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    Treatment of Unruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: Primum Non Nocere | American Journal of Neuroradiology  
    



















    

































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Article Commentary

  
      

  
      
Treatment of Unruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: Primum Non Nocere
  
    	
M. Niemczyk

  
    	
American Journal of Neuroradiology February 2016,  37 (2) 294-295; DOI: https://doi.org/10.3174/ajnr.A4538 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
Autosomal dominant polycystic kidney disease (ADPKD) belongs to the most common genetic disorders, with approximately 12.5 million individuals involved worldwide. The disease is a well-known risk factor for intracranial aneurysms (IAs).1 The rupture of an IA is associated with a high risk of serious complications or death,2,3 yet universal screening for IAs in ADPKD remains controversial. It is mainly due to the potential risk connected to pre-emptive treatment of IAs and the cost of screening.4
Indeed, according to the study of Rozenfeld et al,5 patients with ADPKD have an increased risk for complications during treatment of unruptured IAs compared with the general population. The difference in the complication rate between patients with and without ADPKD is especially striking in cases of endovascular coiling. Most probably, it is attributable to ADPKD-specific, ciliopathy-related, dysfunction of the vascular wall, which is nota bene the main pathomechanism of vascular manifestations of ADPKD, including aneurysm formation, hypertension, and others.6
However, quitting or reducing screening for IAs is not a solution because screening potentially leads to the protection of life or health of numerous relatively young people; the average age at IA rupture in ADPKD is approximately 40 years, and the risk of death or persistent disability after the rupture is estimated to be almost 50%.2,7 On the other hand, most IAs detected by screening are small; thus, the risk for their rupture is low.8 Additionally, the risk for progression of IAs in ADPKD is quite low and comparable with that in the general population.9,10 Therefore, the key issue is to make decisions on treatment only in patients with substantial risk for IA rupture; in most patients with ADPKD and IA, watchful surveillance is required rather than treatment.
The problem is that the rupture-risk assessment is still challenging. Current treatment guidelines are similar in patients with and without ADPKD.11 However, due to the differences in pathogenesis and clinical characteristics between IAs in ADPKD and the general population, IAs in ADPKD may be considered a distinct clinical entity. Therefore, treatment rules applicable for the general population may not be fully appropriate in ADPKD. There is effort to improve the assessment of risk for IA progression and rupture with clinical and radiographic features12 and a molecular biology approach.13,14 However, these new risk factors have to be tested in the ADPKD population to verify their utility in this particular group.
Until now, data on risk factors for IA rupture in ADPKD are limited. According to Ring and Spiegelhalter,15 IA rupture tends to cluster in ADPKD families, which strongly suggests a role of genetic factors, which, however, still need to be identified. Among clinical features, headache was recently proposed as a factor predictive for IA rupture.16 Most surprising, headache was previously not even considered as an indication for screening for IAs in ADPKD.17
In summary, considering the relatively low risk for rupture in most IAs in patients with ADPKD and the increased risk of complications connected to their treatment, the treatment decisions must always be cautious and individualized. Additionally, effort should be made to improve the assessment of the IA rupture risk, including searching for ADPKD-specific risk factors.
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Treatment of Unruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: Primum Non Nocere
  
    	
M. Niemczyk

  
    	
American Journal of Neuroradiology Feb 2016, 37 (2) 294-295; DOI: 10.3174/ajnr.A4538 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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