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<meta name="DC.Title" content="FLAIR2: A Combination of FLAIR and T2 for Improved MS Lesion Detection" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4514" />
<meta name="DC.Date" content="2016-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2016 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: FLAIR and double inversion recovery are important MR imaging scans for MS. The suppression of signal from CSF in FLAIR and the additional suppression of WM signal in double inversion recovery improve contrast between lesions, WM and GM, albeit at a reduced SNR. However, whether the acquisition of double inversion recovery is necessary is still debated. Here, we present an approach that allows obtaining CSF-suppressed images with improved contrast between lesions, WM and GM without strongly penalizing SNR.

MATERIALS AND METHODS: 3D T2-weighted and 3D-FLAIR data acquired from September 2014 to April 2015 in healthy volunteers (23.4 ± 2.4 years of age; female/male ratio, 3:2) and patients (44.1 ± 14.0 years of age; female/male ratio, 4:5) with MS were coregistered and multiplied (FLAIR2). SNR and contrast-to-noise measurements were performed for focal lesions and GM and WM. Furthermore, data from 24 subjects with relapsing-remitting and progressive MS were analyzed retrospectively (52.7 ± 8.1 years of age; female/male ratio, 14:10).

RESULTS: The GM-WM contrast-to-noise ratio was by 133% higher in FLAIR2 than in FLAIR and improved between lesions and WM by 31%, 93%, and 158% compared with T2, DIR, and FLAIR, respectively. Cortical and juxtacortical lesions were more conspicuous in FLAIR2. Furthermore, the 3D nature of FLAIR2 allowed reliable visualization of callosal and infratentorial lesions.

CONCLUSIONS: We present a simple approach for obtaining CSF suppression with an improved contrast-to-noise ratio compared with conventional FLAIR and double inversion recovery without the acquisition of additional data. FLAIR2 can be computed retrospectively if T2 and FLAIR scans are available.

CNR
:   contrast-to-noise ratio
DIR
:   double inversion recovery" />
<meta name="DC.Contributor" content="V. Wiggermann" />
<meta name="DC.Contributor" content="E. Hernández-Torres" />
<meta name="DC.Contributor" content="A. Traboulsee" />
<meta name="DC.Contributor" content="D.K.B. Li" />
<meta name="DC.Contributor" content="A. Rauscher" />
<meta name="article:published_time" content="2016-02-01" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="FLAIR2: A Combination of FLAIR and T2 for Improved MS Lesion Detection" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;FLAIR and double inversion recovery are important MR imaging scans for MS. The suppression of signal from CSF in FLAIR and the additional suppression of WM signal in double inversion recovery improve contrast between lesions, WM and GM, albeit at a reduced SNR. However, whether the acquisition of double inversion recovery is necessary is still debated. Here, we present an approach that allows obtaining CSF-suppressed images with improved contrast between lesions, WM and GM without strongly penalizing SNR.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;3D T2-weighted and 3D-FLAIR data acquired from September 2014 to April 2015 in healthy volunteers (23.4 ± 2.4 years of age; female/male ratio, 3:2) and patients (44.1 ± 14.0 years of age; female/male ratio, 4:5) with MS were coregistered and multiplied (FLAIR&lt;sup&gt;2&lt;/sup&gt;). SNR and contrast-to-noise measurements were performed for focal lesions and GM and WM. Furthermore, data from 24 subjects with relapsing-remitting and progressive MS were analyzed retrospectively (52.7 ± 8.1 years of age; female/male ratio, 14:10).&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The GM-WM contrast-to-noise ratio was by 133% higher in FLAIR&lt;sup&gt;2&lt;/sup&gt; than in FLAIR and improved between lesions and WM by 31%, 93%, and 158% compared with T2, DIR, and FLAIR, respectively. Cortical and juxtacortical lesions were more conspicuous in FLAIR&lt;sup&gt;2&lt;/sup&gt;. Furthermore, the 3D nature of FLAIR&lt;sup&gt;2&lt;/sup&gt; allowed reliable visualization of callosal and infratentorial lesions.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;We present a simple approach for obtaining CSF suppression with an improved contrast-to-noise ratio compared with conventional FLAIR and double inversion recovery without the acquisition of additional data. FLAIR&lt;sup&gt;2&lt;/sup&gt; can be computed retrospectively if T2 and FLAIR scans are available.&lt;/p&gt;" />
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<meta name="twitter:title" content="FLAIR2: A Combination of FLAIR and T2 for Improved MS Lesion Detection" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: FLAIR and double inversion recovery are important MR imaging scans for MS. The suppression of signal from CSF in FLAIR and the additional suppression of WM signal in double inversion recovery improve contrast between lesions, WM and GM, albeit at a reduced SNR. However, whether the acquisition of double inversion recovery is necessary is still debated. Here, we present an approach that allows obtaining CSF-suppressed images with improved contrast between lesions, WM and GM without strongly penalizing SNR.

MATERIALS AND METHODS: 3D T2-weighted and 3D-FLAIR data acquired from September 2014 to April 2015 in healthy volunteers (23.4 ± 2.4 years of age; female/male ratio, 3:2) and patients (44.1 ± 14.0 years of age; female/male ratio, 4:5) with MS were coregistered and multiplied (FLAIR2). SNR and contrast-to-noise measurements were performed for focal lesions and GM and WM. Furthermore, data from 24 subjects with relapsing-remitting and progressive MS were analyzed retrospectively (52.7 ± 8.1 years of age; female/male ratio, 14:10).

RESULTS: The GM-WM contrast-to-noise ratio was by 133% higher in FLAIR2 than in FLAIR and improved between lesions and WM by 31%, 93%, and 158% compared with T2, DIR, and FLAIR, respectively. Cortical and juxtacortical lesions were more conspicuous in FLAIR2. Furthermore, the 3D nature of FLAIR2 allowed reliable visualization of callosal and infratentorial lesions.

CONCLUSIONS: We present a simple approach for obtaining CSF suppression with an improved contrast-to-noise ratio compared with conventional FLAIR and double inversion recovery without the acquisition of additional data. FLAIR2 can be computed retrospectively if T2 and FLAIR scans are available.

CNR
:   contrast-to-noise ratio
DIR
:   double inversion recovery" />
<meta name="og-title" property="og:title" content="FLAIR2: A Combination of FLAIR and T2 for Improved MS Lesion Detection" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/37/2/259" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: FLAIR and double inversion recovery are important MR imaging scans for MS. The suppression of signal from CSF in FLAIR and the additional suppression of WM signal in double inversion recovery improve contrast between lesions, WM and GM, albeit at a reduced SNR. However, whether the acquisition of double inversion recovery is necessary is still debated. Here, we present an approach that allows obtaining CSF-suppressed images with improved contrast between lesions, WM and GM without strongly penalizing SNR.

MATERIALS AND METHODS: 3D T2-weighted and 3D-FLAIR data acquired from September 2014 to April 2015 in healthy volunteers (23.4 ± 2.4 years of age; female/male ratio, 3:2) and patients (44.1 ± 14.0 years of age; female/male ratio, 4:5) with MS were coregistered and multiplied (FLAIR2). SNR and contrast-to-noise measurements were performed for focal lesions and GM and WM. Furthermore, data from 24 subjects with relapsing-remitting and progressive MS were analyzed retrospectively (52.7 ± 8.1 years of age; female/male ratio, 14:10).

RESULTS: The GM-WM contrast-to-noise ratio was by 133% higher in FLAIR2 than in FLAIR and improved between lesions and WM by 31%, 93%, and 158% compared with T2, DIR, and FLAIR, respectively. Cortical and juxtacortical lesions were more conspicuous in FLAIR2. Furthermore, the 3D nature of FLAIR2 allowed reliable visualization of callosal and infratentorial lesions.

CONCLUSIONS: We present a simple approach for obtaining CSF suppression with an improved contrast-to-noise ratio compared with conventional FLAIR and double inversion recovery without the acquisition of additional data. FLAIR2 can be computed retrospectively if T2 and FLAIR scans are available.

CNR
:   contrast-to-noise ratio
DIR
:   double inversion recovery" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node14312--5" data-node-nid="14312" id="top-node-14312--6448433303" data-pisa="ajnr;37/2/259" data-pisa-master="ajnr;ajnr.A4514" data-apath="/ajnr/37/2/259.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">FLAIR<sup>2</sup>: A Combination of FLAIR and T2 for Improved MS Lesion Detection</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">V. Wiggermann</span>, <span class="highwire-citation-author" data-delta="1">E. Hernández-Torres</span>, <span class="highwire-citation-author" data-delta="2">A. Traboulsee</span>, <span class="highwire-citation-author" data-delta="3">D.K.B. Li</span> and <span class="highwire-citation-author" data-delta="4">A. Rauscher</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">259-265; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4514 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14312--6448433303" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">V. Wiggermann </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Physics and Astronomy (V.W.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Pediatrics (V.W., E.H.T., A.R.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>University of British Columbia MRI Research Centre (V.W., E.H.T., A.R.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.%2BWiggermann%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wiggermann%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AV.%2BWiggermann%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-5236-3039" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for V. Wiggermann</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E. Hernández-Torres </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pediatrics (V.W., E.H.T., A.R.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>University of British Columbia MRI Research Centre (V.W., E.H.T., A.R.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BHern%C3%A1ndez-Torres%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hern%C3%A1ndez-Torres%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BHern%25C3%25A1ndez-Torres%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-2873-5693" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. Hernández-Torres</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A. Traboulsee </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Medicine (Neurology) (A.T., D.K.B.L.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BTraboulsee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Traboulsee%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BTraboulsee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-0351-9639" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Traboulsee</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">D.K.B. Li </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Medicine (Neurology) (A.T., D.K.B.L.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Radiology (D.K.B.L.)</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Centre for Brain Health (D.K.B.L., A.R.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.K.B.%2BLi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Li%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.K.B.%2BLi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-1121-5571" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D.K.B. Li</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">A. Rauscher </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pediatrics (V.W., E.H.T., A.R.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>University of British Columbia MRI Research Centre (V.W., E.H.T., A.R.)</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Centre for Brain Health (D.K.B.L., A.R.)</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Child and Family Research Institute (A.R.), University of British Columbia, Vancouver, British Columbia, Canada.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BRauscher%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rauscher%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BRauscher%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-1961-8252" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Rauscher</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.1" data-doi="10.1016/S0140-6736(84)90584-1"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Stewart</span>  <span class="cit-name-given-names">WA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hall</span>  <span class="cit-name-given-names">LD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Berry</span>  <span class="cit-name-given-names">K</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Correlation between NMR scan and brain slice data in multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Lancet</abbr> <span class="cit-pub-date">1984</span>;<span class="cit-vol">2</span>:<span class="cit-fpage">412</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>6147494</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S0140-6736(84)90584-1&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=6147494&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1984TE58300055&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.2" data-doi="10.1016/j.nic.2008.07.001"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Traboulsee</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Li</span>  <span class="cit-name-given-names">DK</span></span></li></ol><cite>. <span class="cit-article-title">Conventional MR imaging</span>. <abbr class="cit-jnl-abbrev">Neuroimaging Clin N Am</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">18</span>:<span class="cit-fpage">651</span>–<span class="cit-lpage">73</span>, <span class="cit-fpage">x</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.nic.2008.07.001</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19068407</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.nic.2008.07.001&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19068407&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000261643100008&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.3"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Simon</span>  <span class="cit-name-given-names">JH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Li</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Traboulsee</span>  <span class="cit-name-given-names">A</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Standardized MR imaging protocol for multiple sclerosis: Consortium of MS Centers consensus guidelines</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">27</span>:<span class="cit-fpage">455</span>–<span class="cit-lpage">61</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16484429</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiRlVMTCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo4OiIyNy8yLzQ1NSI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zNy8yLzI1OS5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.4" data-doi="10.1148/radiology.212.3.r99se07793"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Okuda</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Korogi</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shigematsu</span>  <span class="cit-name-given-names">Y</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Brain lesions: when should fluid-attenuated inversion-recovery sequences be used in MR evaluation?</span> <abbr class="cit-jnl-abbrev">Radiology</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">212</span>:<span class="cit-fpage">793</span>–<span class="cit-lpage">98</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1148/radiology.212.3.r99se07793</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10478248</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiology.212.3.r99se07793&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10478248&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.5" data-doi="10.1002/ana.410360721"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Paty</span>  <span class="cit-name-given-names">DW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Li</span>  <span class="cit-name-given-names">DK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Oger</span>  <span class="cit-name-given-names">JJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Magnetic resonance imaging in the evaluation of clinical trials in multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Ann Neurol</abbr> <span class="cit-pub-date">1994</span>;<span class="cit-vol">36</span>(<span class="cit-supplement">suppl</span>):<span class="cit-fpage">S95</span>–<span class="cit-lpage">96</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/ana.410360721</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>8017896</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/ana.410360721&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=8017896&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">6.</span><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6. in text" id="ref-6">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.6" data-doi="10.1016/j.nic.2008.06.008"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Bermel</span>  <span class="cit-name-given-names">RA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fisher</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cohen</span>  <span class="cit-name-given-names">JA</span></span></li></ol><cite>. <span class="cit-article-title">The use of MR imaging as an outcome measure in multiple sclerosis clinical trials</span>. <abbr class="cit-jnl-abbrev">Neuroimaging Clin N Am</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">18</span>:<span class="cit-fpage">687</span>–<span class="cit-lpage">701</span>, <span class="cit-fpage">xi</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.nic.2008.06.008</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19068409</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.nic.2008.06.008&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19068409&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">7.</span><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7. in text" id="ref-7">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.7" data-doi="10.1093/brain/awh641"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Kutzelnigg</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lucchinetti</span>  <span class="cit-name-given-names">CF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stadelmann</span>  <span class="cit-name-given-names">C</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cortical demyelination and diffuse white matter injury in multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Brain</abbr> <span class="cit-pub-date">2005</span>;<span class="cit-vol">128</span>(<span class="cit-issue">pt 11</span>):<span class="cit-fpage">2705</span>–<span class="cit-lpage">12</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/brain/awh641</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16230320</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToiYnJhaW4iO3M6NToicmVzaWQiO3M6MTE6IjEyOC8xMS8yNzA1IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzM3LzIvMjU5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">8.</span><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8. in text" id="ref-8">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.8" data-doi="10.1056/NEJMoa1100648"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Lucchinetti</span>  <span class="cit-name-given-names">CF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Popescu</span>  <span class="cit-name-given-names">BF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bunyan</span>  <span class="cit-name-given-names">RF</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Inflammatory cortical demyelination in early multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">365</span>:<span class="cit-fpage">2188</span>–<span class="cit-lpage">97</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1056/NEJMoa1100648</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22150037</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1056/NEJMoa1100648&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22150037&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000297731400004&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">9.</span><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9. in text" id="ref-9">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.9" data-doi="10.1177/1352458509106510"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Calabrese</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gallo</span>  <span class="cit-name-given-names">P</span></span></li></ol><cite>. <span class="cit-article-title">Magnetic resonance evidence of cortical onset of multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Mult Scler</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">15</span>:<span class="cit-fpage">933</span>–<span class="cit-lpage">41</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1177/1352458509106510</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19667021</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToic3Btc2oiO3M6NToicmVzaWQiO3M6ODoiMTUvOC85MzMiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMzcvMi8yNTkuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">10.</span><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10. in text" id="ref-10">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.10" data-doi="10.1016/j.jns.2005.09.021"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Kutzelnigg</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lassmann</span>  <span class="cit-name-given-names">H</span></span></li></ol><cite>. <span class="cit-article-title">Cortical demyelination in multiple sclerosis: a substrate for cognitive deficits?</span> <abbr class="cit-jnl-abbrev">J Neurol Sci</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">245</span>:<span class="cit-fpage">123</span>–<span class="cit-lpage">26</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jns.2005.09.021</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16650874</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.jns.2005.09.021&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16650874&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000238462500021&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">11.</span><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11. in text" id="ref-11">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.11" data-doi="10.1212/WNL.0b013e3182a08ce8"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Nielsen</span>  <span class="cit-name-given-names">AS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kinkel</span>  <span class="cit-name-given-names">RP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Madigan</span>  <span class="cit-name-given-names">N</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS</span>. <abbr class="cit-jnl-abbrev">Neurology</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">81</span>:<span class="cit-fpage">641</span>–<span class="cit-lpage">49</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1212/WNL.0b013e3182a08ce8</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23864311</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6IjgxLzcvNjQxIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzM3LzIvMjU5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">12.</span><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12. in text" id="ref-12">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.12" data-doi="10.1093/brain/aws246"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Calabrese</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Poretto</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Favaretto</span>  <span class="cit-name-given-names">A</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cortical lesion load associates with progression of disability in multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Brain</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">135</span>:<span class="cit-fpage">2952</span>–<span class="cit-lpage">61</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/brain/aws246</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23065788</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToiYnJhaW4iO3M6NToicmVzaWQiO3M6MTE6IjEzNS8xMC8yOTUyIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzM3LzIvMjU5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">13.</span><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13. in text" id="ref-13">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.13" data-doi="10.1002/ana.23882"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Calabrese</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Romualdi</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Poretto</span>  <span class="cit-name-given-names">V</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">The changing clinical course of multiple sclerosis: a matter of gray matter</span>. <abbr class="cit-jnl-abbrev">Ann Neurol</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">74</span>:<span class="cit-fpage">76</span>–<span class="cit-lpage">83</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/ana.23882</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23494723</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/ana.23882&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23494723&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">14.</span><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14. in text" id="ref-14">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.14" data-doi="10.1259/0007-1285-67-804-1258"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Redpath</span>  <span class="cit-name-given-names">TW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Smith</span>  <span class="cit-name-given-names">FW</span></span></li></ol><cite>. <span class="cit-article-title">Technical note: use of a double inversion recovery pulse sequence to image selectively grey or white brain matter</span>. <abbr class="cit-jnl-abbrev">Br J Radiol</abbr> <span class="cit-pub-date">1994</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">1258</span>–<span class="cit-lpage">63</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1259/0007-1285-67-804-1258</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>7874427</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NzoiYmpyYWRpbyI7czo1OiJyZXNpZCI7czoxMToiNjcvODA0LzEyNTgiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMzcvMi8yNTkuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">15.</span><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15. in text" id="ref-15">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.15" data-doi="10.1212/WNL.0b013e31824528a0"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Seewann</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kooi</span>  <span class="cit-name-given-names">EJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Roosendaal</span>  <span class="cit-name-given-names">SD</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Postmortem verification of MS cortical lesion detection with 3D DIR</span>. <abbr class="cit-jnl-abbrev">Neurology</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">78</span>:<span class="cit-fpage">302</span>–<span class="cit-lpage">08</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1212/WNL.0b013e31824528a0</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22218278</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6Ijc4LzUvMzAyIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzM3LzIvMjU5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">16.</span><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16. in text" id="ref-16">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.16" data-doi="10.1177/1352458511406575"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Seewann</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vrenken</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kooi</span>  <span class="cit-name-given-names">EJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Imaging the tip of the iceberg: visualization of cortical lesions in multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Mult Scler</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">17</span>:<span class="cit-fpage">1202</span>–<span class="cit-lpage">10</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1177/1352458511406575</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21561955</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToic3Btc2oiO3M6NToicmVzaWQiO3M6MTA6IjE3LzEwLzEyMDIiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMzcvMi8yNTkuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">17.</span><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17. in text" id="ref-17">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.17" data-doi="10.3174/ajnr.A3289"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Kilsdonk</span>  <span class="cit-name-given-names">ID</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">de Graaf</span>  <span class="cit-name-given-names">WL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Soriano</span>  <span class="cit-name-given-names">AL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Multicontrast MR imaging at 7T in multiple sclerosis: highest lesion detection in cortical gray matter with 3D-FLAIR</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">34</span>:<span class="cit-fpage">791</span>–<span class="cit-lpage">96</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A3289</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23042930</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo4OiIzNC80Lzc5MSI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zNy8yLzI1OS5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">18.</span><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18. in text" id="ref-18">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.18" data-doi="10.1148/radiology.216.3.r00au46891"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Mugler</span>  <span class="cit-name-given-names">JP</span>  <span class="cit-name-suffix">3rd</span>.</span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bao</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mulkern</span>  <span class="cit-name-given-names">RV</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Optimized single-slab three-dimensional spin-echo MR imaging of the brain</span>. <abbr class="cit-jnl-abbrev">Radiology</abbr> <span class="cit-pub-date">2000</span>;<span class="cit-vol">216</span>:<span class="cit-fpage">891</span>–<span class="cit-lpage">99</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1148/radiology.216.3.r00au46891</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10966728</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiology.216.3.r00au46891&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10966728&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000088964900042&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">19.</span><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19. in text" id="ref-19">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.19" data-doi="10.1007/s00330-008-1009-7"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Moraal</span>  <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Roosendaal</span>  <span class="cit-name-given-names">SD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pouwels</span>  <span class="cit-name-given-names">PJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis</span>. <abbr class="cit-jnl-abbrev">Eur Radiol</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">18</span>:<span class="cit-fpage">2311</span>–<span class="cit-lpage">20</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s00330-008-1009-7</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18509658</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s00330-008-1009-7&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18509658&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000259141900034&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">20.</span><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20. in text" id="ref-20">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.20" data-doi="10.1016/S1053-8119(02)91132-8"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Jenkinson</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bannister</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brady</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Improved optimization for the robust and accurate linear registration and motion correction of brain images</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2002</span>;<span class="cit-vol">17</span>:<span class="cit-fpage">825</span>–<span class="cit-lpage">41</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1006/nimg.2002.1132</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12377157</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1053-8119(02)91132-8&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12377157&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000178642000027&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">21.</span><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21. in text" id="ref-21">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.21" data-doi="10.1016/S1361-8415(01)00036-6"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Jenkinson</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Smith</span>  <span class="cit-name-given-names">S</span></span></li></ol><cite>. <span class="cit-article-title">A global optimisation method for robust affine registration of brain images</span>. <abbr class="cit-jnl-abbrev">Med Image Anal</abbr> <span class="cit-pub-date">2001</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">143</span>–<span class="cit-lpage">56</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1361-8415(01)00036-6</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11516708</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1361-8415(01)00036-6&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11516708&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000169672400005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">22.</span><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22. in text" id="ref-22">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.22" data-doi="10.1118/1.596566"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Price</span>  <span class="cit-name-given-names">RR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Axel</span>  <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Morgan</span>  <span class="cit-name-given-names">T</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Quality assurance methods and phantoms for magnetic resonance imaging: report of AAPM nuclear magnetic resonance Task Group No. 1</span>. <abbr class="cit-jnl-abbrev">Med Phys</abbr> <span class="cit-pub-date">1990</span>;<span class="cit-vol">17</span>:<span class="cit-fpage">287</span>–<span class="cit-lpage">95</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1118/1.596566</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>2333055</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1118/1.596566&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=2333055&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">23.</span><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23. in text" id="ref-23">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.23" data-doi="10.1002/(SICI)1522-2594(199911)42:5&lt;952::AID-MRM16&gt;3.0.CO;2-S"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Pruessmann</span>  <span class="cit-name-given-names">KP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Weiger</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Scheidegger</span>  <span class="cit-name-given-names">MB</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">SENSE: sensitivity encoding for fast MRI</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">42</span>:<span class="cit-fpage">952</span>–<span class="cit-lpage">62</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10542355</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/(SICI)1522-2594(199911)42:5&lt;952::AID-MRM16&gt;3.0.CO;2-S&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10542355&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000083447900016&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">24.</span><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24. in text" id="ref-24">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.24" data-doi="10.1212/WNL.0b013e31820d8b1d"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Okuda</span>  <span class="cit-name-given-names">DT</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mowry</span>  <span class="cit-name-given-names">EM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cree</span>  <span class="cit-name-given-names">BA</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome</span>. <abbr class="cit-jnl-abbrev">Neurology</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">76</span>:<span class="cit-fpage">686</span>–<span class="cit-lpage">92</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1212/WNL.0b013e31820d8b1d</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21270417</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6Ijc2LzgvNjg2IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzM3LzIvMjU5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">25.</span><a class="rev-xref-ref" href="#xref-ref-25-1" title="View reference 25. in text" id="ref-25">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.25"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Bastianello</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bozzao</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Paolillo</span>  <span class="cit-name-given-names">A</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Fast spin-echo and fast fluid-attenuated inversion-recovery versus conventional spin-echo sequences for MR quantification of multiple sclerosis lesions</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">1997</span>;<span class="cit-vol">18</span>:<span class="cit-fpage">699</span>–<span class="cit-lpage">704</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9127033</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo4OiIxOC80LzY5OSI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zNy8yLzI1OS5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">26.</span><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26. in text" id="ref-26">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.26" data-doi="10.1016/j.neuroimage.2012.06.064"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Prasloski</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rauscher</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">MacKay</span>  <span class="cit-name-given-names">AL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">63</span>:<span class="cit-fpage">533</span>–<span class="cit-lpage">39</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2012.06.064</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22776448</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2012.06.064&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22776448&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">27.</span><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27. in text" id="ref-27">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.27"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Loevner</span>  <span class="cit-name-given-names">LA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Grossman</span>  <span class="cit-name-given-names">RI</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">McGowan</span>  <span class="cit-name-given-names">JC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Characterization of multiple sclerosis plaques with T1-weighted MR and quantitative magnetization transfer</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">1995</span>;<span class="cit-vol">16</span>:<span class="cit-fpage">1473</span>–<span class="cit-lpage">79</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>7484636</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo5OiIxNi83LzE0NzMiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvMzcvMi8yNTkuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span></span></a></div></div></li><li><span class="ref-label">28.</span><a class="rev-xref-ref" href="#xref-ref-28-1" title="View reference 28. in text" id="ref-28">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.28" data-doi="10.1148/radiology.204.1.9205259"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Reichenbach</span>  <span class="cit-name-given-names">JR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Venkatesan</span>  <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schillinger</span>  <span class="cit-name-given-names">DJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent</span>. <abbr class="cit-jnl-abbrev">Radiology</abbr> <span class="cit-pub-date">1997</span>;<span class="cit-vol">204</span>:<span class="cit-fpage">272</span>–<span class="cit-lpage">77</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1148/radiology.204.1.9205259</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9205259</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiology.204.1.9205259&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9205259&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1997XF19400050&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">29.</span><a class="rev-xref-ref" href="#xref-ref-29-1" title="View reference 29. in text" id="ref-29">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.29" data-doi="10.1002/mrm.20198"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Haacke</span>  <span class="cit-name-given-names">EM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Xu</span>  <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cheng</span>  <span class="cit-name-given-names">YC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Susceptibility weighted imaging (SWI)</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med</abbr> <span class="cit-pub-date">2004</span>;<span class="cit-vol">52</span>:<span class="cit-fpage">612</span>–<span class="cit-lpage">18</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/mrm.20198</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>15334582</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/mrm.20198&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15334582&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000223529200023&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">30.</span><a class="rev-xref-ref" href="#xref-ref-30-1" title="View reference 30. in text" id="ref-30">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.30" data-doi="10.1002/jmri.21995"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Denk</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rauscher</span>  <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Susceptibility weighted imaging with multiple echoes</span>. <abbr class="cit-jnl-abbrev">J Magn Reson Imaging</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">31</span>:<span class="cit-fpage">185</span>–<span class="cit-lpage">91</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/jmri.21995</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20027586</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/jmri.21995&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20027586&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">31.</span><a class="rev-xref-ref" href="#xref-ref-31-1" title="View reference 31. in text" id="ref-31">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.31" data-doi="10.1212/WNL.0b013e31829bfd63"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wiggermann</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hernández Torres</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vavasour</span>  <span class="cit-name-given-names">IM</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Magnetic resonance frequency shifts during acute MS lesion formation</span>. <abbr class="cit-jnl-abbrev">Neurology</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">81</span>:<span class="cit-fpage">211</span>–<span class="cit-lpage">18</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1212/WNL.0b013e31829bfd63</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23761621</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6IjgxLzMvMjExIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzM3LzIvMjU5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">32.</span><a class="rev-xref-ref" href="#xref-ref-32-1" title="View reference 32. in text" id="ref-32">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.32" data-doi="10.1148/radiol.13130474"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Walsh</span>  <span class="cit-name-given-names">AJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Blevins</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lebel</span>  <span class="cit-name-given-names">RM</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Longitudinal MR imaging of iron in multiple sclerosis: an imaging marker of disease</span>. <abbr class="cit-jnl-abbrev">Radiology</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">270</span>:<span class="cit-fpage">186</span>–<span class="cit-lpage">96</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1148/radiol.13130474</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23925273</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiol.13130474&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23925273&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">33.</span><a class="rev-xref-ref" href="#xref-ref-33-1" title="View reference 33. in text" id="ref-33">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.33" data-doi="10.1002/jmri.22452"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Grabner</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Dal-Bianco</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schernthaner</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Analysis of multiple sclerosis lesions using a fusion of 3.0 T FLAIR and 7.0 T SWI phase: FLAIR SWI</span>. <abbr class="cit-jnl-abbrev">J Magn Reson Imaging</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">33</span>:<span class="cit-fpage">543</span>–<span class="cit-lpage">49</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/jmri.22452</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21563237</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/jmri.22452&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21563237&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">34.</span><a class="rev-xref-ref" href="#xref-ref-34-1" title="View reference 34. in text" id="ref-34">↵</a><div class="cit ref-cit ref-journal" id="cit-37.2.259.34" data-doi="10.1148/radiol.12120208"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Sati</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">George</span>  <span class="cit-name-given-names">IC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shea</span>  <span class="cit-name-given-names">CD</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">FLAIR*: a combined MR contrast technique for visualizing white matter lesions and parenchymal veins</span>. <abbr class="cit-jnl-abbrev">Radiology</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">265</span>:<span class="cit-fpage">926</span>–<span class="cit-lpage">32</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1148/radiol.12120208</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23074257</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1148/radiol.12120208&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23074257&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F2%2F259.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000311420300031&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li></ol></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 37</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 2 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Feb 2016 </div></div>
      
      
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      <div class="highwire-cite-title">FLAIR<sup>2</sup>: A Combination of FLAIR and T2 for Improved MS Lesion Detection</div>  
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      <div class="highwire-cite-title">FLAIR<sup>2</sup>: A Combination of FLAIR and T2 for Improved MS Lesion Detection</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Wiggermann</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Hernández-Torres</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Traboulsee</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.K.B.</span> <span class="nlm-surname">Li</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Rauscher</span></span></span></div>
  
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