hyperintensities of presumed vascular origin in elderly patients with hypertension may be part of a general cerebral perfusion deficit, involving not only the white matter hyperintensities but also the surrounding normal-appearing white matter and gray matter. We aimed to study the relation between white matter hyperintensity volume and CBF and assess whether white matter hyperintensities are related to a general perfusion deficit.

MATERIALS AND METHODS: In 185 participants of the Prevention of Dementia by Intensive Vascular Care trial between 72 and 80 years of age with systolic hypertension, white matter hyperintensity volume and CBF were derived from 3D FLAIR and arterial spin-labeling MR imaging, respectively. We compared white matter hyperintensity CBF, normal-appearing white matter CBF, and GM CBF across quartiles of white matter hyperintensity volume and assessed the continuous relation between these CBF estimates and white matter hyperintensity volume by using linear regression.

RESULTS: Mean white matter hyperintensity CBF was markedly lower in higher quartiles of white matter hyperintensity volume, and white matter hyperintensity volume and white matter hyperintensity CBF were negatively related (standardized β = −0.248, P = .001) in linear regression. We found no difference in normal-appearing white matter or GM CBF across quartiles of white matter hyperintensity volume or any relation between white matter hyperintensity volume and normal-appearing white matter CBF (standardized β = −0.065, P = .643) or GM CBF (standardized β = −0.035, P = .382) in linear regression.

CONCLUSIONS: Higher white matter hyperintensity volume in elderly individuals with hypertension was associated with lower perfusion within white matter hyperintensities, but not with lower perfusion in the surrounding normal-appearing white matter or GM. These findings suggest that white matter hyperintensities in elderly individuals with hypertension relate to local microvascular alterations rather than a general cerebral perfusion deficit.

ATT
:   arterial transit time
β
:   standardized β
NAWM
:   normal-appearing white matter
preDIVA
:   Prevention of Dementia by Intensive Vascular Care trial
preDIVA-M
:   MRI substudy of the preDIVA trial
WMH
:   white matter hyperintensity" />
<meta name="DC.Contributor" content="J.W. van Dalen" />
<meta name="DC.Contributor" content="H.J.M.M. Mutsaerts" />
<meta name="DC.Contributor" content="A.J. Nederveen" />
<meta name="DC.Contributor" content="H. Vrenken" />
<meta name="DC.Contributor" content="M.D. Steenwijk" />
<meta name="DC.Contributor" content="M.W.A. Caan" />
<meta name="DC.Contributor" content="C.B.L.M. Majoie" />
<meta name="DC.Contributor" content="W.A. van Gool" />
<meta name="DC.Contributor" content="E. Richard" />
<meta name="article:published_time" content="2016-10-01" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;White matter hyperintensities of presumed vascular origin in elderly patients with hypertension may be part of a general cerebral perfusion deficit, involving not only the white matter hyperintensities but also the surrounding normal-appearing white matter and gray matter. We aimed to study the relation between white matter hyperintensity volume and CBF and assess whether white matter hyperintensities are related to a general perfusion deficit.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;In 185 participants of the Prevention of Dementia by Intensive Vascular Care trial between 72 and 80 years of age with systolic hypertension, white matter hyperintensity volume and CBF were derived from 3D FLAIR and arterial spin-labeling MR imaging, respectively. We compared white matter hyperintensity CBF, normal-appearing white matter CBF, and GM CBF across quartiles of white matter hyperintensity volume and assessed the continuous relation between these CBF estimates and white matter hyperintensity volume by using linear regression.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Mean white matter hyperintensity CBF was markedly lower in higher quartiles of white matter hyperintensity volume, and white matter hyperintensity volume and white matter hyperintensity CBF were negatively related (standardized β = −0.248, &lt;i&gt;P&lt;/i&gt; = .001) in linear regression. We found no difference in normal-appearing white matter or GM CBF across quartiles of white matter hyperintensity volume or any relation between white matter hyperintensity volume and normal-appearing white matter CBF (standardized β = −0.065, &lt;i&gt;P&lt;/i&gt; = .643) or GM CBF (standardized β = −0.035, &lt;i&gt;P&lt;/i&gt; = .382) in linear regression.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Higher white matter hyperintensity volume in elderly individuals with hypertension was associated with lower perfusion within white matter hyperintensities, but not with lower perfusion in the surrounding normal-appearing white matter or GM. These findings suggest that white matter hyperintensities in elderly individuals with hypertension relate to local microvascular alterations rather than a general cerebral perfusion deficit.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=Journal of Alzheimer's disease :  JAD;citation_journal_abbrev=J Alzheimers Dis;citation_author=DC. Alsop;citation_author=W. Dai;citation_author=M. Grossman;citation_title=Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease.;citation_pages=871-880;citation_volume=20;citation_year=2010;citation_issue=3;citation_pmid=20413865;citation_doi=10.3233/JAD-2010-091699" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage Clin;citation_author=MD. Steenwijk;citation_author=PJ. Pouwels;citation_author=M. Daams;citation_title=Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs);citation_pages=462-69;citation_volume=3;citation_year=2013;citation_pmid=24273728;citation_doi=10.1016/j.nicl.2013.10.003" />
<meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=HJ. Mutsaerts;citation_author=JW. van Dalen;citation_author=DF. Heijtel;citation_title=Cerebral perfusion measurements in elderly with hypertension using arterial spin labeling;citation_pages=e0133717;citation_volume=10;citation_year=2015;citation_pmid=26241897;citation_doi=10.1371/journal.pone.0133717" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=J. Wang;citation_author=DC. Alsop;citation_author=HK. Song;citation_title=Arterial transit time imaging with flow encoding arterial spin tagging (FEAST).;citation_pages=599-607;citation_volume=50;citation_year=2003;citation_issue=3;citation_pmid=12939768;citation_doi=10.1002/mrm.10559" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=RB. Buxton;citation_author=LR. Frank;citation_author=EC. Wong;citation_title=A general kinetic model for quantitative perfusion imaging with arterial spin labeling.;citation_pages=383-396;citation_volume=40;citation_year=1998;citation_issue=3;citation_pmid=9727941;citation_doi=10.1002/mrm.1910400308" />
<meta name="citation_reference" content="citation_journal_abbrev=NeuroImage;citation_author=M. Jenkinson;citation_author=CF. Beckmann;citation_author=TE. Behrens;citation_title=FSL.;citation_pages=782-790;citation_volume=62;citation_year=2012;citation_issue=2;citation_pmid=21979382;citation_doi=10.1016/j.neuroimage.2011.09.015" />
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<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=Y. Yang;citation_author=W. Engelien;citation_author=S. Xu;citation_title=Transit time, trailing time, and cerebral blood flow during brain activation: measurement using multislice, pulsed spin-labeling perfusion imaging.;citation_pages=680-685;citation_volume=44;citation_year=2000;citation_issue=5;citation_pmid=11064401;citation_doi=10.1002/1522-2594(200011)44:5&lt;680::AID-MRM4&gt;3.0.CO;2-Q" />
<meta name="citation_reference" content="citation_journal_title=NeuroImage;citation_journal_abbrev=Neuroimage;citation_author=W. Wen;citation_author=P. Sachdev;citation_author=R. Shnier;citation_title=Effect of white matter hyperintensities on cortical cerebral blood volume using perfusion MRI.;citation_pages=1350-1356;citation_volume=21;citation_year=2004;citation_issue=4;citation_pmid=15050560;citation_doi=10.1016/j.neuroimage.2003.11.015" />
<meta name="citation_reference" content="citation_journal_title=Ann Neurol;citation_author=J. Conklin;citation_author=FL. Silver;citation_author=DJ. Mikulis;citation_title=Are acute infarcts the cause of leukoaraiosis? Brain mapping for 16 consecutive weeks;citation_pages=899-904;citation_volume=76;citation_year=2014;citation_pmid=25283088;citation_doi=10.1002/ana.24285" />
<meta name="citation_reference" content="citation_journal_title=Lancet;citation_author=AI. Qureshi;citation_author=LR. Caplan;citation_title=Intracranial atherosclerosis;citation_pages=984-98;citation_volume=383;citation_year=2014;citation_pmid=24007975;citation_doi=10.1016/S0140-6736(13)61088-0" />
<meta name="citation_reference" content="citation_journal_title=Neurobiol Aging;citation_author=MR. Benedictus;citation_author=JD. Goos;citation_author=MA. Binnewijzend;citation_title=Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease;citation_pages=2488-94;citation_volume=34;citation_year=2013;citation_pmid=23731952;citation_doi=10.1016/j.neurobiolaging.2013.04.023" />
<meta name="citation_reference" content="citation_journal_title=Journal of Alzheimer's disease :  JAD;citation_journal_abbrev=J Alzheimers Dis;citation_author=JC. de la Torre;citation_title=Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease.;citation_pages=553-567;citation_volume=32;citation_year=2012;citation_issue=3;citation_pmid=22842871;citation_doi=10.3233/JAD-2012-120793" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=BJ. Macintosh;citation_author=L. Marquardt;citation_author=UG. Schulz;citation_title=Hemodynamic alterations in vertebrobasilar large artery disease assessed by arterial spin-labeling MR imaging;citation_volume=33;citation_year=2012;citation_pmid=22555580;citation_doi=10.3174/ajnr.A3090" />
<meta name="citation_reference" content="citation_journal_title=Hypertension;citation_author=D. Tryambake;citation_author=J. He;citation_author=MJ. Firbank;citation_title=Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension;citation_pages=1309-15;citation_volume=61;citation_year=2013;citation_pmid=23529166;citation_doi=10.1161/HYPERTENSIONAHA.112.200972" />
<meta name="citation_reference" content="citation_journal_title=Journal of hypertension;citation_journal_abbrev=J Hypertens;citation_author=M. Muller;citation_author=Y. van der Graaf;citation_author=FL. Visseren;citation_title=Blood pressure, cerebral blood flow, and brain volumes. The SMART-MR study.;citation_pages=1498-1505;citation_volume=28;citation_year=2010;citation_issue=7;citation_pmid=20453669;citation_doi=10.1097/HJH.0b013e32833951ef" />
<meta name="citation_reference" content="citation_author=The Netherlands National Institute for Health and the Environment (RIVM) blood pressure statistics (Dutch)" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=P. van Gelderen;citation_author=JA. de Zwart;citation_author=JH. Duyn;citation_title=Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling.;citation_pages=788-795;citation_volume=59;citation_year=2008;citation_issue=4;citation_pmid=18383289;citation_doi=10.1002/mrm.21515" />
<meta name="citation_reference" content="citation_journal_title=British Journal of Radiology;citation_journal_abbrev=Br. J. Radiol.;citation_author=ET. Petersen;citation_author=I. Zimine;citation_author=YC. Ho;citation_title=Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques;citation_pages=688-701;citation_volume=79;citation_year=2006;citation_issue=944;citation_pmid=16861326;citation_doi=10.1259/bjr/67705974" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage Clin;citation_author=HJ. Mutsaerts;citation_author=E. Richard;citation_author=DF. Heijtel;citation_title=Gray matter contamination in arterial spin labeling white matter perfusion measurements in patients with dementia;citation_pages=139-44;citation_volume=4;citation_year=2014;citation_pmid=24371796;citation_doi=10.1016/j.nicl.2013.11.003" />
<meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=WC. Wu;citation_author=SC. Lin;citation_author=DJ. Wang;citation_title=Measurement of cerebral white matter perfusion using pseudocontinuous arterial spin labeling 3T magnetic resonance imaging: an experimental and theoretical investigation of feasibility;citation_pages=e82679;citation_volume=8;citation_year=2013;citation_pmid=24324822;citation_doi=10.1371/journal.pone.0082679" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=MJ. van Osch;citation_author=WM. Teeuwisse;citation_author=MA. van Walderveen;citation_title=Can arterial spin labeling detect white matter perfusion signal?;citation_pages=165-173;citation_volume=62;citation_year=2009;citation_issue=1;citation_pmid=19365865;citation_doi=10.1002/mrm.22002" />
<meta name="citation_reference" content="citation_journal_title=Neurosci Lett;citation_author=AM. Brickman;citation_author=VA. Guzman;citation_author=M. Gonzalez-Castellon;citation_title=Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated;citation_pages=54-58;citation_volume=592;citation_year=2015;citation_pmid=25748319;citation_doi=10.1016/j.neulet.2015.03.005" />
<meta name="citation_reference" content="citation_journal_title=J Neurol Neurosurg Psychiatry;citation_author=J. Birns;citation_author=J. Jarosz;citation_author=HS. Markus;citation_title=Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease;citation_volume=80;citation_year=2009;citation_pmid=19535355;citation_doi=10.1136/jnnp.2009.174607" />
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<meta name="twitter:title" content="White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: White matter hyperintensities of presumed vascular origin in elderly patients with hypertension may be part of a general cerebral perfusion deficit, involving not only the white matter hyperintensities but also the surrounding normal-appearing white matter and gray matter. We aimed to study the relation between white matter hyperintensity volume and CBF and assess whether white matter hyperintensities are related to a general perfusion deficit.

MATERIALS AND METHODS: In 185 participants of the Prevention of Dementia by Intensive Vascular Care trial between 72 and 80 years of age with systolic hypertension, white matter hyperintensity volume and CBF were derived from 3D FLAIR and arterial spin-labeling MR imaging, respectively. We compared white matter hyperintensity CBF, normal-appearing white matter CBF, and GM CBF across quartiles of white matter hyperintensity volume and assessed the continuous relation between these CBF estimates and white matter hyperintensity volume by using linear regression.

RESULTS: Mean white matter hyperintensity CBF was markedly lower in higher quartiles of white matter hyperintensity volume, and white matter hyperintensity volume and white matter hyperintensity CBF were negatively related (standardized β = −0.248, P = .001) in linear regression. We found no difference in normal-appearing white matter or GM CBF across quartiles of white matter hyperintensity volume or any relation between white matter hyperintensity volume and normal-appearing white matter CBF (standardized β = −0.065, P = .643) or GM CBF (standardized β = −0.035, P = .382) in linear regression.

CONCLUSIONS: Higher white matter hyperintensity volume in elderly individuals with hypertension was associated with lower perfusion within white matter hyperintensities, but not with lower perfusion in the surrounding normal-appearing white matter or GM. These findings suggest that white matter hyperintensities in elderly individuals with hypertension relate to local microvascular alterations rather than a general cerebral perfusion deficit.

ATT
:   arterial transit time
β
:   standardized β
NAWM
:   normal-appearing white matter
preDIVA
:   Prevention of Dementia by Intensive Vascular Care trial
preDIVA-M
:   MRI substudy of the preDIVA trial
WMH
:   white matter hyperintensity" />
<meta name="og-title" property="og:title" content="White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/37/10/1824" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: White matter hyperintensities of presumed vascular origin in elderly patients with hypertension may be part of a general cerebral perfusion deficit, involving not only the white matter hyperintensities but also the surrounding normal-appearing white matter and gray matter. We aimed to study the relation between white matter hyperintensity volume and CBF and assess whether white matter hyperintensities are related to a general perfusion deficit.

MATERIALS AND METHODS: In 185 participants of the Prevention of Dementia by Intensive Vascular Care trial between 72 and 80 years of age with systolic hypertension, white matter hyperintensity volume and CBF were derived from 3D FLAIR and arterial spin-labeling MR imaging, respectively. We compared white matter hyperintensity CBF, normal-appearing white matter CBF, and GM CBF across quartiles of white matter hyperintensity volume and assessed the continuous relation between these CBF estimates and white matter hyperintensity volume by using linear regression.

RESULTS: Mean white matter hyperintensity CBF was markedly lower in higher quartiles of white matter hyperintensity volume, and white matter hyperintensity volume and white matter hyperintensity CBF were negatively related (standardized β = −0.248, P = .001) in linear regression. We found no difference in normal-appearing white matter or GM CBF across quartiles of white matter hyperintensity volume or any relation between white matter hyperintensity volume and normal-appearing white matter CBF (standardized β = −0.065, P = .643) or GM CBF (standardized β = −0.035, P = .382) in linear regression.

CONCLUSIONS: Higher white matter hyperintensity volume in elderly individuals with hypertension was associated with lower perfusion within white matter hyperintensities, but not with lower perfusion in the surrounding normal-appearing white matter or GM. These findings suggest that white matter hyperintensities in elderly individuals with hypertension relate to local microvascular alterations rather than a general cerebral perfusion deficit.

ATT
:   arterial transit time
β
:   standardized β
NAWM
:   normal-appearing white matter
preDIVA
:   Prevention of Dementia by Intensive Vascular Care trial
preDIVA-M
:   MRI substudy of the preDIVA trial
WMH
:   white matter hyperintensity" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node14605" data-node-nid="14605" id="top-node-14605--2836001280" data-pisa="ajnr;37/10/1824" data-pisa-master="ajnr;ajnr.A4828" data-apath="/ajnr/37/10/1824.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J.W. van Dalen</span>, <span class="highwire-citation-author" data-delta="1">H.J.M.M. Mutsaerts</span>, <span class="highwire-citation-author" data-delta="2">A.J. Nederveen</span>, <span class="highwire-citation-author" data-delta="3">H. Vrenken</span>, <span class="highwire-citation-author" data-delta="4">M.D. Steenwijk</span>, <span class="highwire-citation-author" data-delta="5">M.W.A. Caan</span>, <span class="highwire-citation-author" data-delta="6">C.B.L.M. Majoie</span>, <span class="highwire-citation-author" data-delta="7">W.A. van Gool</span> and <span class="highwire-citation-author" data-delta="8">E. Richard</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1824-1830; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4828 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14605--2836001280" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J.W. van Dalen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurology (J.W.v.D., W.A.v.G., E.R.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.W.%2Bvan%2BDalen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Dalen%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.W.%2Bvan%2BDalen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-3439-8841" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.W. van Dalen</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">H.J.M.M. Mutsaerts </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (H.J.M.M.M., A.J.N., M.W.A.C., C.B.L.M.M.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.J.M.M.%2BMutsaerts%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mutsaerts%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.J.M.M.%2BMutsaerts%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-0894-0307" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.J.M.M. Mutsaerts</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A.J. Nederveen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (H.J.M.M.M., A.J.N., M.W.A.C., C.B.L.M.M.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.J.%2BNederveen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nederveen%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.J.%2BNederveen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5477-973X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.J. Nederveen</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">H. Vrenken </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Radiology and Nuclear Medicine (H.V., M.D.S.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Physics and Medical Technology (H.V.), Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BVrenken%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vrenken%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BVrenken%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-9106-1172" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Vrenken</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">M.D. Steenwijk </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Radiology and Nuclear Medicine (H.V., M.D.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.D.%2BSteenwijk%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Steenwijk%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.D.%2BSteenwijk%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8346-9044" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.D. Steenwijk</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M.W.A. Caan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (H.J.M.M.M., A.J.N., M.W.A.C., C.B.L.M.M.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.W.A.%2BCaan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Caan%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.W.A.%2BCaan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5162-8880" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.W.A. Caan</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">C.B.L.M. Majoie </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (H.J.M.M.M., A.J.N., M.W.A.C., C.B.L.M.M.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.B.L.M.%2BMajoie%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Majoie%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.B.L.M.%2BMajoie%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7600-9568" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.B.L.M. Majoie</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">W.A. van Gool </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurology (J.W.v.D., W.A.v.G., E.R.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.A.%2Bvan%2BGool%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Gool%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.A.%2Bvan%2BGool%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-3174-8233" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.A. van Gool</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">E. Richard </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurology (J.W.v.D., W.A.v.G., E.R.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurology (E.R.), Radboud University Medical Center, Nijmegen, the Netherlands.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BRichard%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Richard%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BRichard%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7250-3390" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.1" data-doi="10.1007/s00401-011-0851-x"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Schmidt</span>  <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schmidt</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Haybaeck</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Heterogeneity in age-related white matter changes</span>. <abbr class="cit-jnl-abbrev">Acta Neuropathol</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">122</span>:<span class="cit-fpage">171</span>–<span class="cit-lpage">85</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s00401-011-0851-x</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21706175</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s00401-011-0851-x&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21706175&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000292780500005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.2" data-doi="10.1136/bmj.c3666"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Debette</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Markus</span>  <span class="cit-name-given-names">HS</span></span></li></ol><cite>. <span class="cit-article-title">The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis</span>. <abbr class="cit-jnl-abbrev">BMJ</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">341</span>:<span class="cit-fpage">c3666</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/bmj.c3666</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20660506</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiYm1qIjtzOjU6InJlc2lkIjtzOjE3OiIzNDEvanVsMjZfMS9jMzY2NiI7czo0OiJhdG9tIjtzOjIxOiIvYWpuci8zNy8xMC8xODI0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.3" data-doi="10.1196/annals.1444.017"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Schmahmann</span>  <span class="cit-name-given-names">JD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Smith</span>  <span class="cit-name-given-names">EE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Eichler</span>  <span class="cit-name-given-names">FS</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates</span>. <abbr class="cit-jnl-abbrev">Ann N Y Acad Sci</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">1142</span>:<span class="cit-fpage">266</span>–<span class="cit-lpage">309</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1196/annals.1444.017</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18990132</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1196/annals.1444.017&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18990132&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000260858700015&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.4" data-doi="10.1111/j.1747-4949.2011.00725.x"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Moran</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Phan</span>  <span class="cit-name-given-names">TG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Srikanth</span>  <span class="cit-name-given-names">VK</span></span></li></ol><cite>. <span class="cit-article-title">Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes</span>. <abbr class="cit-jnl-abbrev">Int J Stroke</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">36</span>–<span class="cit-lpage">46</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1747-4949.2011.00725.x</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22111922</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToic3B3c28iO3M6NToicmVzaWQiO3M6NjoiNy8xLzM2IjtzOjQ6ImF0b20iO3M6MjE6Ii9ham5yLzM3LzEwLzE4MjQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.5" data-doi="10.1016/S1474-4422(10)70104-6"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Pantoni</span>  <span class="cit-name-given-names">L</span></span></li></ol><cite>. <span class="cit-article-title">Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges</span>. <abbr class="cit-jnl-abbrev">Lancet Neurol</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">9</span>:<span class="cit-fpage">689</span>–<span class="cit-lpage">701</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1474-4422(10)70104-6</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20610345</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1474-4422(10)70104-6&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20610345&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000279286900014&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">6.</span><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6. in text" id="ref-6">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.6" data-doi="10.1111/j.1365-2990.2010.01139.x"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span>  <span class="cit-name-given-names">WR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thore</span>  <span class="cit-name-given-names">CR</span></span></li></ol><cite>. <span class="cit-article-title">Review: cerebral microvascular pathology in ageing and neurodegeneration</span>. <abbr class="cit-jnl-abbrev">Neuropathol Appl Neurobiol</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">37</span>:<span class="cit-fpage">56</span>–<span class="cit-lpage">74</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1365-2990.2010.01139.x</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20946471</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1111/j.1365-2990.2010.01139.x&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20946471&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000286062500005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">7.</span><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7. in text" id="ref-7">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.7" data-doi="10.3174/ajnr.A1091"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Bastos-Leite</span>  <span class="cit-name-given-names">AJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kuijer</span>  <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rombouts</span>  <span class="cit-name-given-names">SA</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">29</span>:<span class="cit-fpage">1296</span>–<span class="cit-lpage">301</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A1091</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18451090</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo5OiIyOS83LzEyOTYiO3M6NDoiYXRvbSI7czoyMToiL2FqbnIvMzcvMTAvMTgyNC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">8.</span><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8. in text" id="ref-8">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.8" data-doi="10.1136/jnnp.69.1.48"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Markus</span>  <span class="cit-name-given-names">HS</span></span></li></ol><cite>. <span class="cit-article-title">Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI</span>. <abbr class="cit-jnl-abbrev">J Neurol Neurosurg Psychiatry</abbr> <span class="cit-pub-date">2000</span>;<span class="cit-vol">69</span>:<span class="cit-fpage">48</span>–<span class="cit-lpage">53</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/jnnp.69.1.48</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10864603</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiam5ucCI7czo1OiJyZXNpZCI7czo3OiI2OS8xLzQ4IjtzOjQ6ImF0b20iO3M6MjE6Ii9ham5yLzM3LzEwLzE4MjQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">9.</span><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9. in text" id="ref-9">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.9" data-doi="10.1212/WNL.59.3.321"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">O'Sullivan</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lythgoe</span>  <span class="cit-name-given-names">DJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pereira</span>  <span class="cit-name-given-names">AC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis</span>. <abbr class="cit-jnl-abbrev">Neurology</abbr> <span class="cit-pub-date">2002</span>;<span class="cit-vol">59</span>:<span class="cit-fpage">321</span>–<span class="cit-lpage">26</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1212/WNL.59.3.321</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12177363</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6IjU5LzMvMzIxIjtzOjQ6ImF0b20iO3M6MjE6Ii9ham5yLzM3LzEwLzE4MjQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">10.</span><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10. in text" id="ref-10">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.10" data-doi="10.1016/j.pscychresns.2008.11.006"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brickman</span>  <span class="cit-name-given-names">AM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zahra</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Muraskin</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging</span>. <abbr class="cit-jnl-abbrev">Psychiatry Res</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">172</span>:<span class="cit-fpage">117</span>–<span class="cit-lpage">20</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.pscychresns.2008.11.006</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19324534</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.pscychresns.2008.11.006&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19324534&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000265779800005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">11.</span><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11. in text" id="ref-11">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.11" data-doi="10.3233/JAD-2012-120964"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Zhang</span>  <span class="cit-name-given-names">Q</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stafford</span>  <span class="cit-name-given-names">RB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wang</span>  <span class="cit-name-given-names">Z</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Microvascular perfusion based on arterial spin labeled perfusion MRI as a measure of vascular risk in Alzheimer's disease</span>. <abbr class="cit-jnl-abbrev">J Alzheimers Dis</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">32</span>:<span class="cit-fpage">677</span>–<span class="cit-lpage">87</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3233/JAD-2012-120964</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22886015</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3233/JAD-2012-120964&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22886015&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">12.</span><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12. in text" id="ref-12">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.12" data-doi="10.1161/01.STR.0000012808.81667.4B"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Marstrand</span>  <span class="cit-name-given-names">JR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Garde</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rostrup</span>  <span class="cit-name-given-names">E</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2002</span>;<span class="cit-vol">33</span>:<span class="cit-fpage">972</span>–<span class="cit-lpage">76</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1161/01.STR.0000012808.81667.4B</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11935046</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjg6IjMzLzQvOTcyIjtzOjQ6ImF0b20iO3M6MjE6Ii9ham5yLzM3LzEwLzE4MjQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">13.</span><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13. in text" id="ref-13">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.13" data-doi="10.1176/appi.neuropsych.16.1.83"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Sachdev</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wen</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shnier</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral blood volume in T2-weighted white matter hyperintensities using exogenous contrast based perfusion MRI</span>. <abbr class="cit-jnl-abbrev">J Neuropsychiatry Clin Neurosci</abbr> <span class="cit-pub-date">2004</span>;<span class="cit-vol">16</span>:<span class="cit-fpage">83</span>–<span class="cit-lpage">92</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>14990763</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1176/appi.neuropsych.16.1.83&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=14990763&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">14.</span><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14. in text" id="ref-14">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.14" data-doi="10.1111/j.1468-1331.2012.03785.x"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Makedonov</span>  <span class="cit-name-given-names">I</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Black</span>  <span class="cit-name-given-names">SE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">MacIntosh</span>  <span class="cit-name-given-names">BJ</span></span></li></ol><cite>. <span class="cit-article-title">Cerebral small vessel disease in aging and Alzheimer's disease: a comparative study using MRI and SPECT</span>. <abbr class="cit-jnl-abbrev">Eur J Neurol</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">20</span>:<span class="cit-fpage">243</span>–<span class="cit-lpage">50</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1468-1331.2012.03785.x</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22742818</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1111/j.1468-1331.2012.03785.x&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22742818&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">15.</span><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15. in text" id="ref-15">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.15" data-doi="10.1016/j.neurobiolaging.2014.06.001"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Benedictus</span>  <span class="cit-name-given-names">MR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Binnewijzend</span>  <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kuijer</span>  <span class="cit-name-given-names">JP</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Brain volume and white matter hyperintensities as determinants of cerebral blood flow in Alzheimer's disease</span>. <abbr class="cit-jnl-abbrev">Neurobiol Aging</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">35</span>:<span class="cit-fpage">2665</span>–<span class="cit-lpage">70</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neurobiolaging.2014.06.001</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25018106</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neurobiolaging.2014.06.001&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25018106&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">16.</span><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16. in text" id="ref-16">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.16" data-doi="10.3389/fnagi.2015.00131"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Crane</span>  <span class="cit-name-given-names">DE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Black</span>  <span class="cit-name-given-names">SE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ganda</span>  <span class="cit-name-given-names">A</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Gray matter blood flow and volume are reduced in association with white matter hyperintensity lesion burden: a cross-sectional MRI study</span>. <abbr class="cit-jnl-abbrev">Front Aging Neurosci</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">131</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3389/fnagi.2015.00131</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26217223</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3389/fnagi.2015.00131&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26217223&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">17.</span><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17. in text" id="ref-17">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.17" data-doi="10.1002/ana.82"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Tzourio</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lévy</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Dufouil</span>  <span class="cit-name-given-names">C</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Low cerebral blood flow velocity and risk of white matter hyperintensities</span>. <abbr class="cit-jnl-abbrev">Ann Neurol</abbr> <span class="cit-pub-date">2001</span>;<span class="cit-vol">49</span>:<span class="cit-fpage">411</span>–<span class="cit-lpage">14</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/ana.82.abs</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11261520</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/ana.82&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11261520&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">18.</span><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18. in text" id="ref-18">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.18" data-doi="10.2337/dc06-0261"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Novak</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Last</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Alsop</span>  <span class="cit-name-given-names">DC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes</span>. <abbr class="cit-jnl-abbrev">Diabetes Care</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">29</span>:<span class="cit-fpage">1529</span>–<span class="cit-lpage">34</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.2337/dc06-0261</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16801574</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NzoiZGlhY2FyZSI7czo1OiJyZXNpZCI7czo5OiIyOS83LzE1MjkiO3M6NDoiYXRvbSI7czoyMToiL2FqbnIvMzcvMTAvMTgyNC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">19.</span><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19. in text" id="ref-19">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.19" data-doi="10.1155/2012/616572"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Heliopoulos</span>  <span class="cit-name-given-names">I</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Artemis</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vadikolias</span>  <span class="cit-name-given-names">K</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Association of ultrasonographic parameters with subclinical white-matter hyperintensities in hypertensive patients</span>. <abbr class="cit-jnl-abbrev">Cardiovasc Psychiatry Neurol</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">2012</span>:<span class="cit-fpage">1</span>–<span class="cit-lpage">8</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1155/2012/616572</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23056917</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1155/2012/616572&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23056917&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">20.</span><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20. in text" id="ref-20">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.20" data-doi="10.1016/j.jash.2013.04.011"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Alosco</span>  <span class="cit-name-given-names">ML</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brickman</span>  <span class="cit-name-given-names">AM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Spitznagel</span>  <span class="cit-name-given-names">MB</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure</span>. <abbr class="cit-jnl-abbrev">J Am Soc Hypertens</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">336</span>–<span class="cit-lpage">43</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jash.2013.04.011</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23735419</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.jash.2013.04.011&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23735419&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">21.</span><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21. in text" id="ref-21">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.21" data-doi="10.1161/STROKEAHA.107.497438"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Holland</span>  <span class="cit-name-given-names">CM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Smith</span>  <span class="cit-name-given-names">EE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Csapo</span>  <span class="cit-name-given-names">I</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">39</span>:<span class="cit-fpage">1127</span>–<span class="cit-lpage">33</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1161/STROKEAHA.107.497438</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18292383</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjk6IjM5LzQvMTEyNyI7czo0OiJhdG9tIjtzOjIxOiIvYWpuci8zNy8xMC8xODI0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">22.</span><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22. in text" id="ref-22">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.22" data-doi="10.1148/radiol.2431052111"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Ten Dam</span>  <span class="cit-name-given-names">VH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van den Heuvel</span>  <span class="cit-name-given-names">DM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">de Craen</span>  <span class="cit-name-given-names">AJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities</span>. <abbr class="cit-jnl-abbrev">Radiology</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">243</span>:<span class="cit-fpage">198</span>–<span class="cit-lpage">203</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1148/radiol.2431052111</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>17329688</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiol.2431052111&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=17329688&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">23.</span><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23. in text" id="ref-23">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.23" data-doi="10.1016/j.nicl.2015.04.012"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Promjunyakul</span>  <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lahna</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kaye</span>  <span class="cit-name-given-names">JA</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures</span>. <abbr class="cit-jnl-abbrev">Neuroimage Clin</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">8</span>:<span class="cit-fpage">224</span>–<span class="cit-lpage">29</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.nicl.2015.04.012</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26106546</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.nicl.2015.04.012&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26106546&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">24.</span><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24. in text" id="ref-24">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.24" data-doi="10.1097/WAD.0b013e31819783a4"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Richard</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Van den Heuvel</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Moll van Charante</span>  <span class="cit-name-given-names">EP</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress</span>. <abbr class="cit-jnl-abbrev">Alzheimer Dis Assoc Disord</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">23</span>:<span class="cit-fpage">198</span>–<span class="cit-lpage">204</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/WAD.0b013e31819783a4</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19812459</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/WAD.0b013e31819783a4&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19812459&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000269909300004&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">25.</span><a class="rev-xref-ref" href="#xref-ref-25-1" title="View reference 25. in text" id="ref-25">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.25" data-doi="10.3233/JAD-2010-091699"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Alsop</span>  <span class="cit-name-given-names">DC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Dai</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Grossman</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease</span>. <abbr class="cit-jnl-abbrev">J Alzheimers Dis</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">20</span>:<span class="cit-fpage">871</span>–<span class="cit-lpage">80</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3233/JAD-2010-091699</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20413865</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3233/JAD-2010-091699&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20413865&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000279538600019&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">26.</span><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26. in text" id="ref-26">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.26" data-doi="10.1016/j.nicl.2013.10.003"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Steenwijk</span>  <span class="cit-name-given-names">MD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pouwels</span>  <span class="cit-name-given-names">PJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Daams</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs)</span>. <abbr class="cit-jnl-abbrev">Neuroimage Clin</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">3</span>:<span class="cit-fpage">462</span>–<span class="cit-lpage">69</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.nicl.2013.10.003</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24273728</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.nicl.2013.10.003&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24273728&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">27.</span><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27. in text" id="ref-27">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.27" data-doi="10.1371/journal.pone.0133717"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Mutsaerts</span>  <span class="cit-name-given-names">HJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van Dalen</span>  <span class="cit-name-given-names">JW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Heijtel</span>  <span class="cit-name-given-names">DF</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral perfusion measurements in elderly with hypertension using arterial spin labeling</span>. <abbr class="cit-jnl-abbrev">PLoS One</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">10</span>:<span class="cit-fpage">e0133717</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1371/journal.pone.0133717</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26241897</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1371/journal.pone.0133717&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26241897&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">28.</span><a class="rev-xref-ref" href="#xref-ref-28-1" title="View reference 28. in text" id="ref-28">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.28" data-doi="10.1002/mrm.10559"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wang</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Alsop</span>  <span class="cit-name-given-names">DC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Song</span>  <span class="cit-name-given-names">HK</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">2003</span>;<span class="cit-vol">50</span>:<span class="cit-fpage">599</span>–<span class="cit-lpage">607</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/mrm.10559</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12939768</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.10559&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12939768&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000185174500019&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">29.</span><a class="rev-xref-ref" href="#xref-ref-29-1" title="View reference 29. in text" id="ref-29">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.29" data-doi="10.1002/mrm.1910400308"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Buxton</span>  <span class="cit-name-given-names">RB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Frank</span>  <span class="cit-name-given-names">LR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wong</span>  <span class="cit-name-given-names">EC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A general kinetic model for quantitative perfusion imaging with arterial spin labeling</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">1998</span>;<span class="cit-vol">40</span>:<span class="cit-fpage">383</span>–<span class="cit-lpage">96</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/mrm.1910400308</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9727941</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.1910400308&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9727941&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000075570500007&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">30.</span><a class="rev-xref-ref" href="#xref-ref-30-1" title="View reference 30. in text" id="ref-30">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.30" data-doi="10.1016/j.neuroimage.2011.09.015"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Jenkinson</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Beckmann</span>  <span class="cit-name-given-names">CF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Behrens</span>  <span class="cit-name-given-names">TE</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">FSL</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">62</span>:<span class="cit-fpage">782</span>–<span class="cit-lpage">90</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2011.09.015</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21979382</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2011.09.015&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21979382&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000306390600032&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">31.</span><a class="rev-xref-ref" href="#xref-ref-31-1" title="View reference 31. in text" id="ref-31">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.31" data-doi="10.1136/jnnp.2009.204685"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Gouw</span>  <span class="cit-name-given-names">AA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Seewann</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van der Flier</span>  <span class="cit-name-given-names">WM</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations</span>. <abbr class="cit-jnl-abbrev">J Neurol Neurosurg Psychiatry</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">82</span>:<span class="cit-fpage">126</span>–<span class="cit-lpage">35</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/jnnp.2009.204685</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20935330</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiam5ucCI7czo1OiJyZXNpZCI7czo4OiI4Mi8yLzEyNiI7czo0OiJhdG9tIjtzOjIxOiIvYWpuci8zNy8xMC8xODI0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">32.</span><a class="rev-xref-ref" href="#xref-ref-32-1" title="View reference 32. in text" id="ref-32">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.32" data-doi="10.1002/1522-2594(200011)44:5&lt;680::AID-MRM4&gt;3.0.CO;2-Q"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Yang</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Engelien</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Xu</span>  <span class="cit-name-given-names">S</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Transit time, trailing time, and cerebral blood flow during brain activation: measurement using multislice, pulsed spin-labeling perfusion imaging</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">2000</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">680</span>–<span class="cit-lpage">85</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11064401</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/1522-2594(200011)44:5&lt;680::AID-MRM4&gt;3.0.CO;2-Q&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11064401&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">33.</span><a class="rev-xref-ref" href="#xref-ref-33-1" title="View reference 33. in text" id="ref-33">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.33" data-doi="10.1016/j.neuroimage.2003.11.015"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wen</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sachdev</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shnier</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Effect of white matter hyperintensities on cortical cerebral blood volume using perfusion MRI</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2004</span>;<span class="cit-vol">21</span>:<span class="cit-fpage">1350</span>–<span class="cit-lpage">56</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2003.11.015</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>15050560</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2003.11.015&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15050560&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">34.</span><a class="rev-xref-ref" href="#xref-ref-34-1" title="View reference 34. in text" id="ref-34">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.34" data-doi="10.1002/ana.24285"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Conklin</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Silver</span>  <span class="cit-name-given-names">FL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mikulis</span>  <span class="cit-name-given-names">DJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Are acute infarcts the cause of leukoaraiosis? Brain mapping for 16 consecutive weeks</span>. <abbr class="cit-jnl-abbrev">Ann Neurol</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">76</span>:<span class="cit-fpage">899</span>–<span class="cit-lpage">904</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/ana.24285</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25283088</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/ana.24285&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25283088&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">35.</span><a class="rev-xref-ref" href="#xref-ref-35-1" title="View reference 35. in text" id="ref-35">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.35" data-doi="10.1016/S0140-6736(13)61088-0"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Qureshi</span>  <span class="cit-name-given-names">AI</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Caplan</span>  <span class="cit-name-given-names">LR</span></span></li></ol><cite>. <span class="cit-article-title">Intracranial atherosclerosis</span>. <abbr class="cit-jnl-abbrev">Lancet</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">383</span>:<span class="cit-fpage">984</span>–<span class="cit-lpage">98</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S0140-6736(13)61088-0</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24007975</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S0140-6736(13)61088-0&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24007975&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">36.</span><a class="rev-xref-ref" href="#xref-ref-36-1" title="View reference 36. in text" id="ref-36">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.36" data-doi="10.1016/j.neurobiolaging.2013.04.023"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Benedictus</span>  <span class="cit-name-given-names">MR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Goos</span>  <span class="cit-name-given-names">JD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Binnewijzend</span>  <span class="cit-name-given-names">MA</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease</span>. <abbr class="cit-jnl-abbrev">Neurobiol Aging</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">34</span>:<span class="cit-fpage">2488</span>–<span class="cit-lpage">94</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neurobiolaging.2013.04.023</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23731952</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neurobiolaging.2013.04.023&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23731952&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000324124000006&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">37.</span><a class="rev-xref-ref" href="#xref-ref-37-1" title="View reference 37. in text" id="ref-37">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.37" data-doi="10.3233/JAD-2012-120793"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">de la Torre</span>  <span class="cit-name-given-names">JC</span></span></li></ol><cite>. <span class="cit-article-title">Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease</span>. <abbr class="cit-jnl-abbrev">J Alzheimers Dis</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">32</span>:<span class="cit-fpage">553</span>–<span class="cit-lpage">67</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3233/JAD-2012-120793</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22842871</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3233/JAD-2012-120793&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22842871&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000310576800005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">38.</span><a class="rev-xref-ref" href="#xref-ref-38-1" title="View reference 38. in text" id="ref-38">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.38" data-doi="10.3174/ajnr.A3090"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Macintosh</span>  <span class="cit-name-given-names">BJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Marquardt</span>  <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schulz</span>  <span class="cit-name-given-names">UG</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Hemodynamic alterations in vertebrobasilar large artery disease assessed by arterial spin-labeling MR imaging</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">33</span>:<span class="cit-fpage">1939</span>–<span class="cit-lpage">44</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A3090</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22555580</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czoxMDoiMzMvMTAvMTkzOSI7czo0OiJhdG9tIjtzOjIxOiIvYWpuci8zNy8xMC8xODI0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">39.</span><a class="rev-xref-ref" href="#xref-ref-39-1" title="View reference 39. in text" id="ref-39">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.39" data-doi="10.1161/HYPERTENSIONAHA.112.200972"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Tryambake</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">He</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Firbank</span>  <span class="cit-name-given-names">MJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension</span>. <abbr class="cit-jnl-abbrev">Hypertension</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">61</span>:<span class="cit-fpage">1309</span>–<span class="cit-lpage">15</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1161/HYPERTENSIONAHA.112.200972</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23529166</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1161/HYPERTENSIONAHA.112.200972&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23529166&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">40.</span><a class="rev-xref-ref" href="#xref-ref-40-1" title="View reference 40. in text" id="ref-40">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.40" data-doi="10.1097/HJH.0b013e32833951ef"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Muller</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van der Graaf</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Visseren</span>  <span class="cit-name-given-names">FL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Blood pressure, cerebral blood flow, and brain volumes: the SMART-MR study</span>. <abbr class="cit-jnl-abbrev">J Hypertens</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">28</span>:<span class="cit-fpage">1498</span>–<span class="cit-lpage">505</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/HJH.0b013e32833951ef</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20453669</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/HJH.0b013e32833951ef&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20453669&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">41.</span><a class="rev-xref-ref" href="#xref-ref-41-1" title="View reference 41. in text" id="ref-41">↵</a><div class="cit ref-cit ref-web" id="cit-37.10.1824.41"><div class="cit-metadata"><cite><span class="cit-auth cit-collab">The Netherlands National Institute for Health and the Environment (RIVM) blood pressure statistics (Dutch)</span>. <span class="cit-comment"><a href="https://www.volksgezondheidenzorg.info/onderwerp/bloeddruk/cijfers-context/huidige-situatie#!node-verhoogde-bloeddruk-naar-leeftijd">https://www.volksgezondheidenzorg.info/onderwerp/bloeddruk/cijfers-context/huidige-situatie#!node-verhoogde-bloeddruk-naar-leeftijd</a>. Accessed November 26, 2015</span>.</cite></div><div class="cit-extra"></div></div></li><li><span class="ref-label">42.</span><a class="rev-xref-ref" href="#xref-ref-42-1" title="View reference 42. in text" id="ref-42">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.42" data-doi="10.1002/mrm.21515"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">van Gelderen</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">de Zwart</span>  <span class="cit-name-given-names">JA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Duyn</span>  <span class="cit-name-given-names">JH</span></span></li></ol><cite>. <span class="cit-article-title">Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">59</span>:<span class="cit-fpage">788</span>–<span class="cit-lpage">95</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/mrm.21515</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18383289</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.21515&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18383289&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">43.</span><a class="rev-xref-ref" href="#xref-ref-43-1" title="View reference 43. in text" id="ref-43">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.43" data-doi="10.1259/bjr/67705974"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Petersen</span>  <span class="cit-name-given-names">ET</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zimine</span>  <span class="cit-name-given-names">I</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ho</span>  <span class="cit-name-given-names">YC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques</span>. <abbr class="cit-jnl-abbrev">Br J Radiol</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">79</span>:<span class="cit-fpage">688</span>–<span class="cit-lpage">701</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1259/bjr/67705974</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16861326</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NzoiYmpyYWRpbyI7czo1OiJyZXNpZCI7czoxMDoiNzkvOTQ0LzY4OCI7czo0OiJhdG9tIjtzOjIxOiIvYWpuci8zNy8xMC8xODI0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">44.</span><a class="rev-xref-ref" href="#xref-ref-44-1" title="View reference 44. in text" id="ref-44">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.44" data-doi="10.1016/j.nicl.2013.11.003"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Mutsaerts</span>  <span class="cit-name-given-names">HJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Richard</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Heijtel</span>  <span class="cit-name-given-names">DF</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Gray matter contamination in arterial spin labeling white matter perfusion measurements in patients with dementia</span>. <abbr class="cit-jnl-abbrev">Neuroimage Clin</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">4</span>:<span class="cit-fpage">139</span>–<span class="cit-lpage">44</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.nicl.2013.11.003</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24371796</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.nicl.2013.11.003&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24371796&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">45.</span><a class="rev-xref-ref" href="#xref-ref-45-1" title="View reference 45. in text" id="ref-45">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.45" data-doi="10.1371/journal.pone.0082679"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wu</span>  <span class="cit-name-given-names">WC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lin</span>  <span class="cit-name-given-names">SC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wang</span>  <span class="cit-name-given-names">DJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Measurement of cerebral white matter perfusion using pseudocontinuous arterial spin labeling 3T magnetic resonance imaging: an experimental and theoretical investigation of feasibility</span>. <abbr class="cit-jnl-abbrev">PLoS One</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">8</span>:<span class="cit-fpage">e82679</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1371/journal.pone.0082679</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24324822</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1371/journal.pone.0082679&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24324822&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">46.</span><a class="rev-xref-ref" href="#xref-ref-46-1" title="View reference 46. in text" id="ref-46">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.46" data-doi="10.1002/mrm.22002"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">van Osch</span>  <span class="cit-name-given-names">MJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Teeuwisse</span>  <span class="cit-name-given-names">WM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van Walderveen</span>  <span class="cit-name-given-names">MA</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Can arterial spin labeling detect white matter perfusion signal?</span> <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">62</span>:<span class="cit-fpage">165</span>–<span class="cit-lpage">73</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/mrm.22002</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19365865</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.22002&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19365865&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">47.</span><a class="rev-xref-ref" href="#xref-ref-47-1" title="View reference 47. in text" id="ref-47">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.47" data-doi="10.1016/j.neulet.2015.03.005"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brickman</span>  <span class="cit-name-given-names">AM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Guzman</span>  <span class="cit-name-given-names">VA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gonzalez-Castellon</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated</span>. <abbr class="cit-jnl-abbrev">Neurosci Lett</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">592</span>:<span class="cit-fpage">54</span>–<span class="cit-lpage">58</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neulet.2015.03.005</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25748319</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neulet.2015.03.005&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25748319&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F10%2F1824.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">48.</span><a class="rev-xref-ref" href="#xref-ref-48-1" title="View reference 48. in text" id="ref-48">↵</a><div class="cit ref-cit ref-journal" id="cit-37.10.1824.48" data-doi="10.1136/jnnp.2009.174607"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Birns</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jarosz</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Markus</span>  <span class="cit-name-given-names">HS</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease</span>. <abbr class="cit-jnl-abbrev">J Neurol Neurosurg Psychiatry</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">80</span>:<span class="cit-fpage">1093</span>–<span class="cit-lpage">98</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/jnnp.2009.174607</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19535355</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiam5ucCI7czo1OiJyZXNpZCI7czoxMDoiODAvMTAvMTA5MyI7czo0OiJhdG9tIjtzOjIxOiIvYWpuci8zNy8xMC8xODI0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li></ol></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 37</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 2016 </div></div>
      
      
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.W.</span> <span class="nlm-surname">van Dalen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">H.J.M.M.</span> <span class="nlm-surname">Mutsaerts</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Nederveen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Vrenken</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.D.</span> <span class="nlm-surname">Steenwijk</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.W.A.</span> <span class="nlm-surname">Caan</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.B.L.M.</span> <span class="nlm-surname">Majoie</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">W.A.</span> <span class="nlm-surname">van Gool</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Richard</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1824-1830; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4828 </span></div>
  
  
  
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      <div class="highwire-cite-title">White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.W.</span> <span class="nlm-surname">van Dalen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">H.J.M.M.</span> <span class="nlm-surname">Mutsaerts</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Nederveen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Vrenken</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.D.</span> <span class="nlm-surname">Steenwijk</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.W.A.</span> <span class="nlm-surname">Caan</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.B.L.M.</span> <span class="nlm-surname">Majoie</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">W.A.</span> <span class="nlm-surname">van Gool</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Richard</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1824-1830; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4828 </span></div>
  
  
  
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